公开(公告)号：WO2015057662A1

公开(公告)日：2015-04-23

申请号：PCT/US2014/060421

申请日：2014-10-14

Applicant: ABBOTT LABORATORIES

Inventor： PEREZ, Alejandro Barranco ,  HERNANDEZ, Enrique Vazquez ,  GONZALEZ, Maria Ramirez ,  CABRERA, Ricardo Rueda

IPC: A61K31/14 ,  A61K31/191 ,  A61K31/405 ,  A61K31/685 ,  A61K31/06 ,  A61P25/26 ,  A61P25/28

CPC classification number: A61K31/191 ,  A01K1/031 ,  A23L33/15 ,  A23L33/16 ,  A23V2002/00 ,  A61K9/0053 ,  A61K31/14 ,  A61K31/405 ,  A61K31/685 ,  A61K33/06 ,  A61K45/06 ,  A61K2300/00

Abstract: Compositions including a combination of a source of choline, a source of magnesium, and a source of L-tryptophan are provided for improving cognitive performance in a subject. The compositions may improve a cognitive impairment and/or brain dysfunction associated with age-related cognitive decline or cognitive decline resulting from a neurodegenerative disease. The compositions may also be effective in improving memory acquisition, memory retention, and recall.

Abstract translation: 提供包括胆碱来源，镁源和L-色氨酸来源的组合物，用于改善受试者的认知表现。 组合物可以改善与由神经变性疾病引起的与年龄相关的认知衰退或认知衰退相关的认知障碍和/或脑功能障碍。 组合物还可以有效地改善记忆获取，记忆保留和回忆。

公开(公告)号：WO2015085077A1

公开(公告)日：2015-06-11

申请号：PCT/US2014/068582

申请日：2014-12-04

Applicant: ABBOTT LABORATORIES

Inventor： MARTÍN, María-Jesús Martín ,  GONZALEZ, Maria Ramirez ,  DELGADO, Elena Oliveros ,  PEREZ, Alejandro Barranco ,  CABRERA, Ricardo Rueda

IPC: A23L1/29 ,  A61K31/191 ,  A61K31/7016 ,  A23L1/308 ,  A23L1/30 ,  A61P25/28

CPC classification number: A61K31/7016 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/7008 ,  A23V2200/322 ,  A23V2250/5438

Abstract: Methods of achieving sustained memory improvements and sustained improvement in learning abilities in an infant are provided. The methods comprise administering an effective amount of sialic acid to an infant or a preterm infant until at least 90 days or three months after birth. The administration results in enhanced brain function, improved learning ability and sustained memory improvement in the infant.

Abstract translation: 提供了实现持续记忆改善和持续改善婴幼儿学习能力的方法。 所述方法包括向婴儿或早产儿施用有效量的唾液酸，直到出生后至少90天或3个月。 该行政管理导致增强脑功能，改善学习能力和持续记忆改善。

公开(公告)号：WO2015100091A1

公开(公告)日：2015-07-02

申请号：PCT/US2014/070758

申请日：2014-12-17

Applicant: ABBOTT LABORATORIES

Inventor： HERNANDEZ, Enrique Vazquez ,  PEREZ, Alejandro Barranco ,  GONZALEZ, Maria Ramirez ,  CABRERA, Ricardo Rueda

IPC: A23L1/308 ,  A23L1/09 ,  A23L1/29

CPC classification number: A23L33/21 ,  A23L21/00 ,  A23L29/30 ,  A23L33/125 ,  A23L33/40

Abstract: Certain aspects of the methods disclosed herein relate to treating neuroinflammation, preventing neuroinflammation, or reducing neuroinflammation, and combinations of the foregoing in a subject by administration of 2-fucosyl-lactose. Other aspects of the methods disclosed herein relate to treating cognitive impairment, preventing cognitive impairment, or reducing cognitive impairment, and combinations of the foregoing in a subject by administration of 2-fucosyl-lactose.

Abstract translation: 本文公开的方法的某些方面涉及通过施用2-岩藻糖基 - 乳糖来治疗神经炎症，预防神经炎症或减少神经炎症，以及受试者中前述组合。 本文公开的方法的其它方面涉及通过施用2-岩藻糖基 - 乳糖来治疗受试者的认知障碍，预防认知障碍或减少认知障碍以及前述组合。

公开(公告)号：WO2014043368A1

公开(公告)日：2014-03-20

申请号：PCT/US2013/059488

申请日：2013-09-12

Applicant: ABBOTT LABORATORIES

Inventor： HERNANDEZ, Enrique Vazquez ,  CABRERA, Ricardo Rueda ,  BUCK, Rachael ,  GONZALEZ, Maria Ramirez ,  PEREZ, Alejandro Barranco

IPC: A23L1/30 ,  A61K31/702 ,  A61P25/28 ,  A61P25/00

CPC classification number: A61K31/702 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/322 ,  A23V2250/0612 ,  A23V2250/156 ,  A23V2250/1842 ,  A23V2250/1862 ,  A23V2250/1882 ,  A23V2250/28 ,  A23V2250/5036 ,  A23V2250/54252 ,  A23V2250/612 ,  A23V2250/70

Abstract: Disclosed are methods for enhancing learning and/or memory, enhancing memory acquisition, memory retention and recall by inducing a higher long-term potentiation in hippocampal neuronal synapsis in individuals. The methods include administration of 2-fucosyl-lactose to an individual.

Abstract translation: 公开的是增加学习和/或记忆的方法，通过在个体中诱导海马神经元突触的更高的长期增强来增强记忆获取，记忆保留和召回。 所述方法包括向个体施用2-岩藻糖基 - 乳糖。

公开(公告)号：WO2014160286A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/026239

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： LAI, Chron-Si ,  BLOCH, Tama ,  SHERRY, Christina ,  GONZALEZ, Maria Ramirez ,  KUCHAN, Matthew ,  KATZ, Gary ,  DELGADO, Elena, Oliveros ,  SANTOS, Angela

IPC: A23L1/30 ,  A23L1/303 ,  A23L1/29 ,  A61K31/202 ,  A61K31/355

CPC classification number: A61K31/685 ,  A23L33/10 ,  A23L33/115 ,  A23L33/12 ,  A23L33/13 ,  A23L33/15 ,  A23L33/155 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/48 ,  A61K9/4808 ,  A61K31/015 ,  A61K31/045 ,  A61K31/047 ,  A61K31/065 ,  A61K31/202 ,  A61K31/355 ,  A61K31/593 ,  A61K2300/00

Abstract: Disclosed are prenatal and lactation supplements for pregnant women and lactating women, which include a combination of RRR-alpha-tocopherol, docosahexaenoic acid (DHA), trans-lutein, phospholipids, and at least one nuclear receptor activating ligand other than RRR-alpha-tocopherol, DHA, and trans-lutein. The supplements may enhance central nervous system development in a fetus or breast-feeding newborn infant.

Abstract translation: 公开了孕妇和哺乳期妇女的产前和哺乳期补品，其中包括RRR-α-生育酚，二十二碳六烯酸（DHA），反式叶黄素，磷脂以及除RRR-α-生育酚之外的至少一种核受体活化配体的组合， 生育酚，DHA和反式叶黄素。 补充剂可以增强胎儿或母乳喂养新生儿的中枢神经系统发育。

公开(公告)号：WO2014043330A1

公开(公告)日：2014-03-20

申请号：PCT/US2013/059436

申请日：2013-09-12

Applicant: ABBOTT LABORATORIES

Inventor： HERNANDEZ, Enrique Vazquez ,  CABRERA, Ricardo Rueda ,  BUCK, Rachael ,  GONZALEZ, Maria Ramirez

IPC: A23L1/29 ,  A23L1/308 ,  A61K31/702 ,  A61K35/20 ,  A61P25/00

CPC classification number: A61K31/702 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095

Abstract: Disclosed are methods of modulating and/or decreasing serum corticosterone levels in an individual affected by stress. Further disclosed are methods of modulating the hypothalamic pituitary adrenal response in an individual. The methods include administration of 2-fucosyl-lactose to an individual.

Abstract translation: 公开了在受压力影响的个体中调节和/或降低血清皮质酮水平的方法。 进一步公开的是调节个体中下丘脑垂体肾上腺反应的方法。 所述方法包括向个体施用2-岩藻糖基 - 乳糖。

公开(公告)号：WO2012112419A1

公开(公告)日：2012-08-23

申请号：PCT/US2012/024817

申请日：2012-02-13

Applicant: ABBOTT LABORATORIES ,  PEDROSA, Jose Maria Lopez ,  MARTIN, Manuel Manzano ,  PEREZ, Alejandro Barranco ,  GONZALEZ, Maria Ramirez ,  CANBRERA, Ricardo Rueda

Inventor： PEDROSA, Jose Maria Lopez ,  MARTIN, Manuel Manzano ,  PEREZ, Alejandro Barranco ,  GONZALEZ, Maria Ramirez ,  CANBRERA, Ricardo Rueda

IPC: A23L1/305

CPC classification number: A61K31/19 ,  A23L33/10 ,  A23L33/175 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/322 ,  A23V2250/06

Abstract: Disclosed are methods for enhancing neural function in an individual, such as an older adult. The methods include administering nutritional compositions comprising HMB to the individual. The nutritional compositions provide benefits for individuals that have or may be at risk of having cognitive decline, cognitive impairment, and neural dysfunction, typically resulting from cognitive diseases associated with neurodegenerative diseases.

Abstract translation: 公开了用于增强个体如老年人中的神经功能的方法。 所述方法包括向个体施用包含HMB的营养组合物。 营养组合物对于具有或可能具有认知衰退，认知障碍和神经功能障碍（通常由与神经变性疾病相关的认知疾病引起）的风险的个体提供益处。