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62 条记录 (耗时 0.018 秒)

    DIASTEREOISOMERS OF 4-HYDROXYISOLEUCINE AND USES THEREOF
    5.
    发明申请
    DIASTEREOISOMERS OF 4-HYDROXYISOLEUCINE AND USES THEREOF 审中-公开
    4-羟基己酸的二异氰酸酯及其用途

    公开(公告)号：WO2006117696A3

    公开(公告)日：2007-01-25

    申请号：PCT/IB2006001758

    申请日：2006-02-17

    申请人： INNODIA INC ,  CENTRE NAT RECH SCIENT ,  UNIV PASTEUR ,  COQUELET CLAUDE ,  MIOSKOWSKI CHARLES ,  WAGNER ALAIN

    发明人： COQUELET CLAUDE ,  MIOSKOWSKI CHARLES ,  WAGNER ALAIN

    IPC分类号： C07C229/22 ,  A61K31/198 ,  A61P3/10 ,  C07D307/32

    CPC分类号： C07D307/33 ,  C07C229/22

    摘要： The invention relates to configurational isomers 4-hydroxyisoleucine, and to lactones, pharmaceutically acceptable salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. The isomers of the invention exhibit insulinotropic activity and thus may be useful for the prevention and treatment of disorders of carbohydrate or lipid metabolism, including diabetes mellitus (type 1 and type 2 diabetes), pre-diabetes, and Metabolic Syndrome.

    摘要翻译： 本发明涉及构型异构体4-羟基异亮氨酸及内酯，其药学上可接受的盐和前药，其制备方法以及包含其的药物组合物。 本发明的异构体显示出促胰岛素活性，因此可用于预防和治疗糖或脂质代谢紊乱，包括糖尿病（1型和2型糖尿病），前期糖尿病和代谢综合征。

    UNSATURATED DIPYRROMETHENE-BORON BOROCARBONS
    6.
    发明申请
    UNSATURATED DIPYRROMETHENE-BORON BOROCARBONS 审中-公开
    不饱和的二溴乙烯 - 硼碳硼烷

    公开(公告)号：WO2006087459A3

    公开(公告)日：2006-12-28

    申请号：PCT/FR2006000333

    申请日：2006-02-14

    申请人： CENTRE NAT RECH SCIENT ,  UNIV PASTEUR ,  ULRICH GILLES ,  ZIESSEL RAYMOND ,  GOZE CHRISTINE

    发明人： ULRICH GILLES ,  ZIESSEL RAYMOND ,  GOZE CHRISTINE

    IPC分类号： C07F5/02

    CPC分类号： C07F5/02

    摘要： The invention relates to unsaturated dipyrromethene-boron borocarbons of formula (I) and the use thereof for fluorescence or electroluminescent analysis. The fluorescent properties are provided by the central ring of 6 atoms comprising the -N-B-N- sequence, R 1 to R 7 permitting the modification of the compound properties (fluorescence emission wavelength, quantitative fluorescent yield), at least one of the substituents S 1 and S 2 has a chromophore end group which permits an excitation of the molecule at wavelengths close to those of the substituent chromophore A preferably selected from the chromophore substituents with a wavelength close to the ultraviolet which significantly increases the Stokes displacement.

    摘要翻译： 本发明涉及式（I）的不饱和二吡咯亚甲基 - 硼硼碳化合物及其用于荧光或电致发光分析的用途。 荧光性质由含6个原子的中心环提供，所述6个原子包含-NBN-序列，R 1至R 7允许修饰化合物特性（荧光发射波长， 定量荧光产率），取代基S 1和S 2中的至少一个具有生色团末端基团，其允许在接近取代基的波长处激发分子 发色团A优选选自波长接近紫外线的发色团取代基，其显着增加斯托克斯位移。

    CONTROLLED RUPTURE OF FURTIVE LIPOSOMES
    8.
    发明申请
    CONTROLLED RUPTURE OF FURTIVE LIPOSOMES 审中-公开
    控制性的脂质体破裂

    公开(公告)号：WO2005030170A3

    公开(公告)日：2005-07-21

    申请号：PCT/FR2004002435

    申请日：2004-09-27

    申请人： UNIV PASTEUR ,  CENTRE NAT RECH SCIENT ,  MARQUES CARLOS ,  SCHROEDER ANDRE ,  FA NATHALIE

    发明人： MARQUES CARLOS ,  SCHROEDER ANDRE ,  FA NATHALIE

    IPC分类号： A61K9/127 ,  A61K47/40

    CPC分类号： A61K9/1271

    摘要： The invention relates to a method for initiating the controlled rupture of the membrane a biocompatible liposome, often called a furtive liposome, thereby releasing the liposome content to the environment thereof. A releasing agent is embodied in the form of a biocompatible molecule, preferably a alpha -cyclodextrine. Said invention relates, in particular to the use of the inventive method /= for therapeutic, diagnostic, experimental, cosmetic and agri-food fields.

    摘要翻译： 本发明涉及一种启动膜的受控破裂的方法，该方法通常被称为隐性脂质体，从而将脂质体内容物释放到其环境中。 释放剂以生物相容性分子的形式体现，优选α-环糊精。 本发明特别涉及本发明方法用于治疗，诊断，实验，化妆和农业食品领域的用途。

    LANTHANIDE COMPLEXES PREPARATION AND USES THEREOF
    9.
    发明申请
    LANTHANIDE COMPLEXES PREPARATION AND USES THEREOF 审中-公开
    兰萨汀复合物的制备及其用途

    公开(公告)号：WO2005014581A2

    公开(公告)日：2005-02-17

    申请号：PCT/FR2004001921

    申请日：2004-07-20

    申请人： CENTRE NAT RECH SCIENT ,  UNIV PASTEUR ,  CHARBONNIERE LOIC ,  ZIESSEL RAYMOND ,  WEIBEL NICOLAS ,  RODA ALDO ,  GUARDIGLI MASSIMO

    发明人： CHARBONNIERE LOIC ,  ZIESSEL RAYMOND ,  WEIBEL NICOLAS ,  RODA ALDO ,  GUARDIGLI MASSIMO

    IPC分类号： C07D213/79 ,  C07D401/14 ,  C07D519/00 ,  C07F9/58 ,  C07F17/00 ,  C09K11/06 ,  G01N33/58

    CPC分类号： C09K11/06 ,  C07D213/79 ,  C07D401/14 ,  C09K2211/182 ,  G01N33/582

    摘要： The invention relates to compounds and the complexes formed thereby with a lanthanide and use of the complexes for fluorescence or NMR-imagery marking. The complex comprises an Ln ion and a R C(X R ) (R ) NR R ligand, where R is a functional group, X is a single bond or a hydrocarbon chain, comprising at least one alkylene or alkenylene group with optionally at least one heteroatom or an arylene, R is an anionic group A , or a C1-C4 alkylene or alkenylene with at least one such group A and optionally comprising at least one heteroatom, R is H or a C1-C5 alkylene or alkenylene, optionally comprising at least one heteroatom and optionally having at least one anionic group A , R is a light-absorbing substituent forming cyclic chelates with Ln and R is a substituent forming cyclic chelates with Ln.

    摘要翻译： 本发明涉及化合物和由此形成的与镧系元素形成的络合物，并且该配合物用于荧光或NMR图像标记。 络合物包含Ln离子和R 2 C（XR 1）（R 3）NR 4 R 5配体，其中R 1是官能团，X是单键 或烃链，其包含至少一个亚烷基或亚烯基与任选至少一个杂原子或亚芳基，R 2是阴离子基团A 2或具有至少一个这样的基团的C 1 -C 4亚烷基或亚烯基 A 2和任选地包含至少一个杂原子，R 3是H或C 1 -C 5亚烷基或亚烯基，任选地包含至少一个杂原子和任选具有至少一个阴离子基团A 3，R 4， 是与Ln形成环状螯合物的光吸收取代基，R 5是与Ln形成环状螯合物的取代基。

    MACROMOLECULES AUTO-ASSEMBLED AND PHOTOPOLYMERISED AROUND CARBON NANOTUBES A METHOD FOR PRODUCTION AND APPLICATION THEREOF
    10.
    发明申请
    MACROMOLECULES AUTO-ASSEMBLED AND PHOTOPOLYMERISED AROUND CARBON NANOTUBES A METHOD FOR PRODUCTION AND APPLICATION THEREOF 审中-公开
    大分子自组装和光聚合碳纳米管生产和应用的方法

    公开(公告)号：WO2004092231A2

    公开(公告)日：2004-10-28

    申请号：PCT/FR2004000906

    申请日：2004-04-13

    申请人： CENTRE NAT RECH SCIENT ,  UNIV PASTEUR ,  MIOSKOWSKI CHARLES ,  RICKLING STEPHANE ,  SCHULTZ PATRICK

    发明人： MIOSKOWSKI CHARLES ,  RICKLING STEPHANE ,  SCHULTZ PATRICK

    IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K47/34 ,  C01B31/02 ,  C08F292/00 ,  C08F38/00

    CPC分类号： B82Y30/00 ,  A61K9/0092 ,  A61K9/1274 ,  A61K47/34 ,  B82Y40/00 ,  C01B32/17 ,  C01B2202/02 ,  C01B2202/06 ,  C01B2202/30 ,  C08F292/00 ,  Y10S977/756 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： The invention relates to macromolecules auto-assembled and photopolymerised around carbon nanotubes. Said macromolecules are essentially formed from rings of lipid compounds, polymerised about the nanotubes, said polymerised compounds being obtained from lipid molecules with one or two chains A, bonded to a group Z where A is a chain, CH3-(CH2)m-CC-CC-(CH2)n-, where n and m, independently = whole numbers from 1 to 16 and Z is a polar head group embodied by a -COOH, -CO-NH-Y, -NH2 or N (R)3, where R is an alkyl with C1 to C4 and Y is a -(CH2)4-C(R1)-N(CH2-COOH)2 group with R= H, or a COOH group, where A is a single lipid chain or a group of structure (I) or (II), where R2 = a COOH, or -CO-NH-Y1 group with Y1 = a -(CH2)4-C(R3)-N(CH2COOH)2 group with R3 = H or a COOH group, where Z and R2 can also be neutral polar head groups of the sugar or polysaccharide type. The above is of application particularly to the protection and purification of nanotubes, as a hydrophobic molecule or membrane protein vector or as a molecular motor. <>

    摘要翻译： 本发明涉及在碳纳米管周围自动组装和光聚合的大分子。 所述大分子基本上由脂质化合物环形成，聚合在纳米管周围，所述聚合化合物由具有一个或两个链A的脂质分子获得，该基团与基团Z键合，其中A是链，CH 3 - （CH 2）m -C CC -C（ - ） - （CH 2）n - ，其中n和m独立地是1至16的整数，Z是由-COOH，-CO-NH-Y，-NH 2或N + R）3，其中R是具有C1-C4的烷基，Y是具有R = H的 - （CH2）4-C（R1）-N（CH2-COOH）2基团或COOH基团，其中A是 单个脂链或一组结构（I）或（II），其中R2 = COOH或具有Y1 =α-（CH2）4-C（R3）-N（CH2COOH）2的-CO-NH-Y1基团 基团，其中R3 = H或COOH基团，其中Z和R2也可以是糖或多糖型的中性极性头基。 以上特别适用于作为疏水性分子或膜蛋白载体或作为分子马达的纳米管的保护和纯化。 <>