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公开(公告)号：WO2021119830A1
公开(公告)日：2021-06-24
申请号：PCT/CA2020/051750
申请日：2020-12-18
发明人： LEBLANC LATOUR, Maxime , HICKEY, Ryan , CUERRIER, Charles M. , PELLING, Andrew E. , TARAR, Maryam , CATELAS, Isabelle
摘要： Provided herein are scaffold biomaterials including a decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularized plant or fungal tissue having a 3-dimensional porous structure; wherein the decellularized plant or fungal tissue may optionally be at least partially coated or mineralized, wherein the scaffold biomaterial may optionally further include a protein-based hydrogel and/or a polysaccharide-based hydrogel, or both. Also provided herein are methods and uses of such scaffold biomaterials, including methods of manufacture as well as methods and uses for bone tissue engineering, for example.
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公开(公告)号：WO2020227835A1
公开(公告)日：2020-11-19
申请号：PCT/CA2020/050655
申请日：2020-05-14
发明人： HICKEY, Ryan , PELLING, Andrew E. , CAMPUZANO, Santiago , DE SOUSA FARIA TISCHER, Paula Cristina , SZERESZEWSKI, Kama
IPC分类号： C12N5/04 , A23L29/00 , A23L33/00 , A61K47/38 , A61K47/46 , A61K9/10 , A61L27/50 , A61L27/52 , A61L27/54 , B01D11/02 , B33Y80/00 , C08J3/075 , C08J3/24 , C08J5/12 , C08L1/02 , C09J5/00 , C12N1/14 , C12N5/00 , C12N5/07 , C12N5/077 , A23L13/00 , A23L17/00 , A23L15/00 , A23L19/09 , A23L29/20 , A23L31/00 , A61L27/34 , A61L27/3637 , A61L27/3683 , A61L27/3826 , A61L27/48 , B01D11/0257 , B01D11/0288 , C08J2301/02 , C09D105/04 , C09D105/08 , C09D105/12 , C09D189/06 , C12N2533/54 , C12N2533/78 , C12N2533/90 , C12N2537/10 , C12N5/0062
摘要： Provided herein are composite scaffold biomaterials including two or more scaffold biomaterial subunits, each including a decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularized plant or fungal tissue having a 3-dimensional porous structure, the two or more scaffold biomaterial subunits being assembled into the composite scaffold biomaterial and held together via gel casting using a hydrogel glue; via complementary interlocking geometry of the two or more scaffold biomaterial subunits; via guided assembly based biolithography (GAB); via chemical cross-linking; or any combinations thereof. Methods for producing such scaffold biomaterials, as well as methods and uses thereof, are also provided.
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公开(公告)号：WO2022099410A1
公开(公告)日：2022-05-19
申请号：PCT/CA2021/051595
申请日：2021-11-09
申请人： UNIVERSITY OF OTTAWA
发明人： HOLMES, Jessica T. , JABERANSARI, Ziba , COLLINS, William , LEBLANC LATOUR, Maxine , MODULEVSKY, Daniel J. , PELLING, Andrew E.
摘要： The disclosure provides a bread-derived scaffold biomaterial for supporting cells, the scaffold comprising a bread crumb and wherein the bread crumb comprises a three-dimensional porous structure to support the cells. Further provided is a use of the scaffold and a method of making same.
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公开(公告)号：WO2023004515A1
公开(公告)日：2023-02-02
申请号：PCT/CA2022/051169
申请日：2022-07-29
申请人： SPIDERWORT INC.
发明人： PELLING, Andrew E. , CANTO, Anna , LOURENCO, Matthew , DE SOUSA FARIA TISCHER, Paula Cristina , SALAMUN, Joshua , HICKEY, Ryan , RUSSELL, Colin
摘要： Disclosed herein is a method of preparing a seeded biomaterial scaffold. The method comprises combining a biomaterial scaffold and a plurality of cells to provide a mixture; and applying a pressure to the mixture to thereby cause the plurality of cells to infiltrate the scaffold, thereby forming the seeded biomaterial scaffold.
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公开(公告)号：WO2021248236A1
公开(公告)日：2021-12-16
申请号：PCT/CA2021/050783
申请日：2021-06-08
申请人： SPIDERWORT INC.
发明人： SZERESZEWSKI, Kama , HICKEY, Ryan , PELLING, Andrew E. , LEBLANC LATOUR, Maxime , STROOBACH, Mark , MILMAN, Pavel , ODDING, Christopher , DE SOUSA FARIA TISCHER, Paula Cristina
IPC分类号： A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/34 , A61L2430/40 , A61L27/3637 , A61L27/3683
摘要： Provided herein are dermal fillers including decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed; as well as methods and uses thereof for cosmetic and/or reconstructive applications. Also provided are methods for preparing such dermal fillers, and dermal filler kits.
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公开(公告)号：WO2022087750A1
公开(公告)日：2022-05-05
申请号：PCT/CA2021/051537
申请日：2021-10-29
申请人： SPIDERWORT INC.
发明人： HICKEY, Ryan , SZERESZEWSKI, Kama , TISCHER, Paula Cristina De Sousa Faria , PELLING, Andrew E. , CANTO, Anna , SALAMUN, Joshua , LOURENCO, Matthew
IPC分类号： C08J9/28 , A23L19/00 , A23L5/00 , A23P10/00 , A23P30/00 , A23P30/40 , A61L27/52 , C08J3/075 , C08K11/00 , C08L1/02
摘要： Provided herein are aerogels and foams including: single structural cells and/or groups of structural cells derived from a plant or fungal tissue, the single structural cells having a decellularized 3D structure lacking cellular materials and nucleic acids of plant or fungal tissue; the single structural cells and/or groups of structural cells being distributed within a carrier derived from a dehydrated, lyophilized, or freeze-dried hydrogel. Also provided herein are methods for preparing aerogels or foams, including steps of: providing a decellularized plant or fungal tissue; obtaining single structural cells and/or groups of structural cells from the decellularized plant or fungal tissue by performing mercerization; mixing or distributing the single structural cells and/or groups of structural cells in a hydrogel, to provide a mixture; and dehydrating, lyophilizing, or freeze-drying the mixture to provide the aerogel or foam. Related methods and uses are also provided.
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公开(公告)号：WO2020227834A1
公开(公告)日：2020-11-19
申请号：PCT/CA2020/050654
申请日：2020-05-14
申请人： SPIDERWORT INC.
发明人： FERKO, Maxime-Alexandre , CUERRIER, Charles , LEBLANC LATOUR, Maxime , HANSON, Stephen , MODULEVSKY, Daniel , PELLING, Andrew E. , SZERESZEWSKI, Kama
IPC分类号： C12N5/04 , A61K47/46 , A61L27/50 , B01D11/02 , C08J5/12 , C09J5/00 , C12N1/14 , C12N5/00 , C12N5/07 , A61L2430/38 , A61L27/3637 , A61L27/3683 , A61L27/3804 , A61L27/54 , B01D11/0257 , B01D11/0288
摘要： Provided herein are scaffold biomaterials including at least one bundle of microchannels, the bundle of microchannels having a plurality of decellularised microchannels isolated from plant or fungal tissue, the decellularised microchannels being arranged substantially parallel to each other within the bundle. Also provided are methods and uses of such scaffold biomaterials and bundles, as well as methods for the production of such scaffold biomaterials and bundles.
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