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公开(公告)号：WO02094441A3
公开(公告)日：2003-04-10
申请号：PCT/US0218357
申请日：2002-05-14
Applicant: NANOSTREAM INC , KARP CHRISTOPH D , GUSTAFSON VINCENT K , O'CONNOR STEPHEN D , HOBBS STEVEN E
Inventor： KARP CHRISTOPH D , GUSTAFSON VINCENT K , O'CONNOR STEPHEN D , HOBBS STEVEN E
CPC classification number: B01L3/0217 , B01L3/5027 , B01L3/502707 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , G01N2035/1062 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/2575
Abstract: A fluidic system includes a vessel 250 having at least one nonplanar wall 253 defining a first aperture 252 therein and a microfluidic device having a port 220, wherein at least a portion of the microfluidic device 200 conforms to at least a portion of the nonplanar wall 253, with the port being co-located with the aperture 252to fluidically couple the device to the vessel. Various embodiments are directed to coupling microfluidic devices with syringes, vials, and pipes. Microfluidic devices may be fabricated constructed with stencil layers. Flexible materials are preferred, including materials having one or self-adhesive surfaces including adhesive tapes. Certain embodiments provide continuously wrapped, rewindable, and/or detachable microfluidic devices.
Abstract translation: 流体系统包括容器250，容器250具有至少一个在其中限定第一孔252的非平面壁253和具有端口220的微流体装置，其中微流体装置200的至少一部分符合非平面壁253的至少一部分 ，其中端口与孔252共同定位，以将装置流体地耦合到容器。 各种实施例涉及将微流体装置与注射器，小瓶和管道连接。 微流体装置可以用模板层制造。 柔性材料是优选的，包括具有一个或自粘表面的材料，包括胶带。 某些实施例提供连续包裹的，可重新缠绕的和/或可拆卸的微流体装置。
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公开(公告)号：WO02055198A3
公开(公告)日：2003-03-13
申请号：PCT/US0142981
申请日：2001-11-06
Applicant: NANOSTREAM INC , O'CONNOR STEPHEN D , KARP CHRISTOPH D , DANTSKER EUGENE
Inventor： O'CONNOR STEPHEN D , KARP CHRISTOPH D , DANTSKER EUGENE
CPC classification number: B01L3/5025 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0689 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0622 , B01L2400/0638 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K99/0028 , F16K99/0044 , F16K99/0046 , F16K99/0051 , F16K99/0055 , F16K99/0059 , F16K99/0061 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , Y10T137/2496 , Y10T137/2559 , Y10T137/2663 , Y10T137/87249
Abstract: Various microfluidic flow control devices are provided. In one embodiment, a regulating device includes overlapping channel segments (139,143) separated by a deformable membrane (133) in fluid communication with one another. In another embodiment, a normally open microfluidic valve provides latching valve operation with at least one adhesive surface. A stencil-based microfluidic valve may be operated by deforming a membrane against a seating surface to prevent flow through an aperture. Configurable microfluidic devices permit flow control among an interconnected microfluidic channel network. Magnetic elements may be integrated into flexible membranes to provide magnetically actuated microfluidic flow control device.
Abstract translation: 提供各种微流控流量控制装置。 在一个实施例中，调节装置包括由可变形膜（133）分开的彼此流体连通的重叠通道段（139,143）。 在另一个实施例中，常开微流体阀提供至少一个粘合剂表面的闭锁操作。 基于模板的微流体阀可以通过使膜抵靠阀座表面变形来防止流过孔。 可配置的微流体装置允许在互连的微流体通道网络之间进行流量控制。 磁性元件可以集成到柔性膜中以提供磁致动微流体流量控制装置。
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公开(公告)号：WO2002085522A1
公开(公告)日：2002-10-31
申请号：PCT/US2002/015034
申请日：2002-04-18
Applicant: NANOSTREAM, INC. , KARP, Christoph, D. , PEZZUTO, Marci , MARESCH, Laird , O'CONNOR, Stephen, D.
Inventor： KARP, Christoph, D. , PEZZUTO, Marci , MARESCH, Laird , O'CONNOR, Stephen, D.
IPC: B01L3/00
CPC classification number: F04B43/043 , B01L3/502738 , B01L2300/0681 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2400/0481 , B01L2400/0622 , B01L2400/0638 , B01L2400/084 , F16K99/0001 , F16K99/0007 , F16K99/003 , F16K99/0057 , F16K2099/008 , F16K2099/0084 , F16K2099/0094
Abstract: A microfluidic flow control device (32) includes a moveable flap (30) capable of intermittently engaging a sealing surface(21A). One-way or check valve utility may be provided. Multiple valves may be coupled to various fluid displacement means to provide pumping utility. Devices may be constructed with stencil layers from various materials, including polymeric materials, adhesive tapes, and/or filter materials. Flow control devices may be passively activated by fluidic contents or by external actuation means.
Abstract translation: 微流体流量控制装置（32）包括能够间歇地接合密封表面（21A）的可移动翼片（30）。 可以提供单向或单向阀实用程序。 多个阀可以联接到各种流体移动装置以提供泵送效用。 装置可以用来自各种材料的模板层构造，包括聚合材料，胶带和/或过滤材料。 流量控制装置可以被流体内容物或外部致动装置被动地激活。
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公开(公告)号：WO02083310A8
公开(公告)日：2003-05-01
申请号：PCT/US0131790
申请日：2001-10-12
Applicant: NANOSTREAM INC , O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
Inventor： O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
CPC classification number: G01N35/08 , B01J2219/00315 , B01L3/0241 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , C40B60/14
Abstract: Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.
Abstract translation: 提供了能够计量流体流量的微流体装置。 描述了流体塞的中继分支计量的装置和方法，其中从体积流体计量一个或多个限定体积的分支通道。 还描述了通过选择第一和第二流体对微流体通道的供应条件来测量至少一个离散塞。 第一流体可以是液体，第二流体是气体。 提供减小区域通道段以帮助计量一个或多个离散流体塞。 在另一方面，通过用流体填充微流体室，密封入口通道，然后提取流体来计量微流体体积。
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公开(公告)号：WO0230560A3
公开(公告)日：2003-01-16
申请号：PCT/US0131563
申请日：2001-10-11
Applicant: NANOSTREAM INC , O'CONNOR STEPHEN D , DANTSKER EUGENE , KARP CHRISTOPH D , PEZZUTO MARCI
Inventor： O'CONNOR STEPHEN D , DANTSKER EUGENE , KARP CHRISTOPH D , PEZZUTO MARCI
CPC classification number: B01L3/5027 , B01L3/502707 , B01L2200/027 , B01L2300/0887 , B01L2400/0487 , G01N35/10 , G01N2035/00326 , Y10T137/2224
Abstract: A modular microfluidic system including a plurality of discrete microfluidic modules and at least one microfluidic coupling device for communicating fluid between the modules is described. The microfluidic modules and coupling devices may be constructed according to various techniques. Each coupling device is fabricated from multiple layers and includes a fluidic inlet port, a fluidic outlet port, and at least one sandwiched stencil layer having a microfluidic channel formed therein. Also described are integrated microfluidic systems capable of performing various functions.
Abstract translation: 描述了包括多个离散微流体模块和用于在模块之间连通流体的至少一个微流体耦合装置的模块化微流体系统。 微流体模块和耦合装置可以根据各种技术构造。 每个联接装置由多个层制成并且包括流体入口端口，流体出口端口以及在其中形成有微流体通道的至少一个夹层模板层。 还描述了能够执行各种功能的集成微流体系统。
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Patent Agency Ranking
公开(公告)号：WO2002083310A3
公开(公告)日：2002-10-24
申请号：PCT/US2001/031790
申请日：2001-10-12
Applicant: NANOSTREAM, INC. , O'CONNOR, Stephen, D. , KARP, Christoph, D. , PEZZUTO, Marci , DANTSKER, Eugene
Inventor： O'CONNOR, Stephen, D. , KARP, Christoph, D. , PEZZUTO, Marci , DANTSKER, Eugene
IPC: B01L3/00
Abstract: Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.
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公开(公告)号：WO02083310A2
公开(公告)日：2002-10-24
申请号：PCT/US0131790
申请日：2001-10-12
Applicant: NANOSTREAM INC , O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
Inventor： O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
CPC classification number: G01N35/08 , B01J2219/00315 , B01L3/0241 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , C40B60/14
Abstract: Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.
Abstract translation: 提供了能够计量流体流量的微流体装置。 描述了流体塞的中继分支计量的装置和方法，其中从体积流体计量一个或多个限定体积的分支通道。 还描述了通过选择第一和第二流体对微流体通道的供应条件来测量至少一个离散塞。 第一流体可以是液体，第二流体是气体。 提供减小区域通道段以帮助计量一个或多个离散流体塞。 在另一方面，通过用流体填充微流体室，密封入口通道，然后提取流体来计量微流体体积。
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公开(公告)号：WO2002094441A2
公开(公告)日：2002-11-28
申请号：PCT/US2002/018357
申请日：2002-05-14
Applicant: NANOSTREAM, INC. , KARP, Christoph, D. , GUSTAFSON, Vincent, K. , O'CONNOR, Stephen, D. , HOBBS, Steven, E.
IPC: B01L3/00
CPC classification number: B01L3/0217 , B01L3/5027 , B01L3/502707 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , G01N2035/1062 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/2575
Abstract: A fluidic system includes a vessel having at least one nonplanar wall defining a first aperture therein and a microfluidic device having a port, wherein at least a portion of the microfluidic device conforms to at least a portion of the nonplanar wall, with the port being co-located with the aperture to fluidically couple the device to the vessel. Various embodiments are directed to coupling microfluidic devices with syringes, vials, and pipes. Microfluidic devices may be fabricated constructed with stencil layers. Flexible materials are preferred, including materials having one or self-adhesive surfaces including adhesive tapes. Certain embodiments provide continuously wrapped, rewindable, and/or detachable microfluidic devices.
Abstract translation: 流体系统包括容器250，容器250具有至少一个在其中限定第一孔252的非平面壁253和具有端口220的微流体装置，其中微流体装置200的至少一部分符合非平面壁253的至少一部分 ，其中端口与孔252共同定位，以将装置流体地耦合到容器。 各种实施例涉及将微流体装置与注射器，小瓶和管道连接。 微流体装置可以用模板层制造。 柔性材料是优选的，包括具有一个或自粘表面的材料，包括胶带。 某些实施例提供连续包裹的，可重新缠绕的和/或可拆卸的微流体装置。
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公开(公告)号：WO2002014926A3
公开(公告)日：2002-02-21
申请号：PCT/US2001/025664
申请日：2001-08-15
Applicant: NANOSTREAM, INC. , O'CONNOR, Stephen, D. , DANTSKER, Eugene , KARP, Christoph D.
Inventor： O'CONNOR, Stephen, D. , DANTSKER, Eugene , KARP, Christoph D.
IPC: G02B26/02
Abstract: Fluidic systems, including microfluidic systems, are used to manipulate light by light-fluid interaction so as to affect reflection, refraction, absorption, optical filtering, or scattering of the beam. One or more fluids may be provided to a channel or chamber and exposed to an incident beam, and the proportion of at least one of a plurality of fluids may be varied. Light may interact with a discrete fluid plug subject to movement within a channel. One or more flexible members may be employed, such as to provide a variable lens. Fluidic optical devices may be used in applications including optical switching, optical filtering, or optical processing. Multiplexed fluidic optical systems are further provided.
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公开(公告)号：WO0214926A2
公开(公告)日：2002-02-21
申请号：PCT/US0125664
申请日：2001-08-15
Applicant: NANOSTREAM INC , KARP CHRISTOPH D , CONNOR STEPHEN D O , DANTSKER EUGENE
Inventor： O'CONNOR STEPHEN D , DANTSKER EUGENE
CPC classification number: G02B5/24 , G02B1/06 , G02B3/14 , G02B6/266 , G02B6/3512 , G02B6/3522 , G02B6/353 , G02B6/3538 , G02B6/3546 , G02B6/3574 , G02B26/005
Abstract: Fluidic systems, including microfluidic systems, are used to manipulate light by light-fluid interaction so as to affect reflection, refraction, absorption, optical filtering, or scattering of the beam. One or more fluids may be provided to a channel or chamber and exposed to an incident beam, and the proportion of at least one of a plurality of fluids may be varied. Light may interact with a discrete fluid plug subject to movement within a channel. One or more flexible members may be employed, such as to provide a variable lens. Fluidic optical devices may be used in applications including optical switching, optical filtering, or optical processing. Multiplexed fluidic optical systems are further provided.
Abstract translation: 流体系统，包括微流体系统，用于通过光 - 流体相互作用来操纵光，以便影响光束的反射，折射，吸收，光学滤波或散射。 可以将一种或多种流体提供到通道或室并且暴露于入射光束，并且多个流体中的至少一个流体的比例可以变化。 光可以与通道内移动的离散流体插塞相互作用。 可以采用一个或多个柔性构件，例如提供可变透镜。 流体光学器件可以用于包括光学开关，光学滤波或光学处理的应用中。 还提供多路复用的流体光学系统。
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