公开(公告)号：WO2020227835A1

公开(公告)日：2020-11-19

申请号：PCT/CA2020/050655

申请日：2020-05-14

申请人： SPIDERWORT INC. ,  UNIVERSITY OF OTTAWA

发明人： HICKEY, Ryan ,  PELLING, Andrew E. ,  CAMPUZANO, Santiago ,  DE SOUSA FARIA TISCHER, Paula Cristina ,  SZERESZEWSKI, Kama

IPC分类号： C12N5/04 ,  A23L29/00 ,  A23L33/00 ,  A61K47/38 ,  A61K47/46 ,  A61K9/10 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  B01D11/02 ,  B33Y80/00 ,  C08J3/075 ,  C08J3/24 ,  C08J5/12 ,  C08L1/02 ,  C09J5/00 ,  C12N1/14 ,  C12N5/00 ,  C12N5/07 ,  C12N5/077 ,  A23L13/00 ,  A23L17/00 ,  A23L15/00 ,  A23L19/09 ,  A23L29/20 ,  A23L31/00 ,  A61L27/34 ,  A61L27/3637 ,  A61L27/3683 ,  A61L27/3826 ,  A61L27/48 ,  B01D11/0257 ,  B01D11/0288 ,  C08J2301/02 ,  C09D105/04 ,  C09D105/08 ,  C09D105/12 ,  C09D189/06 ,  C12N2533/54 ,  C12N2533/78 ,  C12N2533/90 ,  C12N2537/10 ,  C12N5/0062

摘要： Provided herein are composite scaffold biomaterials including two or more scaffold biomaterial subunits, each including a decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularized plant or fungal tissue having a 3-dimensional porous structure, the two or more scaffold biomaterial subunits being assembled into the composite scaffold biomaterial and held together via gel casting using a hydrogel glue; via complementary interlocking geometry of the two or more scaffold biomaterial subunits; via guided assembly based biolithography (GAB); via chemical cross-linking; or any combinations thereof. Methods for producing such scaffold biomaterials, as well as methods and uses thereof, are also provided.