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    REAGENT PACKAGING DEVICES AND USES THEREOF
    1.
    发明申请
    REAGENT PACKAGING DEVICES AND USES THEREOF 审中-公开

    公开(公告)号：WO2018208982A1

    公开(公告)日：2018-11-15

    申请号：PCT/US2018/031893

    申请日：2018-05-09

    Applicant: CYTOCHIP, INC.

    Inventor： SHI, Wendian ,  DING, Yuzhe

    IPC: B01L3/00 ,  B65B29/10 ,  G01N1/00 ,  G01N1/02 ,  G01N1/10 ,  G01N1/20 ,  G01N1/28

    Abstract: The present disclosure relates to new types of fluid packaging devices and methods of making and using such fluid packaging devices. In various embodiments, the present disclosure provides devices, systems, and methods for packaging fluids. In various embodiments, the present disclosure provides a device that comprises: a storage compartment; a fluid stored in the storage compartment; a first aperture on the storage compartment, wherein the first aperture is initially sealed or closed before the use of the device and configured to be opened to receive a pneumatic pressure; and a second aperture on the storage compartment, wherein the second aperture is initially sealed or closed before the use of the device and configured to be opened to allow the fluid exiting or entering the storage compartment via the opened second aperture.

    DEVICES AND METHODS FOR SAMPLE ANALYSIS WITH SERIAL DILUTION
    2.
    发明申请
    DEVICES AND METHODS FOR SAMPLE ANALYSIS WITH SERIAL DILUTION 审中-公开

    公开(公告)号：WO2019168835A1

    公开(公告)日：2019-09-06

    申请号：PCT/US2019/019555

    申请日：2019-02-26

    Applicant: CYTOCHIP, INC.

    Inventor： SHI, Wendian ,  GAO, Yuan ,  DING, Yuzhe

    IPC: G01N1/20

    Abstract: The disclosure relates to devices and methods for analyzing a sample. In various embodiments, the present disclosure provides devices and methods for preparing a serial dilution of a sample. In various embodiments, the present disclosure provides devices and methods for preparing a serial dilution of a sample and conducting sample analysis. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device, wherein the reader instrument device receives, operates, and/or actuates the cartridge device to prepare a serial dilution of a sample and conduct sample analysis

    FLUIDIC CARTRIDGE FOR CYTOMETRY AND ADDITIONAL ANALYSIS
    3.
    发明申请
    FLUIDIC CARTRIDGE FOR CYTOMETRY AND ADDITIONAL ANALYSIS 审中-公开
    流式细胞仪的细胞计数和附加分析

    公开(公告)号：WO2018085678A1

    公开(公告)日：2018-05-11

    申请号：PCT/US2017/059965

    申请日：2017-11-03

    Applicant: CYTOCHIP INC.

    Inventor： SHI, Wendian ,  DING, Yuzhe

    IPC: B01L3/00 ,  B01F5/00 ,  B01F13/00 ,  G01F1/56 ,  G01F22/00 ,  G01F23/22

    Abstract: The disclosure relates to devices and methods for analyzing particles in a sample. In various embodiments, the present disclosure provides devices and methods for cytometry and additional analysis. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device, wherein the reader instrument device receives, operates, and/or actuates the cartridge device. In various embodiments, the present disclosure provides a method of using a device as disclosed herein for analyzing particles in a sample.

    Abstract translation: 本公开涉及用于分析样本中的粒子的设备和方法。 在各种实施方案中，本公开提供了用于细胞计量术和额外分析的装置和方法。 在各种实施例中，本公开提供了一种盒装置和一种读取器仪器装置，其中该读取器仪器装置接收，操作和/或致动该盒装置。 在各种实施例中，本公开提供了使用本文公开的用于分析样本中的粒子的装置的方法。

    DEVICES AND METHODS FOR CELL ANALYSIS
    4.
    发明申请
    DEVICES AND METHODS FOR CELL ANALYSIS 审中-公开

    公开(公告)号：WO2018231835A1

    公开(公告)日：2018-12-20

    申请号：PCT/US2018/037114

    申请日：2018-06-12

    Applicant: CYTOCHIP, INC.

    Inventor： SHI, Wendian ,  MENG, Zhaokai ,  DING, Yuzhe

    IPC: G01F22/00 ,  G01F1/00 ,  G01N15/02 ,  G01N15/14 ,  G01N21/05 ,  G01N21/64 ,  G01N33/52

    Abstract: The present disclosure relates to devices, device systems, and methods for analyzing cells (e.g., blood cells) and particles in a sample. The present disclosure provides various devices and device systems that can include: a light source, a collecting lens, and one, two or more detectors. These devices and device systems can also include a flow cell or a cartridge device that comprises a flow cell. The present disclosure provides various methods that can include steps of: using a light source to emit an irradiation light; using the irradiation light to illuminate a sample flow; using a collecting lens to collect both scattered light and fluorescent light from the sample flow; and using one, two or more detectors to detect the collected scattered light and fluorescent light. These methods can include using a flow cell to form a sample flow. These methods can also include the steps of: receiving a sample into a cartridge device that comprises a flow cell; using the cartridge device to mix the sample with a reagent to form a measurement sample; and using the flow cell to form a sample flow of the measurement sample.

    VOLUME SENSING IN FLUIDIC CARTRIDGE
    7.
    发明申请
    VOLUME SENSING IN FLUIDIC CARTRIDGE 审中-公开
    流体盒中的体积感应

    公开(公告)号：WO2017011554A1

    公开(公告)日：2017-01-19

    申请号：PCT/US2016/042089

    申请日：2016-07-13

    Applicant: CYTOCHIP INC.

    Inventor： SHI, Wendian ,  DING, Yuzhe

    IPC: G01N11/04 ,  B01L3/00 ,  C12M1/34 ,  G01N1/28 ,  G01N30/04 ,  G01N1/38

    CPC classification number: G01F22/00 ,  G01F23/265

    Abstract: Methods and apparatuses for measuring parameters based on the presence or absence of fluid at a plurality of fluid sensing zones in a disposable cassette are described herein. In an embodiment, a fluidic device includes a disposable cartridge including a fluid channel, an instrument configured to receive the disposable cartridge, the instrument including at least one sensor having a plurality of fluid sensing zones spaced along the fluid channel when the disposable cartridge is received by the disposable cartridge, each fluid sensing zone configured to determine a presence or absence of fluid at a respective portion of the fluid channel, and a control unit configured to determine at least one of a fluid volume, a volume displacement, a flow rate, a flow velocity or a volume ratio of gas bubbles of the fluid based on the presence or absence of the fluid at each of the fluid sensing zones.

    Abstract translation: 本文描述了基于一次性盒中的多个流体感测区域处的流体存在或不存在来测量参数的方法和装置。 在一个实施例中，流体装置包括一个包括流体通道的一次性药筒，被配置为容纳一次性药筒的器械，该仪器包括至少一个传感器，当接收到一次性药筒时，该传感器具有沿流体通道间隔开的多个流体感测区 通过所述一次性盒，每个流体感测区域被配置为确定所述流体通道的相应部分处的流体存在或不存在;以及控制单元，被配置为确定流体体积，体积位移，流速， 基于每个流体感测区域处的流体的存在或不存在，流体的气泡的流速或体积比。

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