公开(公告)号：WO2020072972A1

公开(公告)日：2020-04-09

申请号：PCT/US2019/054819

申请日：2019-10-04

Applicant: MAGIC LEAP, INC. ,  MOHAN, Anush ,  TAYLOR, Robert, Blake ,  MIRANDA, Jeremy, Dwayne ,  TORRES, Rafael, Domingos ,  OLSHANSKY, Daniel ,  SHAROKNI, Ali ,  GUENDELMAN, Eran ,  KRAMER, Nick ,  TOSSELL, Ken ,  MILLER, Samuel A. ,  TAJIK, Jehangir ,  SWAMINATHAN, Ashwin ,  AGARWAL, Lomesh ,  SINGHAL, Prateek ,  HOLDER, Joel, David ,  ZHAO, Xuan ,  CHOUDHARY, Siddharth ,  SUZUKI, Helder, Toshiro ,  BAROT, Hiral, Honar

Inventor： MOHAN, Anush ,  TAYLOR, Robert, Blake ,  MIRANDA, Jeremy, Dwayne ,  TORRES, Rafael, Domingos ,  OLSHANSKY, Daniel ,  SHAHROKNI, Ali ,  GUENDELMAN, Eran ,  KRAMER, Nick ,  TOSSELL, Ken ,  MILLER, Samuel A. ,  TAJIK, Jehangir ,  SWAMINATHAN, Ashwin ,  AGARWAL, Lomesh ,  SINGHAL, Prateek ,  HOLDER, Joel, David ,  ZHAO, Xuan ,  CHOUDHARY, Siddharth ,  SUZUKI, Helder, Toshiro ,  BAROT, Hiral, Honar ,  MOORE, Christian Ivan Robert

IPC: G06T19/00 ,  G06F3/0482 ,  G06F3/0486 ,  G06K9/46 ,  G06K9/52 ,  G06F3/04815 ,  G06K9/00671 ,  G06K9/00765 ,  G06K9/4671 ,  G06K9/629 ,  G06T19/006

Abstract: A cross reality system that provides an immersive user experience by storing persistent spatial information about the physical world that one or multiple user devices can access to determine position within the physical world and that applications can access to specify the position of virtual objects within the physical world. Persistent spatial information enables users to have a shared virtual, as well as physical, experience when interacting with the cross reality system. Further, persistent spatial information may be used in maps of the physical world, enabling one or multiple devices to access and localize into previously stored maps, reducing the need to map a physical space before using the cross reality system in it. Persistent spatial information may be stored as persistent coordinate frames, which may include a transformation relative to a reference orientation and information derived from images in a location corresponding to the persistent coordinate frame.

公开(公告)号：WO2006138463A3

公开(公告)日：2008-08-14

申请号：PCT/US2006023307

申请日：2006-06-15

Applicant: NEKTAR THERAPEUTICS AL CORP ,  BURTON KEVIN ,  ZHAO XUAN ,  BENTLEY MICHAEL D

Inventor： BURTON KEVIN ,  ZHAO XUAN ,  BENTLEY MICHAEL D

IPC: A61K47/48 ,  A61P29/00

CPC classification number: C08G65/329 ,  A61K47/60

Abstract: Provided herein are water-soluble polymer conjugates and polymer-based compositions of non-steroidal anti-inflammatory drugs. Also provided are methods for synthesizing and administering such conjugates and compositions.

Abstract translation: 本文提供的是非甾体抗炎药的水溶性聚合物缀合物和基于聚合物的组合物。 还提供了用于合成和施用这种缀合物和组合物的方法。

公开(公告)号：WO9934833A9

公开(公告)日：2005-03-17

申请号：PCT/US9900594

申请日：1999-01-06

Applicant: SHEARWATER POLYMERS INC ,  HARRIS J MILTON ,  ZHAO XUAN

Inventor： HARRIS J MILTON ,  ZHAO XUAN

IPC: A61K47/48 ,  C08F299/00 ,  C08G65/329 ,  C08G81/00

CPC classification number: C08L71/02 ,  A61K47/60 ,  C08G65/329 ,  C08G65/3322 ,  C08L2203/02 ,  Y10S530/81 ,  Y10S530/816 ,  C08L2666/04

Abstract: A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.

Abstract translation: 提供具有水解可降解键的异双功能聚（乙二醇），包含丙烯酸酯基的第一末端，和包含诸如蛋白质或药物的靶的第二末端或能够与靶偶合的反应性部分。 水凝胶可以制备。 水凝胶可用作可以以受控方式容易地释放的蛋白质或药剂的载体。

公开(公告)号：WO03037384A3

公开(公告)日：2003-08-28

申请号：PCT/US0234666

申请日：2002-10-29

Applicant: SHEARWATER CORP ,  BENTLEY MICHAEL DAVID ,  ZHAO XUAN

Inventor： BENTLEY MICHAEL DAVID ,  ZHAO XUAN

IPC: C07D403/14 ,  A61K31/404 ,  A61K45/00 ,  A61K47/48 ,  A61P3/10 ,  A61P9/00 ,  A61P11/06 ,  A61P17/06 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C08G65/333

CPC classification number: A61K47/60

Abstract: The invention provides polymer conjugates of protein kinase C (PKC) inhibitors comprising a polymer, such as poly(ethylene glycol), covalently attached to a PKC inhibitor, such as a bisindolylmaleimide molecule. The linkage between the polymer and the PKC inhibitor is preferably hydrolytically degradable. The invention also includes a pharmaceutical composition comprising a polymer conjugate of a PKC inhibitor and a method of treating any condition responsive to a PKC inhibitor by administering a polymer conjugate of the invention.

Abstract translation: 本发明提供蛋白激酶C（PKC）抑制剂的聚合物缀合物，其包含共价连接到PKC抑制剂如双吲哚基马来酰亚胺分子的聚（乙二醇）等聚合物。 聚合物和PKC抑制剂之间的连接优选是可水解降解的。 本发明还包括药物组合物，其包含PKC抑制剂的聚合物缀合物和通过施用本发明的聚合物缀合物来治疗对PKC抑制剂有反应的任何病症的方法。

公开(公告)号：WO2003040211A2

公开(公告)日：2003-05-15

申请号：PCT/US2002/035759

申请日：2002-11-07

Applicant: SHEARWATER CORPORATION ,  BENTLEY, Michael, David ,  ZHAO, Xuan ,  SHEN, Xiaoming ,  BATTLE, William, Dudley, III

Inventor： BENTLEY, Michael, David ,  ZHAO, Xuan ,  SHEN, Xiaoming ,  BATTLE, William, Dudley, III

IPC: C08G65/329

CPC classification number: C08G65/48 ,  A61K47/60 ,  A61K47/6901 ,  C07K17/08 ,  C08G65/329 ,  C08G65/3322 ,  C08L2203/02 ,  C12N9/96

Abstract: The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, -O-alkylene-O-, -alkylene-O-alkylene-, -aryl-O-, -O-aryl-, (-O-alkylene-) m , or (-alkylene-O-) m linkage, wherein m is 1-10.

Abstract translation: 本发明涉及包含至少两个聚合物臂（例如聚乙二醇）的支化反应性水溶性聚合物，所述聚合物臂通过杂原子连接与中心脂族烃核心分子连接。 支化聚合物带有至少一个官能团，用于与生物活性剂反应形成生物活性缀合物。 支化聚合物的官能团可以直接连接到脂族烃核上或经由插入的键例如杂原子，亚烷基-O-亚烷基-O-， - 亚烷基-O-亚烷基 - ， - 芳基 - O-，-O-芳基 - ，（-O-亚烷基 - ）m或（ - 亚烷基-O-）m连接，其中m是1-10。

公开(公告)号：WO2005058367A2

公开(公告)日：2005-06-30

申请号：PCT/US2004042661

申请日：2004-12-16

Applicant: NEKTAR THERAPEUTICS AL CORP ,  BENTLEY MICHAEL D ,  VIEGAS TACEY X ,  GOODIN RICHARD R ,  CHENG LIN ,  ZHAO XUAN

Inventor： BENTLEY MICHAEL D ,  VIEGAS TACEY X ,  GOODIN RICHARD R ,  CHENG LIN ,  ZHAO XUAN

IPC: A61K31/765 ,  A61K31/785 ,  A61K47/48 ,  C08G65/08

CPC classification number: C08G65/337 ,  A61K47/60 ,  C08G65/332 ,  C08G65/33317 ,  C08G65/33396 ,  C08L2203/02

Abstract: The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.

Abstract translation: 本发明提供了通过共价连接由单分散或双峰水溶性低聚物组合物获得的水溶性低聚物进行化学修饰的小分子药物。 当与多种施用途径中的任何一种施用时，本发明的缀合物与未附着于水溶性低聚物的小分子药物的生物膜交联率相比，显示出降低的生物膜交叉率。

公开(公告)号：WO2004060977A1

公开(公告)日：2004-07-22

申请号：PCT/US2003/041332

申请日：2003-12-24

Applicant: NEKTAR THERAPEUTICS AL, CORPORATION ,  ZHAO, Xuan, S. ,  REN, Zhongxu ,  EMOTO, Kazunori

Inventor： ZHAO, Xuan, S. ,  REN, Zhongxu ,  EMOTO, Kazunori

IPC: C08G81/02

CPC classification number: A61K9/5146 ,  A61K47/34 ,  A61K47/60 ,  A61K47/64 ,  C08G65/329 ,  C08L71/02 ,  C08L2203/02 ,  C08L2205/05 ,  C08L2666/26

Abstract: The invention provides a mufti-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The mufti-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.

Abstract translation: 本发明提供了用于递送各种生物活性剂的多臂嵌段共聚物。 本发明的共聚物含有中心核，多个（3个或更多个）共聚物臂可从中心芯延伸。 每个共聚物臂具有内部多肽片段和外部亲水性聚合物片段。 因此，共聚物的总体结构包括内核区域，其包含中心核心和内部多肽区段，而外核区域本质上是亲水性的。 本发明的三臂共聚物特别可用于递送可被包埋在内芯区内的生物活性剂。

公开(公告)号：WO2003070805A1

公开(公告)日：2003-08-28

申请号：PCT/US2003/005113

申请日：2003-02-14

Applicant: NEKTAR THERAPEUTICS AL, CORPORATION ,  BENTLEY, Michael, D. ,  HARRIS, J., Milton ,  ZHAO, Xuan ,  BATTLE, William, Dudley, III

Inventor： BENTLEY, Michael, D. ,  HARRIS, J., Milton ,  ZHAO, Xuan ,  BATTLE, William, Dudley, III

IPC: C08G65/00

CPC classification number: C08G65/04 ,  A61K9/00 ,  A61K9/06 ,  A61K47/34 ,  C08G64/183 ,  C08G65/329 ,  C08G65/333 ,  C08G65/33337 ,  C08G65/33344 ,  C08G65/33396 ,  C08L2203/02

Abstract: The present invention provides a water soluble, nonpeptidic polymer comprising two or more alkylene oxide-based oligomers linked together by hydrolytically degradable linkages such as carbonates. Typically, the oligomer portion of the polymer is an amphiphilic triblock copolymer having a central propylene oxide block or butylene oxide block positioned between two ethylene oxide blocks. The polymer can be hydrolytically degraded into oligomers under physiological conditions. In aqueous media, the polymer preferably forms thermally reversible, hydrolytically degradable hydrogels that can be used, for example, for drug delivery and related biomedical applications.

Abstract translation: 本发明提供了一种水溶性非肽性聚合物，其包含通过可水解可降解的键如碳酸酯连接在一起的两个或更多个基于环氧烷的低聚物。 通常，聚合物的低聚物部分是具有位于两个环氧乙烷嵌段之间的中心环氧丙烷嵌段或环氧丁烷嵌段的两亲性三嵌段共聚物。 聚合物可以在生理条件下水解降解成低聚物。 在水性介质中，聚合物优选形成热可逆的水解可降解水凝胶，其可用于例如药物递送和相关的生物医学应用。

公开(公告)号：WO2003037385A1

公开(公告)日：2003-05-08

申请号：PCT/US2002/036421

申请日：2002-10-30

Applicant: SHEARWATER CORPORATION ,  BENTLEY, Michael, David ,  ZHAO, Xuan ,  LEACH, Chester ,  KUO, Mei-Chang ,  CHARAN, Chatan, K.

Inventor： BENTLEY, Michael, David ,  ZHAO, Xuan ,  LEACH, Chester ,  KUO, Mei-Chang ,  CHARAN, Chatan, K.

IPC: A61K47/48

CPC classification number: A61K9/0075 ,  A61K9/1641 ,  A61K47/60 ,  Y02A50/406

Abstract: The present invention provides water-soluble polymer conjugates of retinoic acid. The conjugates of the invention are prepared by covalent attachment of a water-soluble and non-peptidic polymer such as polyethylene glycol to a retinoid such as retinoic acid. The polymer portion of the conjugate may be linear (i.e., prepared using an end-capped or methoxy PEG or a linear bifunctional PEG), branched or forked. The conjugates of the invention are water soluble, and are, in particular, useful for inhalation therapy of conditions of the respiratory tract responsive to retinoid therapy.

Abstract translation: 本发明提供视黄酸的水溶性聚合物共轭物。 本发明的缀合物通过将水溶性和非肽类聚合物如聚乙二醇共价连接到类视黄醇如维甲酸来制备。 缀合物的聚合物部分可以是线性的（即使用端封端或甲氧基PEG或线性双功能PEG制备），分支或分叉。 本发明的缀合物是水溶性的，特别是用于对类视黄醇治疗有效的呼吸道病症的吸入治疗。

公开(公告)号：WO2003037384A2

公开(公告)日：2003-05-08

申请号：PCT/US2002/034666

申请日：2002-10-29

Applicant: SHEARWATER CORPORATION ,  BENTLEY, Michael, David ,  ZHAO, Xuan

Inventor： BENTLEY, Michael, David ,  ZHAO, Xuan

IPC: A61K47/48

CPC classification number: A61K47/60

Abstract: The invention provides polymer conjugates of protein kinase C (PKC) inhibitors comprising a polymer, such as poly(ethylene glycol), covalently attached to a PKC inhibitor, such as a bisindolylmaleimide molecule. The linkage between the polymer and the PKC inhibitor is preferably hydrolytically degradable. The invention also includes a pharmaceutical composition comprising a polymer conjugate of a PKC inhibitor and a method of treating any condition responsive to a PKC inhibitor by administering a polymer conjugate of the invention.

Abstract translation: 本发明提供蛋白激酶C（PKC）抑制剂的聚合物缀合物，其包含共价连接至PKC抑制剂如双吲哚基马来酰亚胺分子的聚合物（例如聚（乙二醇））。 聚合物和PKC抑制剂之间的连接优选是可水解降解的。 本发明还包括药物组合物，其包含PKC抑制剂的聚合物缀合物和通过施用本发明的聚合物缀合物来治疗对PKC抑制剂有响应的任何病症的方法。