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公开(公告)号：WO2002085522A1
公开(公告)日：2002-10-31
申请号：PCT/US2002/015034
申请日：2002-04-18
Applicant: NANOSTREAM, INC. , KARP, Christoph, D. , PEZZUTO, Marci , MARESCH, Laird , O'CONNOR, Stephen, D.
Inventor： KARP, Christoph, D. , PEZZUTO, Marci , MARESCH, Laird , O'CONNOR, Stephen, D.
IPC: B01L3/00
CPC classification number: F04B43/043 , B01L3/502738 , B01L2300/0681 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2400/0481 , B01L2400/0622 , B01L2400/0638 , B01L2400/084 , F16K99/0001 , F16K99/0007 , F16K99/003 , F16K99/0057 , F16K2099/008 , F16K2099/0084 , F16K2099/0094
Abstract: A microfluidic flow control device (32) includes a moveable flap (30) capable of intermittently engaging a sealing surface(21A). One-way or check valve utility may be provided. Multiple valves may be coupled to various fluid displacement means to provide pumping utility. Devices may be constructed with stencil layers from various materials, including polymeric materials, adhesive tapes, and/or filter materials. Flow control devices may be passively activated by fluidic contents or by external actuation means.
Abstract translation: 微流体流量控制装置（32）包括能够间歇地接合密封表面（21A）的可移动翼片（30）。 可以提供单向或单向阀实用程序。 多个阀可以联接到各种流体移动装置以提供泵送效用。 装置可以用来自各种材料的模板层构造，包括聚合材料，胶带和/或过滤材料。 流量控制装置可以被流体内容物或外部致动装置被动地激活。
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公开(公告)号：WO0178893A9
公开(公告)日：2002-07-04
申请号：PCT/US0112244
申请日：2001-04-13
Applicant: NANOSTREAM INC , O'CONNOR STEPHEN D , DANTSKER GENE , PEZZUTO MARCI
Inventor： O'CONNOR STEPHEN D , DANTSKER GENE , PEZZUTO MARCI
IPC: G01N37/00 , B01J19/00 , B01L3/00 , B81B1/00 , B81C1/00 , F15C1/02 , F15C5/00 , F15D1/02 , F16K99/00
CPC classification number: B01L3/502738 , B01L3/502746 , B01L2200/0605 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , B01L2400/0688 , F15C1/02 , F15D1/02 , F16K99/0001 , F16K99/0017 , F16K99/0028 , F16K99/0049 , F16K99/0055 , F16K99/0057 , F16K2099/008 , Y10T137/0491 , Y10T137/2191 , Y10T137/2224 , Y10T137/598 , Y10T137/8242 , Y10T137/86035
Abstract: The invention provides microfluidic devices with embedded fluidic impedances. Such impedancesdo not allow fluid to pass at a low differential pressure, but allow fluid to flow at a higher differential pressure. Impedances are formed by the three dimensional overlap of two or more channels contained within layers of the device. Such devices can be rapidly protyped and can be assembled to contain multiple fluidic impedances to perform complex fluid handling tasks, including metering defined volumes of samples and dividing samples into aliquots.
Abstract translation: 本发明提供具有嵌入式流体阻抗的微流体装置。 这种阻抗不允许流体在低压差下通过，而是允许流体以较高的压差流动。 通过包含在器件的层内的两个或更多个沟道的三维重叠形成阻抗。 这样的装置可以快速制成并且可以被组装成包含多个流体阻抗以执行复杂的流体处理任务，包括计量定义的体积的样品并将样品分成等分试样。
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公开(公告)号：WO02083310A8
公开(公告)日：2003-05-01
申请号：PCT/US0131790
申请日：2001-10-12
Applicant: NANOSTREAM INC , O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
Inventor： O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
CPC classification number: G01N35/08 , B01J2219/00315 , B01L3/0241 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , C40B60/14
Abstract: Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.
Abstract translation: 提供了能够计量流体流量的微流体装置。 描述了流体塞的中继分支计量的装置和方法，其中从体积流体计量一个或多个限定体积的分支通道。 还描述了通过选择第一和第二流体对微流体通道的供应条件来测量至少一个离散塞。 第一流体可以是液体，第二流体是气体。 提供减小区域通道段以帮助计量一个或多个离散流体塞。 在另一方面，通过用流体填充微流体室，密封入口通道，然后提取流体来计量微流体体积。
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Patent Agency Ranking
公开(公告)号：WO0230560A3
公开(公告)日：2003-01-16
申请号：PCT/US0131563
申请日：2001-10-11
Applicant: NANOSTREAM INC , O'CONNOR STEPHEN D , DANTSKER EUGENE , KARP CHRISTOPH D , PEZZUTO MARCI
Inventor： O'CONNOR STEPHEN D , DANTSKER EUGENE , KARP CHRISTOPH D , PEZZUTO MARCI
CPC classification number: B01L3/5027 , B01L3/502707 , B01L2200/027 , B01L2300/0887 , B01L2400/0487 , G01N35/10 , G01N2035/00326 , Y10T137/2224
Abstract: A modular microfluidic system including a plurality of discrete microfluidic modules and at least one microfluidic coupling device for communicating fluid between the modules is described. The microfluidic modules and coupling devices may be constructed according to various techniques. Each coupling device is fabricated from multiple layers and includes a fluidic inlet port, a fluidic outlet port, and at least one sandwiched stencil layer having a microfluidic channel formed therein. Also described are integrated microfluidic systems capable of performing various functions.
Abstract translation: 描述了包括多个离散微流体模块和用于在模块之间连通流体的至少一个微流体耦合装置的模块化微流体系统。 微流体模块和耦合装置可以根据各种技术构造。 每个联接装置由多个层制成并且包括流体入口端口，流体出口端口以及在其中形成有微流体通道的至少一个夹层模板层。 还描述了能够执行各种功能的集成微流体系统。
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公开(公告)号：WO2002086332A1
公开(公告)日：2002-10-31
申请号：PCT/US2001/031825
申请日：2001-10-12
Applicant: NANOSTREAM, INC. , PEZZUTO, Marci , O'CONNOR, Stephen, D.
Inventor： PEZZUTO, Marci , O'CONNOR, Stephen, D.
IPC: F15C5/00
CPC classification number: F16K99/0025 , B01L3/502707 , B01L3/502738 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2400/0418 , B01L2400/0487 , B01L2400/0688 , B01L2400/084 , F16K99/0001 , F16K99/0028 , F16K99/0036 , F16K99/0057 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , Y10T137/0318 , Y10T137/206 , Y10T137/2196 , Y10T137/2224
Abstract: Microfluidic devices having porous materials that impede or restrict the passage of fluid for a given pressure are provided. Such devices may serve as valves, and multiple valves having different impedance characteristics may be constructed in a single device to control the overall direction of fluid flow. Impedance regions may be constructed in various ways, such as, for example: by inserting porous materials into or between channels; by sandwiching a sheet or layer of porous material (181, 182) between other layers of the device (180, 183) (preferably in stencil form); or by adding a liquid, solution, slurry, or suspension into microfluidic channels, and then permitting the formation of porous deposits. Various types of adhesive tape may be used for one or more layers of the device.
Abstract translation: 提供了具有妨碍或限制给定压力下的流体通过的多孔材料的微流体装置。 这样的装置可以用作阀，并且可以在单个装置中构造具有不同阻抗特性的多个阀，以控制流体流动的总体方向。 阻抗区域可以以各种方式构造，例如：通过将多孔材料插入通道之间或通道之间; 通过在设备（180,183）的其它层（优选以模板形式）之间夹住多孔材料（181,182）的片材或层。 或通过将液体，溶液，浆液或悬浮液加入到微流体通道中，然后允许形成多孔沉积物。 各种类型的胶带可用于该装置的一层或多层。
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公开(公告)号：WO2002083310A3
公开(公告)日：2002-10-24
申请号：PCT/US2001/031790
申请日：2001-10-12
Applicant: NANOSTREAM, INC. , O'CONNOR, Stephen, D. , KARP, Christoph, D. , PEZZUTO, Marci , DANTSKER, Eugene
Inventor： O'CONNOR, Stephen, D. , KARP, Christoph, D. , PEZZUTO, Marci , DANTSKER, Eugene
IPC: B01L3/00
Abstract: Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.
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公开(公告)号：WO02083310A2
公开(公告)日：2002-10-24
申请号：PCT/US0131790
申请日：2001-10-12
Applicant: NANOSTREAM INC , O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
Inventor： O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
CPC classification number: G01N35/08 , B01J2219/00315 , B01L3/0241 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , C40B60/14
Abstract: Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.
Abstract translation: 提供了能够计量流体流量的微流体装置。 描述了流体塞的中继分支计量的装置和方法，其中从体积流体计量一个或多个限定体积的分支通道。 还描述了通过选择第一和第二流体对微流体通道的供应条件来测量至少一个离散塞。 第一流体可以是液体，第二流体是气体。 提供减小区域通道段以帮助计量一个或多个离散流体塞。 在另一方面，通过用流体填充微流体室，密封入口通道，然后提取流体来计量微流体体积。
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公开(公告)号：WO0178893A2
公开(公告)日：2001-10-25
申请号：PCT/US0112244
申请日：2001-04-13
Applicant: NANOSTREAM INC , CONNOR STEPHEN D O , DANTSKER GENE , PEZZUTO MARCI
Inventor： O'CONNOR STEPHEN D , DANTSKER GENE , PEZZUTO MARCI
IPC: G01N37/00 , B01J19/00 , B01L3/00 , B81B1/00 , B81C1/00 , F15C1/02 , F15C5/00 , F15D1/02 , F16K99/00 , B01L
CPC classification number: B01L3/502738 , B01L3/502746 , B01L2200/0605 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , B01L2400/0688 , F15C1/02 , F15D1/02 , F16K99/0001 , F16K99/0017 , F16K99/0028 , F16K99/0049 , F16K99/0055 , F16K99/0057 , F16K2099/008 , Y10T137/0491 , Y10T137/2191 , Y10T137/2224 , Y10T137/598 , Y10T137/8242 , Y10T137/86035
Abstract: The invention provides microfluidic devices with embedded fluidic impedances. Such impedancesdo not allow fluid to pass at a low differential pressure, but allow fluid to flow at a higher differential pressure. Impedances are formed by the three dimensional overlap of two or more channels contained within layers of the device. Such devices can be rapidly protyped and can be assembled to contain multiple fluidic impedances to perform complex fluid handling tasks, including metering defined volumes of samples and dividing samples into aliquots.
Abstract translation: 本发明提供具有嵌入式流体阻抗的微流体装置。 这种阻抗不允许流体在低压差下通过，而是允许流体以较高的压差流动。 通过包含在器件的层内的两个或更多个沟道的三维重叠形成阻抗。 这样的装置可以快速制成并且可以被组装成包含多个流体阻抗以执行复杂的流体处理任务，包括计量定义的体积的样品并将样品分成等分试样。
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