公开(公告)号：WO2011084465A3

公开(公告)日：2011-11-17

申请号：PCT/US2010060474

申请日：2010-12-15

Applicant: INCEPT LLC ,  CAMPBELL PATRICK ,  SAWHNEY AMARPREET S

Inventor： CAMPBELL PATRICK ,  SAWHNEY AMARPREET S

IPC: A61L27/50 ,  A61L27/14 ,  A61L27/54 ,  A61L27/58 ,  A61L31/12

CPC classification number: A61K49/0442 ,  A61K49/0419 ,  A61K51/1244 ,  A61K2123/00 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  A61L31/145 ,  A61L31/148 ,  A61L31/18

Abstract: Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.

Abstract translation: 可植入材料可用于医源性部位。 应用包括用于基准标记的不透射线材料。

公开(公告)号：WO2010129510A3

公开(公告)日：2011-05-12

申请号：PCT/US2010033488

申请日：2010-05-04

Applicant: INCEPT LLC ,  CAMPBELL PATRICK ,  SAWHNEY AMARPREET S

Inventor： CAMPBELL PATRICK ,  SAWHNEY AMARPREET S

IPC: A61M5/14 ,  A61M37/00

CPC classification number: A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00557 ,  A61B2017/0065 ,  A61B2017/00654 ,  A61L31/06 ,  A61L31/145 ,  A61L31/148

Abstract: Embodiments include coatings for adherence of biomaterials to a tissue. Systems and methods for adapting such coated materials to vascular access closure are further proved.

Abstract translation: 实施方案包括用于将生物材料粘附到组织上的涂层。 进一步证明了将这种涂覆材料适应于血管通路闭合的系统和方法。

公开(公告)号：WO2007127198A2

公开(公告)日：2007-11-08

申请号：PCT/US2007009934

申请日：2007-04-24

Applicant: INCEPT LLC ,  PATHAK CHANDRASHEKHAR P ,  SAWHNEY AMARPREET S

Inventor： PATHAK CHANDRASHEKHAR P ,  SAWHNEY AMARPREET S

IPC: A61K38/39 ,  A61K39/02 ,  A61K39/12 ,  C08G63/91

CPC classification number: A61L24/0005 ,  A61K47/60 ,  A61L24/0031 ,  A61L24/046 ,  A61L24/06 ,  A61L24/108 ,  C08H1/00 ,  C08L89/00 ,  C08L71/02 ,  C08L39/06

Abstract: Some aspects of this disclosure relate to a method for crosslinking a biological fluid comprising combining a biological fluid with a crosslinker to covalently crosslink proteins endogenous to the biological fluid to form a crosslinked gel. Examples of a biological fluid are blood, plasma, or serum.

Abstract translation: 本公开的一些方面涉及用于交联生物流体的方法，包括将生物流体与交联剂组合以共价交联生物流体内源的蛋白质以形成交联凝胶。 生物流体的实例是血液，血浆或血清。

公开(公告)号：WO2010093873A3

公开(公告)日：2011-04-14

申请号：PCT/US2010024029

申请日：2010-02-12

Applicant: INCEPT LLC ,  SAWHNEY AMARPREET S ,  JARRETT PETER ,  BASSETT MICHAEL ,  BLIZZARD CHARLES D

Inventor： SAWHNEY AMARPREET S ,  JARRETT PETER ,  BASSETT MICHAEL ,  BLIZZARD CHARLES D

IPC: A61M31/00 ,  A61F2/02 ,  A61F9/007 ,  A61K9/06 ,  A61K31/437 ,  A61K47/30 ,  A61M5/00 ,  A61P27/02

CPC classification number: A61K9/0051 ,  A61B17/12099 ,  A61B17/12159 ,  A61B17/1219 ,  A61F9/00772 ,  A61F2250/0067 ,  A61K31/135 ,  A61K31/437

Abstract: An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.

Abstract translation: 一个实施方案是用于阻断或减少穿过人眼的泪点或泪管的泪液的药物假体，并将药物递送至眼睛，该药物包括脱水的共价交联的合成亲水性聚合物水凝胶，其尺寸通过泪点，脱水 水凝胶吸收生理水以横截面宽度膨胀至至少1mm，并且顺应地配合小孔，其中水凝胶包含分散在水凝胶中的治疗剂以释放至眼睛，水凝胶的水含量至少约为 当在生理盐水中体外充分水合时，其重量为50％或体积。

公开(公告)号：WO2009059217A2

公开(公告)日：2009-05-07

申请号：PCT/US2008082102

申请日：2008-10-31

Applicant: INCEPT LLC ,  SAWHNEY AMARPREET S ,  KHOSRAVI FARHAD ,  PAI SURESH S ,  SERSHEN SCOTT R

Inventor： SAWHNEY AMARPREET S ,  KHOSRAVI FARHAD ,  PAI SURESH S ,  SERSHEN SCOTT R

IPC: A61B17/08 ,  A61B17/04

CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B2017/00004 ,  A61B2017/00477 ,  A61B2017/00495 ,  A61B2017/0065 ,  A61B2017/00654 ,  A61B2017/22047 ,  A61F2/92 ,  A61F2210/0076 ,  A61L24/0015 ,  A61L24/0031 ,  A61L2400/04

Abstract: Apparatus and methods for sealing a puncture through tissue or otherwise treating a body lumen of a patient. The carrier includes at least one, but not all, of the adherent layer components required to form a tacky or sticky adherent layer on the carrier. The remaining adherent layer precursor(s) are delivered to the carrier in situ to form a sticky and/or tacky adherent layer on the carrier that enhances the attachment and retention of the carrier to tissue surrounding a target treatment location in which the carrier is delivered. The carrier may include hydrogel and/or other porous material, e.g., for releasing one or more agents carried by the carrier at the treatment location.

Abstract translation: 用于密封刺穿组织或以其他方式治疗患者体腔的装置和方法。 载体包括至少一种但不是全部的在载体上形成粘性或粘性粘附层所需的粘附层组分。 将剩余的粘附层前体原位递送到载体以在载体上形成粘性和/或粘性粘附层，其增强载体附着和保持在其中递送载体的目标处理位置周围的组织 。 载体可以包括水凝胶和/或其他多孔材料，例如用于在治疗位置释放由载体携带的一种或多种药剂。

公开(公告)号：WO9629370A3

公开(公告)日：1996-11-07

申请号：PCT/US9603834

申请日：1996-03-22

Applicant: FOCAL INC ,  UNIV TEXAS ,  SAWHNEY AMARPREET S ,  MELANSON DAVID A ,  PATHAK CHANDRASHEKAR P ,  HUBBELL JEFFREY A ,  AVILA LUIS Z ,  KIERAS MARK T

Inventor： SAWHNEY AMARPREET S ,  MELANSON DAVID A ,  PATHAK CHANDRASHEKAR P ,  HUBBELL JEFFREY A ,  AVILA LUIS Z ,  KIERAS MARK T

IPC: A61B17/00 ,  A61B17/08 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61L29/00 ,  A61L31/00 ,  C08F2/48 ,  C08F4/40 ,  C08F265/04 ,  C08F271/00 ,  C08F283/00 ,  C08F289/00 ,  C08F290/06 ,  C08F290/14 ,  C08F291/00 ,  C09D4/00 ,  C09D7/00 ,  C09D171/00 ,  C09J151/00 ,  A61L25/00 ,  A61L27/00

CPC classification number: C09D4/00 ,  A61B17/00491 ,  A61B17/085 ,  A61B2017/00495 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/06 ,  A61L2300/00 ,  C08F2/48 ,  C08F265/04 ,  C08F271/00 ,  C08F283/00 ,  C08F289/00 ,  C08F290/06 ,  C08F290/062 ,  C08F290/14 ,  C08F291/00 ,  C08L2666/02 ,  C09J151/00 ,  Y10S602/904 ,  C08L71/02 ,  C08L33/04 ,  C08F220/00

Abstract: An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.

公开(公告)号：WO2017091749A8

公开(公告)日：2017-07-06

申请号：PCT/US2016063633

申请日：2016-11-23

Applicant: INCEPT LLC

Inventor： JARRETT PETER ,  MCGRATH MICHAEL J ,  JARRETT TIMOTHY S ,  EL-HAYEK RAMI ,  VANSLETTE ANDREW C ,  ROSALES COURTNEY A ,  BLIZZARD CHARLES D ,  SAWHNEY AMARPREET S

IPC: A61K9/00 ,  A61K31/00 ,  A61K47/10 ,  A61P27/02

CPC classification number: A61K9/2072 ,  A61K9/0051 ,  A61K9/2031 ,  A61K31/00 ,  A61K31/4439 ,  A61K47/10

Abstract: Drug delivery using bio-affecting drugs, particularly with shape changing drug delivery devices. Embodiments are included for depots for delivery of a therapeutic agent that change from an elongated state ex vivo to a coil in vivo where the agent is released.

Abstract translation: 使用生物影响药物进行药物输送，特别是使用改变形状的药物输送装置。 包括用于递送治疗剂的仓库的实施方式，所述治疗剂从释放药剂的体内延长状态变为体内卷曲。

公开(公告)号：WO2016065245A8

公开(公告)日：2016-10-13

申请号：PCT/US2015057091

申请日：2015-10-23

Applicant: INCEPT LLC

Inventor： CAMPBELL PATRICK ,  SAWHNEY AMARPREET S ,  KHOSRAVI FARHAD

IPC: A61F2/945

CPC classification number: A61F2/945 ,  A61B17/00491 ,  A61B2017/00654 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61F2/82 ,  A61F2002/823 ,  A61F2250/0067 ,  A61L31/145 ,  A61M25/104 ,  A61M2025/105

Abstract: Methods and devices for treating a luminal pathology affecting an anatomical lumen of a patient comprising forming, in situ, a continuous cohesive layer of covalently-crosslinked hydrogel in a luminal wall of the anatomical lumen.

Abstract translation: 用于治疗影响患者解剖腔的腔病变的方法和装置，包括在解剖腔的腔壁内原位形成共价交联水凝胶的连续粘性层。