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    アゾ化合物、インク組成物及び着色体
    4.
    发明申请
    アゾ化合物、インク組成物及び着色体 审中-公开
    AZO化合物，墨水组合物和彩色物体

    公开(公告)号：WO2005097912A1

    公开(公告)日：2005-10-20

    申请号：PCT/JP2005/006780

    申请日：2005-04-06

    Applicant: 日本化薬株式会社 ,  松井 貴彦 ,  大野 博昭 ,  米田 孝 ,  白崎 康夫

    Inventor： 松井 貴彦 ,  大野 博昭 ,  米田 孝 ,  白崎 康夫

    IPC: C09B35/58

    CPC classification number: C07D231/46 ,  C09B35/58 ,  C09D11/17 ,  C09D11/328

    Abstract: A novel azo compound represented by the following formula (1) wherein A represents the following formula (2) and is located preferably in a position meta or para to the azo group; R and R each independently represents hydrogen, carboxy, sulfo, nitro, C1-4 alkoxy, etc.; R and R each independently represents hydrogen, halogeno, cyano, carboxy, sulfo, nitro, C1-4 alkyl, hydroxy, or C1-4 alkoxy; and n is 0 or 1. [In the formula (2), R represents cyano, carboxy, C1-4 alky, C1-4 alkoxycarbonyl, or phenyl; and R , R , and R each independently represents hydrogen, halogeno, cyano, carboxy, sulfo, nitro, C1-4 alkyl, C1-4 alkoxy, or acylamino.] The compound is useful as a black dye, especially one for ink compositions for, e.g., ink-jet prints. Also provided are: an ink composition which contains the compound and has excellent storage stability; and a print obtained through recording with the ink. The print is excellent in light resistance, ozone resistance, fastness to moisture, etc.

    Abstract translation: 由下式（1）表示的新型偶氮化合物，其中A表示下式（2），优选位于偶氮基的间位或对位; R 1和R 2各自独立地表示氢，羧基，磺基，硝基，C 1-4烷氧基等; R 3和R 4各自独立地表示氢，卤素，氰基，羧基，磺基，硝基，C 1-4烷基，羟基或C 1-4烷氧基; 并且n为0或1. [式（2）中，R 5表示氰基，羧基，C 1-4烷基，C 1-4烷氧基羰基或苯基; 和R 6，R 7和R 8各自独立地表示氢，卤代，氰基，羧基，磺基，硝基，C 1-4烷基，C 1-4烷氧基或酰氨基。]该化合物可用作 黑色染料，特别是用于例如喷墨印刷品的油墨组合物。 还提供：含有该化合物并具有优异储存稳定性的油墨组合物; 以及通过用墨水记录获得的印刷品。 该印刷品的耐光性，耐臭氧性，耐潮湿性等优异。

    THROMBOPOIETIN MIMETICS
    5.
    发明申请
    THROMBOPOIETIN MIMETICS 审中-公开
    THROMBOPOIETINMIMTCS

    公开(公告)号：WO2003103686A1

    公开(公告)日：2003-12-18

    申请号：PCT/US2003/017837

    申请日：2003-06-06

    Applicant: SMITHKLINE BEECHAM CORPORATION ,  HEERDING, Dirk, A.

    Inventor： HEERDING, Dirk, A.

    IPC: A61K31/655

    CPC classification number: C07D417/12 ,  C07C205/56 ,  C07C229/44 ,  C07C243/20 ,  C07C2601/08 ,  C07D231/20 ,  C07D231/46 ,  C07F9/65031

    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy­1-azobenzene derivative.

    Abstract translation: 发明的是非肽TPO模拟物。 还发明了用于制备本发明化合物的新方法和中间体。 还发明了一种在有需要的哺乳动物（包括人）中治疗血小板减少症的方法，其包括向所述哺乳动物施用有效量的选择的羟基-1-偶氮苯衍生物。

    COMPOUND, COMPOSITION AND USE
    6.
    发明申请
    COMPOUND, COMPOSITION AND USE 审中-公开
    化合物，组合物和用途

    公开(公告)号：WO99024871A1

    公开(公告)日：1999-05-20

    申请号：PCT/GB1998/003388

    申请日：1998-11-11

    IPC: C07D231/46 ,  G03G9/09 ,  G03G9/097

    CPC classification number: G03G9/091 ,  C07D231/46 ,  G03G9/09758

    Abstract: There is described a negative charge control agent for use in electroreprography which comprises one or more azopyrazolones of Formula (I) which includes all electroreprographically effective forms of such compounds selected from one or more of the following (including mixtures thereof and combinations thereof in the same species): stereoisomers, zwitterions, polymorphs, solvates, isotopic forms; and salts thereof; where in Formula (I) n represents an integer from 0 to 4 inclusive; R represents one or more substituents selected from one or more of: hydroxy, mercapto, amino, nitro, sulpho, sulpheno, sulphino, carboxy, halo, cyano, optionally substituted C1-30hydrocarbyl and an optionally substituted aryl ring fused to the ring to which R is attached, R and R , which may be the same or different, each independently represents optionally substituted C1-30hydrocarbyl.

    Abstract translation: 描述了一种用于电制品的负电荷控制剂，其包含一种或多种式（I）的唑吡唑酮，其包括选自以下一种或多种的所有电解有效形式的化合物（包括其混合物及其组合在同一种 物种）：立体异构体，两性离子，多晶型物，溶剂合物，同位素形式; 及其盐; 式（I）中，n表示0〜4的整数， R 1表示一个或多个选自以下的一个或多个取代基：羟基，巯基，氨基，硝基，磺基，磺基，亚磺酰基，羧基，卤素，氰基，任选取代的C 1-30烃基和任选取代的芳基 R 1，R 2和R 3可以相同或不同，各自独立地表示任选取代的C 1-30烃基。

    NOVEL ELTROMBOPAG SALT AND PREPARATION THEREOF
    8.
    发明申请
    NOVEL ELTROMBOPAG SALT AND PREPARATION THEREOF 审中-公开
    新型醋酸盐及其制备方法

    公开(公告)号：WO2017042839A1

    公开(公告)日：2017-03-16

    申请号：PCT/IS2016/050013

    申请日：2016-09-08

    Applicant: ACTAVIS GROUP PTC EHF.

    Inventor： ALI, Nasir Ali Shafakat ,  SHARMA, Vijay Hariprasad ,  JOSHI, Ashutosh Vijay ,  LUTHRA, Parven Kumar

    IPC: C07D231/46 ,  A61K31/4152 ,  A61P7/00

    CPC classification number: C07D231/46

    Abstract: A eltrombopag tromethamine salt has been obtained and characterized . Pharmaceutical compositions comprising the elthrombopag tromethamine salt form can be used for treatment of diseases, including thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. Process of preparing the elthrombopag tromethamine salt form is also provided.

    Abstract translation: 已经获得了埃曲波泊特氨基硫胺盐，并且表征。 包含氯沙坦氨基丁糖胺盐形式的药物组合物可用于治疗慢性免疫（特发性）血小板减少性紫癜（ITP），对皮质类固醇，免疫球蛋白或脾切除术的反应不足的疾病，包括血小板减少症。 还提供了制备氯沙坦氨基甲酸盐形式的方法。

    艾曲波帕的制备方法
    9.
    发明申请
    艾曲波帕的制备方法 审中-公开

    公开(公告)号：WO2015139536A1

    公开(公告)日：2015-09-24

    申请号：PCT/CN2015/072138

    申请日：2015-02-03

    Applicant: 苏州明锐医药科技有限公司 ,  哲人药业南京有限公司

    Inventor： 许学农

    IPC: C07D231/46

    CPC classification number: C07D231/46

    Abstract: 本发明揭示了一种艾曲波帕(Eltrombopag)的制备方法，其制备包括如下步骤：用3'-氨基-2'-羟基联苯基-3-羧酸(II)和乙酰乙酸烷基酯发生重氮偶联反应得到(Z)-2-[3'-(2'-羟基-3-羧酸联苯基)亚肼基]-3-氧代丁酸烷基酯(III)，中间体(III)与3，4-二甲基苯肼进行缩合环化反应制得艾曲波帕(I)。该工艺过程简洁，原料易得，经济环保，有利于实现工业化，可促进艾曲波帕原料药的经济技术发展。

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