公开(公告)号：WO2009026546A2

公开(公告)日：2009-02-26

申请号：PCT/US2008/074075

申请日：2008-08-22

Applicant: APPLIED BIOSYSTEMS INC. ,  GREINER, Douglas ,  STUART, Jeremy ,  TAING, Meng ,  MENCHEN, Steven, M.

Inventor： GREINER, Douglas ,  STUART, Jeremy ,  TAING, Meng ,  MENCHEN, Steven, M.

IPC: C40B40/04 ,  C40B20/04 ,  C40B40/06 ,  C40B50/18 ,  C40B40/08 ,  C07C335/20 ,  C07H21/00 ,  C12Q1/68 ,  C40B80/00

CPC classification number: C40B20/04 ,  C07B2200/11 ,  C07C335/20 ,  C07H21/00 ,  C12Q1/6869 ,  C40B40/04 ,  C40B40/06 ,  C40B40/08 ,  C40B50/18 ,  C40B80/00 ,  C12Q2565/518 ,  C12Q2521/501 ,  C12Q2523/107 ,  C12Q2533/101

Abstract: Methods of modifying a nucleophilic surface of a support are described. The methods involve reacting a multifunctional electrophilic reagent with nucleophilic groups on the surface of the support. The resulting electrophilic surface can be used for the covalent attachment of particles (e.g., beads) having nucleophilic functional groups. For example, nucleic acid templates with nucleophilic (e.g., amine) groups can be attached to a surface of the particles. The nucleophilic groups on the nucleic acid templates can then be used to attach the particles to the modified surface of the support. The resulting support-bound particles can be used to analyze (e.g., sequence) the nucleic acid templates on the particles.

Abstract translation: 描述了改变载体的亲核表面的方法。 所述方法包括使多功能亲电试剂与载体表面上的亲核基团反应。 所得亲电表面可用于共价连接具有亲核官能团的颗粒（例如珠）。 例如，具有亲核（例如胺）基团的核酸模板可以附着于颗粒的表面。 然后核酸模板上的亲核基团可用于将颗粒附着到载体的改性表面上。 得到的载体结合颗粒可用于分析（例如，序列）颗粒上的核酸模板。

公开(公告)号：WO2010122341A3

公开(公告)日：2011-01-20

申请号：PCT/GB2010050655

申请日：2010-04-22

Applicant: WILKIE STUART JEREMY PETER

Inventor： WILKIE STUART JEREMY PETER

IPC: B60K7/00

CPC classification number: B60K7/0007 ,  B60K2007/0038 ,  B60K2007/0092 ,  B60L7/14 ,  B60L2200/10 ,  B60L2200/26 ,  B60L2220/44 ,  H02K7/14 ,  Y02T10/641

Abstract: An electrically powered wheel for vehicles comprises an outer ring forming a rotor and an inner portion forming a stator; said outer ring being configured to drive the rotation of a tyre when fitted to said wheel and incorporating an arrangement of magnetic material or being constituted of magnetic material; said inner portion incorporating a powered conductive arrangement with a plurality of distinct winding portions; a connection for connecting said wheel to a controller which varies the mode of the powering of said distinct winding portions; whereby dependent upon the magnetic relationship between said magnetic material and said plurality of distinct winding portions, rotation of said outer ring is achieved, in use, whilst the inner portion remains static; wherein said wheel is configured to support the load of a vehicle.

Abstract translation: 用于车辆的电动车轮包括形成转子的外圈和形成定子的内部部分; 所述外圈构造成在装配到所述车轮上时驱动轮胎的旋转并且包括磁性材料的布置或由磁性材料构成; 所述内部部分包括具有多个不同绕组部分的动力传导装置; 用于将所述车轮连接到改变所述不同绕组部分的供电模式的控制器的连接; 由此取决于所述磁性材料与所述多个不同绕组部分之间的磁性关系，在使用中实现所述外环的旋转，同时内部部分保持静止; 其中所述车轮构造成支撑车辆的负载。

公开(公告)号：WO2009026546A3

公开(公告)日：2009-05-14

申请号：PCT/US2008074075

申请日：2008-08-22

Applicant: APPLIED BIOSYSTEMS ,  GREINER DOUGLAS ,  STUART JEREMY ,  TAING MENG ,  MENCHEN STEVEN M

Inventor： GREINER DOUGLAS ,  STUART JEREMY ,  TAING MENG ,  MENCHEN STEVEN M

IPC: C40B40/04 ,  C07C335/20 ,  C07H21/00 ,  C12Q1/68 ,  C40B20/04 ,  C40B40/06 ,  C40B40/08 ,  C40B50/18 ,  C40B80/00

CPC classification number: C40B20/04 ,  C07B2200/11 ,  C07C335/20 ,  C07H21/00 ,  C12Q1/6869 ,  C40B40/04 ,  C40B40/06 ,  C40B40/08 ,  C40B50/18 ,  C40B80/00 ,  C12Q2565/518 ,  C12Q2521/501 ,  C12Q2523/107 ,  C12Q2533/101

Abstract: Methods of modifying a nucleophilic surface of a support are described. The methods involve reacting a multifunctional electrophilic reagent with nucleophilic groups on the surface of the support. The resulting electrophilic surface can be used for the covalent attachment of particles (e.g., beads) having nucleophilic functional groups. For example, nucleic acid templates with nucleophilic (e.g., amine) groups can be attached to a surface of the particles. The nucleophilic groups on the nucleic acid templates can then be used to attach the particles to the modified surface of the support. The resulting support-bound particles can be used to analyze (e.g., sequence) the nucleic acid templates on the particles.

Abstract translation: 描述了改变载体的亲核表面的方法。 该方法包括使多官能亲电子试剂与载体表面上的亲核基团反应。 所得到的亲电表面可以用于共价连接具有亲核官能团的颗粒（例如珠粒）。 例如，具有亲核（例如胺）基团的核酸模板可以连接到颗粒的表面。 然后可以使用核酸模板上的亲核基团将颗粒附着到载体的改性表面。 得到的载体结合颗粒可用于分析（例如，测序）颗粒上的核酸模板。

公开(公告)号：WO2010122341A2

公开(公告)日：2010-10-28

申请号：PCT/GB2010/050655

申请日：2010-04-22

Applicant: WILKIE, Stuart, Jeremy, Peter

Inventor： WILKIE, Stuart, Jeremy, Peter

CPC classification number: B60K7/0007 ,  B60K2007/0038 ,  B60K2007/0092 ,  B60L7/14 ,  B60L2200/10 ,  B60L2200/26 ,  B60L2220/44 ,  H02K7/14 ,  Y02T10/641

Abstract: An electrically powered wheel for vehicles comprises an outer ring forming a rotor and an inner portion forming a stator; said outer ring being configured to drive the rotation of a tyre when fitted to said wheel and incorporating an arrangement of magnetic material or being constituted of magnetic material; said inner portion incorporating a powered conductive arrangement with a plurality of distinct winding portions; a connection for connecting said wheel to a controller which varies the mode of the powering of said distinct winding portions; whereby dependent upon the magnetic relationship between said magnetic material and said plurality of distinct winding portions, rotation of said outer ring is achieved, in use, whilst the inner portion remains static; wherein said wheel is configured to support the load of a vehicle.

Abstract translation: 用于车辆的电动车轮包括形成转子的外圈和形成定子的内部部分; 所述外圈构造成在装配到所述车轮上时驱动轮胎的旋转并且包括磁性材料的布置或由磁性材料构成; 所述内部部分包括具有多个不同绕组部分的动力传导装置; 用于将所述车轮连接到改变所述不同绕组部分的供电模式的控制器的连接; 由此取决于所述磁性材料与所述多个不同绕组部分之间的磁性关系，在使用中实现所述外环的旋转，同时内部部分保持静止; 其中所述车轮构造成支撑车辆的负载。