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    BODY SOAP COMPOSITION
    3.
    发明申请
    BODY SOAP COMPOSITION 审中-公开
    身体肥皂组合物

    公开(公告)号：WO1997027279A1

    公开(公告)日：1997-07-31

    申请号：PCT/JP1997000121

    申请日：1997-01-22

    Applicant: JOHNSON & JOHNSON KABUSHIKI KAISHA ,  HAMADA, Sachio ,  YAMAMOTO, Norihiro ,  TANIUCHI, Shinji ,  WATANABE, Hitoshi ,  KAZAMA, Satoshi

    Inventor： JOHNSON & JOHNSON KABUSHIKI KAISHA

    IPC: C11D10/04

    CPC classification number: A61K8/361 ,  A61K8/463 ,  A61K2800/596 ,  A61K2800/75 ,  A61Q19/10 ,  C11D1/29 ,  C11D1/667 ,  C11D1/74 ,  C11D1/90 ,  C11D10/04 ,  C11D10/042

    Abstract: A problem of conventional body soaps consisting mainly of higher fatty acid soaps has been a stiff feeling of the face skin after use and problems of soaps comprising polyoxyethylene alkyl ether sulfate has caused difficulty of rinsing after use and a stiff feeling remaining especially on the face skin after washing. Further soaps with lower irritation, higher foam stability and washing power than conventional soaps have been expected. A body soap comprising 1 to 30 % fatty acid soap and 1 to 30 % polyoxyethylene alkyl ether sulfate by weight and the weight ratio thereof is 8:2 to 3:7 is provided, further it is preferred to contain either amphoteric surface active agents such as betain type or nonionic surface active agents such as sorbitan type and polyoxyethylene glycol type or both in order to exhibit high foam stability, washing power and reduced irritation.

    Abstract translation: 主要由高级脂肪酸皂组成的常规身体肥皂的问题是使用后的脸部皮肤的僵硬感，并且包含聚氧乙烯烷基醚硫酸盐的肥皂的问题使得使用后的漂洗困难，特别是在面部皮肤上残留的僵硬感 洗后。 预期具有比常规皂更低的刺激性，更高的泡沫稳定性和洗涤力的肥皂。 提供包含1至30％脂肪酸皂和1至30％聚氧乙烯烷基醚硫酸钠的肥皂，其重量比为8:2至3:7，此外优选含有两性表面活性剂如 作为甜菜碱型或非离子表面活性剂如脱水山梨糖醇型和聚氧乙烯二醇型或两者，以显示高泡沫稳定性，洗涤力和刺激性降低。

    ENZYMATIC COUPLING OF L-PHENYLALANINE METHYL ESTER AND N-BENZYLOXYCARBONYL-L-ASPARTIC ACID IN A CONTINUOUS OR FED-BATCH PROCESS
    5.
    发明申请
    ENZYMATIC COUPLING OF L-PHENYLALANINE METHYL ESTER AND N-BENZYLOXYCARBONYL-L-ASPARTIC ACID IN A CONTINUOUS OR FED-BATCH PROCESS 审中-公开
    连续或FED-BATCH方法中L-苯乙胺甲酯和N-苄氧羰基-L-十六烷酸的酶联

    公开(公告)号：WO02098905A3

    公开(公告)日：2003-10-16

    申请号：PCT/NL0200364

    申请日：2002-06-04

    Applicant: HOLLAND SWEETENER CO ,  TOKUDA AKIRA ,  YAMAMOTO NORIHIRO ,  NAKAMURA SHIICHIRO ,  QUAEDFLIEG PETER JAN LEONARD M

    Inventor： TOKUDA AKIRA ,  YAMAMOTO NORIHIRO ,  NAKAMURA SHIICHIRO ,  QUAEDFLIEG PETER JAN LEONARD M

    IPC: C07K5/072 ,  C07K5/075 ,  C12P21/02

    CPC classification number: C07K5/0613 ,  C12P21/02

    Abstract: The invention relates to a process for the preparation of N-benzyloxycarbonyl- alpha -L-aspartyl-L-phenylalanine methyl ester (Z-APM) by high-conversion enzymatic coupling of N-benzyloxycarbonyl-L-aspartic acid (Z-Asp) and L-phenylalanine methyl ester (L-PM) in a reaction mixture comprising an aqueous medium, a neutral protease as enzyme and an alkali metal salt, alkaline earth metal salt or ammonium salt, with formation of a precipitate. The enzymatic coupling of Z-Asp and L-PM is carried out in a continuous or fed-batch process at a pH of from 5.0 to 6.5 and an average charged molar ratio of Z-Asp and L-PM between 1:1 and 2:1 and wherein the actual molar ratio of Z-Asp and L-PM is higher than the average charge molar ratio. Preferably the alkali metal salt, alkaline earth metal salt or ammonium salt is present in an amount of from 3 to 25 %, calculated as % by weight based on the total reaction mixture.

    Abstract translation: 本发明涉及N-苄氧羰基-L-天冬氨酸（Z-Asp）的高转化酶偶联制备N-苄氧羰基-α-L-天冬氨酰-L-苯丙氨酸甲酯（Z-APM）的方法， 和L-苯丙氨酸甲酯（L-PM），其包含水性介质，中性蛋白酶作为酶和碱金属盐，碱土金属盐或铵盐，形成沉淀物。 Z-Asp和L-PM的酶偶联在连续或补料分批过程中进行，pH为5.0至6.5，Z-Asp和L-PM的平均带电摩尔比为1:1至2:1 ：1，其中Z-Asp和L-PM的实际摩尔比高于平均电荷摩尔比。 优选地，碱金属盐，碱土金属盐或铵盐的存在量为3至25％，以基于总反应混合物的重量％计。

    THREE-DIMENSIONAL FABRICATION APPARATUS, CONTROLLER, AND CONTROL METHOD
    7.
    发明申请
    THREE-DIMENSIONAL FABRICATION APPARATUS, CONTROLLER, AND CONTROL METHOD 审中-公开

    公开(公告)号：WO2019244568A1

    公开(公告)日：2019-12-26

    申请号：PCT/JP2019/020930

    申请日：2019-05-27

    Applicant: RICOH COMPANY, LTD. ,  YAMAMOTO Norihiro

    Inventor： YAMAMOTO Norihiro

    IPC: B29C64/386 ,  B29C64/393

    Abstract: An object of the present disclosure is to provide a fabrication apparatus, a controller, and a method to fabricate a desired three-dimensional object. A fabrication apparatus to fabricate a three-dimensional object, the fabrication apparatus includes a fabricated-object-shape measurement unit (340) to measure a planar shape of a fabrication layer, a displaced-shape prediction unit (350) to predict a displacement amount of a shape of the fabrication layer after a predetermined time has elapsed since fabrication of the fabrication layer, and a correction-vector output unit (370) to correct fabrication data of a next fabrication layer to be fabricated next to the fabrication layer based on planar shape data of the fabrication layer measured by the fabricated-object-shape measurement unit (340) and the displacement amount predicted by the displaced-shape prediction unit (350).

    ENZYMATIC COUPLING OF L-PHENYLALANINE METHYL ESTER AND N-BENZYLOXYCARBONYL-L-ASPARTIC ACID IN A CONTINUOUS OR FED-BATCH PROCESS
    8.
    发明申请
    ENZYMATIC COUPLING OF L-PHENYLALANINE METHYL ESTER AND N-BENZYLOXYCARBONYL-L-ASPARTIC ACID IN A CONTINUOUS OR FED-BATCH PROCESS 审中-公开
    连续或FED-BATCH方法中L-苯乙胺甲酯和N-苄氧羰基-L-十六烷酸的酶联

    公开(公告)号：WO2002098905A2

    公开(公告)日：2002-12-12

    申请号：PCT/NL2002/000364

    申请日：2002-06-04

    Applicant: HOLLAND SWEETENER COMPANY V.O.F. ,  TOKUDA, Akira ,  YAMAMOTO, Norihiro ,  NAKAMURA, Shiichiro ,  QUAEDFLIEG, Peter, Jan, Leonard, Mario

    Inventor： TOKUDA, Akira ,  YAMAMOTO, Norihiro ,  NAKAMURA, Shiichiro ,  QUAEDFLIEG, Peter, Jan, Leonard, Mario

    IPC: C07K5/06

    CPC classification number: C07K5/0613 ,  C12P21/02

    Abstract: The invention relates to a process for the preparation of N-benzyloxycarbonyl-α-L-aspartyl-L-phenylalanine methyl ester (Z-APM) by high-conversion enzymatic coupling of N-benzyloxycarbonyl-L-aspartic acid (Z-Asp) and L-phenylalanine methyl ester (L-PM) in a reaction mixture comprising an aqueous medium, a neutral protease as enzyme and an alkali metal salt, alkaline earth metal salt or ammonium salt, with formation of a precipitate. The enzymatic coupling of Z-Asp and L-PM is carried out in a continuous or fed-batch process at a pH of from 5.0 to 6.5 and an average charged molar ratio of Z-Asp and L-PM between 1:1 and 2:1 and wherein the actual molar ratio of Z-Asp and L-PM is higher than the average charge molar ratio. Preferably the alkali metal salt, alkaline earth metal salt or ammonium salt is present in an amount of from 3 to 25 %, calculated as % by weight based on the total reaction mixture.

    Abstract translation: 本发明涉及N-苄氧羰基-L-天冬氨酸（Z-Asp）的高转化酶偶联制备N-苄氧羰基-α-L-天冬氨酰-L-苯丙氨酸甲酯（Z-APM）的方法， 和L-苯丙氨酸甲酯（L-PM），其包含水性介质，中性蛋白酶作为酶和碱金属盐，碱土金属盐或铵盐，形成沉淀物。 Z-Asp和L-PM的酶偶联在连续或补料分批过程中进行，pH为5.0至6.5，Z-Asp和L-PM的平均带电摩尔比为1:1至2:1 ：1，其中Z-Asp和L-PM的实际摩尔比高于平均电荷摩尔比。 优选地，碱金属盐，碱土金属盐或铵盐的存在量为3至25％，以基于总反应混合物的重量％计。

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