公开(公告)号：WO2003006151A1

公开(公告)日：2003-01-23

申请号：PCT/GB2002/003135

申请日：2002-07-09

Applicant: AVECIA LIMITED ,  LEY, Steven, Victor ,  RAMARAO, Chandrashekar ,  SHIRLEY, Ian, Malcolm ,  SMITH, Stephen, Christopher ,  TAPOLCZAY, David, Joszef

Inventor： LEY, Steven, Victor ,  RAMARAO, Chandrashekar ,  SHIRLEY, Ian, Malcolm ,  SMITH, Stephen, Christopher ,  TAPOLCZAY, David, Joszef

IPC: B01J13/18

CPC classification number: B01J31/04 ,  B01J13/18 ,  B01J31/06 ,  B01J31/165 ,  B01J31/1805 ,  B01J31/24 ,  B01J31/28 ,  B01J35/0013 ,  B01J37/0219 ,  B01J2231/32 ,  B01J2231/341 ,  B01J2231/4211 ,  B01J2231/4255 ,  B01J2231/4261 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/82 ,  C07B37/04 ,  C07B2200/07 ,  C07C5/03 ,  C07C5/08 ,  C07C17/263 ,  C07C29/17 ,  C07C29/48 ,  C07C41/26 ,  C07C41/30 ,  C07C45/30 ,  C07C45/62 ,  C07C45/68 ,  C07C67/31 ,  C07C67/343 ,  C07C67/36 ,  C07C201/12 ,  C07C209/36 ,  C07C209/52 ,  C07C253/30 ,  C07C2523/44 ,  C07C2601/14 ,  Y02P20/582 ,  C07C49/403 ,  C07C47/228 ,  C07C49/84 ,  C07C49/813 ,  C07C255/33 ,  C07C211/47 ,  C07C211/48 ,  C07C205/06 ,  C07C205/35 ,  C07C205/45 ,  C07C205/56 ,  C07C33/26 ,  C07C31/20 ,  C07C35/21 ,  C07C69/732 ,  C07C43/1782 ,  C07C43/2055 ,  C07C43/225 ,  C07C43/205 ,  C07C69/76 ,  C07C33/24 ,  C07C69/618 ,  C07C25/18 ,  C07C15/02 ,  C07C13/28 ,  C07C15/18 ,  C07C33/28

Abstract: A microencapsulated catalyst is prepared by dissolving or dispersing a catalyst in a first phase (for example an organic phase), dispersing the first phase in a second, continuous phase (for example an aqueous phase) to form an emulsion, reacting one or more microcapsule wall-forming materials at the interface between the dispersed first phase and the continuous second phase to form a microcapsule polymer shell encapsulating the dispersed first phase core and optionally recovering the microcapsules from the continuous phase. The catalyst is preferably a transition metal catalyst and the encapsulated catalyst may be used for conventional catalysed reactions. The encapsulated catalyst may recovered from the reaction medium and re-cycled.

Abstract translation: 通过将催化剂溶解或分散在第一相（例如有机相）中制备微胶囊化催化剂，将第一相分散在第二连续相（例如水相）中以形成乳液，使一种或多种微胶囊 在分散的第一相和连续的第二相之间的界面处的壁形成材料形成包封分散的第一相核的微胶囊聚合物壳，并任选地从连续相中回收微胶囊。 催化剂优选为过渡金属催化剂，并且包封的催化剂可用于常规催化反应。 包封的催化剂可以从反应介质中回收并重新循环。

公开(公告)号：WO2008038042A1

公开(公告)日：2008-04-03

申请号：PCT/GB2007/050577

申请日：2007-09-24

Applicant: PHOENIX CHEMICALS LIMITED ,  PITTS, Michael Robert ,  TAPOLCZAY, David Joszef

Inventor： PITTS, Michael Robert ,  TAPOLCZAY, David Joszef

IPC: C07D233/56 ,  B01J19/12 ,  H05B6/64

CPC classification number: C07D233/56

Abstract: The present invention relates to a process for displacing one or more nitro groups on a substrate compound with a heterocyclic compound comprising the steps: a) mixing the substrate compound with the heterocyclic compound to form a mixture; b) subjecting the mixture to microwave energy effective to heat the mixture to a temperature for a reaction time effective to allow the nitro displacement to take place and a product to be formed; c) recovering the product from the mixture; and optionally d) further purifying the product and/or processing it further. The present invention also relates to a compound produced by the process.

Abstract translation: 本发明涉及一种用杂环化合物置换底物化合物上的一个或多个硝基的方法，包括以下步骤：a）将底物化合物与杂环化合物混合以形成混合物; b）使混合物经受有效的微波能量以将混合物加热至反应时间的温度以有效地进行硝基置换并形成产物; c）从混合物中回收产物; 并且任选地d）进一步纯化产物和/或进一步加工。 本发明还涉及通过该方法制备的化合物。

公开(公告)号：WO1994004486A1

公开(公告)日：1994-03-03

申请号：PCT/EP1993002219

申请日：1993-08-19

Applicant: GLAXO GROUP LIMITED ,  TAPOLCZAY, David, Joszef ,  MEERHOLZ, Clive, Alwin ,  TURNBULL, John, Peter ,  HALTER, Bernard, Charles ,  SCHILLING, Mark, Brian

Inventor： GLAXO GROUP LIMITED

IPC: C07C233/81

CPC classification number: C07C215/42 ,  C07C211/27 ,  C07C217/52 ,  C07C233/74 ,  C07C233/81 ,  C07C2601/08 ,  C07C2601/10 ,  C07D209/52

Abstract: A process is claimed for preparing [1S(1 alpha , 2 beta , 4 beta )]-4-amino-2-hydroxymethyl-1-cyclopentanol from cis-4-((R)-benzoylamino)-2-cyclopentenecarboxylic acid, methyl ester in five steps. The invention also describes a number of novel intermediates useful in the synthesis of [1S(1 alpha , 2 beta , 4 beta )]-4-amino-2-hydroxymethyl-1-cyclopentanol.

Abstract translation: 要求从顺式-4 - （（R） - 苯甲酰氨基）-2-环戊烯甲酸制备[1S（1α，2β，4β）] -4-氨基-2-羟甲基-1-环戊醇的方法， 酯五步。 本发明还描述了许多可用于合成[1S（1α，2β，4β）] -4-氨基-2-羟甲基-1-环戊醇的新型中间体。