公开(公告)号：WO2017198988A3

公开(公告)日：2017-11-23

申请号：PCT/GB2017/000080

申请日：2017-05-22

Applicant: THE UNIVERSITY OF DUNDEE

Inventor： HICKERSON, Robyn Patricia ,  CONNEELY, Michael John

IPC: A01N1/02 ,  C12N5/071

Abstract: A skin sample culture apparatus is disclosed, which uses a culture medium to maintain the viability of the sample and comprises means for maintaining the sample under tension. In an embodiment the apparatus (171) has a base (173), a securing member (175) and a tensioner cap (177). The skin sample (183) is placed between the base and securing member. Through holes (187) in the securing member are aligned with holes (174) in the base, and screws or other suitable fixings are tightened to secure the skin sample in position. Tension adjustment is provided by the cap, which is positioned on top of the securing member and has a tension adjustment mechanism (179) comprising a screw (195) extending through the cap into the securing member, wherein tightening of the screw increases the tension across the sample.

公开(公告)号：WO2016193111A1

公开(公告)日：2016-12-08

申请号：PCT/EP2016/061887

申请日：2016-05-26

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED ,  THE UNIVERSITY OF DUNDEE

Inventor： BRAND, Stephen ,  GAZA, Elisabet Viayna ,  GILBERT, Ian ,  KO, Eun Jung ,  THOMAS, Michael George ,  MARCO MARTIN, Maria ,  MILES, Timothy James ,  SANDBERG, Lars, Henrik

IPC: C07D487/04 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/553 ,  A61P33/02

CPC classification number: C07D487/04 ,  A61K31/53 ,  A61K31/5377 ,  A61K45/06 ,  A61P33/02

Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT) and leishmaniasis, particularly visceral leishmaniasis (VL).

Abstract translation: 式（I）化合物或其盐包含该化合物的组合物，其制备方法及其在治疗中的用途，例如治疗寄生虫病例如恰加斯病，人非洲锥虫病（HAT）和利什曼病， 特别是内脏利什曼病（VL）。

公开(公告)号：WO2015114291A1

公开(公告)日：2015-08-06

申请号：PCT/GB2015/000024

申请日：2015-01-27

Applicant: THE UNIVERSITY OF DUNDEE

Inventor： ABDOLVAND, Amin

IPC: C03C27/08 ,  C03C21/00 ,  C03C23/00 ,  B23K26/18

CPC classification number: C03C27/08 ,  B23K26/0063 ,  B23K26/082 ,  B23K26/18 ,  B23K26/32 ,  B23K26/324 ,  B23K26/53 ,  B23K26/57 ,  B23K2203/54 ,  C03B23/203 ,  C03B25/025 ,  C03C17/06 ,  C03C21/005 ,  C03C23/0025 ,  C03C2218/32

Abstract: A method for welding together glass workpieces where one of the workpieces has metal nanoparticles positioned at or near the surface to be welded. The method comprises positioning the workpieces in operative contact at an interface where a weld is to be formed, applying a laser beam to be incident upon the interface wherein energy from the laser beam is absorbed by the nanoparticle bearing workpiece and the energy from the laser beam is transferred to the glass surrounding the metal nanoparticles to heat the glass and to weld the workpieces together.

Abstract translation: 一种用于将玻璃工件焊接在一起的方法，其中一个工件具有位于待焊接表面处或附近的金属纳米颗粒。 该方法包括将工件定位在要形成焊缝的界面处的有效接触处，施加要入射到界面的激光束，其中来自激光束的能量被纳米颗粒承载的工件吸收并且来自激光束的能量 转移到围绕金属纳米颗粒的玻璃上以加热玻璃并将工件焊接在一起。

公开(公告)号：WO2014009682A2

公开(公告)日：2014-01-16

申请号：PCT/GB2013/000296

申请日：2013-07-09

Applicant: THE UNIVERSITY OF DUNDEE ,  UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS

Inventor： PITTS, Nigel ,  LONGBOTTOM, Christopher ,  CRAYSTON, Joseph

IPC: A61N1/30

CPC classification number: A61C19/06 ,  A61C1/0015 ,  A61K9/0009 ,  A61K33/42 ,  A61K47/64 ,  A61M37/0092 ,  A61N1/30 ,  A61N1/306 ,  A61N1/325 ,  C01B25/32 ,  C01B25/455 ,  C07K14/4732

Abstract: According to the present invention, there is provided an apparatus for mineralising a biological material, the apparatus comprising an ultrasonic source, operable to generate an ultrasonic signal, an ultrasonic probe and one or more mineralising probes, operable to receive a mineralising agent, wherein the mineralising agent is transferred from at least one mineralising probe to the biological material using the ultrasonic signal. There is also provided a mineralisation agent and a method of mineralising a biological material, said method comprising the steps of: providing an ultrasound source, providing a mineralising agent, generating an ultrasonic signal from the ultrasound source, applying the ultrasonic signal and the mineralising agent to the biological material separately, sequentially or simultaneously.

Abstract translation: 根据本发明，提供了一种用于使生物材料矿化的设备，该设备包括可操作以产生超声信号的超声源，超声探测器和一个或多个矿化探测器，可操作的 以接收矿化剂，其中使用超声波信号将矿化剂从至少一种矿化探针转移到生物材料。 还提供了矿化剂和使生物材料矿化的方法，所述方法包括以下步骤：提供超声源，提供矿化剂，从超声源产生超声信号，施加超声信号和矿化剂 生物材料分开，依次或同时进行。

公开(公告)号：WO2012131497A2

公开(公告)日：2012-10-04

申请号：PCT/IB2012/000872

申请日：2012-04-26

Applicant: THE UNIVERSITY OF DUNDEE ,  NEWLANDS, Moray, David ,  CSETENYI, Laszlo, Jozsef ,  ZHENG, Li

Inventor： NEWLANDS, Moray, David ,  CSETENYI, Laszlo, Jozsef ,  ZHENG, Li

IPC: C04B28/04

CPC classification number: C04B28/14 ,  C04B28/04 ,  C04B2111/82 ,  Y02W30/91 ,  C04B14/06 ,  C04B18/0481 ,  C04B24/023 ,  C04B24/20 ,  C04B2103/402 ,  C04B2103/406

Abstract: A multi-component admixture containing a surfactant which is adapted to provide an interface between hydrophobic toner particles and a hydrophilic cement-based or gypsum-based mix such as concrete or plaster to facilitate homogeneous mixing of the two materials.

Abstract translation: 包含表面活性剂的多组分混合物，其适于在疏水性调色剂颗粒与亲水性水泥基或石膏基混合物如混凝土或石膏之间提供界面以促进两者的均匀混合 材料

公开(公告)号：WO2010084317A1

公开(公告)日：2010-07-29

申请号：PCT/GB2010/000091

申请日：2010-01-21

Applicant: THE UNIVERSITY OF DUNDEE ,  RAFAILOV, Edik ,  ABDOLVAND, Amin ,  KALKANDJIEV, Todor

Inventor： RAFAILOV, Edik ,  ABDOLVAND, Amin ,  KALKANDJIEV, Todor

IPC: G02B27/09 ,  H01S3/06

CPC classification number: H01S3/09415 ,  G02B27/0927 ,  G02B27/0938 ,  H01S3/0014 ,  H01S3/08 ,  H01S3/094053 ,  H01S3/1611 ,  H01S3/1675 ,  H01S2301/203

Abstract: An optical system (31) with an input optical source (33) for projecting an input beam along an optical axis and an optical element (37, 43) which creates a cone refracted beam (41) from the input beam (35) then reconstructs the input beam (49). The optical element may comprise a first cone refractive element (37) which creates a cone refracted beam and reconstructs the beam using a reconstructing optical element (43) to apply a phase shift to the cone refracted beam. The optical system may be used to form a laser or a gain medium for a laser.

Abstract translation: 具有用于沿光轴投影输入光束的输入光源（33）和从输入光束（35）产生锥形折射光束（41）的光学元件（37,43）的光学系统（31） 输入光束（49）。 光学元件可以包括第一锥形折射元件（37），其产生锥形折射光束并且使用重建光学元件（43）重建光束，以向锥形折射光束施加相移。 光学系统可用于形成用于激光的激光或增益介质。

公开(公告)号：WO2010013071A2

公开(公告)日：2010-02-04

申请号：PCT/GB2009/050967

申请日：2009-07-31

Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE ,  PALMER, Colin ,  FOERSTER, John ,  SITHESWARAN, Nainamalai

Inventor： PALMER, Colin ,  FOERSTER, John ,  SITHESWARAN, Nainamalai

IPC: C12Q1/68

CPC classification number: A01K67/0275 ,  A01K2207/15 ,  A01K2207/20 ,  A01K2217/00 ,  A01K2217/052 ,  A01K2217/203 ,  A01K2227/105 ,  A01K2267/0368 ,  C07K14/4702 ,  C12N15/8509 ,  C12N2830/008 ,  C12N2840/002

Abstract: Non-human animals which overexpress PPARd or which express transgenic PPARd are useful as models for inflammatory skin conditions such as psoriasis. Test substances can be screened to assess their suitability for the treatment of inflammatory skin conditions such as psoriasis. Methyl 3-({[2-(methoxy)-4-phenyl]amino}sulfonyl)-2-thiophenecarboxylate can be administered topically for the prevention or treatment of psoriasis.

Abstract translation: 过表达PPARd或表达转基因PPARd的非人动物可用作炎性皮肤病症如牛皮癣的模型。 可以筛选测试物质以评估其适用于治疗炎症性皮肤病症如银屑病。 可以局部施用3 - （{[2-（甲氧基）-4-苯基]氨基}磺酰基）-2-噻吩甲酸甲酯，用于预防或治疗牛皮癣。

公开(公告)号：WO2010004283A2

公开(公告)日：2010-01-14

申请号：PCT/GB2009/001705

申请日：2009-07-09

Applicant: THE UNIVERSITY OF DUNDEE ,  JOVANOVIC, Aleksandar

Inventor： JOVANOVIC, Aleksandar

IPC: A61K48/00 ,  A61K31/455 ,  A61K31/565 ,  A61K31/57 ,  C12Q1/68 ,  A61P9/10 ,  A61P19/00 ,  A61P21/00

CPC classification number: A61K48/005 ,  A01K2267/0375 ,  A61K31/455 ,  A61K31/565 ,  A61K31/57 ,  A61K45/06 ,  C07K14/705 ,  C12Q1/6883 ,  Y02A50/414 ,  Y02A50/465

Abstract: We disclose agents useful in the treatment of diseases or conditions that would benefit from improved muscle function and including pharmaceutical compositions and diagnostic tests for determining the predisposition of a subject, in particular a male subject, to cardiovascular disease.

Abstract translation: 我们公开了可用于治疗可以从改善的肌肉功能中获益的疾病或病症的药剂，包括用于确定受试者，特别是男性受试者对心血管疾病的易感性的药物组合物和诊断测试。

公开(公告)号：WO2009040512A2

公开(公告)日：2009-04-02

申请号：PCT/GB2008/003221

申请日：2008-09-22

Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE ,  WATTS, Colin ,  ZARU, Rossana

Inventor： WATTS, Colin ,  ZARU, Rossana

IPC: A61K31/7048 ,  A61P29/00 ,  A61K31/4985

CPC classification number: A61K31/7048 ,  A61K31/4985

Abstract: The present invention relates to specific compounds for use in controlling inflammatory cell function and their potential use in modulating an immune response or inflammation. The present invention also relates to the identification of an alternative RSK pathway in, for example, dendritic cells and the development of assays for the identification of compounds capable of modulating the alternative RSK associated pathway in dendritic cells/macrophage cells and their potential use in enhancing, or controlling an immune response or in treating inflammation.

Abstract translation: 本发明涉及用于控制炎性细胞功能的具体化合物及其在调节免疫应答或炎症中的潜在用途。 本发明还涉及在例如树突状细胞中鉴定替代的RSK途径以及开发用于鉴定能够调节树突状细胞/巨噬细胞中的替代RSK相关途径的化合物的测定及其在增强中的潜在用途 ，或控制免疫应答或治疗炎症。

公开(公告)号：WO2009030890A1

公开(公告)日：2009-03-12

申请号：PCT/GB2008/002967

申请日：2008-09-02

Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE ,  COHEN, Philip

Inventor： COHEN, Philip

IPC: A61K31/506 ,  A61P27/06 ,  A61P35/00 ,  A61P31/04

CPC classification number: A61K31/506

Abstract: The present invention relates to the use of certain pyrimidine compounds to inhibit, for example, TBKl and/or IKK epsilon and which may therefore find application in treating cancer septic shock and/or Primary open Angle Glaucoma (POAG).

Abstract translation: 本发明涉及某些嘧啶化合物用于抑制例如TBK1和/或IKKε的应用，并因此可用于治疗癌症脓毒性休克和/或原发性开角型青光眼（ POAG）。