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    MEMBRANES HAVING IMPROVED PERFORMANCE
    4.
    发明申请
    MEMBRANES HAVING IMPROVED PERFORMANCE 审中-公开
    具有改进性能的膜

    公开(公告)号：WO2010133613A1

    公开(公告)日：2010-11-25

    申请号：PCT/EP2010/056845

    申请日：2010-05-19

    Applicant: GAMBRO LUNDIA AB ,  KRAUSE, Bernd ,  ZWEIGART, Carina ,  BEHR, Heinrich

    Inventor： KRAUSE, Bernd ,  ZWEIGART, Carina ,  BEHR, Heinrich

    IPC: B01D69/08 ,  B01D71/56 ,  B01D71/68 ,  D01F1/08

    CPC classification number: B01D69/088 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3496 ,  A61M2205/15 ,  B01D71/56 ,  B01D71/68

    Abstract: The present invention relates to permselective asymmetric membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved performance, allowing for enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The improved sieving characteristics are due to a narrow pore size distribution of the membranes created in the production process. The invention also relates to processes for the preparation of said membranes, devices comprising said membranes, and the use of said membranes in hemodialysis, hemodiafiltration or hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.

    Abstract translation: 本发明涉及选择性不对称膜，例如合适的。 用于血液透析，血液透析过滤和血液的血液滤过，并且具有改善的性能，允许增强中等分子量物质的去除，例如， 具有20至40kDa分子量的炎性介质。 改进的筛分特性是由于在生产过程中产生的膜的孔径分布窄。 本发明还涉及制备所述膜的方法，包括所述膜的装置，以及所述膜在血液透析，血液透析滤过或血液过滤中的用途，以及生物处理，血浆分级分离和蛋白质溶液的制备。

    PLASMA SEPARATION MEMBRANE
    5.
    发明申请
    PLASMA SEPARATION MEMBRANE 审中-公开
    等离子体分离膜

    公开(公告)号：WO2008003610A1

    公开(公告)日：2008-01-10

    申请号：PCT/EP2007/056325

    申请日：2007-06-25

    Applicant: GAMBRO LUNDIA AB ,  KRAUSE, Bernd ,  HORNUNG, Markus ,  GOEHL, Herman

    Inventor： KRAUSE, Bernd ,  HORNUNG, Markus ,  GOEHL, Herman

    IPC: B01D71/68 ,  B01D71/28 ,  B01D69/08 ,  B01D67/00

    CPC classification number: B01D69/087 ,  A61M1/3496 ,  B01D67/0011 ,  B01D69/02 ,  B01D69/08 ,  B01D71/44 ,  B01D71/68 ,  B01D2323/12 ,  Y10T428/1376 ,  Y10T428/139

    Abstract: A process for manufacturing of an asymmetric hollow fibre membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fibre spinning nozzle, simul- taneously extruding a centre fluid through the inner bore of the hollow fibre spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP), 55 to 75 wt-% N-alkyl-2-pyrrolidone (NAP) and 3 to 9 wt-% water the centre fluid con- tains 70 to 90 wt-% N-alkyl-2-pyrrolidone (NAP) and 10 to 30 wt-% water, and the precipitation bath contains 0 to 20 wt-% N-alkyl-2-pyrrolidone (NAP) and 80 to 100 wt-% water.

    Abstract translation: 一种不对称中空纤维膜的制造方法，其特征在于，包括以下步骤：通过中空纤维纺丝喷嘴的外圈狭缝挤压聚合物溶液，将中心流体通过中空丝纺丝喷嘴的内孔同时挤出成为 沉淀浴，由此聚合物​​溶液含有10-26重量％的聚砜（PSU），聚醚砜（PES）或聚芳醚砜（PAES），8-15重量％聚乙烯吡咯烷酮（PVP），55-75重量％ 烷基-2-吡咯烷酮（NAP）和3至9重量％的水，中心流体含有70至90重量％的N-烷基-2-吡咯烷酮（NAP）和10至30重量％的水，并且沉淀 浴含有0〜20重量％的N-烷基-2-吡咯烷酮（NAP）和80〜100重量％的水。

    LIVER SUPPORT SYSTEM
    7.
    发明申请
    LIVER SUPPORT SYSTEM 审中-公开
    肝支持系统

    公开(公告)号：WO2014079681A2

    公开(公告)日：2014-05-30

    申请号：PCT/EP2013/073058

    申请日：2013-11-05

    Applicant: GAMBRO LUNDIA AB

    Inventor： FLIEG, Ralf ,  ALDINGER, Stephan ,  STORR, Markus ,  KRAUSE, Bernd

    IPC: A61M1/36

    CPC classification number: A61M1/1627 ,  A61M1/1633 ,  A61M1/3679 ,  A61M2210/1071 ,  B01D61/243 ,  B01D63/021 ,  B01D63/046 ,  B01D69/02 ,  B01D2313/40 ,  B01D2325/20 ,  B01J20/103 ,  B01J20/20 ,  B01J20/205 ,  B01J20/261 ,  B01J47/014

    Abstract: The present disclosure relates to an artificial, extracorporeal system for liver replacement and/or assistance, comprising a liver dialysis device for conducting hemodialysis on a patient suffering from liver failure, which is characterized in that it comprises a first standard hollow fiber membrane dialyzer which does not allow passage of an essential amount of albumin over the membrane wall and which is perfused with the patient's blood, and a second hollow fiber membrane dialyzer which allows the passage of essential but defined amounts of albumin over the membrane wall and which receives the blood of the first standard hemodialyzer and wherein the filtrate space is closed off from the lumen space of the hollow fibers and is populated by adsorbent material which may comprise one or more different adsorbents.

    Abstract translation: 本公开涉及用于肝脏置换和/或辅助的人造体外系统，其包括用于对患有肝衰竭的患者进行血液透析的肝透析装置，其特征在于，其包括第一标准中空纤维膜透析器 不允许将必需量的白蛋白通过膜壁并与患者的血液灌注;以及第二中空纤维膜透析器，其允许基本但限定量的白蛋白通过膜壁并且接收血液中的血液 所述第一标准血液透析器，其中所述滤液空间与所述中空纤维的管腔空间封闭，并且由可包含一种或多种不同吸附剂的吸附材料填充。

    MEMBRANES HAVING IMPROVED PERFORMANCE
    10.
    发明申请
    MEMBRANES HAVING IMPROVED PERFORMANCE 审中-公开
    具有改进性能的膜

    公开(公告)号：WO2010133612A1

    公开(公告)日：2010-11-25

    申请号：PCT/EP2010/056844

    申请日：2010-05-19

    Applicant: GAMBRO LUNDIA AB ,  KRAUSE, Bernd ,  ZWEIGART, Carina

    Inventor： KRAUSE, Bernd ,  ZWEIGART, Carina

    IPC: B01D69/08 ,  B01D71/40 ,  B01D71/68 ,  B01D67/00 ,  D01F1/08

    CPC classification number: B01D69/08 ,  B01D67/0088 ,  B01D67/0093 ,  B01D71/40 ,  B01D71/68 ,  B01D71/76

    Abstract: The present invention relates to permselective asymmetric membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved sieving characteristics allowing for enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The membranes comprise polyethersulfone and polyvinylpyrrolidone and are coated with hyaluronic acid or copolymers of 2-methacryloyloxyethyl phosphoryl choline and other vinyl polymerizable monomers. The invention also relates to processes for the preparation of said membranes, devices comprising said membranes, and the use of said membranes in hemodialysis, hemodiafiltration or hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.

    Abstract translation: 本发明涉及选择性不对称膜，例如合适的。 用于血液透析，血液透析过滤和血液的血液滤过，并且具有改善的筛分特性，允许增强中等分子量物质的去除。 具有20至40kDa分子量的炎性介质。 膜包含聚醚砜和聚乙烯吡咯烷酮，并用透明质酸或2-甲基丙烯酰氧基乙基磷酰胆碱和其它乙烯基可聚合单体的共聚物涂覆。 本发明还涉及制备所述膜的方法，包括所述膜的装置，以及所述膜在血液透析，血液透析滤过或血液血液滤过以及生物处理，血浆分级分离和蛋白质溶液制备中的用途。

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