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    TARGETED FUSION PROTEINS AND METHODS FOR THE CHARACTERIZATION OF CELLULAR MEMBRANE DOMAINS
    3.
    发明申请
    TARGETED FUSION PROTEINS AND METHODS FOR THE CHARACTERIZATION OF CELLULAR MEMBRANE DOMAINS 审中-公开
    有针对性的融合蛋白和细胞膜结构域特征的方法

    公开(公告)号：WO2003006606A2

    公开(公告)日：2003-01-23

    申请号：PCT/US2002/021495

    申请日：2002-07-09

    申请人： OKLAHOMA MEDICAL RESEARCH FOUNDATION ,  RODGERS, William

    发明人： RODGERS, William

    IPC分类号： C12N

    CPC分类号： C12N9/1205 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/033 ,  C07K2319/60 ,  G01N33/5041 ,  G01N33/92

    摘要： Cell membranes containing glycolipid-enriched membrane (GEM) and non-glycolipid-enriched membrane (non-GEM) domains are targeted using fusion proteins that are anchored in the cell membrane. Fusion proteins to target GEM (or non-GEM) domains are comprised of a selected fluorescent polypeptide, a membrane-targeting sequence of p56 lck (or pp60 c-Src for non GEM domains) and a linker inserted between the polypeptide and the membrane targeting sequence. Localization of fusion proteins in GEM and non-GEM domains is assessed using techniques including confocal microscopy, fluorescence-based techniques, and membrane fractionation. Using these techniques, compounds are screened for their effect on GEM and non-GEM domains of live cells. These fusion proteins therefore represent useful tools for studying subcellular trafficking and the function of discrete compartments in the plasma membrane.

    摘要翻译： 含有富含脂肪糖的膜（GEM）和非糖脂富集膜（非GEM）结构域的细胞膜使用锚定在细胞膜中的融合蛋白进行靶向。 靶向GEM（或非GEM）结构域的融合蛋白由选择的荧光多肽，p56 的膜靶向序列（或非GEM结构域的pp60 ）和插入多肽 和膜靶向序列。 使用包括共焦显微镜，基于荧光的技术和膜分级技术的技术来评估GEM和非GEM结构域中融合蛋白的定位。 使用这些技术，筛选化合物对活细胞的GEM和非GEM结构域的影响。 因此，这些融合蛋白是用于研究亚细胞运输和质膜中离散隔室功能的有用工具。

    COUNTER-FLOW LIQUID CLARIFIER
    6.
    发明申请
    COUNTER-FLOW LIQUID CLARIFIER 审中-公开
    逆流液体澄清器

    公开(公告)号：WO1997034677A1

    公开(公告)日：1997-09-25

    申请号：PCT/AU1997000159

    申请日：1997-03-12

    申请人： RODGERS, William

    IPC分类号： B01D21/26

    CPC分类号： B03D3/06 ,  B01D17/00 ,  B01D17/0205 ,  B01D17/0208 ,  B01D17/0214 ,  B01D17/0217 ,  B01D17/041 ,  B01D17/047 ,  B01D17/08 ,  B01D17/12 ,  B01D21/0003 ,  B01D21/0012 ,  B01D21/0027 ,  B01D21/01 ,  B01D21/08 ,  B01D21/2411 ,  B01D21/2433 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/2461 ,  B01D21/2488 ,  B01D21/2494 ,  B01D21/26 ,  B01D21/267 ,  B01D21/30 ,  B01D21/305 ,  B01D21/32 ,  B01D21/34 ,  B03D1/028 ,  B03D1/1418 ,  B03D1/1431 ,  B03D1/1468

    摘要： An apparatus for clarifying raw water containing suspended particulate matter comprises an upright conduit (1) with diameters increasing from an inlet for raw water at the top to an exit for clear water at the bottom. The inlet raw water is dosed with coagulant and/or flocculant and aerated with fine air bubbles before entry into the conduit. The bubbles become attached to flocs as they form in the upper part of the conduit. As the liquid descends in the conduit, the flaw velocity decreases enabling the flocs to float counter to the water stream and form a floating body within the conduit which functions as a filter medium. Clear water flows out of the conduit under an underflow weir and the outflowing clear water is raised by an exit duct to a level ensuring the duct remains full of water. Accumulated material is extracted from the bottom of the body through a co-axial discharge duct at a rate substantially equal to the rate of increase of fresh material from the influent raw water so that a steady state condition is achieved.

    摘要翻译： 用于澄清含有悬浮颗粒物质的原水的装置包括直径从顶部的原水入口到底部的清水的出口直径增加的直立导管（1）。 入口原水在凝结剂和/或絮凝剂中加入，并在进入管道之前用精细的气泡充气。 当气泡在导管的上部形成时，气泡变得附着在絮状物上。 当液体在管道中下降时，裂纹速度降低，使得絮凝物能够与水流相反地浮动，并在导管内形成用作过滤介质的浮体。 清澈的水在下溢堰下流出导管，流出的清水通过出口管道升高至确保管道保持充满水的水平。 累积材料通过同轴排放管道从主体的底部以与来自进水原水的新鲜物质的增加速率基本相等的速率提取，从而达到稳定状态。

    MIXING DRUM DRIVE RING
    9.
    发明申请
    MIXING DRUM DRIVE RING 审中-公开
    混合鼓驱动环

    公开(公告)号：WO2005018895B1

    公开(公告)日：2005-05-12

    申请号：PCT/US0325438

    申请日：2003-08-15

    申请人： MC NEILUS TRUCK & MFG INC ,  FAVCO COMPOSITE TECHNOLOGY US ,  FAVCO TRUCK MIXERS INTERNAT PT ,  COMPOSITE TECHNOLOGY R & D PTY ,  KHOURI ANTHONY JAMES ,  RODGERS WILLIAM ,  PIHKOVICH VADIM ,  CHRISTENSON RONALD E ,  DALY TED

    发明人： PIHKOVICH VADIM ,  CHRISTENSON RONALD E ,  DALY TED

    IPC分类号： B28C5/08 ,  B28C5/20 ,  B28C5/42 ,  B29C45/14 ,  B28C5/38

    CPC分类号： B28C5/0831 ,  B28C5/2054 ,  B28C5/421 ,  B28C5/4268 ,  B29C45/14

    摘要： A composite, heavy duty rotary concrete mixing drum (16) for coupling to a vehicle having a drivetrain (18) for rotating the drum (16) comprises a wall and a drive ring. The wall defines a first end of the drum and a second end of the drum. The drive ring (39) is coupled to the first end of the drum and includes a hub (108, 252) and a plurality of extensions (110, 254). The hub is operatively coupled to the drivetrain. The plurality of extensions (110, 254) extend outwardly from the hub (108, 252) into the wall of the drum. At least one of the extensions includes an aperture (121, 126) extending therethrough. Rotation of the hub by the second drivetrain causes rotation of the drum.

    摘要翻译： 一种用于联接到具有用于旋转滚筒（16）的传动系（18）的车辆的复合重型旋转混凝土搅拌筒（16）包括壁和驱动环。 该壁限定滚筒的第一端和滚筒的第二端。 所述驱动环（39）联接到所述滚筒的第一端并且包括轮毂（108,252）和多个延伸部（110,254）。 轮毂可操作地联接到动力传动系。 多个延伸部（110,254）从轮毂（108,252）向外延伸到滚筒的壁中。 延伸部中的至少一个包括延伸穿过其中的孔（121,126）。 轮毂由第二传动系的旋转引起滚筒旋转。