SEPARATING MATERIAL
    3.
    发明申请
    SEPARATING MATERIAL 审中-公开
    分离材料

    公开(公告)号:WO2005026224A1

    公开(公告)日:2005-03-24

    申请号:PCT/EP2004/051953

    申请日:2004-08-30

    Abstract: The present invention provides a separating material producable by a) providing a solid substrate, having amino­functional groups coupled to the substrate surface, b) covalently coupling of the amino-functional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate. The present invention further provides a method for the production of a separating material by a) providing a solid substrate, having aminofunctional groups coupled to the substrate surface, b) covalently coupling of the aminofunctional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate.

    Abstract translation: 本发明提供了一种分离材料,其可通过以下方式提供:a)提供具有与基底表面偶联的氨基官能团的固体基质,b)将氨基官能团与热不稳定的自由基引发剂共价偶联,c)将基底表面与 在可发生单体的热引发接枝共聚的条件下,可聚合单体的溶液在基材表面上形成相邻的官能聚合物链的结构。 本发明还提供了一种用于生产分离材料的方法,该方法是:a)提供具有偶联到基底表面的氨基官能团的固体基质,b)使氨基官能团与热不稳定的自由基引发剂共价偶联,c) 在单体发生热引发的接枝共聚的条件下,在基材表面上形成相邻的官能聚合物链的结构的条件下,可聚合单体的溶液的底物表面。

    LIVER SUPPORT SYSTEM
    4.
    发明申请
    LIVER SUPPORT SYSTEM 审中-公开
    肝支持系统

    公开(公告)号:WO2014079681A2

    公开(公告)日:2014-05-30

    申请号:PCT/EP2013/073058

    申请日:2013-11-05

    Abstract: The present disclosure relates to an artificial, extracorporeal system for liver replacement and/or assistance, comprising a liver dialysis device for conducting hemodialysis on a patient suffering from liver failure, which is characterized in that it comprises a first standard hollow fiber membrane dialyzer which does not allow passage of an essential amount of albumin over the membrane wall and which is perfused with the patient's blood, and a second hollow fiber membrane dialyzer which allows the passage of essential but defined amounts of albumin over the membrane wall and which receives the blood of the first standard hemodialyzer and wherein the filtrate space is closed off from the lumen space of the hollow fibers and is populated by adsorbent material which may comprise one or more different adsorbents.

    Abstract translation: 本公开涉及用于肝脏置换和/或辅助的人造体外系统,其包括用于对患有肝衰竭的患者进行血液透析的肝透析装置,其特征在于,其包括第一标准中空纤维膜透析器 不允许将必需量的白蛋白通过膜壁并与患者的血液灌注;以及第二中空纤维膜透析器,其允许基本但限定量的白蛋白通过膜壁并且接收血液中的血液 所述第一标准血液透析器,其中所述滤液空间与所述中空纤维的管腔空间封闭,并且由可包含一种或多种不同吸附剂的吸附材料填充。

    FILTRATION MEMBRANE
    7.
    发明申请
    FILTRATION MEMBRANE 审中-公开
    过滤膜

    公开(公告)号:WO2006106133A1

    公开(公告)日:2006-10-12

    申请号:PCT/EP2006/061396

    申请日:2006-04-06

    Abstract: The invention is directed to a ultrafiltration membrane that is capable for the retention of endotoxines and cytokine inducing substances (CIS) including bacterial DNA and/or DNA fragments from fluid and/or liquid media. The invention is further directed to a method of manufacturing such ultrafiltration membranes in a high quality and in an effective and time saving procedure, and to the use of such membranes for the retention of substances from fluids or liquids. The ultrafiltration membrane of the invention consists of a polymer blend comprising at least one hydrophobic polymer containing sulfur in its back bone, at least one hydrophilic, uncharged homo-polymer of polyvinylpyrrolidone and at least one polymer containing cationic charges. The method of manufacturing such a ultrafiltration membrane comprises dissolving at least one hydrophobic polymer containing sulfur in its back bone and at least one hydrophilic, uncharged polyvinylpyrrolidone and at least one polymer containing cationic charges in at least one solvent to form a polymer solution, subjecting the formed polymer solution to a diffusion- induced phase separation to prepare a ultrafiltration membrane, washing and subsequently drying of the ultrafiltration membrane.

    Abstract translation: 本发明涉及能够从流体和/或液体介质中保留包含细菌DNA和/或DNA片段的内毒素和细胞因子诱导物质(CIS)的超滤膜。 本发明进一步涉及以高质量和有效且节省时间的方法制造这种超滤膜的方法,以及使用这种膜来保持来自流体或液体的物质。 本发明的超滤膜由包含至少一种在其背骨中含有硫的疏水性聚合物,至少一种亲水的,不带电的聚乙烯吡咯烷酮的聚合物和至少一种含有阳离子电荷的聚合物组成的聚合物共混物构成。 制造这种超滤膜的方法包括将至少一种含有硫的疏水性聚合物溶解在其背骨中,并且至少一种亲水的,不带电的聚乙烯吡咯烷酮和至少一种含至少一种溶剂中的阳离子电荷的聚合物形成聚合物溶液, 形成聚合物溶液进行扩散诱导相分离以制备超滤膜,洗涤并随后干燥超滤膜。

    DOPED MEMBRANES
    9.
    发明申请
    DOPED MEMBRANES 审中-公开
    DOPED膜

    公开(公告)号:WO2013087552A1

    公开(公告)日:2013-06-20

    申请号:PCT/EP2012/074899

    申请日:2012-12-10

    Abstract: The present disclosure relates to synthetic membranes for the removal, isolation or purification of substances from a liquid, comprising at least one hydrophobic and at least one hydrophilic polymer, wherein 5-40 wt.-% of particles having an average particles size of between 0.1 and 15 µm are entrapped and wherein the membrane has a wall thickness of below 150 µm. Further disclosed are methods for preparing such membranes in various geometries and their use for the adsorption, isolation and/or purification of substances from a liquid.

    Abstract translation: 本公开涉及用于从液体中除去,分离或纯化物质的合成膜,其包含至少一种疏水性和至少一种亲水性聚合物,其中5-40重量%的平均粒度为0.1 和15μm被截留,并且其中膜具有低于150μm的壁厚。 进一步公开的是制备各种几何形状的这种膜的方法及其用于从液体中吸附,分离和/或纯化物质的用途。

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