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公开(公告)号：WO2013030246A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/066797
申请日：2012-08-29
Applicant: GENERAL ELECTRIC COMPANY , GE HEALTHCARE UK LIMITED , CONWAY, Kenneth, Roger , YAZDANFAR, Siavash , NECULAES, Vasile, Bogdan , DAVIS, Brian, Michael , GARNER, Allen, Lawrence , LOGHIN, Evelina, Roxana , JOO, Chulmin , DYLOV, Dmitry, Vladimirovich
Inventor： CONWAY, Kenneth, Roger , YAZDANFAR, Siavash , NECULAES, Vasile, Bogdan , DAVIS, Brian, Michael , GARNER, Allen, Lawrence , LOGHIN, Evelina, Roxana , JOO, Chulmin , DYLOV, Dmitry, Vladimirovich
IPC: C12M3/00
CPC classification number: C12M35/02
Abstract: A system for delivering exogenous molecules, comprises a support for containing cells and exogenous molecules;an infra-red (IR) light source that generates an IR optical beam with an average power density in an order of at least greater than10 4 W/cm 2 ; one or more optical elements; an imaging system to image the cells in a field of view;a processor that generates a signal for localization of cells in the field of view; a light pattern shaper for temporal focusing of the optical beam to generate wide field illumination on the cells to permeabilise the cell membrane for delivering the exogenous molecules; and a controller that switches the optical beam from the wide field illumination to a focused illumination. The processor is operatively coupled to the imaging system and the light pattern shaper and transmits the signal for the localization of cells to ensure the temporal focusing of the optical beam on the cells.
Abstract translation: 用于递送外源分子的系统包括用于容纳细胞和外源分子的载体;红外（IR）光源，其产生具有至少大于104W / cm 2量级的平均功率密度的IR光束; 一个或多个光学元件; 成像系统，用于在视场中对单元进行成像;处理器，其产生用于在视野中定位细胞的信号; 用于光束的时间聚焦以在细胞上产生宽场照明的光图案整形器以透过细胞膜以传递外源分子; 以及将光束从宽场照明切换到聚焦照明的控制器。 处理器可操作地耦合到成像系统和光图案整形器，并且传输信号用于细胞的定位，以确保光束在细胞上的时间聚焦。
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公开(公告)号：WO2013096707A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/071103
申请日：2012-12-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： NECULAES, Vasile, Bogdan , VASCONCELLOS, Stephen, Robert , MOORE, Brian , MURRAY, Anthony, John , KLIMASH, June , CONWAY, Kenneth , PAXON, Tracy , SALERNO, Michael , RENKO, Casey, L.
Abstract: Methods for treatment of sludge with microwave irradiation for improving its dewatering are provided. In one embodiment, the method includes exposing the sludge to microwave irradiation at a power density of between about 3 W/ml and about 17 W/ml. Turbidity, total solids content and overall dewaterability are improved when the microwave irradiation treatment is combined with another method for dewatering sludge, such as enzyme treatment, conditioning with a flocculating agent and mechanical dewatering.
Abstract translation: 提供了利用微波辐射处理污泥以改善其脱水的方法。 在一个实施方案中，该方法包括以约3W / ml至约17W / ml的功率密度将污泥暴露于微波照射。 当微波照射处理与另一种用于脱水污泥的方法（如酶处理，用絮凝剂调理和机械脱水）相结合时，浊度，总固体含量和总脱水性得到改善。
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公开(公告)号：WO2013030245A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/066796
申请日：2012-08-29
Applicant: GENERAL ELECTRIC COMPANY , GE HEALTHCARE UK LIMITED , CONWAY, Kenneth, Roger , YAZDANFAR, Siavash , NECULAES, Vasile, Bogdan , DAVIS, Brian, Michael , GARNER, Allen, Lawrence , LOGHIN, Evelina, Roxana , JOO, Chulmin , DYLOV, Dmitry, Vladimirovich
Inventor： CONWAY, Kenneth, Roger , YAZDANFAR, Siavash , NECULAES, Vasile, Bogdan , DAVIS, Brian, Michael , GARNER, Allen, Lawrence , LOGHIN, Evelina, Roxana , JOO, Chulmin , DYLOV, Dmitry, Vladimirovich
CPC classification number: C12N13/00 , A61K48/0083 , C12N15/87
Abstract: A method of delivering exogenous molecules, comprising: providing a plurality of cells having a cell membrane; adding a plurality of exogenous molecules to the cells; exposing the cells to a defocused infrared (IR) light to permeabilize the cell membrane of the cells; and delivering the exogenous molecules to the cells through the permeablized cell membrane,wherein an intensity of the IR light at the optical focus is at least greater than or equal to an order of 10 4 W/cm 2
Abstract translation: 一种递送外源性分子的方法，包括：提供多个具有细胞膜的细胞; 向细胞中加入多种外源性分子; 将细胞暴露于散焦的红外（IR）光以使细胞的细胞膜透化; 并且通过透过细胞膜将外源性分子递送至细胞，其中所述光学焦点处的IR光的强度至少大于或等于104W / cm 2
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Patent Agency Ranking
公开(公告)号：WO2012082259A1
公开(公告)日：2012-06-21
申请号：PCT/US2011/059680
申请日：2011-11-08
Applicant: GENERAL ELECTRIC COMPANY , POLIZZOTTI, David, M. , MOORE, Brian, Christopher , NECULAES, Vasile, Bogdan , KHWAJA, Abdul, Rafi , PETERSEN, Matthew, Alan
Inventor： POLIZZOTTI, David, M. , MOORE, Brian, Christopher , NECULAES, Vasile, Bogdan , KHWAJA, Abdul, Rafi , PETERSEN, Matthew, Alan
IPC: C02F9/00 , E21B43/40 , E21B43/24 , C02F1/28 , C02F1/30 , C02F1/42 , C02F1/44 , C02F1/46 , C02F1/52 , C02F1/72 , C02F3/00 , C02F5/02 , C02F103/36
CPC classification number: C02F9/00 , C02F1/28 , C02F1/302 , C02F1/42 , C02F1/441 , C02F1/442 , C02F1/46 , C02F1/52 , C02F1/72 , C02F3/00 , C02F5/025 , C02F2103/365 , E21B43/2406 , E21B43/40
Abstract: A system for treating produced water, for example from a SAGD bitumen production operation, has a treatment unit using chemical oxidation (CO) or electromagnetic treatment (ET) to destroy or degrade organics in the produced water. The treatment module may use CO or ET in combination with biological treatment or sorption processes or both. When the treatment module is used upstream of a steam generator, it reduces fouling in the steam generator and in any blowdown water treatment device. A brine concentrator or a crystallizer may be used to treat the blowdown water. The treatment module may be used in combination with a nanofiltration (NF) or reverse osmosis (RO) membrane filter. Optionally, the produced water may be treated with an ET process such as microwaves directly upstream of a steam generator or upstream of a concentrator or crystallizer in a blowdown water stream.
Abstract translation: 用于处理例如来自SAGD沥青生产操作的生产水的系统具有使用化学氧化（CO）或电磁处理（ET）的处理单元来破坏或降解生产水中的有机物。 处理模块可以使用CO或ET与生物处理或吸附过程或两者结合使用。 当处理模块用于蒸汽发生器的上游时，可以减少蒸汽发生器和任何排污水处理装置中的污垢。 盐水浓缩器或结晶器可用于处理排污水。 处理模块可以与纳滤（NF）或反渗透（RO）膜过滤器组合使用。 任选地，生产的水可以用ET工艺如蒸汽发生器的直接上游的微波处理，或者在排污水流中的浓缩器或结晶器的上游处理。
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5.发明申请
公开(公告)号：WO2014182394A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/032835
申请日：2014-04-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： LEE, Yongjae , OBI, Aghogho, Atemu , KIM, Seog, Tae , PLATT, William, Chester , BRAY, James, William , PLOTNIKOV, Yuri, Alexeyevich , WEBSTER, Jack, Mathew , NECULAES, Vasile, Bogdan
Abstract: A system for measuring nutritional parameters of food items is provided. The system includes a holding cavity. The system further includes a sensor assembly that includes a transmitter antenna and at least one receiver antenna. The transmitter antenna is configured to transmit signals to a food item in the holding cavity. The receiver antenna is configured to receive response signals from the food item. The system includes at least one switch coupled to each antenna. The switch, in a first state, is configured to set the sensor assembly to an electric potential equal to that of the holding cavity. In a second state, the switch is configured to couple the sensor assembly to a power source. The system also includes a processing unit to process the signals received to determine the nutritional parameters of the food item.
Abstract translation: 提供了一种用于测量食品营养参数的系统。 该系统包括一个保持腔。 该系统还包括传感器组件，其包括发射器天线和至少一个接收器天线。 发射机天线被配置为将信号发送到保持腔中的食物。 接收器天线被配置为从食品接收响应信号。 该系统包括耦合到每个天线的至少一个开关。 在第一状态下的开关被配置成将传感器组件设置成等于保持腔的电位。 在第二状态下，开关被配置成将传感器组件耦合到电源。 该系统还包括处理单元，用于处理所接收的信号以确定食品的营养参数。
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公开(公告)号：WO2017117385A2
公开(公告)日：2017-07-06
申请号：PCT/US2016/069197
申请日：2016-12-29
Applicant: GENERAL ELECTRIC COMPANY
CPC classification number: C12N13/00 , A61K33/06 , A61K35/19 , A61K38/18 , A61K41/00 , C12N5/0644 , A61K2300/00
Abstract: The present disclosure relates to the generation of an activated platelet product in which one or more of the presence or absence of clots, the timing of clot formation (if present), and/or the mechanical strength of clots (if present) is controlled by the presence or concentration of calcium ions during the activation process. In certain embodiments, the calcium ion concentration is controlled in the presence of pulsed electric fields or a chemical activator (e.g., thrombin) as part of the activation process.
Abstract translation: 本公开涉及产生活化的血小板产品，其中凝块的存在或不存在，凝块形成的时机（如果存在的话）和/或机械强度为 凝块（如果存在的话）由激活过程中钙离子的存在或浓度控制。 在某些实施方案中，作为激活过程的一部分，在存在脉冲电场或化学活化剂（例如凝血酶）的情况下控制钙离子浓度。
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公开(公告)号：WO2015108778A1
公开(公告)日：2015-07-23
申请号：PCT/US2015/010817
申请日：2015-01-09
Applicant: GENERAL ELECTRIC COMPANY
Inventor： NECULAES, Vasile, Bogdan , TORRES, Andrew, Soliz , CAIAFA, Antonio , LEE, Brian, Duh-Lan , GARNER, Allen, Lawrence
CPC classification number: A61K38/1858 , A61K35/19 , C12N13/00 , G01N33/48707 , G01N33/49
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
Abstract translation: 公开了用于释放生长因子的方法和系统。 在某些实施方案中，将血液样品暴露于一个或多个电脉冲的序列以触发样品中生长因子的释放。 在某些实施方案中，生长因子释放不伴随血液样品内的凝血。
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公开(公告)号：WO2015108619A1
公开(公告)日：2015-07-23
申请号：PCT/US2014/066484
申请日：2014-11-20
Applicant: GENERAL ELECTRIC COMPANY
Inventor： CAIAFA, Antonio , NECULAES, Vasile, Bogdan , GARNER, Allen, Lawrence , TORRES, Andrew, Soliz
CPC classification number: C12N13/00 , A61B5/150755 , C12M35/02 , G01N33/49 , H03K3/53
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
Abstract translation: 根据本公开，描述了通过电容耦合将样本暴露于一个或多个电脉冲。 在某些实施方案中，样品可以是使用脉冲电场处理或修饰的生物样品。 在某些实施例中，电脉冲可以使用电容耦合传送到负载。 在其他实施例中，电脉冲可以是双极性脉冲。
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