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    SHAPE CONFORMING FLEXIBLE DIELECTRIC BARRIER DISCHARGE PLASMA GENERATORS
    6.
    发明申请
    SHAPE CONFORMING FLEXIBLE DIELECTRIC BARRIER DISCHARGE PLASMA GENERATORS 审中-公开
    形状柔性柔性介质阻挡放电等离子体发生器

    公开(公告)号：WO2015088948A8

    公开(公告)日：2015-06-18

    申请号：PCT/US2014/069013

    申请日：2014-12-08

    Applicant: EP TECHNOLOGIES LLC

    Inventor： KALGHATGI, Sameer ,  TSAI, Tsung-Chan ,  ANTONAKAS, Daphne, Pappas ,  GRAY, Robert, L.

    IPC: H01J37/32 ,  H05H1/24 ,  A61N1/04 ,  A61L2/14

    Abstract: Exemplary embodiments of shape conforming dielectric barrier discharge (DBD) plasma generators are disclosed herein. One exemplary embodiment includes a flexible pad and a plurality of electrodes located in the pad within close proximity of each other, and a flexible dielectric barrier surrounding the plurality of electrodes and separating the plurality of electrodes from each other. Wherein when a high voltage pulse is applied to one or more of the plurality of electrodes, plasma is produced between a surface of the flexible pad and a portion of the body in close proximity to the flexible pad.

    Abstract translation: 这里公开了符合形状的介质阻挡放电（DBD）等离子体发生器的示例性实施例。 一个示例性实施例包括柔性衬垫和位于彼此紧密接近的衬垫中的多个电极，以及围绕多个电极并将多个电极彼此分开的柔性电介质阻挡层。 其中，当高电压脉冲施加到多个电极中的一个或多个时，在柔性垫的表面和靠近柔性垫的身体部分之间产生等离子体。

    METHOD AND APPARATUS FOR INTRACELLULAR AND INTERCELLULAR DELIVERY OF MOLECULES, DRUGS, VACCINES AND THE LIKE
    9.
    发明申请
    METHOD AND APPARATUS FOR INTRACELLULAR AND INTERCELLULAR DELIVERY OF MOLECULES, DRUGS, VACCINES AND THE LIKE 审中-公开
    分子，药物，疫苗和类似物的细胞间和细胞内递送的方法和装置

    公开(公告)号：WO2015116970A1

    公开(公告)日：2015-08-06

    申请号：PCT/US2015/013846

    申请日：2015-01-30

    Applicant: EP TECHNOLOGIES LLC

    Inventor： KALGHATGI, Sameer ,  TSAI, Tsung-Chan ,  ANTONAKAS, Daphne, Pappas ,  GRAY, Robert, L.

    IPC: A61N1/32

    CPC classification number: A61N1/44 ,  A61M35/00 ,  A61N1/327

    Abstract: An exemplary method of delivering drugs or vaccines includes applying a series of first electrical signals to an electrode to generate plasma. The first electrical pulses having a first duration, first voltage amplitude, and first rise time. Applying molecules, drugs or vaccines to an area of skin contacted by the plasma; and applying a series of second electrical signals to the electrode to generate plasma to contact the area of the skin. The second electrical pulses have a second duration, second voltage amplitude, and second rise time. The duration for the first electrical pulses is shorter than the duration for the second electrical pulses. The voltage amplitude of the second electrical pulses is larger than the first electrical pulses. The rise time of the second electrical pulses is shorter than the first electrical pulses.

    Abstract translation: 递送药物或疫苗的示例性方法包括将一系列第一电信号施加到电极以产生血浆​​。 第一电脉冲具有第一持续时间，第一电压幅度和第一上升时间。 将分子，药物或疫苗应用于与血浆接触的皮肤区域; 以及将一系列第二电信号施加到所述电极以产生等离子体以接触皮肤区域。 第二电脉冲具有第二持续时间，第二电压幅度和第二上升时间。 第一电脉冲的持续时间短于第二电脉冲的持续时间。 第二电脉冲的电压幅度大于第一电脉冲。 第二电脉冲的上升时间比第一电脉冲短。

    METHODS AND SOLUTIONS FOR RAPIDLY KILLING OR DEACTIVATING SPORES
    10.
    发明申请
    METHODS AND SOLUTIONS FOR RAPIDLY KILLING OR DEACTIVATING SPORES 审中-公开
    快速杀死或消除体育活动的方法和解决方案

    公开(公告)号：WO2014145570A1

    公开(公告)日：2014-09-18

    申请号：PCT/US2014/030361

    申请日：2014-03-17

    Applicant: EP TECHNOLOGIES LLC

    Inventor： TSAI, Tsung-Chan ,  KALGHATGI, Sameer ,  ANTONAKAS, Daphne, Pappas ,  GRAY, Robert, L.

    IPC: A01N59/00 ,  C02F1/00 ,  A01P1/00

    CPC classification number: A61L2/14 ,  A01N31/00 ,  A01N59/00 ,  A01N61/00 ,  A61L2/0011 ,  A61L2/0088 ,  A61L2/18 ,  A61L2/186 ,  A01N31/02

    Abstract: Exemplary methods and systems for killing or deactivating spores include applying a fluid to a surface containing a spore; and applying direct or indirect plasma to the surface for a period of time. In some embodiments, the fluid includes water. In some embodiments, the spore is Clostridium difficile and in some is Bacillus Anthracis. In some embodiments, the fluid is in the form of a vapor, a fog, a spray, a mist or an aerosol, which may be activated prior to or after applying the fluid to a surface. In some embodiments, peroxynitrite is created in the fluid during the method. Another exemplary embodiment of killing or deactivating a spore includes treating spores with direct plasma or indirect plasma for a period of time and applying an antimicrobial to the spores. In some embodiments, the antimicrobial is an alcohol, a bleach or an alcohol-based sanitizer.

    Abstract translation: 用于杀死或灭活孢子的示例性方法和系统包括将流体施加到包含孢子的表面; 并将直接或间接的等离子体施加到表面一段时间。 在一些实施例中，流体包括水。 在一些实施方案中，孢子是艰难梭菌，在一些实例中，是炭疽芽孢杆菌。 在一些实施方案中，流体是蒸气，雾，喷雾，雾或气溶胶的形式，其可以在将流体施加到表面之前或之后被活化。 在一些实施方案中，在方法期间在流体中产生过氧亚硝酸盐。 杀死或灭活孢子的另一个示例性实施方案包括用直接等离子体或间接血浆处理孢子一段时间并对孢子施用抗微生物剂。 在一些实施方案中，抗微生物剂是醇，漂白剂或基于醇的消毒剂。

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