公开(公告)号：WO0214377A3

公开(公告)日：2002-06-20

申请号：PCT/EP0109469

申请日：2001-08-16

Applicant: BASF AG ,  SYMYX TECHNOLOGIES INC

Inventor： SCHROF WOLFGANG ,  SEUFERT MICHAEL ,  HEGER ROBERT ,  IDEN RUEDIGER ,  HORN DIETER ,  KOLTZENBURG SEBASTIAN ,  NIELSEN RALPH B ,  CARLSON ERIC ,  CHANG HAN-TING ,  PETRO MIROSLAV ,  KUEBLER SIGRID

IPC: B82B3/00 ,  C08F2/00 ,  C08F212/08 ,  B01J19/00

CPC classification number: C08F2/00 ,  C08F212/08 ,  C08F220/06 ,  C08F226/06

Abstract: Disclosed is a method of making an array of n nanoparticular dispersion formulations, wherein said nanoparticular dispersion formulations each comprise -at least one nanodispersant, -at least one application media, -an active ingredient said method comprising the following steps: c) making said array of n nanoparticular dispersion formulations by c1) a parallelized solid solution route, or c2) a parallelized general precipitation route, or c3) a parallelized reactive precipitation route, d) parallelized, rapid serial or semi-parallel characterizing of said obtained n nanoparticular dispersion formulations; an array of at least 8 different nanoparticular dispersion formulations; a method of making an array of m nanodipersants by a parallel polymerization process; an array of at least 8 different nanodispersants; a method of making an array of n solid solutions by a parallelized solid solution route; and an array of at least 8 different.

Abstract translation: 公开了制备n个纳米颗粒分散体制剂阵列的方法，其中所述纳米颗粒分散体制剂各自包含至少一个纳米分散剂 - 至少一种施用介质 - 活性成分，所述方法包括以下步骤：c）制备所述阵列 通过c1）平行化固溶体途径，或c2）平行化的一般沉淀途径，或c3）平行化的反应沉淀途径，d）所述获得的n个纳米颗粒分散体配方的平行，快速连续或半平行表征 ; 至少8种不同的纳米粒子分散体配方的阵列; 通过平行聚合方法制备m纳米二极体阵列的方法; 至少8种不同的纳米分散剂阵列; 通过并行固溶途径制备n个固溶体阵列的方法; 和至少8个不同的阵列。

公开(公告)号：WO0064414A3

公开(公告)日：2001-05-31

申请号：PCT/EP0003232

申请日：2000-04-11

Applicant: BASF AG ,  HEGER ROBERT ,  SCHROF WOLFGANG ,  RIEGER JENS ,  VOELKEL RUEDIGER ,  BREITENBACH JOERG ,  ZEIDLER JUERGEN ,  LIEPOLD BERND ,  BERNDL GUNTHER ,  BINDER RUDOLF

Inventor： HEGER ROBERT ,  SCHROF WOLFGANG ,  RIEGER JENS ,  VOELKEL RUEDIGER ,  BREITENBACH JOERG ,  ZEIDLER JUERGEN ,  LIEPOLD BERND ,  BERNDL GUNTHER ,  BINDER RUDOLF

IPC: A61K47/22 ,  A61K9/16 ,  A61K31/4184 ,  A61K31/4439 ,  A61K45/00 ,  A61K47/34 ,  A61K47/42 ,  A61P1/00 ,  A61P1/04 ,  A61P35/00

CPC classification number: A61K9/1617 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1658 ,  A61K31/4184 ,  A61K31/4439

Abstract: The invention relates to a solid preparation, containing an acid-sensitive proton-pump blocker as the active substance, whereby said active substance is present in an x-ray amorphous form and is embedded in molecularly dispersed form in an auxiliary agent matrix.

Abstract translation: 含有固体制剂，作为活性物质可使用酸不稳定的质子泵抑制剂，其特征在于所述活性物质是X射线无定形并且被嵌入在分子中的赋形剂基质中。

公开(公告)号：WO03039254A8

公开(公告)日：2004-05-21

申请号：PCT/EP0212401

申请日：2002-11-06

Applicant: BASF AG ,  SYMYX TECHNOLOGIES INC ,  KOLTZENBURG SEBASTIAN ,  SCHROF WOLFGANG ,  SEUFERT MICHAEL ,  HEGER ROBERT ,  LEHMANN STEPHAN ,  KARDORFF UWE ,  ZAGAR CYRILL ,  BRATZ MATTHIAS ,  CARLSON ERIC D ,  CHANG HAN TING ,  KUEBLER SIGRID C

Inventor： KOLTZENBURG SEBASTIAN ,  SCHROF WOLFGANG ,  SEUFERT MICHAEL ,  HEGER ROBERT ,  LEHMANN STEPHAN ,  KARDORFF UWE ,  ZAGAR CYRILL ,  BRATZ MATTHIAS ,  CARLSON ERIC D ,  CHANG HAN TING ,  KUEBLER SIGRID C

IPC: A01N43/38 ,  A01N25/04 ,  A01N25/10 ,  A01N37/32 ,  A01N37/46 ,  C08F220/60

CPC classification number: A01N25/10 ,  A01N37/32 ,  A01N37/46 ,  A01N25/12 ,  A01N25/04 ,  A01N2300/00 ,  A01N25/14

Abstract: The invention relates to a solid crop protection formulation comprising a) cinidon-ethyl as a crop protection agent; b) at least one random radical copolymer comprising as polymerized units at least one hydrophilic and at least one hydrophobic monomer; and c) optionally further additives, wherein at least 50 % of the dispersed cinidon-ethyl particles in said solid crop protection formulation are in an X-ray amorphous state and an aqueous dispersion formulation thereof. Additionally, the invention relates to processes for preparing said formulations and the use of said formulations in agriculture. Further, the invention relates to a random radical copolymer essentially consisting of as polymerized units a) 5 to 95 % by weight of styrene as component A; b) 5 to 95 % by weight of DMAPMAM (dimethylaminopropyl methacrylic amide) as component B; c) 0 to 98 % by weight of methyl acrylate and/or vinyl acetate as component C.

Abstract translation: 本发明涉及一种固体作物保护制剂，其包含a）作为作物保护剂的cinidon-ethyl; b）至少一种含有至少一种亲水和至少一种疏水单体作为聚合单元的无规自由基共聚物; 和c）任选的其它添加剂，其中所述固体作物保护制剂中至少50％的分散的cinidon-ethyl颗粒是X射线非晶态，以及其水分散体制剂。 此外，本发明涉及制备所述制剂的方法和所述制剂在农业中的用途。 此外，本发明涉及一种基本上由作为聚合单元a）5至95重量％的作为组分A的苯乙烯组成的无规自由基共聚物; b）5至95重量％的作为组分B的DMAPMAM（二甲基氨基丙基甲基丙烯酰胺）; c）0至98重量％的丙烯酸甲酯和/或作为组分C的乙酸乙烯酯。

公开(公告)号：WO0214391A2

公开(公告)日：2002-02-21

申请号：PCT/EP0109386

申请日：2001-08-14

Applicant: BASF AG ,  SYMYX TECHNOLOGIES INC

Inventor： HEGER ROBERT ,  SCHROF WOLFGANG ,  SEUFERT MICHAEL ,  AUWETER HELMUT ,  MAECHTLE WALTER ,  IDEN RUEDIGER ,  HORN DIETER ,  NIELSEN RALPH B ,  CARLSON ERIC ,  CHANG HAN TING ,  KUEBLER SIGRID ,  PETRO MIROSLAV

IPC: B41J2/01 ,  B01F17/34 ,  B01F17/52 ,  C08F212/04 ,  C08F212/08 ,  C08F220/34 ,  C08F226/06 ,  C09B1/54 ,  C09B67/20 ,  C09B67/46 ,  C09D11/00 ,  C09D11/10 ,  C09D17/00 ,  C09D133/14 ,  C09D135/06 ,  C09D139/08 ,  C08F220/00

CPC classification number: B82Y30/00 ,  C08F212/04 ,  C08F220/34 ,  C09B67/0085 ,  C09D11/106 ,  C09D11/30 ,  C09D133/14 ,  C09D135/06 ,  C09D139/08

Abstract: Disclosed are random radical (co)polymers containing -20 to 50 mol% of styrene as component A, -15 to 35 mol% of acrylic acid as component B, and -15 to 60 mol% of dimethylaminoethylmethacrylate (DMAEM) or 4-vinyl pyridine as component C; and dispersion formulations containing said (co)polymer, a dye selected from the group consisting of a monoazo dye, a quinophtalone dye, an anthraquinone dye, optionally further assistants, and an aqueous system; solid solutions containing said (co)polmyer, a dye selected from the group consisting of a monoazo dye, a quinophthalone dye, an anthraquinone dye, optionally further assistants; and dyeing formulations and formulations of inks for ink-jets comprising said dispersion formulation and optionally conventional dyeing auxiliaries.

Abstract translation: 公开了含有作为组分A的苯乙烯-20至50mol％，作为组分B的丙烯酸-15至35mol％和甲基丙烯酸二甲基氨基乙酯（DMAEM）或4-乙烯基的-15至60mol％的无规自由基（共）聚合物 吡啶作为组分C; 和含有所述（共）聚合物的分散体制剂，选自单偶氮染料，喹诺酮染料，蒽醌染料，任选的其它辅助剂和水性体系的染料; 含有所述（共）聚偏聚物的固体溶液，选自单偶氮染料，喹酞酮染料，蒽醌染料，任选的其它辅助剂的染料; 以及用于包含所述分散体制剂和任选的常规染色助剂的喷墨的油墨的染色配方和配方。

公开(公告)号：WO03039249A2

公开(公告)日：2003-05-15

申请号：PCT/EP0212399

申请日：2002-11-06

Applicant: BASF AG ,  SCHROF WOLFGANG ,  HEGER ROBERT ,  BRATZ MATTHIAS ,  ZAGAR CYRILL

Inventor： SCHROF WOLFGANG ,  HEGER ROBERT ,  BRATZ MATTHIAS ,  ZAGAR CYRILL

IPC: A01N25/10 ,  A01N25/00 ,  A01N25/04 ,  A01N25/08 ,  A01N25/14 ,  A01N25/24 ,  C08K5/00 ,  C08L101/02 ,  A01N

CPC classification number: A01N25/10 ,  A01N25/14

Abstract: The invention relates to a solid crop protection formulation comprising a) at least one crop protection agent selected from the group consisting of herbicides, pesticides and fungicides, with the proviso that cinidon-ethyl is not included; b) at least one random radical copolymer comprising as polymerized units at least one hydrophilic and at least one hydrophobic monomer; and c) optionally further additives, wherein at least 50% of the dispersed particles of the at least one crop protection agent in said solid crop protection formulation are in X-ray amorphous state. Additionally, the invention relates to processes for preparing said formulations and the use of said formulations in agriculture.

Abstract translation: 本发明涉及一种固体作物保护制剂，其包含a）至少一种选自除草剂，农药和杀真菌剂的作物保护剂，条件是不包括cinidon-ethyl; b）至少一种含有至少一种亲水和至少一种疏水单体作为聚合单元的无规自由基共聚物; 和c）任选的另外的添加剂，其中所述固体作物保护制剂中的至少一种作物保护剂的至少50％的分散颗粒是X射线无定形状态。 此外，本发明涉及制备所述制剂的方法和所述制剂在农业中的用途。

公开(公告)号：WO0214876A2

公开(公告)日：2002-02-21

申请号：PCT/EP0109470

申请日：2001-08-16

Applicant: BASF AG

Inventor： HEGER ROBERT ,  SCHROF WOLFGANG ,  SEUFERT MICHAEL ,  NORD SIMON ,  KOEHLE HARALD

IPC: G01N33/15 ,  A61K9/10 ,  A61K9/107 ,  B01J4/00 ,  B01J19/00 ,  C07B61/00 ,  G01N13/00 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/08 ,  G01N35/10 ,  G01N37/00

CPC classification number: G01N35/10 ,  A61K9/10 ,  A61K9/107 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00479 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/0072 ,  C40B40/00 ,  G01N2013/006 ,  G01N2035/00198 ,  G01N2035/1032

Abstract: The invention relates to a test unit for the discovery and/or identification of stable formulations, containing the following components: at least one agent which is poorly soluble or insoluble in a dispersion medium, at least one formulation adjunct, a dispersion medium and optionally at least one solvent, whereby said test unit comprises a robot for accessing a matrix of positions on a substrate, with at least one robotic arm, characterised in that a mixing chamber is integrated in the robotic arm. The invention further relates to a method for the generation of an array containing n formulations, each in a known position of m positions on a substrate, whereby n and m are each a natural number greater than or equal to 2 and m is greater than or equal to n, an array containing n formulations and the use of said array for identification and/or discovery of stable formulations and the test unit for the production of said array.

Abstract translation: 本发明涉及一种用于检测和/或包含以下组分的至少一种微溶在Dipsergiermedium或不溶的活性成分，至少一种制剂助剂，分散介质，和任选的至少一种溶剂的稳定制剂的鉴定的试验装置，其中，所述测试单元包括用于Ansteurerung机器人 具有在基板上的位置的矩阵，包括：至少一个机器人臂，其特征在于，在混合室中的机器人手臂进行积分。 此外，本发明提供了用于制备关乎包含n制剂，其中，每个所述n制剂是从M个位置的基片上的已知位置，其中n和m各自为大于或等于2的未米大于或等于自然数的阵列的方法 m是包含n和制剂和用于制备阵列的使用阵列鉴定和/或稳定的Fromulierung发现和测试单元的阵列。

公开(公告)号：WO0033820A3

公开(公告)日：2000-10-12

申请号：PCT/EP9909545

申请日：1999-12-07

Applicant: BASF AG ,  HEGER ROBERT ,  AUWETER HELMUT ,  BREITENBACH JOERG ,  BOHN HERIBERT

Inventor： HEGER ROBERT ,  AUWETER HELMUT ,  BREITENBACH JOERG ,  BOHN HERIBERT

IPC: A61K47/30 ,  A61K8/02 ,  A61K8/04 ,  A61K8/11 ,  A61K8/72 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61K9/20 ,  A61K9/51 ,  A61K9/70 ,  A61K31/426 ,  A61K47/42 ,  A61Q19/00 ,  A61K9/50

CPC classification number: A61Q19/00 ,  A61K8/11 ,  A61K9/0007 ,  A61K9/0075 ,  A61K9/008 ,  A61K9/06 ,  A61K9/2081 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5169 ,  A61K9/5192 ,  A61K9/7023 ,  A61K2800/412 ,  A61K2800/413 ,  A61Q7/00 ,  B82Y5/00

Abstract: Nanoparticulate preparations of pharmaceutical and cosmetic active substances with a core-shell structure, whereby the active substance is present in an X-ray amorphous form, together with a polymer matrix and the shell consists of a stabilizing sheathing matrix.

Abstract translation: 的纳米微粒制剂药物和化妆品活性成分的存在具有核 - 壳结构，其中，X射线无定形药物的核心连同聚合物基质和壳由的稳定涂层基质组成。

公开(公告)号：WO0191727A3

公开(公告)日：2002-05-10

申请号：PCT/EP0106116

申请日：2001-05-29

Applicant: BASF AG ,  BERNDL GUNTHER ,  BREITENBACH JOERG ,  HEGER ROBERT ,  STADLER MICHAEL ,  WILKE PETER ,  ROSENBERG JOERG

Inventor： BERNDL GUNTHER ,  BREITENBACH JOERG ,  HEGER ROBERT ,  STADLER MICHAEL ,  WILKE PETER ,  ROSENBERG JOERG

IPC: A61F13/53 ,  A23P1/02 ,  A23P1/08 ,  A61F13/49 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

CPC classification number: A61K9/107 ,  A61K9/1075 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  B29C47/0011 ,  B29C47/8895

Abstract: The invention relates to self-emulsifying formulations based on an active substance constituent and on a formulation base with a lipid constituent and with a binding agent constituent. The invention also relates to the use of this formulation as a dosed form in the area of life science. The invention also relates to a method for producing self-emulsifying formulations by mixing the formulation constituents while forming a plastic mixture and optionally while preparing the formulations as a dosed form, advantageously while using melt extrusion. The formulations spontaneously form emulsions in water or in aqueous fluids.

Abstract translation: 本发明涉及基于一种药物成分和与脂质成分和粘合剂成分，以及使用该制剂的如在生命科学领域的剂型的制剂底座上自乳化制剂。 本发明还描述了通过混合制剂组分以形成一个塑料混合物制备的自乳化制剂的方法，和任选的嵌合时的制剂的作为剂型，有利地使用熔融挤出。 在水或含水液体，所述制剂自发形成乳液。

公开(公告)号：WO0130372A2

公开(公告)日：2001-05-03

申请号：PCT/EP0010205

申请日：2000-10-17

Applicant: BASF AG ,  HEGER ROBERT ,  BREITENBACH JOERG ,  BERNDL GUNTHER ,  BINDER RUDOLF

Inventor： HEGER ROBERT ,  BREITENBACH JOERG ,  BERNDL GUNTHER ,  BINDER RUDOLF

IPC: A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K38/00 ,  A61K38/13 ,  A61K9/20

CPC classification number: A61K9/5138 ,  A61K9/5084 ,  A61K9/5146

Abstract: The invention relates to solid pharmaceutical galenic forms comprising an agent in the form of a physical mixture of two different preparations with regard to the physical state of the agent.

Abstract translation: 本发明涉及包含至少两种不同的物理混合物的形式的活性成分相对于所述药物制剂的物理状态的固体药物剂型。

公开(公告)号：WO9959541A2

公开(公告)日：1999-11-25

申请号：PCT/EP9903002

申请日：1999-05-04

Applicant: BASF AG ,  HEGER ROBERT ,  AUWETER HELMUT ,  PFLUEGER PETER ,  BREITENBACH JOERG ,  BINDER RUDOLF ,  ZEIDLER JUERGEN ,  BERNDL GUNTHER

Inventor： HEGER ROBERT ,  AUWETER HELMUT ,  PFLUEGER PETER ,  BREITENBACH JOERG ,  BINDER RUDOLF ,  ZEIDLER JUERGEN ,  BERNDL GUNTHER

IPC: A61K9/16 ,  A61K9/51 ,  A61K38/00 ,  A61K38/13 ,  A61K47/14 ,  A61K47/36 ,  A61P37/06 ,  A61K9/00

CPC classification number: A61K9/5123 ,  A61K9/0095 ,  A61K9/1617 ,  A61K9/1658 ,  A61K9/5169 ,  A61K38/13

Abstract: The invention relates to solid or liquid cyclosporin preparations for oral administration in which the cyclosporin is presented in the form of solid X-amorphous particles embedded in a coating matrix in a colloidally dispersed manner.

Abstract translation: 存在嵌入在涂层基质的固体或液体环孢菌素制剂用于口服给药的，其中以固体，X射线无定形的颗粒形式的环孢菌素kolloidaldispers。