AFFINITY CHROMATOGRAPHY DEVICES
    5.
    发明申请
    AFFINITY CHROMATOGRAPHY DEVICES 审中-公开
    亲水色谱装置

    公开(公告)号:WO2017014817A1

    公开(公告)日:2017-01-26

    申请号:PCT/US2016/026863

    申请日:2016-04-11

    摘要: The present invention is directed to affinity chromatography devices that separate a targeted protein or antibody from an aqueous mixture containing the targeted protein or antibody, The chromatography device may contain a stacked membrane assembly or a wound membrane assembly. The membrane assemblies include at least one polymer membrane that contains therein inorganic particles. The polymer membrane and/or the inorganic particles have an affinity Iigand bonded thereto. The affinity Iigand may be a protein, an antibody, or a polysaccharide that reversibly binds to the targeted protein or antibody. The chromatography device may be repeatedly used and may be cleaned with a caustic solution between uses. The chromatography devices may have a dynamic binding capacity (DBC) of at least 30 mg/ml (or 0.07 micromol/ml) at 10% breakthrough at a residence time of 20 seconds or less.

    摘要翻译: 本发明涉及从含有目标蛋白质或抗体的水性混合物中分离靶向蛋白质或抗体的亲和层析装置。色谱装置可包含层叠膜组件或缠绕膜组件。 膜组件包括至少一个在其中含有无机颗粒的聚合物膜。 聚合物膜和/或无机颗粒具有与其结合的亲和性配体。 亲和力配体可以是可逆结合靶向蛋白质或抗体的蛋白质,抗体或多糖。 色谱装置可以重复使用,并且可以在使用之间用苛性碱溶液清洗。 在20秒或更短的停留时间下,色谱装置可以具有至少30mg / ml(或0.07微摩尔/ ml)的10%穿透的动态结合能力(DBC)。

    CHEMICAL ADDITIVES FOR ENHANCEMENT OF WATER FLUX OF A MEMBRANE
    6.
    发明申请
    CHEMICAL ADDITIVES FOR ENHANCEMENT OF WATER FLUX OF A MEMBRANE 审中-公开
    化学添加剂用于提高膜的水通量

    公开(公告)号:WO2016196821A1

    公开(公告)日:2016-12-08

    申请号:PCT/US2016/035559

    申请日:2016-06-02

    申请人: LG NANOH2O, INC.

    摘要: Provided is an interfacial polymerization process for preparation of a highly permeable thin film composite membrane, which can be used for nanofiltration, forward osmosis, or reverse osmosis, particularly for use with brackish water at low energy conditions. The process includes contacting a porous support membrane with an aqueous phase containing a polyamine and a flux enhancing combination of additives that includes a metal chelate additive containing a bidentate ligand and a metal atom or metal ion and a phosphoramide to form a coated support membrane, and applying an organic phase containing a polyfunctional acid halide to the coated support membrane to interfacially polymerize the polyamine and the polyfunctional acid halide to form a discrimination layer of the thin film composite membrane. Also provided are the membranes prepared by the methods and reverse osmosis modules containing the membranes.

    摘要翻译: 提供了用于制备高渗透性薄膜复合膜的界面聚合方法,其可用于纳滤,前向渗透或反渗透,特别是用于在低能量条件下的微咸水。 该方法包括使多孔支撑膜与含有多胺的水相和增强助焊剂的组合使得该添加剂包含含有二齿配体和金属原子或金属离子的金属螯合添加剂和磷酰胺形成涂覆的支撑膜,以及 将包含多官能酰卤的有机相施加到涂覆的支撑膜上以使多胺和多官能酰卤交联聚合以形成薄膜复合膜的鉴别层。 还提供了通过包含膜的方法和反渗透模块制备的膜。

    POLYMER COMPOSITIONS CONTAINING POLYURETHANE
    7.
    发明申请
    POLYMER COMPOSITIONS CONTAINING POLYURETHANE 审中-公开
    含聚氨酯的聚合物组合物

    公开(公告)号:WO2016184945A1

    公开(公告)日:2016-11-24

    申请号:PCT/EP2016/061213

    申请日:2016-05-19

    申请人: BASF SE

    摘要: Polymer composition comprising a) an oligo- or polyurethane U of the formula (I) wherein k and n independently are numbers from 1 to 100, m is from the range 1-100, (X) is a block of formula (II) and (Y) is a block of the formula (III), (A) is a residue of an aliphatic or aromatic diisocyanate linker, (B) is a residue of a linear oligo- or polysiloxane containing alkanol end groups, and optionally further containing one or more aliphatic ether moieties, and (C) is an aromatic oligo- or polyarylene ether block that is at least partly etherified at its terminal positions with one alkylene glycol unit; or a mixture of such oligo- or polyurethanes; and b) one or more further organic polymers P selected from the group consisting of polyvinyl pyrrolidone, polyvinyl acetates, cellulose acetates, polyacrylonitriles, polyamides, polyole- fines, polyesters, polyarylene ethers, polysulfones, polyethersulfones, polyphenylenesulfones, polycarbonates, polyether ketones, sulfonated polyether ketones, polyamide sul- fones, polyvinylidene fluorides, polyvinylchlorides, polystyrenes and polytetrafluorethylenes, copolymers thereof, and mixtures thereof; preferably selected from the group consisting of polysulfones, polyphenylenes, polyethersulfones, polyvinylidene fluorides, polyamides, cellulose acetate and mixtures thereof.

    摘要翻译: 聚合物组合物,其包含a)式(I)的寡聚或尿素U,其中k和n独立地为1至100的数,m为1-100的范围,(X)为式(II)的嵌段和 (Y)是式(III)的嵌段,(A)是脂族或芳族二异氰酸酯接头的残基,(B)是含有链烷醇端基的直链低聚或聚硅氧烷的残基,并且任选地还含有一个 或更多的脂族醚部分,和(C)是芳族低聚或聚亚芳基醚嵌段,其在其末端与一个亚烷基二醇单元至少部分醚化; 或这种低聚或聚氨酯的混合物; 和b)选自聚乙烯吡咯烷酮,聚乙酸乙烯酯,乙酸纤维素,聚丙烯腈,聚酰胺,聚烯烃,聚酯,聚亚芳基醚,聚砜,聚醚砜,聚苯砜,聚碳酸酯,聚醚酮,磺化的一种或多种其它有机聚合物P 聚醚酮,聚酰胺磺酸酯,聚偏二氟乙烯,聚氯乙烯,聚苯乙烯和聚四氟乙烯,其共聚物及其混合物; 优选选自聚砜,聚苯,聚醚砜,聚偏二氟乙烯,聚酰胺,醋酸纤维素及其混合物。