公开(公告)号：WO2004014871A8

公开(公告)日：2005-04-07

申请号：PCT/US0325191

申请日：2003-08-08

申请人： AMGEN INC ,  CHAKRABARTI PARTHA P ,  CHEN NING ,  DOHERTY ELIZABETH M ,  DOMINGUEZ CELIA ,  FALSEY JAMES RICHARD ,  FOTSH CHRISTOPHER H ,  HULME CHRISTOPHER ,  KATON JODIE ,  NIXEY THOMAS ,  NORMAN MARK H ,  OGNYANOV VASSIL I ,  PETTUS LIPING H ,  RZASA ROBERT MICHAEL ,  STEC MARKIAN ,  WANG HUI-LING ,  ZHU JIAWANG

发明人： CHKRABARTI PARTHA P ,  CHEN NING ,  DOHERTY ELIZABETH M ,  DOMINGUEZ CELIA ,  FALSEY JAMES RICHARD ,  FOTSH CHRISTOPHER H ,  HULME CHRISTOPHER ,  KATON JODIE ,  NIXEY THOMAS ,  NORMAN MARK H ,  OGNYANOV VASSIL I ,  PETTUS LIPING H ,  RZASA ROBERT MICHAEL ,  STEC MARKIAN ,  WANG HUI-LING ,  ZHU JIAWANG

IPC分类号： A61P29/00 ,  C07D209/08 ,  C07D209/12 ,  C07D209/42 ,  C07D209/48 ,  C07D213/26 ,  C07D213/64 ,  C07D213/643 ,  C07D213/74 ,  C07D213/75 ,  C07D215/22 ,  C07D215/227 ,  C07D215/38 ,  C07D217/04 ,  C07D231/40 ,  C07D231/56 ,  C07D233/38 ,  C07D239/42 ,  C07D239/90 ,  C07D241/42 ,  C07D263/56 ,  C07D265/36 ,  C07D277/62 ,  C07D277/82 ,  C07D307/79 ,  C07D319/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D239/34 ,  A61K31/4427 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  C07D239/38 ,  C07D401/14 ,  C07D405/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

CPC分类号： C07D231/40 ,  C07D209/08 ,  C07D209/12 ,  C07D209/42 ,  C07D209/48 ,  C07D213/26 ,  C07D213/643 ,  C07D213/74 ,  C07D213/75 ,  C07D215/227 ,  C07D215/38 ,  C07D217/04 ,  C07D231/56 ,  C07D233/38 ,  C07D239/42 ,  C07D239/90 ,  C07D241/42 ,  C07D263/56 ,  C07D265/36 ,  C07D277/62 ,  C07D277/82 ,  C07D307/79 ,  C07D319/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

摘要翻译： 具有通用结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般性头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，具有炎性成分的皮肤病，慢性炎症，炎性疼痛和相关的痛觉过敏和异常性疼痛，神经性疼痛和相关的痛觉过敏和异常性疼痛， 呼吸系统，泌尿生殖系统，胃肠或血管区域的伤害，伤口，烧伤，过敏性皮肤反应，瘙痒症，白癜风，一般性胃肠道疾病，躁狂症， G 牙周溃疡，十二指肠溃疡，腹泻，由坏死剂引起的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

公开(公告)号：WO2004014871A1

公开(公告)日：2004-02-19

申请号：PCT/US2003/025191

申请日：2003-08-08

申请人： AMGEN INC. ,  CHKRABARTI, Partha, P ,  CHEN, Ning ,  DOHERTY, Elisabeth, M. ,  DOMINGUEZ, Celia ,  FALSEY, James, Richard ,  FOTSH, Christopher, H. ,  HULME, Christopher ,  KATON, Jodie ,  NIXEY, Thomas ,  NORMAN, Mark, H. ,  OGNYANOV, Vassil, I. ,  PETTUS, Liping, H. ,  RZASA, Robert, Michael ,  STEC, Markian ,  WANG, Hui-Ling ,  ZHU, Jiawang

发明人： CHKRABARTI, Partha, P ,  CHEN, Ning ,  DOHERTY, Elisabeth, M. ,  DOMINGUEZ, Celia ,  FALSEY, James, Richard ,  FOTSH, Christopher, H. ,  HULME, Christopher ,  KATON, Jodie ,  NIXEY, Thomas ,  NORMAN, Mark, H. ,  OGNYANOV, Vassil, I. ,  PETTUS, Liping, H. ,  RZASA, Robert, Michael ,  STEC, Markian ,  WANG, Hui-Ling ,  ZHU, Jiawang

IPC分类号： C07D239/34

CPC分类号： C07D231/40 ,  C07D209/08 ,  C07D209/12 ,  C07D209/42 ,  C07D209/48 ,  C07D213/26 ,  C07D213/643 ,  C07D213/74 ,  C07D213/75 ,  C07D215/227 ,  C07D215/38 ,  C07D217/04 ,  C07D231/56 ,  C07D233/38 ,  C07D239/42 ,  C07D239/90 ,  C07D241/42 ,  C07D263/56 ,  C07D265/36 ,  C07D277/62 ,  C07D277/82 ,  C07D307/79 ,  C07D319/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

摘要翻译： 具有通用结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙齿疼痛，一般性头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，张力 头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，具有炎性成分的皮肤病，慢性炎症，炎性疼痛和相关的痛觉过敏和异常性疼痛，神经性疼痛和相关 痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经维持性疼痛，传入神经缺失综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸系统，泌尿生殖系统，胃肠或血管区域内脏运动障碍，伤口， 瘙痒症，白癜风，一般胃肠道 l溃疡，胃溃疡，十二指肠溃疡，腹泻，由坏死物质诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。