公开(公告)号：WO2016176118A1

公开(公告)日：2016-11-03

申请号：PCT/US2016/028896

申请日：2016-04-22

Applicant: ELI LILLY AND COMPANY

Inventor： REMICK, David Michael ,  RICHARDS, Simon James ,  SANDERSON, Adam Jan

IPC: C07D513/04 ,  A61K31/542 ,  A61P25/28

CPC classification number: C07D513/04 ,  C07C309/04 ,  C07C309/31

Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐。

公开(公告)号：WO2016091149A1

公开(公告)日：2016-06-16

申请号：PCT/CN2015/096648

申请日：2015-12-08

Applicant: 中国石油天然气股份有限公司

Inventor： 冯涛 ,  翟月奎 ,  于军

IPC: C07C309/31 ,  C07C303/32

CPC classification number: C07C303/32 ,  C07C309/31

Abstract: 本发明提供了一种将烷基苯磺酸钙转化为烷基苯磺酸钠的方法。该方法包括以下步骤：将烷基苯磺酸钙分散于氢氧化钠溶液中，烷基苯磺酸钙与氢氧化钠的摩尔比为1:1.2-2.5，将溶液加热至30-60℃，搅拌条件下，向溶液中通入CO 2 气体，当pH值为7-8时，停止反应，得到反应液，反应液冷却后进行过滤处理，除去沉淀物，得到滤液，蒸除滤液中的溶剂，得到烷基苯磺酸钠。本发明所提供的方法操作简单，除钙效率高，有利于后续对此类烷基苯磺酸盐的分析。

公开(公告)号：WO2014169055A1

公开(公告)日：2014-10-16

申请号：PCT/US2014/033528

申请日：2014-04-09

Applicant: MATERIA, INC.

Inventor： JOHNS, Adam, M. ,  PEDERSON, Richard, L. ,  KISER, Rosemary, Conrad ,  NICKEL, Andrew

IPC: C04B24/20 ,  C07C6/02 ,  C07F9/02

CPC classification number: C07C67/283 ,  C07C2/02 ,  C07C2/32 ,  C07C5/03 ,  C07C6/04 ,  C07C29/147 ,  C07C41/26 ,  C07C67/343 ,  C07C67/347 ,  C07C67/475 ,  C07C303/06 ,  C07C303/24 ,  C07C2521/18 ,  C07C2523/44 ,  C07C2531/22 ,  C07C2531/24 ,  C07F11/00 ,  C07F15/0046 ,  C07C11/21 ,  C07C15/44 ,  C07C15/107 ,  C07C309/31 ,  C07C305/04 ,  C07C69/587 ,  C07C69/145

Abstract: This invention describes processes to make products by cross metathesis of functionalized or non- functionalized olefins with poly-branched poly-olefins such as terpenes (e.g., farnesene(s), α-farnesene, β- farnesene, β-myrcene, etc.) and compositions made by such methods. More particularly, the present invention relates to methods of making (i) cross metathesis products by a cross metathesis reaction between at least one hydrovinylated olefinic substrate and at least one hydrovinylated cross metathesis substrate in the presence of at least one olefin metathesis catalyst; (ii) cross metathesis products by a cross metathesis reaction between at least one hydrovinylated olefinic substrate and at least one cross metathesis substrate in the presence of at least one olefin metathesis catalyst; and (iii) cross metathesis products by a cross metathesis reaction between at least one olefinic substrate and at least one hydrovinylated cross metathesis substrate in the presence of at least one olefin metathesis catalyst; as well as compositions made by such methods.

Abstract translation: 本发明描述了通过官能化或非官能化烯烃与多支链聚烯烃如萜烯（例如法呢烯，α-法呢烯，法呢烯，二茂铁等）的交叉复分解产生产物的方法 ）和通过这些方法制成的组合物。 更具体地说，本发明涉及制备（i）在至少一种烯烃复分解催化剂存在下，通过至少一个加氢乙烯化的烯属基材与至少一个加氢的交联复分解基材之间的交叉复分解反应来交叉复分解产物的方法; （ii）在至少一种烯烃复分解催化剂存在下，通过至少一个加氢乙烯化的烯属基材与至少一个交叉复分解基材之间的交叉复分解反应进行交叉复分解产物; 和（iii）在至少一种烯烃复分解催化剂存在下，通过至少一种烯属基质和至少一个加氢的交联复分解基质之间的交叉复分解反应来交叉复分解产物; 以及通过这些方法制成的组合物。

公开(公告)号：WO2013012486A2

公开(公告)日：2013-01-24

申请号：PCT/US2012/041193

申请日：2012-06-07

Applicant: UOP LLC ,  MAJUMDER, Debarshi ,  SOHN, Stephen W. ,  GLOVER, Bryan K. ,  BOZZANO, Andrea G.

Inventor： MAJUMDER, Debarshi ,  SOHN, Stephen W. ,  GLOVER, Bryan K. ,  BOZZANO, Andrea G.

IPC: C07C2/04 ,  C07C5/10 ,  C07C9/00 ,  C07C2/64 ,  C07C15/073

CPC classification number: C07C6/04 ,  C07C2/06 ,  C07C2/64 ,  C07C5/32 ,  C07C303/06 ,  C10G50/00 ,  C10G69/126 ,  C07C11/02 ,  C07C11/10 ,  C07C11/107 ,  C07C15/107 ,  C07C309/31

Abstract: Processes for making C X to C Y olefins are provided. The processes include reacting a feedstock comprising C 5 and C 6 olefins under dimerization or oligomerization conditions to provide a dimerization or oligomerization product. The product is separated into a stream comprising unreacted C 5 and C 6 paraffins, a stream comprising C 10 to C X-1 olefins, and a stream comprising C X to C Y olefins, wherein X is at least 14 and Y is greater than X and less than or equal to 36.

Abstract translation: 提供了用于将C≡X取代为C≡Y烯烃的方法。 该方法包括在二聚或低聚条件下使包含C5和C6烯烃的原料反应以提供二聚或低聚产物。 将产物分离成包含未反应的C 5和C 6链烷烃的物流，包含C 10到C X-1的物流 烯烃和包含C≡X至C≡Y烯烃的物流，其中X至少为14并且Y大于X且小于或等于36

公开(公告)号：WO2008107463A3

公开(公告)日：2009-08-06

申请号：PCT/EP2008052692

申请日：2008-03-05

Applicant: UNILEVER PLC ,  UNILEVER NV ,  UNILEVER HINDUSTAN ,  DAS SUBIR KUMAR ,  PERINCHEERY ARAVINDAKSHAN ,  PRAMANIK AMITAVA

Inventor： DAS SUBIR KUMAR ,  PERINCHEERY ARAVINDAKSHAN ,  PRAMANIK AMITAVA

IPC: C07C303/32 ,  C07C309/31 ,  C11D1/22

CPC classification number: C07C303/32 ,  C11D1/22 ,  C11D3/06 ,  C11D3/10 ,  C11D11/04 ,  C11D17/0073 ,  C11D17/065 ,  C07C309/31

Abstract: A process to prepare solid form of magnesium salt of linear alkyl benzene sulphonic acid which comprises the step of neutralization of linear alkyl benzene sulphonic acids with a magnesium-based alkali in the presence of 3 to 28% water by weight of the reaction mixture in a high shear mixer. A solid detergent composition comprising (i) from 5 to 90 % magnesium salt of linear alkyl benzene sulphonic acid and (ii) from 5 to 70 % builder.

Abstract translation: 制备直链烷基苯磺酸的固体形式的镁盐的方法，其包括在3至28重量％的反应混合物的水溶液存在下，使用镁基碱中和直链烷基苯磺酸的步骤 高剪切混合机。 一种固体洗涤剂组合物，其包含（i）5-90％直链烷基苯磺酸镁盐和（ii）5-70％助洗剂。

公开(公告)号：WO2008088727A3

公开(公告)日：2008-10-30

申请号：PCT/US2008000384

申请日：2008-01-11

Applicant: CONCERT PHARMACEUTICALS INC ,  HARBESON SCOTT L

Inventor： HARBESON SCOTT L

IPC: C07D239/69 ,  A61K31/506 ,  A61P11/00 ,  C07C311/21

CPC classification number: C07D239/69 ,  C07B2200/05 ,  C07C309/31 ,  C07C309/86 ,  C07C311/16

Abstract: This invention relates to novel endothelin receptor antagonists of the formula (I), derivatives, acceptable acid addition salts, solvates, hydrates and polymorphs thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by compounds that block the endothelin signaling pathway that leads to vasoconstriction and -in particular those diseases or conditions beneficially treated by endothelin receptor antagonists.

Abstract translation: 本发明涉及式（I）的新型内皮素受体拮抗剂，其衍生物，可接受的酸加成盐，溶剂合物，水合物及其多晶型物。 本发明还提供了包含本发明化合物的组合物以及这些组合物在治疗疾病和病症的方法中的用途，所述疾病和病症有利地通过阻断导致血管收缩的内皮素信号通路的化合物治疗，特别是那些有益处理的疾病或病症 通过内皮素受体拮抗剂。

公开(公告)号：WO2005018300A3

公开(公告)日：2005-06-23

申请号：PCT/US2004025328

申请日：2004-08-04

Applicant: CHEVRON ORONITE CO ,  CAMPBELL CURT B ,  SINQUIN GILLES P

Inventor： CAMPBELL CURT B ,  SINQUIN GILLES P

IPC: C07C309/00 ,  C07C309/31 ,  C09K3/00 ,  C09K8/584 ,  E21B43/22

CPC classification number: C09K8/584 ,  C07C309/31

Abstract: The present invention is directed to alkylxylene sulfonate for enhanced oil recovery processes. The alkylxylene moiety in the alkylxylene sulfonate contains a high percentage of the 4-alkyl-1,2-dimethyl benzene isomer and a high percentage of alkyl group attachment to the xylene ring at positions higher than the 2-position on the alkyl carbon chain. The present invention is also directed to a method for enhancing the recovery of oil from a subterranean reservoir which method employs the alkylxylene sulfonate of the present invention. The alkylxylene sulfonate is employed in an aqueous media. The method optionally employs co-surfactants. It has surprisingly been discovered that the high percentage of the 4-alkyl-1,2-dimethyl benzene isomer and the high percentage alkyl group attachment to the xylene moiety at positions higher than the 2-position along the alkyl carbon chain on the alkylxylene sulfonate of the present invention provides an enhanced oil recovery (EOR) surfactant having low Interfacial Tension (IFT).

Abstract translation: 本发明涉及用于增强采油工艺的烷基二甲苯磺酸盐。 烷基二甲苯磺酸中的烷基二甲苯部分含有高百分比的4-烷基-1,2-二甲基苯异构体，并且在高于烷基碳链上的2-位的位置上高的百分比的烷基连接到二甲苯环。 本发明还涉及一种用于增强从地下储层中回收油的方法，该方法采用本发明的烷基二甲苯磺酸盐。 烷基二甲苯磺酸盐用于水性介质中。 该方法任选地使用助表面活性剂。 令人惊讶地发现，高烷基1,2-二甲基苯异构体的高百分比和在烷基二甲苯磺酸盐上沿着烷基碳链的2-位高的二甲苯部分附着的高百分比烷基 的本发明提供了具有低界面张力（IFT）的增强油回收（EOR）表面活性剂。

公开(公告)号：WO2004092096A2

公开(公告)日：2004-10-28

申请号：PCT/EP2004/003928

申请日：2004-04-14

Applicant: BASF AKTIENGESELLSCHAFT ,  NARBESHUBER, Thomas ,  STEINBRENNER, Ulrich ,  UNGER, Jörg ,  ZEHNER, Peter ,  ZIMDAHL, Soeren ,  BENFER, Regina

Inventor： NARBESHUBER, Thomas ,  STEINBRENNER, Ulrich ,  UNGER, Jörg ,  ZEHNER, Peter ,  ZIMDAHL, Soeren ,  BENFER, Regina

IPC: C07C2/70

CPC classification number: C07C303/08 ,  C07C2/66 ,  C07C15/107 ,  C07C303/06 ,  C07C309/31

Abstract: In einem Verfahren zur Herstellung von alkylaromatischen Verbindungen durch Umsetzung von C 3-30 -Olefinen oder Alkoholen, aus denen bei den Umsetzungsbedingungen C 3-30 -Olefine gebildet werden, mit einem aromatischen Kohlenwasserstoff in Gegenwart eines Alkylierungskatalysators, wird die Umsetzung in einer Reaktorkaskade aus mindestens zwei Reaktoren durchgeführt, wobei jeder der Reaktoren den Alkylierungskatalysator enthält, mindestens 80 % des aromatischen Kohlenwasserstoffs in den ersten Reaktor der Reaktorkaskade eingespeist werden und mindestens 40 % der Olefine nach dem ersten Reaktor zwischeneingespeist werden.

Abstract translation: 在由C3-30烯烃或醇从在烷基化催化剂的存在下在反应条件下C3-30烯烃形成与芳族烃时，该反应在至少两个反应器级联反应为烷基芳族化合物的制备方法 反应器中进行，每个所述含烷基化催化剂的反应器中，芳烃的至少80％的被进料到反应器级联的第一反应器中，烯烃的至少40％被供给至第一反应器之间。

公开(公告)号：WO2003082783A1

公开(公告)日：2003-10-09

申请号：PCT/US2002/009310

申请日：2002-03-25

Applicant: UOP LLC ,  KULPRATHIPANJA, Santi ,  MARINANGELI, Richard, E. ,  SOHN, Stephen, W. ,  FRITSCH, Thomas, R. ,  LAWSON, R., Joe

Inventor： KULPRATHIPANJA, Santi ,  MARINANGELI, Richard, E. ,  SOHN, Stephen, W. ,  FRITSCH, Thomas, R. ,  LAWSON, R., Joe

IPC: C07C7/13

CPC classification number: C07C15/107 ,  C07C303/06 ,  C07C303/08 ,  C10M105/06 ,  C10M135/10 ,  C10M177/00 ,  C10M2203/06 ,  C10M2219/044 ,  C10M2219/046 ,  C10N2260/10 ,  C10N2270/00 ,  C07C309/31

Abstract: A process for producing phenyl-alkanes, the process comprising the steps of: a) passing a feed stream comprising a first concentration of a first acyclic paraffin having a carbon range of C 8 -C 28 and 2 or 3 primary carbon atoms and at least a second acyclic paraffin to an adsorption zone comprising a bed of an adsorbent comprising silicalite at adsorption promoting conditions to selectively adsorb at least a portion of the first acyclic paraffin contacting the bed of adsorbent with a desorbent stream comprising at least one component selected from the group consisting of a C 5 -C 8 cycloparaffin, a C 5 -C 8 normal paraffin, and a C 5 - C¿8 branched paraffin and recovering from the adsorption zone an adsorption extract having a second concentration of the first acyclic paraffin that is greater than the first concentration; b) passing at least a portion of the adsorption extract to a dehydrogenation zone, operating the dehydrogenation zone at dehydrogenation conditions sufficient to dehydrogenate the first acyclic paraffin and recovering from the dehydrogenation zone a dehydrogenated product stream comprising an acyclic monoolefin having a carbon range of C 8 -C 28 and 2 or 3 primary.carbon atoms; c) passing .a feedstock comprising a phenyl compound and passing at least a portion of the dehydrogenated product stream comprising the acyclic monoolefin to an alkylation zone, operating the alkylation zone at alkylation conditions sufficient to alkylate the phenyl compound with the acyclic monoolefin in the presence of an alkylation catalyst to form a phenyl-alkane comprising a molecule having one phenyl portion and one C 8 -C 28 aliphatic alkyl portion; wherein the aliphatic alkyl portion has 2 or 3 primary carbon atoms and no quaternary carbon atoms that are not bonded by a carbon-carbon bond with a carbon atom of the phenyl portion; and wherein the alkylation has a selectivity to 2-phenyl-alkanes of from 40 to 100 and a selectivity to internal quaternary phenyl-alkanes of less than 10; and recovering the phenyl-alkane from the alkylation zone.

Abstract translation: 一种生产苯基烷烃的方法，该方法包括以下步骤：a）使包含第一浓度的碳范围为C 8 -C 28和2或3个伯碳原子的第一无环状链烷烃的进料流和至少第二 非吸收性石蜡包括吸附剂床，所述吸附床包括硅沸石，吸附促进条件下，选择性地将至少一部分与吸附床接触的第一非循环石蜡与解吸剂流接触，所述解吸剂流包含至少一种选自以下的组分： C 5 -C 8环烷烃，C5-C8正链烷烃和C5-C8支链石蜡，并从吸附区回收具有大于第一浓度的第一无环石蜡的第二浓度的吸附提取物; b）将至少一部分吸附提取物通入脱氢区，在脱氢条件下操作脱氢条件，该脱氢条件足以使第一无环烷烃脱氢并从脱氢区回收包含碳范围为C8的无环单烯烃的脱氢产物流 -C28和2或3个原子碳原子; c）使包含苯基化合物的原料通过并将包含非环状单烯烃的脱氢产物流的至少一部分通入烷基化区，在烷基化条件下操作烷基化区，该烷基化条件足以使苯基化合物与非环状单烯烃在存在下烷基化 的烷基化催化剂以形成包含具有一个苯基部分和一个C 8 -C 28脂族烷基部分的分子的苯基烷烃; 其中所述脂族烷基部分具有2或3个伯碳原子，并且不具有与所述苯基部分的碳原子不与碳 - 碳键键合的季碳原子; 并且其中所述烷基化对2-苯基烷烃具有40至100的选择性和小于10的内部季苯基烷烃的选择性; 并从烷基化区回收苯基 - 烷烃。

公开(公告)号：WO2003033460A1

公开(公告)日：2003-04-24

申请号：PCT/EP2002/010738

申请日：2002-09-25

Applicant: HUNTSMAN INTERNATIONAL LLC ,  FRICK, Hendrick, Petrus ,  KUMAR, Ajit ,  URBAIN, Jean-Luc, Yves, Leon ,  HAUSS, Didier ,  SOLASTIOUK, Pierre

Inventor： FRICK, Hendrick, Petrus ,  KUMAR, Ajit ,  URBAIN, Jean-Luc, Yves, Leon ,  HAUSS, Didier ,  SOLASTIOUK, Pierre

IPC: C07C303/44

CPC classification number: C07C309/31 ,  C07C303/44 ,  C07C309/30

Abstract: A novel, storage-stable, free-flowing, solid product consisting essentially of an alkyl benzene sulphonic acid having 1 to 4 aliphatic carbon atoms and from 7 to 11 % water based on the weight of the product, said alkyl benzene sulphonic acid comprising at least 90 % by weight of a single isomer based on the total weight of organic material in the product, is prepared by drying a storage-unstable, solid alkyl benzene sulphonic acid having more than 11 % by weight water, said drying being effected at sub atmospheric pressure and at a temperature below the softening point of the product.

Abstract translation: 一种基于产物重量的基本上由具有1至4个脂族碳原子的烷基苯磺酸和7至11％水组成的新型储存稳定的自由流动的固体产物，所述烷基苯磺酸包含 通过干燥具有超过11重量％水的储存不稳定的固体烷基苯磺酸制备基于产物中有机材料总重量的单一异构体的至少90重量％，所述干燥在亚 大气压力和低于产品软化点的温度。