公开(公告)号：WO2008086809A1

公开(公告)日：2008-07-24

申请号：PCT/DK2008/050002

申请日：2008-01-04

Applicant: SCANDINAVIAN MICRO BIODEVICES ApS ,  KRING, Ole ,  JONSMANN, Jacques ,  BAU-MADSEN, Niels Kristian

Inventor： KRING, Ole ,  JONSMANN, Jacques ,  BAU-MADSEN, Niels Kristian

IPC: B01L3/00 ,  G01N33/543

CPC classification number: B01L3/502746 ,  B01L2300/0636 ,  B01L2300/0825 ,  B01L2300/089 ,  B01L2300/165 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/088

Abstract: The invention relates to a microfluidic device comprising a flow path with a first and a second opposite solid flow path surfaces (1) and a liquid inlet for said flow path. In the microfluid device at least one solid side wall free section (2) of the flow path (1) is provided by the first and the second opposite solid flow path surfaces in at least said one solid side wall free section (2) and a pair of borderlines (3, 31) defines the edges of the side wall free section (2) of said flow path (1). The pair of borderlines is placed on the first surface of a first and a second opposite surfaces to define the flow path surfaces of said first and second opposite surfaces. The pair of borderlines (3, 31) is defined by an abrupt change of the first and/or the second surface, e.g. in the form of an abrupt change of surface tension and/or an abrupt change of distance between the first and second surfaces beyond and adjacent to the borderlines (3, 31). For example the borderlines (3, 31) may be arranged with a sharp edge with an angle between a flow path surface in the side wall free flow path section and the respective surfaces beyond and, adjacent to the borderlines which is less than 135 degrees, such as about 90 degrees. The flow path comprises an immobilized capture reagent (7) downstream from or in said solid side wall free flow path section (2), said immobilized capture reagent (7) preferably being immobilized onto at least one of said first and second opposite solid flow path surfaces.

Abstract translation: 本发明涉及一种微流体装置，其包括具有第一和第二相对的固体流动路径表面（1）的流动路径和用于所述流动路径的液体入口。 在微流体装置中，流路（1）的至少一个固体侧壁自由部分（2）由至少所述一个实心侧壁自由部分（2）中的第一和第二相对的固体流动通道表面提供，并且 一对边界线（3,31）限定了所述流动路径（1）的侧壁自由部分（2）的边缘。 一对边界线放置在第一和第二相对表面的第一表面上，以限定所述第一和第二相对表面的流动路径表面。 一对边界线（3,31）由第一和/或第二表面的突然变化限定，例如， 其形式是表面张力的突然变化和/或第一和第二表面之间的距离和边界线（3,31）之间的距离的突然变化。 例如，边界线（3,31）可以布置成具有在侧壁自由流动路径部分中的流动路径表面与超过小于135度的边界线的相邻表面之间的角度的尖锐边缘， 如约90度。 流动路径包括在所述固体侧壁自由流动路段部分（2）中或所述固体侧壁自由流动路段部分（2）下游的固定的捕获试剂（7），所述固定化捕获试剂（7）优选固定在所述第一和第二相对固体流动路径中的至少一个 表面。

公开(公告)号：WO2015192855A1

公开(公告)日：2015-12-23

申请号：PCT/DK2015/050166

申请日：2015-06-15

Applicant: SCANDINAVIAN MICRO BIODEVICES APS

Inventor： BAU-MADSEN, Niels Kristian ,  NIELSEN, Lars Bue ,  HELLER, Martin ,  KRING, Ole ,  ORDEIG, Olga ,  OVERBY, Bent

IPC: G01N21/00 ,  B01L3/00 ,  G01N35/00

CPC classification number: B01L3/502715 ,  B01L9/527 ,  B01L2200/025 ,  B01L2300/02 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  G01N21/05 ,  G01N21/25 ,  G01N21/255 ,  G01N21/31 ,  G01N21/6428 ,  G01N27/403 ,  G01N35/00029 ,  G01N35/00732 ,  G01N2021/0346 ,  G01N2021/6439 ,  G01N2035/00237 ,  G01N2035/00752 ,  G01N2035/00811 ,  G01N2035/00851 ,  G01N2201/062 ,  G01N2201/0627

Abstract: The present invention relates to a microfluidic detection system comprising a microfluidic cartridge and a detector assembly. The microfluidic cartridge comprises a first and a second side and at least one flow channel and an inlet to the flow channel(s) for feeding a liquid sample, the flow channel(s) comprises a plurality of first optical detection sites. The detector assembly comprises a slot for inserting the microfluidic cartridge and a first fixed light source with a beam path and an optical reader for reading out optical signals from at least one of said first optical detection site(s). The detector assembly and the microfluidic cartridge are constructed such that when said microfluidic cartridge is inserted to a first predetermined position into said slot, one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source, and when said cartridge is inserted to a second predetermined position into said slot, another one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source.

Abstract translation: 微流体检测系统技术领域本发明涉及一种微流体检测系统，其包括微流控盒和检测器组件。 微流体盒包括第一和第二侧以及至少一个流动通道和用于供给液体样品的流动通道的入口，所述流动通道包括多个第一光学检测位置。 检测器组件包括用于插入微流体盒的槽和具有光束路径的第一固定光源和用于从所述第一光学检测位置中的至少一个读出光信号的光学读取器。 检测器组件和微流体盒被构造成使得当所述微流体盒插入到所述槽中的第一预定位置时，微流体盒的第一光学检测位置之一被定位在第一光源的光束路径中，并且 当所述盒被插入到所述槽中的第二预定位置时，微流体盒的第一光学检测位置中的另一个位于第一光源的光束路径中。

公开(公告)号：WO2017133741A1

公开(公告)日：2017-08-10

申请号：PCT/DK2017/050020

申请日：2017-01-31

Applicant: SCANDINAVIAN MICRO BIODEVICES APS

Inventor： BAU-MADSEN, Niels Kristian ,  OVERBY, Bent

IPC: B01L3/00 ,  G01N21/64 ,  G01N33/52

CPC classification number: G01N21/645 ,  B01L3/50273 ,  B01L7/52 ,  B01L2300/0816 ,  B01L2300/123 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0481 ,  B01L2400/0655 ,  G01N21/64 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2021/6484

Abstract: A microfluidic assay system including a microfluidic cartridge and an associated microfluidic operator system. The microfluidic cartridge comprises a base part, having a first face with a recess and a foil fixed to the base part for covering the recess and providing a microfluidic cartridge foil face. The base part with the recess and the foil forms a flow channel and a sink in fluid communication with each other. The microfluidic cartridge comprises an inlet opening into the flow channel upstream to the reaction section. The operator system includes a piston, a temperature regulating element and an actuator positioned such that the foil face of the microfluidic cartridge can be positioned in contact with the operative system with the reaction section in close proximity to the temperature regulating element while the actuator is associated to the sink section to depress the foil covering the sink section and the piston is associated to the flow channel at an upstream valve section to depress the foil to close off the flow channel upstream to the reaction section.

Abstract translation: 微流体测定系统包括微流体盒和相关的微流体操作系统。 微流体盒包括基部，基部具有带凹部的第一面和固定到基部的箔，用于覆盖凹部并提供微流体盒箔面。 具有凹部和箔片的底座部分形成彼此流体连通的流动通道和水槽。 微流体盒包括进入反应部分上游的流动通道的入口。 操作员系统包括活塞，温度调节元件和致动器，所述致动器被定位成使得微流体盒的箔面能够定位成与操作系统接触，其中反应部分紧邻温度调节元件，同时致动器关联 到沉降部分以压下覆盖沉降部分的箔片，并且活塞与上游阀部分处的流动通道相关联以压下箔片以关闭反应部分上游的流动通道。

公开(公告)号：WO2017125111A1

公开(公告)日：2017-07-27

申请号：PCT/DK2017/050009

申请日：2017-01-17

Applicant: SCANDINAVIAN MICRO BIODEVICES APS ,  CHR. HANSEN A/S

Inventor： KRING, Ole ,  OVERBY, Bent ,  HELLER, Martin ,  BAU-MADSEN, Niels Kristian ,  MOGENSEN, Lars

IPC: G06Q10/08

CPC classification number: G06Q10/0631 ,  G06Q10/047 ,  G06Q10/0832 ,  G06Q10/0838

Abstract: The invention comprises a system for collecting batches of food from food suppliers. The system comprises at least one movable collecting unit with an associated data receiver; a food parameter determining system for determining at least one batch parameter of a collected food batch; a database system for storing food supplier data comprising at least one food collecting address identification for each food supplier, food receiver data comprising at least one food delivering address identification for each of at least one food receiver station and reference data comprising threshold data for said at least one batch parameter or derived parameter correlated to said batch parameter. The system further comprises a server system coupled to said database system and being in data communication with said data receiver. The server system receives at least data from the database system and batch parameter data and calculates logistic plan(s) for the movable collecting unit(s).

Abstract translation: 本发明包括用于从食品供应商收集批次食物的系统。 该系统包括至少一个具有相关数据接收器的可移动收集单元; 食物参数确定系统，用于确定收集的食物批料的至少一个批次参数; 用于存储食物供应者数据的数据库系统，所述数据库系统包括用于每个食物供应者的至少一个食物收集地址标识符，食物接收者数据包括用于至少一个食物接收者站点中的每一个的至少一个食物传送地址标识符和包括所述at 至少一个批量参数或与所述批量参数相关的派生参数。 该系统还包括耦合到所述数据库系统并与所述数据接收器进行数据通信的服务器系统。 服务器系统至少接收来自数据库系统的数据和批量参数数据并计算可移动收集单元的物流计划。

公开(公告)号：WO2008083687A1

公开(公告)日：2008-07-17

申请号：PCT/DK2008/050001

申请日：2008-01-04

Applicant: SCANDINAVIAN MICRO BIODEVICES ApS ,  BAU-MADSEN, Niels Kristian ,  JONSMANN, Jacques ,  LARSEN, Søren

Inventor： BAU-MADSEN, Niels Kristian ,  JONSMANN, Jacques ,  LARSEN, Søren

IPC: B01L3/00 ,  G01N33/49

CPC classification number: B01L3/50273 ,  B01L3/502738 ,  B01L3/502769 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0688 ,  Y10T436/143333

Abstract: The invention relates to a microfluidic device comprising at least one test channel (2) comprising an upper test channel section (6) with an upstream end and a sampling region (4) at its upstream end and at least one reference channel (12) comprising an upper reference channel section (16) with an upstream end and a sampling region (4) at its upstream end. The test channel and the reference channel have a merging region (7) downstream to said upper test channel section and a common downstream channel section (8). The merging region (7) and the common downstream channel section (8) are arranged such that a reference liquid flowing from the upper reference channel section into the merging region will block a test liquid flow in the upper test channel section when said test liquid flow has not yet reached the merging section. The microfluid device may preferably be used for detecting change of flow properties e.g. due to agglomeration, agglutination rpr viscosity change in a liquid preferably selected from the group of water, urine, blood, and blood plasma.

Abstract translation: 本发明涉及一种微流体装置，其包括至少一个测试通道（2），其包括具有上游端的上测试通道部分（6）和在其上游端的采样区域（4）和至少一个参考通道（12），所述参考通道包括 具有上游端的上参考通道部分（16）和在其上游端的采样区域（4）。 测试信道和参考信道具有在所述上测试信道部分和公共下行信道部分（8）的下游的合并区域（7）。 合并区域（7）和公共下游通道部分（8）被布置成使得当所述测试液体流动时，从上部参考通道部分流入合并区域的参考液体将阻挡上部测试通道部分中的测试液体流动 尚未达到合并部分。 微流体装置可以优选地用于检测流动特性的变化，例如， 由于聚集，优选选自水，尿，血液和血浆的液体中的凝集rpr粘度变化。

公开(公告)号：WO2013189502A1

公开(公告)日：2013-12-27

申请号：PCT/DK2013/050208

申请日：2013-06-21

Applicant: SCANDINAVIAN MICRO BIODEVICES APS

Inventor： HELLER, Martin ,  OVERBY, Bent ,  BAU-MADSEN, Niels Kristian

IPC: G01N33/50 ,  G01N33/543 ,  G01N33/58

CPC classification number: G01N33/54333 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/043 ,  B01L2400/0481 ,  B01L2400/049 ,  B82Y15/00 ,  G01N21/6428 ,  G01N21/6489 ,  G01N33/04 ,  G01N33/12 ,  G01N33/5005 ,  G01N33/53 ,  G01N33/54326 ,  G01N33/54386 ,  G01N33/569 ,  G01N33/582 ,  G01N33/587 ,  G01N33/588 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2033/0095

Abstract: The invention relates to a method and a system for quantitative or qualitative determination of a target component in a liquid sample. The method comprises i) providing a plurality of magnetic particle comprising one or more capture sites for the target component on their respective surfaces; ii) providing a plurality of fluorophores configured to bind to the capture sites of the magnetic particles; iii) bringing the liquid sample into contact with the fluorophores and the magnetic particles in a flow channel of a micro fluidic device comprising a transparent window; and iv) at least temporally immobilizing the magnetic particles adjacent to the transparent window using a magnet, emitting exciting electromagnetic beam towards the immobilized magnetic particles, reading signals emitted from fluorophores captured by the immobilized magnetic particles and performing a quantitative or qualitative determination of the target component based on the read signal. The invention also relates to a suitable micro fluidic device for use in the method/system and a kit for preparing a liquid sample.

Abstract translation: 本发明涉及用于定量或定性测定液体样品中的目标组分的方法和系统。 该方法包括：i）在其各自的表面上提供包括一个或多个靶组分的捕获位点的多个磁性颗粒; ii）提供配置成结合到磁性颗粒的捕获位点的多个荧光团; iii）使液体样品与包含透明窗的微流体装置的流动通道中的荧光团和磁性颗粒接触; 以及iv）使用磁体至少在时间上固定与透明窗口相邻的磁性颗粒，向固定的磁性颗粒发射激发电磁波，读取由固定的磁性颗粒捕获的荧光团发射的信号，并对目标进行定量或定性测定 基于读取信号的分量。 本发明还涉及用于方法/系统的合适的微流体装置和用于制备液体样品的试剂盒。

公开(公告)号：WO2009112038A2

公开(公告)日：2009-09-17

申请号：PCT/DK2009/050058

申请日：2009-03-13

Applicant: SCANDINAVIAN MICRO BIODEVICES ApS ,  BAU-MADSEN, Niels Kristian ,  JONSMANN, Jacques ,  OVERBY, Bent ,  BERENDSEN, Christianus

Inventor： BAU-MADSEN, Niels Kristian ,  JONSMANN, Jacques ,  OVERBY, Bent ,  BERENDSEN, Christianus

IPC: G01N33/49 ,  G01N33/86 ,  B01L3/00

CPC classification number: G01N33/4905 ,  B01L3/5027 ,  B01L2200/0684 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0883 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0487 ,  G01N33/5304 ,  G01N33/86

Abstract: The invention relates to a microfluidic system comprising a microfluidic device having a first and a second opposite surfaces and an optical detector, the microfluidic device comprises a flow channel with a detection channel section having a length of at least about 1mm, the microfluidic device comprises at least one aperture section comprising at least a part of said detection channel section and a transparent window into said detection channel section, the optical detector is arranged to be in optical communication with said aperture section to determining at least one optical property of said aperture section as a function of time. The flow channel may have capillary dimensions and/or it may wholly or fully be arranged to drive a fluid flow by applying external forces. The optical detector may preferably be arranged to transmit light onto the aperture section and to detect a light transmission from the aperture section, wherein the light transmission from the aperture section being selected from light transmitted through the sample,reflectance scattering of light, transmittance scattering of light and any combinations thereof. The micro fluid device may be used to determine various properties of a sample fluid, for example it may be used to determine a samples coagulation properties and/or reactions of one or more components in a fluid sample as a function of time.

Abstract translation: 本发明涉及一种微流体系统，其包括具有第一和第二相对表面的微流体装置和光学检测器，所述微流体装置包括具有至少约1mm长度的检测通道部分的流动通道，所述微流体装置包括 至少一个孔径部分，其包括所述检测通道部分的至少一部分和在所述检测通道部分中的透明窗口，所述光学检测器布置成与所述孔部分光学连通，以将所述孔部分的至少一个光学特性确定为 时间的功能。 流动通道可以具有毛细管尺寸和/或其可以完全或完全地布置成通过施加外力来驱动流体流动。 光检测器可以优选地被布置成将光透射到孔部分上并且检测从孔部分的光透射，其中来自孔部分的光透射选自透过样品的光，光的反射散射，透射散射 光及其任何组合。 微流体装置可以用于确定样品流体的各种性质，例如其可用于确定样品凝固性质和/或作为时间的函数的流体样品中的一种或多种组分的反应。