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65 条记录 (耗时 0.047 秒)

    NOVEL EPSTEIN BARR VIRUS IMMUNOTHERAPIES
    1.
    发明申请
    NOVEL EPSTEIN BARR VIRUS IMMUNOTHERAPIES 审中-公开

    公开(公告)号：WO2023034828A1

    公开(公告)日：2023-03-09

    申请号：PCT/US2022/075703

    申请日：2022-08-30

    申请人： WEINER, David ,  ZHU, Xizhou

    发明人： WEINER, David ,  ZHU, Xizhou

    IPC分类号： A61K39/245 ,  A61P35/00 ,  C07K16/08

    摘要： The present invention generally relates to immunogenic compositions (e.g., vaccines and immunotherapies) that induce an immune response against Epstein Barr Virus (EBV)-associated antigens. The present invention also relates to methods of use thereof for the treatment and prevention of EBV infection, EBV-associated cancer, or a combination thereof. In various embodiments, the EBV antigen comprises BamHI-A rightward frame 1 (BARF1).

    DNA ANTIBODY CONSTRUCTS FOR USE AGAINST PSEUDOMONAS AERUGINOSA
    3.
    发明申请
    DNA ANTIBODY CONSTRUCTS FOR USE AGAINST PSEUDOMONAS AERUGINOSA 审中-公开
    用于抗假单胞菌的DNA抗体构建体

    公开(公告)号：WO2017193101A1

    公开(公告)日：2017-11-09

    申请号：PCT/US2017/031449

    申请日：2017-05-05

    申请人： WEINER, David ,  PATEL, Ami ,  YAN, Jian

    发明人： WEINER, David ,  PATEL, Ami ,  YAN, Jian

    IPC分类号： A61K39/40 ,  C07K16/00 ,  C07K16/12

    摘要： Disclosed herein are mono and bispecific DNA antibodies (DMAbs) targeting Pseudomonas aeruginosa. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the DMAbs to the subject. The disclosure also provides a method of preventing and/or treating Pseudomonas aeruginosa infection in a subject using said composition and method of generation.

    摘要翻译： 本文公开了靶向铜绿假单胞菌的单特异性和双特异性DNA抗体（DMAbs）。 本文还公开了通过将DMAb施用于受试者而在受试者中产生合成抗体的方法。 本公开还提供了使用所述组合物和产生方法预防和/或治疗受试者中的铜绿假单胞菌感染的方法。

    ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    8.
    发明申请
    ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
    ALDOLASES，编码它们的核酸以及制备和使用它们的方法

    公开(公告)号：WO2007103389A2

    公开(公告)日：2007-09-13

    申请号：PCT/US2007/005718

    申请日：2007-03-07

    申请人： CARGILL, INCORPORATED ,  BURKE, Ellen ,  GORT, Steven, John ,  HICKS, Paula, M. ,  LUGINBUHL, Peter ,  MCFARLAN, Sara, C. ,  RICHARDSON, Toby ,  SOLHEID, Christopher ,  WEINER, David ,  ZHAO, Lishan

    发明人： BURKE, Ellen ,  GORT, Steven, John ,  HICKS, Paula, M. ,  LUGINBUHL, Peter ,  MCFARLAN, Sara, C. ,  RICHARDSON, Toby ,  SOLHEID, Christopher ,  WEINER, David ,  ZHAO, Lishan

    IPC分类号： C12P17/00 ,  C07D209/20 ,  C12N9/88 ,  A23L1/22

    CPC分类号： C12P17/10 ,  C12N9/88 ,  C12P13/001 ,  Y02P20/52

    摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R3R and S5R configurations, and salts thereof.

    摘要翻译： 本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸以及制备和使用这些多核苷酸和多肽的方法。 在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性（包括热稳定性和耐热活性），以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和 多肽。 根据本发明的多肽可以用于各种制药，农业和工业环境中。 在一些实施方案中，本发明提供了用于生产R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体诸如R的多肽和生物合成途径 ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，如R3R和S5R构型及其盐。