公开(公告)号：WO2004068218A2

公开(公告)日：2004-08-12

申请号：PCT/US2004001986

申请日：2004-01-23

Applicant: UNIV WASHINGTON ,  CROSSMAN-BOSWORTH JANET ,  SEIBEL ERIC ,  FAUVER MARK

Inventor： CROSSMAN-BOSWORTH JANET ,  SEIBEL ERIC ,  FAUVER MARK

IPC: A61B19/00 ,  G02B6/00 ,  G02B6/25 ,  G02B6/255 ,  G02B6/26 ,  G02B6/32 ,  G02B26/08 ,  G02B26/10 ,  G02F

CPC classification number: G02B26/0875 ,  A61B2090/3614 ,  G02B6/25 ,  G02B6/2552 ,  G02B6/262 ,  G02B6/32 ,  G02B26/101 ,  G02B2006/0098

Abstract: An optical fiber having a reduced cross sectional region adjacent its distal end, which is fused to an optical component, is vibrated, rotating the optical component to scan a region. The optical component has a back focal point substantially coincident with an effective light source of the optical fiber, so the light emanating from the optical component is either substantially collimated or convergent. The optical component is either a ball lens, a drum lens, a graded index lens, or a diffractive optical element. A vibratory node is also made substantially coincident with the back focal point of the optical component, producing a compact scanner with extensive field of view. The optical fiber is preferably reduced in cross sectional area after the optical component is fused to the optical fiber, by immersion in a three layer etch apparatus having an etch stop layer, an etch layer, and a solvent layer.

Abstract translation: 具有与其远端相邻并且与光学部件熔合的横截面减小的光纤被振动，使光学部件旋转以扫描区域。 光学部件具有与光纤的有效光源大致一致的后焦点，因此从光学部件发出的光基本上是准直的或会聚的。 光学部件是球形透镜，鼓形透镜，渐变折射率透镜或衍射光学元件。 振动节点也基本上与光学部件的后焦点重合，产生具有广泛视场的紧凑型扫描仪。 光学元件通过浸入具有蚀刻停止层，蚀刻层和溶剂层的三层蚀刻装置中而在光学元件熔合到光纤之后，优选地减小横截面积。

公开(公告)号：WO0197902B1

公开(公告)日：2002-10-10

申请号：PCT/US0116844

申请日：2001-05-23

Applicant: UNIV WASHINGTON

Inventor： SEIBEL ERIC

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B5/00 ,  A61B5/107 ,  A61B18/20 ,  A61N5/06 ,  G01N21/27 ,  G01Q20/02 ,  G02B6/26 ,  G02B6/32 ,  G02B6/35 ,  G02B26/10 ,  H04N7/18 ,  A61B6/00

CPC classification number: G02B6/262 ,  A61B1/00048 ,  A61B1/0008 ,  A61B1/00165 ,  A61B1/00167 ,  A61B1/00172 ,  A61B1/00183 ,  A61B1/00193 ,  A61B1/0051 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/1076 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/063 ,  G02B6/241 ,  G02B6/32 ,  G02B6/3502 ,  G02B6/3566 ,  G02B6/357 ,  G02B6/3572 ,  G02B6/3578 ,  G02B26/10

Abstract: An integrated endoscopic image acquisition and therapeutic delivery system (50) for use in minimally invasive medical procedures (MIMPs). The system uses directed and scanned optical illumination provided by a scanning optical electromechnical actuator included at a distal end of an integrated imaging and diagnostic/therapeuric instrument. The directed illumination provides high resolution imaging, at a wide field of view (FOV), and in full color that matches or excels the images produced by conventional flexible endoscopes. When using scanned optical illumination, the size and number of the photon detectors do not limit the resolution and number of pixels of the resulting image. Additional features include enhancement of topographical features, stereoscopic viewing, and accurate measurement of feature sizes of a region of interest in a patient's body that facilitate providing diagnosis, monitoring, and/or therapy with the instrument.

Abstract translation: 用于微创医疗程序（MIMP）的集成内窥镜图像采集和治疗传送系统（50）。 该系统使用由集成成像和诊断/手术器械的远端处包括的扫描光学机电致动器提供的定向和扫描光学照明。 定向照明在宽视场（FOV）和全彩色下提供高分辨率成像，匹配或优于传统柔性内窥镜产生的图像。 当使用扫描光学照明时，光子探测器的大小和数量不会限制所得图像的分辨率和像素数量。 另外的特征包括地形特征的增强，立体观看以及患者体内感兴趣区域的特征尺寸的准确测量，这有助于提供对器械的诊断，监测和/或治疗。

公开(公告)号：WO2006004743A3

公开(公告)日：2007-04-19

申请号：PCT/US2005022913

申请日：2005-06-28

Applicant: UNIV WASHINGTON ,  SEIBEL ERIC ,  LI XINGDE ,  LIU XIUMEI

Inventor： SEIBEL ERIC ,  LI XINGDE ,  LIU XIUMEI

IPC: A61B6/00 ,  B29C63/00 ,  B31B7/00 ,  B65D5/56 ,  G02B6/26 ,  G02B6/32 ,  G02B6/35 ,  G02B26/10

CPC classification number: A61B5/6852 ,  A61B3/102 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  B31B2105/001 ,  G02B6/262 ,  G02B6/32 ,  G02B6/3502 ,  G02B7/08 ,  G02B21/0028 ,  G02B21/0036 ,  G02B21/006 ,  G02B21/0076 ,  G02B23/2423 ,  G02B26/103

Abstract: An optical fiber scanner is used for multiphoton excitation imaging, optical coherence tomography, or for confocal imaging in which transverse scans are carried out at a plurality of successively different depths within tissue. The optical fiber scanner is implemented as a scanning endoscope using a cantilevered optical fiber that is driven into resonance or near resonance by an actuator. The actuator is energized with drive signals that cause the optical fiber to scan in a desired pattern at successively different depths as the depth of the focal point is changed. Various techniques can be employed for depth focus tracking at a rate that is much slower than the transverse scanning carried out by the vibrating optical fiber. The optical fiber scanner can be used for confocal imaging, multiphoton fluorescence imaging, nonlinear harmonic generation imaging, or in an OCT system that includes a phase or frequency modulator and delay line.

Abstract translation: 光纤扫描器用于多光子激发成像，光学相干断层扫描或用于共焦成像，其中横向扫描在组织内的多个连续不同的深度进行。 光纤扫描器被实现为使用由致动器驱动到共振或接近谐振的悬臂光纤的扫描内窥镜。 致动器通过驱动信号通电，当驱动信号使焦点的深度改变时，光纤以连续不同的深度以所需的图案扫描。 可以采用比由振动光纤执行的横向扫描慢得多的速度进行深度聚焦跟踪的各种技术。 光纤扫描器可用于共焦成像，多光子荧光成像，非线性谐波生成成像，或在包括相位或频率调制器和延迟线的OCT系统中。

公开(公告)号：WO2006093655A2

公开(公告)日：2006-09-08

申请号：PCT/US2006004828

申请日：2006-02-09

Applicant: UNIV WASHINGTON ,  SEIBEL ERIC ,  KIMMEY MICHAEL ,  JOHNSTON RICHARD

Inventor： SEIBEL ERIC ,  KIMMEY MICHAEL ,  JOHNSTON RICHARD

CPC classification number: A61B1/2733 ,  A61B1/00009 ,  A61B1/00055 ,  A61B1/0008 ,  A61B1/00087 ,  A61B1/00147 ,  A61B1/00172 ,  A61B1/015 ,  A61B1/041 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0661 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/4233 ,  A61N5/0603 ,  A61N5/062 ,  A61N2005/0609

Abstract: Capsule is coupled to a tether that is manipulated to position the capsule and a scanner included within the capsule at desired location within a lumen in a patient's body. Images produced by scanner can be used to detect Barrett's Esophagus (BE) and early (asymptomatic) esophageal cancer after capsule is swallowed and positioned with the tether to enable the scanner in the capsule to scan a region of the esophagus above the stomach to detect a characteristic dark pink color indicative of BE. The scanner moves in a desired pattern to illuminate a portion of the inner surface. Light from the inner surface is then received by detectors in the capsule, or conveyed externally through a waveguide to external detectors. Electrical signals are applied to energize an actuator that moves the scanner. The capsule can also be used for diagnostic and/or therapeutic purposes in other lumens.

Abstract translation: 胶囊被联接到系绳，其被操纵以将胶囊和包括在胶囊内的扫描仪定位在患者体内的内腔内的期望位置。 由扫描仪产生的图像可用于检测Barrett食管（BE）和早期（无症状）食管癌，胶囊被吞入并与系绳定位，以使胶囊中的扫描仪能够扫描胃上方的食道区域以检测 特征深粉红色指示BE。 扫描器以期望的图案移动以照亮内表面的一部分。 然后，来自内表面的光由胶囊中的检测器接收，或者通过波导从外部传送到外部检测器。 施加电信号以激励移动扫描器的致动器。 胶囊还可以用于其他腔内的诊断和/或治疗目的。

公开(公告)号：WO2007106075A3

公开(公告)日：2008-11-06

申请号：PCT/US2006007704

申请日：2006-03-03

Applicant: UNIV WASHINGTON ,  SEIBEL ERIC ,  JOHNSTON RICHARD ,  MELVILLE CHARLES DAVID

Inventor： SEIBEL ERIC ,  JOHNSTON RICHARD ,  MELVILLE CHARLES DAVID

IPC: A61B18/18

CPC classification number: A61B18/22 ,  A61B1/0008 ,  A61B1/0017 ,  A61B1/00172 ,  A61B1/07 ,  A61B2018/2238 ,  A61B2090/373

Abstract: A multi-cladding optical fiber includes a core that conveys visible light used by a scanner for imaging a site within a patient's body, and an inner cladding that conveys high-power light, such as infrared light, used for providing therapy to site. The distal end of multi-cladding optical fiber is driven to scan the site when imaging or rendering therapy using an actuator. High-power light is coupled into inner cladding at proximal end of optical fiber using several different techniques. Some techniques use an axicon to direct the high-power light into the inner cladding, while visible light is coupled directly into the core. Another technique uses a multimode optical fiber in a coupling relationship with the multi-cladding optical fiber, to transfer high-power light from a core of the multimode fiber into the inner cladding of the multi-cladding optical fiber.

Abstract translation: 多层包层光纤包括传送用于对患者体内的部位进行成像的扫描仪所使用的可见光的芯和传送用于向现场提供治疗的高功率光（例如红外光）的内包层。 当使用致动器进行成像或渲染治疗时，多包层光纤的远端被驱动以扫描该部位。 使用几种不同的技术将大功率光耦合到光纤近端的内包层。 一些技术使用旋转三棱镜将高功率光引导到内包层中，而可见光直接耦合到芯中。 另一种技术使用与多包层光纤耦合关系的多模光纤，以将来自多模光纤的芯的大功率光转移到多包层光纤的内包层中。

公开(公告)号：WO02056792A3

公开(公告)日：2002-10-10

申请号：PCT/US0200204

申请日：2002-01-04

Applicant: UNIV WASHINGTON

Inventor： PARKER DONALD ,  DUH BEEN-LIRN ,  FURNESS THOMAS ,  PROTHERO JERROLD ,  SEIBEL ERIC

IPC: A61M21/00

CPC classification number: A61M21/00 ,  A61M2021/005 ,  G02B27/0093 ,  G02B27/017 ,  G02B2027/0178 ,  G06F3/011

Abstract: Independent visual background (IVB) display provides visual reference of perceptions of person's vestibular system, reducing/eliminating motion sickness occuring from mismatch between visual perception of motion/non-motion and sensations of vestibular system. If user, wearing head-mounted display, is moving or in moving environment, motion tracking system or motion sensors produce signals indicative of motion of environment and/or person. Signals are processed using vestibular model, producing modified signal corresponding to perception of motion by user's vestibular system. Using modified signal, the IVB is displayed to user, providing visual reference of perception of the vestibular system. If user is in a fixed environment and watching a moveable/moving display, the IVB can be included on the image or in peripheral area around display. Perceptibility of the IVB can be adjusted to minimize distracting impact on visual task, while ensuring sufficient perceptibility to avoid motion sickness.

Abstract translation: 独立视觉背景（IVB）显示提供对人前庭系统感知的视觉参考，减少/消除运动/非运动的视觉感知和前庭系统的感觉之间的错配发生的运动疾病。 如果用户佩戴头戴式显示器正在移动或处于移动环境中，运动跟踪系统或运动传感器产生指示环境和/或人的运动的信号。 使用前庭模型处理信号，产生对应于用户前庭系统的运动感觉的修改信号。 使用修改的信号，IVB被显示给用户，提供对前庭系统的感知的视觉参考。 如果用户处于固定环境并观看可移动/移动的显示器，IVB可以包含在图像或显示器周围的周边区域中。 可以调整IVB的感知度，以尽量减少对视觉任务的影响，同时确保足够的感觉以避免晕车。

公开(公告)号：WO0197902A2

公开(公告)日：2001-12-27

申请号：PCT/US0116844

申请日：2001-05-23

Applicant: UNIV WASHINGTON

Inventor： SEIBEL ERIC

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B5/00 ,  A61B5/107 ,  A61B18/20 ,  A61N5/06 ,  G01N21/27 ,  G01Q20/02 ,  G02B6/26 ,  G02B6/32 ,  G02B6/35 ,  G02B26/10 ,  H04N7/18 ,  A61N

CPC classification number: G02B6/262 ,  A61B1/00048 ,  A61B1/0008 ,  A61B1/00165 ,  A61B1/00167 ,  A61B1/00172 ,  A61B1/00183 ,  A61B1/00193 ,  A61B1/0051 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/1076 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/063 ,  G02B6/241 ,  G02B6/32 ,  G02B6/3502 ,  G02B6/3566 ,  G02B6/357 ,  G02B6/3572 ,  G02B6/3578 ,  G02B26/10

Abstract: An integrated endoscopic image acquisition and therapeutic delivery system (50) for use in minimally invasive medical procedures (MIMPs). The system uses directed and scanned optical illumination provided by a scanning optical electromechnical actuator included at a distal end of an integrated imaging and diagnostic/therapeuric instrument. The directed illumination provides high resolution imaging, at a wide field of view (FOV), and in full color that matches or excels the images produced by conventional flexible endoscopes. When using scanned optical illumination, the size and number of the photon detectors do not limit the resolution and number of pixels of the resulting image. Additional features include enhancement of topographical features, stereoscopic viewing, and accurate measurement of feature sizes of a region of interest in a patient's body that facilitate providing diagnosis, monitoring, and/or therapy with the instrument.

Abstract translation: 一种用于微创医疗程序（MIMP）的综合内窥镜图像采集和治疗传递系统（50）。 该系统使用由集成成像和诊断/治疗仪器的远端包括的扫描光学电致动器提供的定向和扫描光学照明。 定向照明在宽视野（FOV）下提供高分辨率成像，并且具有与常规柔性内窥镜产生的图像匹配或优异的全色。 当使用扫描光学照明时，光子检测器的尺寸和数量不会限制所得图像的分辨率和像素数。 附加特征包括增强地形特征，立体观察以及对患者体内感兴趣区域的特征尺寸的精确测量，其有利于提供诊断，监测和/或治疗仪器。

公开(公告)号：WO2006093655B1

公开(公告)日：2007-09-20

申请号：PCT/US2006004828

申请日：2006-02-09

Applicant: UNIV WASHINGTON ,  SEIBEL ERIC ,  KIMMEY MICHAEL ,  JOHNSTON RICHARD

Inventor： SEIBEL ERIC ,  KIMMEY MICHAEL ,  JOHNSTON RICHARD

IPC: A61B1/06 ,  A61B1/273

CPC classification number: A61B1/2733 ,  A61B1/00009 ,  A61B1/00055 ,  A61B1/0008 ,  A61B1/00087 ,  A61B1/00147 ,  A61B1/00172 ,  A61B1/015 ,  A61B1/041 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0661 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/4233 ,  A61N5/0603 ,  A61N5/062 ,  A61N2005/0609

Abstract: Capsule (20) is coupled to a tether (22) that is manipulated to position the capsule and a scanner (26) included within the capsule at desired location within a lumen in a patient's body. Images produced by scanner can be used to detect Barrett's Esophagus (BE) and early (asymptomatic) esophageal cancer after capsule is swallowed and positioned with the tether to enable the scanner in the capsule to scan a region of the esophagus above the stomach to detect a characteristic dark pink color indicative of BE. The scanner moves in a desired pattern to illuminate a portion of the inner surface. Light from the inner surface is then received by detectors in the capsule, or conveyed externally through a waveguide to external detectors. Electrical signals are applied to energize an actuator (28) that moves the scanner. The capsule can also be used for diagnostic and/or therapeutic purposes in other lumens.

Abstract translation: 胶囊（20）联接到系绳（22），系绳（22）被操纵以将胶囊和包含在胶囊内的扫描仪（26）定位在患者体内的内腔内的期望位置。 由扫描仪产生的图像可用于检测Barrett食管（BE）和早期（无症状）食管癌，胶囊被吞入并与系绳定位，以使胶囊中的扫描仪能够扫描胃上方的食道区域以检测 特征深粉红色指示BE。 扫描器以期望的图案移动以照亮内表面的一部分。 然后，来自内表面的光由胶囊中的检测器接收，或者通过波导从外部传送到外部检测器。 施加电信号以激励移动扫描器的致动器（28）。 胶囊还可以用于其他腔内的诊断和/或治疗目的。

公开(公告)号：WO2005058137A3

公开(公告)日：2006-05-11

申请号：PCT/US2004041713

申请日：2004-12-10

Applicant: UNIV WASHINGTON ,  SOPER TIMOTHY ,  GLENNY ROBB ,  SEIBEL ERIC

Inventor： SOPER TIMOTHY ,  GLENNY ROBB ,  SEIBEL ERIC

IPC: A61B20060101 ,  A61B1/00 ,  A61B1/04 ,  A61B1/267 ,  A61B5/06 ,  A61B5/08 ,  A61B10/00

CPC classification number: A61B5/066 ,  A61B1/00009 ,  A61B1/00016 ,  A61B1/00045 ,  A61B1/0008 ,  A61B1/00172 ,  A61B1/005 ,  A61B1/04 ,  A61B1/07 ,  A61B1/2676 ,  A61B5/06 ,  A61B5/062 ,  A61B5/065 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/7285 ,  A61B6/541 ,  A61B34/20 ,  A61B2034/2051 ,  A61B2090/3762

Abstract: Visual assisted guidance of an ultra thin flexible endoscope (24) to a predetermined region of interest within a lung during a bronchoscopy procedure. The region may be an opacity identified by non invasive imaging methods, such as high resolution computed tomography (HRCT) or as a malignant lung mass that was diagnosed in a previous examination. An embedded position sensor (84) on the flexible endoscope (24) indicates the position of the distal tip of the probe in a Cartesian coordinate system during the procedure. A visual display (62) is continually updated, showing the present position and orientation of the marker in a 3-D graphical airway model generated from image reconstruction. The visual display (62) also includes windows depicting a virtual fly through perspective and real time video images acquired at the head of the endoscope, which can be stored as data, with an audio or textual account.

Abstract translation: 在支气管镜检查程序期间将超薄柔性内窥镜（24）视觉辅助引导到肺内的预定感兴趣区域。 该区域可以是通过非侵入性成像方法识别的不透明度，例如高分辨率计算机断层摄影（HRCT）或作为在先前检查中诊断的恶性肺肿块。 柔性内窥镜（24）上的嵌入位置传感器（84）在该过程期间指示探针的远端在笛卡尔坐标系中的位置。 持续地更新视觉显示（62），显示从图像重建产生的3-D图形气道模型中的标记的当前位置和方向。 视觉显示器（62）还包括描绘通过透视的虚拟飞行的窗口和在内窥镜的头部处获取的实时视频图像，其可以作为数据存储，具有音频或文本帐户。

公开(公告)号：WO2005024496A3

公开(公告)日：2006-05-04

申请号：PCT/US2004029295

申请日：2004-09-03

Applicant: UNIV WASHINGTON ,  WANG WEI-CHIH ,  SEIBEL ERIC ,  REINHALL PER ,  FAUVER MARK ,  BROWN CHRIS

Inventor： WANG WEI-CHIH ,  SEIBEL ERIC ,  REINHALL PER ,  FAUVER MARK ,  BROWN CHRIS

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B5/00 ,  A61B5/107 ,  A61B18/20 ,  A61N5/06 ,  G01N21/27 ,  G01Q20/02 ,  G02B6/26 ,  G02B6/32 ,  G02B6/35 ,  G02B23/24 ,  G02B26/08 ,  G02B26/10 ,  H04N7/18 ,  A61B6/00

CPC classification number: A61B5/0062 ,  A61B1/00048 ,  A61B1/0008 ,  A61B1/00165 ,  A61B1/00167 ,  A61B1/00172 ,  A61B1/00183 ,  A61B1/00193 ,  A61B1/0051 ,  A61B1/043 ,  A61B1/063 ,  A61B1/0638 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1076 ,  A61N5/0601 ,  A61N5/062 ,  G02B6/262 ,  G02B6/32 ,  G02B6/3502 ,  G02B6/3566 ,  G02B6/357 ,  G02B6/3572 ,  G02B6/3578 ,  G02B23/2484 ,  G02B26/0875 ,  G02B26/10 ,  G02B26/101

Abstract: An apparatus and method for providing image acquisition and/or image display in a limited region of interest (ROI). The apparatus comprises a micro electromechanical system (MEMS), preferably integrating a light source, a cantilever, a lens, an actuator, a light detector, and a position sensor. The light source provides light for illuminating the ROI, displaying an image, providing a therapy, and/or performing other functions. The cantilever comprises a resin waveguide with a fixed end attached to a substrate that supports many or all other components. A free end of the cantilever is released from the substrate during fabrication and includes the lens. The actuator scans the free end in orthogonal directions to illuminate the ROI or display an image. The position sensors detect the position of the free end for control. The light detector receives light backscattered from the ROI separate from, or at the fixed end the cantilever.

Abstract translation: 一种用于在有限的感兴趣区域（ROI）中提供图像采集和/或图像显示的装置和方法。 该装置包括微机电系统（MEMS），优选地集成光源，悬臂，透镜，致动器，光检测器和位置传感器。 光源提供用于照明ROI，显示图像，提供治疗和/或执行其他功能的光。 悬臂包括具有固定端附着到支撑多个或所有其它部件的基板的树脂波导。 悬臂的自由端在制造过程中从基板释放并且包括透镜。 致动器沿正交方向扫描自由端以照亮ROI或显示图像。 位置传感器检测自由端的位置进行控制。 光检测器接收来自ROI的反向散射光，或者在固定端处悬臂。