公开(公告)号：WO2004041101A2

公开(公告)日：2004-05-21

申请号：PCT/US2003/033899

申请日：2003-10-27

Applicant: MEDTRONIC, INC.

Inventor： JAHNS, Scott, E. ,  FRANCISCHELLI, David, E. ,  LUTTERMAN, Alison ,  KEOGH, James, R. ,  BRISCOE, Roderick, E. ,  O"NEILL, William, G. ,  BILITZ, Mark, R. ,  GOODMAN, Jack ,  DAIGLE, Tom, P. ,  ROTHSTEIN, Paul, T. ,  PODBELSKI, Adam, A. ,  RODDY, Stephen, J. ,  KIM, David, J., S.

IPC: A61B18/14

CPC classification number: A61B18/1445 ,  A61B2018/1861

Abstract: A hemostat-type device for ablative treatment of tissue, particularly for treatment of atrial fibrillation, is constructed with features that provide easy and effective treatment. A swiveling head assembly can allow the jaws to be adjusted in pitch and roll. Malleable jaws can permit curved lesion shapes. A locking detent can secure the jaws in a closed position during the procedure. An illuminated indicator provides confirmation that the device is operating. A fluid delivery system simplifies irrigated ablation procedures.

Abstract translation: 用于消融治疗组织的止血剂型装置，特别是用于治疗心房纤维性颤动的装置，其构造具有提供容易和有效治疗的特征。 旋转头组件可以允许钳口在俯仰和滚动中进行调节。 韧性的钳口可以允许弯曲的损伤形状。 在操作过程中，锁定爪可以将夹爪固定在关闭位置。 照明指示灯提供设备正在运行的确认。 流体输送系统简化了灌溉消融程序。

公开(公告)号：WO2007127841A2

公开(公告)日：2007-11-08

申请号：PCT/US2007/067494

申请日：2007-04-26

Applicant: MEDTRONIC, INC. ,  YONCE, Laura, A. ,  KANAYINKAL, Tessy ,  MULLINS-HIRTE, Debra, J. ,  HUANG, Trevor, C. ,  CARIAPPA, Rohit ,  MERTE, Kenneth, E. ,  KEOGH, James, R. ,  MCINTOSH, Kevin, D. ,  STEFFENS, Brian, J. ,  NAYAK, Asha, S. ,  JOHNSON, Erick. L.

Inventor： YONCE, Laura, A. ,  KANAYINKAL, Tessy ,  MULLINS-HIRTE, Debra, J. ,  HUANG, Trevor, C. ,  CARIAPPA, Rohit ,  MERTE, Kenneth, E. ,  KEOGH, James, R. ,  MCINTOSH, Kevin, D. ,  STEFFENS, Brian, J. ,  NAYAK, Asha, S. ,  JOHNSON, Erick. L.

IPC: A61K38/36 ,  C07K14/745

CPC classification number: C12N9/6429 ,  A61K35/14 ,  A61K35/16 ,  A61K35/19 ,  C07K14/745 ,  C12N5/0644 ,  C12Y304/21005

Abstract: The present invention provides biological compositions and methods for making the same.

Abstract translation: 本发明提供了生物组合物及其制备方法。

公开(公告)号：WO2006060431A1

公开(公告)日：2006-06-08

申请号：PCT/US2005/043200

申请日：2005-11-30

Applicant: MEDTRONIC, INC. ,  BONNER, Matthew, D. ,  ROTHSTEIN, Paul, T. ,  HINIDUMA-LOKUGE, Prasanga, D. ,  KEOGH, James, R. ,  USHER, Raymond, W. ,  JAHNS, Scott, E. ,  CHEN, Victor, T.

Inventor： BONNER, Matthew, D. ,  ROTHSTEIN, Paul, T. ,  HINIDUMA-LOKUGE, Prasanga, D. ,  KEOGH, James, R. ,  USHER, Raymond, W. ,  JAHNS, Scott, E. ,  CHEN, Victor, T.

IPC: A61B17/34

CPC classification number: A61B17/3478 ,  A61B17/00234 ,  A61B17/205 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/2926 ,  A61B2017/2936 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2018/00392 ,  A61B2090/034 ,  A61M25/0084

Abstract: Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.

Abstract translation: 将生物制剂注入组织的装置和方法。 提供了具有细长轴和远端注射头的装置，用于将针驱动到组织中并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以转换成针驱动力。 一些装置提供可控制的针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

公开(公告)号：WO2002102252A1

公开(公告)日：2002-12-27

申请号：PCT/US2002/013387

申请日：2002-04-26

Applicant: MEDTRONIC, INC.

Inventor： JAHNS, Scott, E. ,  KEOGH, James, R. ,  O'NEILL, William, G. ,  PIGNATO, Paul, A. ,  MONTPETIT, Karen ,  DAIGLE, Thomas ,  GUBBIN, Douglas, H. ,  COLSON, Michael, A. ,  GUENST, Gary, W. ,  OLIG, Chris ,  JOLLY, Katherine

IPC: A61B17/02

CPC classification number: A61B17/0206 ,  A61B17/22004 ,  A61B2017/0243 ,  A61B2017/2905 ,  A61B2017/308 ,  A61N1/36114

Abstract: This invention provides a system and method for positioning, manipulating, holding, grasping, immobilizing and/or stabilizing a heart including one or more tissue-engaging devices, one or more suction sources (20), one or more fluid sources (40), one or more energy sources (50), one or more sensors (60) and one or more processors (70). The system and method may include an indifferent electrode, a drug delivery device and an illumination device. The system's tissue-engaging device may comprise a tissue-engaging head, a support apparatus and a clamping mechanism for attaching the tissue-engaging device to a stable object. The system may be used during various medical procedures including the deployment of an anastomotic device, intermittently stopping and starting of the heart, ablation of cardiac tissues and the placement of cardiac leads.

Abstract translation: 本发明提供了一种用于定位，操纵，保持，抓住，固定和/或稳定心脏的系统和方法，所述心脏包括一个或多个组织接合装置，一个或多个抽吸源（20），一个或多个流体源（40） 一个或多个能量源（50），一个或多个传感器（60）和一个或多个处理器（70）。 该系统和方法可以包括无关电极，药物递送装置和照明装置。 系统的组织接合装置可以包括组织接合头，支撑装置和用于将组织接合装置附接到稳定物体的夹紧机构。 该系统可以在各种医疗过程中使用，包括部署吻合装置，间歇性地停止和起始心脏，消融心脏组织和放置心脏引线。

公开(公告)号：WO2008048572A3

公开(公告)日：2008-04-24

申请号：PCT/US2007/022033

申请日：2007-10-16

Applicant: MEDTRONIC, INC.

Inventor： CLAGUE, Cynthia, T. ,  HOBDAY, Michael, J. ,  USHER, Raymond, W. ,  BRISCOE, Roderick, E. ,  JOLLY, Katherine, S. ,  BUHR, Rebecca, A. ,  OLIG, Christopher, P. ,  MEYER, Eric, A. ,  CHRISTIAN, Steven, C. ,  DAIGLE, Thomas, P. ,  REETZ, Robert, H. ,  SANDSTROM, Jeffrey, D. ,  KEOGH, James, R. ,  BONNER, Matthew, D. ,  JAHNS, Scott, E. ,  HAARSTAD, Philip, J.

IPC: A61F2/04

Abstract: Embodiments of the invention provide a cutting device and method of vessel harvesting. The cutting device can include at least one tubular member, a cutting element, and a centering member. The cutting device can include at least one tubular member with a flexible section and a cutting element. The method of vessel harvesting can include spacing a cutting element of the cutting device from the vessel as the cutting element is advanced over the vessel.

公开(公告)号：WO2007127834A3

公开(公告)日：2007-11-08

申请号：PCT/US2007/067486

申请日：2007-04-26

Applicant: MEDTRONIC, INC. ,  YONCE, Laura, A. ,  KANAYINKAL, Tessy ,  MULLINS-HIRTE, Debra, J. ,  HUANG, Trevor, C. ,  CARIAPPA, Rohit ,  MERTE, Kenneth, E. ,  KEOGH, James, R. ,  MCINTOSH, Kevin, D. ,  STEFFENS, Brian, J. ,  NAYAK, Asha, S. ,  JOHNSON, Erick, L.

Inventor： YONCE, Laura, A. ,  KANAYINKAL, Tessy ,  MULLINS-HIRTE, Debra, J. ,  HUANG, Trevor, C. ,  CARIAPPA, Rohit ,  MERTE, Kenneth, E. ,  KEOGH, James, R. ,  MCINTOSH, Kevin, D. ,  STEFFENS, Brian, J. ,  NAYAK, Asha, S. ,  JOHNSON, Erick, L.

IPC: A61K38/36 ,  C07K14/745

Abstract: The present invention provides biological compositions and methods for making the same.

公开(公告)号：WO2005113068A1

公开(公告)日：2005-12-01

申请号：PCT/US2005/016860

申请日：2005-05-13

Applicant: MEDTRONIC, INC. ,  STEWART, Mark, T. ,  FRANCISCHELLI, David, E. ,  SKARDA, James, R. ,  KEOGH, James, R. ,  HISSONG, James, B.

Inventor： STEWART, Mark, T. ,  FRANCISCHELLI, David, E. ,  SKARDA, James, R. ,  KEOGH, James, R. ,  HISSONG, James, B.

IPC: A61N7/02

CPC classification number: A61N7/022 ,  A61B8/4281 ,  A61B17/2202 ,  A61B18/1492 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00363 ,  A61B2018/00839 ,  A61B2018/1472

Abstract: A method of thermal ablation using high intensity focused ultrasound energy includes the steps of positioning one or more ultrasound emitting members within a patient, emitting ultrasound energy from the one or more ultrasound emitting members, focusing the ultrasound energy, ablating with the focused ultrasound energy to form an ablated tissue area and removing the ultrasound emitting member.

Abstract translation: 使用高强度聚焦超声能量的热消融的方法包括将一个或多个超声发射部件定位在患者体内的步骤，从一个或多个超声发射部件发射超声能量，将超声能量聚焦，用聚焦的超声能量消融到 形成消融的组织区域并移除超声发射构件。

公开(公告)号：WO2005053788A1

公开(公告)日：2005-06-16

申请号：PCT/US2004/039413

申请日：2004-11-23

Applicant: MEDTRONIC, INC. ,  WHALEN, Lisa, L. ,  LAPORTE, Steve ,  KEOGH, James, R. ,  HILL, Michael, R.S. ,  BONNER, Matthew, D.

Inventor： WHALEN, Lisa, L. ,  LAPORTE, Steve ,  KEOGH, James, R. ,  HILL, Michael, R.S. ,  BONNER, Matthew, D.

IPC: A61N1/05

CPC classification number: A61N1/36114 ,  A61N1/056 ,  A61N1/3622 ,  A61N1/36514 ,  A61N1/3962

Abstract: A method of performing a medical procedure is provided. The medical procedure includes stimulation of a patient's heart while stimulating a nerve of the patient in order to modulate the patient's inflammatory process. More particularly, the medical procedure includes pacing the ventricles of the patient's heart while stimulating the vagal nerve of the patient. Systems and devices for performing the medical procedure are also provided.

Abstract translation: 提供了一种执行医疗程序的方法。 医疗过程包括刺激患者的心脏同时刺激患者的神经以调节患者的炎症过程。 更具体地，医疗过程包括在刺激患者的迷走神经的同时起搏患者心脏的心室。 还提供用于执行医疗程序的系统和设备。

公开(公告)号：WO2003026741A1

公开(公告)日：2003-04-03

申请号：PCT/US2002/030443

申请日：2002-09-25

Applicant: MEDTRONIC,INC.

Inventor： HILL, Micheal, R.S. ,  JAHNS, Scott, E. ,  KEOGH, James, R. ,  EULER, David, E. ,  UJHELYI, Michael, R. ,  RAKOW, Nancy ,  COLSON, Michael, A.

IPC: A61N1/362

CPC classification number: A61N1/0517 ,  A61M5/14276 ,  A61N1/0519 ,  A61N1/0556 ,  A61N1/056 ,  A61N1/36007 ,  A61N1/3601 ,  A61N1/36114 ,  A61N1/362 ,  A61N1/385 ,  A61N1/39

Abstract: A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. Systems and devices for performing the medical procedure are also provided.

Abstract translation: 提供了一种执行诸如手术的医疗程序的方法。 刺激神经以将心脏的跳动调节到第一状态，例如停止或减缓的状态。 医疗程序在心脏或另一个器官上进行。 停止对神经的刺激，以便将心脏的跳动调节到第二状态，例如打浆状态。 心脏本身也可能被刺激到跳动状态，例如通过起搏。 可以继续刺激神经以允许继续医疗程序。 还提供用于执行医疗程序的系统和设备。

公开(公告)号：WO2017106052A1

公开(公告)日：2017-06-22

申请号：PCT/US2016/065983

申请日：2016-12-09

Applicant: MEDTRONIC INC.

Inventor： ROTHSTEIN, Paul ,  KEOGH, James, R.

IPC: A61F2/24 ,  A61F2/966

CPC classification number: A61F2/2439 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2/2469 ,  A61F2/966 ,  A61F2002/826 ,  A61F2002/9665 ,  A61F2230/0006 ,  A61F2230/0069 ,  A61F2250/006

Abstract: A delivery system for transcatheter implantation of a heart valve prosthesis. The delivery system includes an outer sheath component (106) defining a lumen therethrough, an elongate tube (136) having at least two flat wires (146) longitudinally extending from a distal end thereof, and self-expanding first and second frames (102, 104) disposed in series within a distal portion of the outer sheath component and held in a compressed delivery configuration therein. The elongate tube and the at least two flat wires are slidably disposed within the lumen of the outer sheath component. In the compressed delivery configuration the at least two flat wires longitudinally extend along exterior portions of the first and second frames and are woven through adjacent ends of the first and second frames to releasably couple them to each other. Proximal retraction of the at least two flat wires from the first and second frames releases at least the first frame from the delivery system.

Abstract translation: 一种用于心脏瓣膜假体的经导管植入的输送系统。 输送系统包括限定穿过其中的内腔的外护套部件（106），具有从其远端纵向延伸的至少两根扁线（146）的细长管（136），以及自扩张的第一和第二框架（102,104） 串联设置在外部护套部件的远侧部分内并且保持在其中的压缩输送构型中。 细长管和至少两根扁线可滑动地设置在外部护套部件的内腔内。 在压缩输送构造中，至少两根扁平线沿着第一和第二框架的外部纵向延伸，并且编织穿过第一和第二框架的相邻端部以将它们可释放地联接到彼此。 至少两根扁线从第一和第二框架向近侧缩回至少从输送系统释放第一框架。