公开(公告)号：WO2012057628A2

公开(公告)日：2012-05-03

申请号：PCT/NL2012/050001

申请日：2012-01-02

Applicant: BENDER ANALYTICAL HOLDING B.V. ,  HOOGENBOOM, Richard ,  BENDER, Johannes Caspar Mathias Elizabeth ,  VAN HEST, Jan Cornelis Maria

Inventor： HOOGENBOOM, Richard ,  BENDER, Johannes Caspar Mathias Elizabeth ,  VAN HEST, Jan Cornelis Maria

IPC: A61K47/48 ,  A61L27/18 ,  A61L31/06 ,  A61L31/14 ,  C08G73/02 ,  C08J3/24

CPC classification number: A61L24/046 ,  A61K47/50 ,  A61L24/06 ,  A61L27/18 ,  A61L31/06 ,  C08G73/0233 ,  C08J3/246 ,  C08J2300/10 ,  C08J2379/02 ,  C08L79/02

Abstract: One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m≥2, n≥2 and m+n ≥5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m≥3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer. The invention further provides a tissue adhesive medical product comprising at least 1% by weight of dry matter of EL-POX, said EL-POX comprising at least 2 electrophilic groups, including at least one pendant electrophilic group. The polymers according to the invention have excellent implant and/or sealing characteristics.

Abstract translation: 本发明的一个方面涉及通过使亲电活化的聚恶唑啉（EL-POX）与亲核性交联剂反应获得的生物相容性共价交联聚合物，所述亲电活化的POX 包含m个亲电子基团; 并且所述亲核交联剂包含n个亲核基团，其中所述m个亲电子基团能够与所述n个亲核基团反应以形成共价键; 其中m≥2，n≥2且m +n≥5; 其中所述m个亲电子基团中的至少一个是侧基亲电子基团和/或其中m≥3; 并且其中相对于亲核交联剂中所含的亲核基团的量，EL-POX包含过量的亲电子基团。 本发明进一步涉及包含这种交联的POX-聚合物的生物相容性医疗产品。 还提供了用于生产生物相容性交联POX聚合物的试剂盒。 本发明还提供了包含至少1重量％干物质EL-POX的组织粘附医药产品，所述EL-POX包含至少2个亲电子基团，包括至少一个侧挂亲电子基团。 根据本发明的聚合物具有优异的植入和/或密封特性。

公开(公告)号：WO2008035971A2

公开(公告)日：2008-03-27

申请号：PCT/NL2007/050458

申请日：2007-09-19

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT, MEER IN HET BIJZONDER HET UNIVERSITAIR MEDISCH CENTRUM ST RADBOUD ,  VERDONSCHOT, Nicolaas, Jacobus, Joseph ,  VAN HEST, Jan, Cornelis, Maria ,  BUMA, Pieter ,  AYRES, Lee ,  VRIEZEMA, Dennis, M.

Inventor： VERDONSCHOT, Nicolaas, Jacobus, Joseph ,  VAN HEST, Jan, Cornelis, Maria ,  BUMA, Pieter ,  AYRES, Lee ,  VRIEZEMA, Dennis, M.

IPC: A61K41/00 ,  A61L27/44 ,  A61L27/34

CPC classification number: A61L31/14 ,  A61K41/0028 ,  A61L31/10 ,  A61L31/148

Abstract: The invention provides a bioresorbable composition comprising a mixture of at least one polymer and capsules, which capsules comprise an inner part which is encapsulated by a shell which shell is at least partly decomposable by application of an external stimulation source. The invention also relates to a medical device comprising said composition.

Abstract translation: 本发明提供了一种包含至少一种聚合物和胶囊的混合物的生物可吸收组合物，该胶囊包含被壳体包封的内部部分，该壳体通过施加外部刺激可至少部分分解 资源。 本发明还涉及包含所述组合物的医疗器械。

公开(公告)号：WO2006080849A2

公开(公告)日：2006-08-03

申请号：PCT/NL2006000052

申请日：2006-01-31

Applicant: NL ORGANISATIE VAN WETENSCHAPP ,  VRIEZEMA DENNIS MANUEL ,  LEANDRO GARCIA PAULA MARIA ,  VAN HEST JAN CORNELIS MARIA ,  ROWAN ALAN EDWARD ,  NOLTE ROELAND JOHANNES MARIA

Inventor： VRIEZEMA DENNIS MANUEL ,  LEANDRO GARCIA PAULA MARIA ,  VAN HEST JAN CORNELIS MARIA ,  ROWAN ALAN EDWARD ,  NOLTE ROELAND JOHANNES MARIA

CPC classification number: C08G73/00 ,  C09J2400/263

Abstract: The present invention relates to polyisocyanide polymersomes, optionally having substances associated therewith, methods of making the same, and to methods of using the same. The polymersomes comprise a vesicular polymer membrane of a PS-PIAT polymer. The substances optionally associated with the polymersomes may comprise catalysts or enzymes, either encapsulated therein, i.e., inside the vesicular membrane of the polymersome, or in the polymeric membrane of the polymersome, or both.

Abstract translation: 本发明涉及任选具有与其相关的物质的多异氰化物聚合物囊泡，其制备方法及其使用方法。 聚合物囊泡包含PS-PIAT聚合物的泡状聚合物膜。 任选地与聚合物组合物相关的物质可以包含被包封在其中的催化剂或酶，即在聚合体的泡囊膜内部，或在聚合体的聚合物膜的聚合物膜中，或者两者。

公开(公告)号：WO2007016931A1

公开(公告)日：2007-02-15

申请号：PCT/EP2005/008079

申请日：2005-07-25

Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ,  NIJMEGEN UNIVERSITY ,  WAGENINGEN UNIVERSITY ,  TRIEU, Hoc Khiem ,  BOLLEROTT, Michael ,  KEMMERLING, Martin ,  HILDEBRAND, Robert ,  VAN HEST, Jan ,  RUTJES, Floris ,  KOCH, Kaspar ,  NIEUWLAND, Pieter ,  VAN BEEK, Teris A. ,  SUDHÖLTER, Ernst J.R. ,  BOOM, Remko M. ,  JANSSEN, Anja E.M.

Inventor： TRIEU, Hoc Khiem ,  BOLLEROTT, Michael ,  KEMMERLING, Martin ,  HILDEBRAND, Robert ,  VAN HEST, Jan ,  RUTJES, Floris ,  KOCH, Kaspar ,  NIEUWLAND, Pieter ,  VAN BEEK, Teris A. ,  SUDHÖLTER, Ernst J.R. ,  BOOM, Remko M. ,  JANSSEN, Anja E.M.

IPC: B01L9/00

CPC classification number: B01L9/00 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/0627 ,  B01L2300/0861 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/185 ,  B01L2400/04 ,  B01L2400/0487

Abstract: A chip-holder for holding a micro-fluidic chip comprises means for detachably fixing the micro-fluidic chip in the chip-holder and at least one process control device configured to support control or monitoring of a chemical process in the micro-fluidic chip, wherein the chip-holder is configured such that the process control device and the micro-fluidic chip are directly and detachably coupled when the micro-fluidic chip is fixed in the chip-holder. Such a chip-holder brings along the advantage that the micro-fluidic chip can easily be removed and exchanged while the process control device can be reused. This reduces running costs of a chemical microreactor system drastically and allows for a very flexible usage of a chemical microreactor system.

Abstract translation: 用于保持微流体芯片的芯片保持器包括用于将微流体芯片可拆卸地固定在芯片保持器中的装置和被配置为支持微流体芯片中的化学过程的控制或监视的至少一个过程控制装置， 其中，所述芯片保持器构造成使得当所述微流体芯片固定在所述芯片保持器中时，所述过程控制装置和所述微流体芯片是直接可拆卸地耦合的。 这样的芯片保持器具有微流体芯片可以容易地被去除和交换而可以重复使用过程控制装置的优点。 这可以显着降低化学微反应器系统的运行成本，并允许非常灵活地使用化学微反应器系统。

公开(公告)号：WO2006111399A2

公开(公告)日：2006-10-26

申请号：PCT/EP2006003677

申请日：2006-04-21

Applicant: DSM IP ASSETS BV ,  THIES JENS CHRISTOPH ,  PIERRE SEBASTIEN ,  CAMERON NEIL RONALD ,  VAN HEST JAN CORNELIS MARIA ,  WYMAN PAUL

Inventor： THIES JENS CHRISTOPH ,  PIERRE SEBASTIEN ,  CAMERON NEIL RONALD ,  VAN HEST JAN CORNELIS MARIA ,  WYMAN PAUL

IPC: C12N11/06 ,  C12N11/08

CPC classification number: C12N11/06 ,  C12N11/08

Abstract: The present invention relates to highly porous polymeric materials comprising covalently grafted biologically active species. The invention also relates to a process for the preparation of highly porous materials comprising functional monomers capable of grafting to a biologically active molecular species comprising the steps of: (a) preparing an emulsion composition comprising a droplet phase and a continuous phase and containing monomers, (b) curing the emulsion and (c) optionally removing the water/droplet phase. The invention further relates to a process for grafting biologically active species to such a highly porous polymeric material comprising the steps of: (i) exposing the highly porous material to a solution of the biologically active species in a suitable solvent medium, (ii) optionally adding an activating agent, (iii) optionally heating, and (iv) rinsing the porous material with solvent medium to remove non-grafted species. The highly porous polymeric materials comprising covalently grafted biologically active species can be used e.g. as a heterogeneous catalyst, in biosensors, for chromatography, in biomedical devices and in implants.

Abstract translation: 本发明涉及包含共价接枝的生物活性物质的高度多孔聚合物材料。 本发明还涉及制备包含能够接枝至生物活性分子物质的官能单体的高度多孔材料的方法，其包括以下步骤：（a）制备包含液滴相和连续相并含有单体的乳液组合物， （b）固化乳液和（c）任选地除去水/液滴相。 本发明进一步涉及将生物活性物质接枝到这种高度多孔聚合物材料上的方法，其包括以下步骤：（i）将高度多孔材料暴露于生物活性物质在合适溶剂介质中的溶液中，（ii）任选地 （iii）任选加热，和（iv）用溶剂介质冲洗多孔材料以除去未接枝物质。 包含共价接枝的生物活性物质的高度多孔聚合物材料可用于例如 作为非均相催化剂，用于生物传感器，用于色谱法，用于生物医学装置和植入物。

公开(公告)号：WO2006080849A3

公开(公告)日：2006-08-03

申请号：PCT/NL2006/000052

申请日：2006-01-31

Applicant: NEDERLANDSE ORGANISATIE VAN WETENSCHAPPELIJK ONDERZOEK ,  VRIEZEMA, Dennis, Manuel ,  LEANDRO GARCIA, Paula, Maria ,  VAN HEST, Jan, Cornelis, Maria ,  ROWAN, Alan, Edward ,  NOLTE, Roeland, Johannes, Maria

Inventor： VRIEZEMA, Dennis, Manuel ,  LEANDRO GARCIA, Paula, Maria ,  VAN HEST, Jan, Cornelis, Maria ,  ROWAN, Alan, Edward ,  NOLTE, Roeland, Johannes, Maria

IPC: C08G73/00

Abstract: The present invention relates to polyisocyanide polymersomes, optionally having substances associated therewith, methods of making the same, and to methods of using the same. The polymersomes comprise a vesicular polymer membrane of a PS-PIAT polymer. The substances optionally associated with the polymersomes may comprise catalysts or enzymes, either encapsulated therein, i.e., inside the vesicular membrane of the polymersome, or in the polymeric membrane of the polymersome, or both.

公开(公告)号：WO2012057628A3

公开(公告)日：2012-06-28

申请号：PCT/NL2012050001

申请日：2012-01-02

Applicant: BENDER ANALYTICAL HOLDING BV ,  HOOGENBOOM RICHARD ,  BENDER JOHANNES CASPAR MATHIAS ELIZABETH ,  VAN HEST JAN CORNELIS MARIA

Inventor： HOOGENBOOM RICHARD ,  BENDER JOHANNES CASPAR MATHIAS ELIZABETH ,  VAN HEST JAN CORNELIS MARIA

IPC: A61K47/48 ,  A61L27/18 ,  A61L31/06 ,  A61L31/14 ,  C08G73/02 ,  C08J3/24 ,  C08L79/02

CPC classification number: A61L24/046 ,  A61L24/06 ,  A61L27/18 ,  A61L31/06 ,  C08G73/0233 ,  C08J3/246 ,  C08J2300/10 ,  C08J2379/02 ,  C08L79/02

Abstract: One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m=2, n=2 and m+n =5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m=3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer. The invention further provides a tissue adhesive medical product comprising at least 1% by weight of dry matter of EL-POX, said EL-POX comprising at least 2 electrophilic groups, including at least one pendant electrophilic group. The polymers according to the invention have excellent implant and/or sealing characteristics.

Abstract translation: 本发明的一个方面涉及通过使亲电子活化的聚恶唑啉（EL-POX）与亲核交联剂反应而获得的生物相容的，共价交联的聚合物，所述亲电活化的POX包含m个亲电基团; 并且所述亲核交联剂包含n个亲核基团，其中m个亲电基团能够与n个亲核基团反应形成共价键; 其中m = 2，n = 2和m + n = 5; 其中所述m亲电子基团中的至少一个是侧链亲电子基团和/或其中m = 3; 并且其中所述EL-POX相对于所述亲核交联剂中所含的亲核基团的量包含过量的亲电子基团。 本发明还涉及包含这种交联的POX-聚合物的生物相容性医疗产品。 还提供了用于生产生物相容的交联POX-聚合物的试剂盒。 本发明还提供了包含至少1重量％的EL-POX的干物质的组织粘合剂医疗产品，所述EL-POX包含至少2个亲电子基团，包括至少一个侧链亲电子基团。 根据本发明的聚合物具有优异的植入物和/或密封特性。

公开(公告)号：WO2011005098A1

公开(公告)日：2011-01-13

申请号：PCT/NL2010/050448

申请日：2010-07-12

Applicant: ABBOTT HEALTHCARE PRODUCTS B.V. ,  UNIVERSITEIT LEIDEN ,  UNIVERSITEIT UTRECHT HOLDING B.V. ,  VAN ROOY, Inge ,  HENNINK, Wilhelmus Everhardus ,  MASTROBATTISTA, Enrico ,  SCHIFFELERS, Raymond Michel ,  DINTER-HEIDORN, Heike ,  BRINKHUIS, Rene Pascal ,  VAN HEST, Jan ,  RUTJES, Floris Peter Johannes Theodorus

Inventor： VAN ROOY, Inge ,  HENNINK, Wilhelmus Everhardus ,  MASTROBATTISTA, Enrico ,  SCHIFFELERS, Raymond Michel ,  DINTER-HEIDORN, Heike ,  BRINKHUIS, Rene Pascal ,  VAN HEST, Jan ,  RUTJES, Floris Peter Johannes Theodorus

IPC: C07K7/08 ,  A61K47/48

CPC classification number: B82Y5/00 ,  A61K47/66 ,  A61K47/6911 ,  A61K47/6915 ,  C07K7/08 ,  C07K2319/01

Abstract: The present invention relates to peptides comprising defined amino acid sequences, compositions comprising said peptides and a pharmaceutically acceptable substance, use of said peptides as a central nervous system targeting principle in the treatment, prophylaxis or diagnosis of a central nervous system disorders, combinations of said peptides with pharmaceutically acceptable substances, use of said combinations for the treatment, prophylaxis or diagnosis of a central nervous system disorders, a method of delivery of said peptide and of a pharmaceutically acceptable substance and a nucleic acid sequence encoding for said peptide sequence.

Abstract translation: 本发明涉及包含确定的氨基酸序列的肽，包含所述肽的组合物和药学上可接受的物质，所述肽用作中枢神经系统靶向原理在治疗，预防或诊断中枢神经系统疾病中的用途，所述 具有药学上可接受的物质的肽，所述组合用于治疗，预防或诊断中枢神经系统病症，递送所述肽和药学上可接受的物质的方法以及编码所述肽序列的核酸序列。

公开(公告)号：WO2008049447A1

公开(公告)日：2008-05-02

申请号：PCT/EP2006/010299

申请日：2006-10-25

Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ,  NIJMEGEN UNIVERSITY ,  TRIEU, Hoc Khiem ,  SLOTKOWSKI, Johann ,  KLIEBER, Robert ,  VAN HEST, Jan Cornelis Maria ,  KOCH, Kaspar ,  RUTJES, Floris Petrus Johannes Theodorus ,  NIEUWLAND, Pieter Jos ,  WIEBE, Peter

Inventor： TRIEU, Hoc Khiem ,  SLOTKOWSKI, Johann ,  KLIEBER, Robert ,  VAN HEST, Jan Cornelis Maria ,  KOCH, Kaspar ,  RUTJES, Floris Petrus Johannes Theodorus ,  NIEUWLAND, Pieter Jos ,  WIEBE, Peter

IPC: B01L9/00

CPC classification number: B01L3/565 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1844

Abstract: A chip holder (10) for holding a fluidic chip (22) and for providing a fluid connection to the fluidic chip comprises a guide (20a, 20b), the guide being adapted such that the fluidic chip can be slid into the chip holder in a guiding direction (24). The chip holder further comprises fastening means (30a), the fastening means being adapted to press a fluidic connection (34) toward the fluidic chip, such that the fluidic chip is fixed within the chip holder. The guide and the fastening means are adapted such that the guiding direction and the direction, in which the fluidic connection is pressed, exhibit an angle in the range between 45° and 135°, including 45° and 135°. A fluidic system comprises a chip holder and a fluidic chip inserted in the chip holder. A chip holder system comprises a chip holder and an extension module attached to the chip holder such that the extension module is in contact with the fluidic chip, when the fluidic chip is inserted in the chip holder.

Abstract translation: 用于保持流体芯片（22）并用于提供与流体芯片的流体连接的芯片保持器（10）包括引导件（20a，20b），引导件适于使得流体芯片可以滑入芯片保持器 引导方向（24）。 芯片保持器还包括紧固装置（30a），紧固装置适于将流体连接（34）压向流体芯片，使得流体芯片固定在芯片保持器内。 引导件和紧固装置适于使得流体连接被挤压的引导方向和方向呈45度到135度之间的角度，包括45度和135度。 流体系统包括芯片保持器和插入芯片保持器中的流体芯片。 芯片保持器系统包括芯片保持器和附接到芯片保持器的延伸模块，使得当流体芯片插入芯片保持器时，延伸模块与流体芯片接触。

公开(公告)号：WO2006111399A3

公开(公告)日：2006-10-26

申请号：PCT/EP2006/003677

申请日：2006-04-21

Applicant: DSM IP ASSETS B.V. ,  THIES, Jens Christoph ,  PIERRE, Sébastien ,  CAMERON, Neil Ronald ,  VAN HEST, Jan Cornelis Maria ,  WYMAN, Paul

Inventor： THIES, Jens Christoph ,  PIERRE, Sébastien ,  CAMERON, Neil Ronald ,  VAN HEST, Jan Cornelis Maria ,  WYMAN, Paul

IPC: C12N11/06 ,  C12N11/08 ,  C08F2/32 ,  A61K47/48

Abstract: The present invention relates to highly porous polymeric materials comprising covalently grafted biologically active species. The invention also relates to a process for the preparation of highly porous materials comprising functional monomers capable of grafting to a biologically active molecular species comprising the steps of: (a) preparing an emulsion composition comprising a droplet phase and a continuous phase and containing monomers, (b) curing the emulsion and (c) optionally removing the water/droplet phase. The invention further relates to a process for grafting biologically active species to such a highly porous polymeric material comprising the steps of: (i) exposing the highly porous material to a solution of the biologically active species in a suitable solvent medium, (ii) optionally adding an activating agent, (iii) optionally heating, and (iv) rinsing the porous material with solvent medium to remove non-grafted species. The highly porous polymeric materials comprising covalently grafted biologically active species can be used e.g. as a heterogeneous catalyst, in biosensors, for chromatography, in biomedical devices and in implants.