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16 条记录 (耗时 0.011 秒)

    SEMI-SYNTHETIC TEREPHTHALIC ACID VIA MICROORGANISMS THAT PRODUCE MUCONIC ACID
    3.
    发明申请
    SEMI-SYNTHETIC TEREPHTHALIC ACID VIA MICROORGANISMS THAT PRODUCE MUCONIC ACID 审中-公开
    通过生产肌酸的微生物的半合成的正十二酸

    公开(公告)号：WO2011017560A1

    公开(公告)日：2011-02-10

    申请号：PCT/US2010/044606

    申请日：2010-08-05

    申请人： GENOMATICA, INC. ,  BURK, Mark, J. ,  OSTERHOUT, Robin, E. ,  SUN, Jun

    发明人： BURK, Mark, J. ,  OSTERHOUT, Robin, E. ,  SUN, Jun

    IPC分类号： C12N1/21 ,  C12P13/04 ,  C12P7/44

    CPC分类号： C12P7/44 ,  C12N9/88 ,  C12Y402/01002

    摘要： The invention provides a non-naturally occurring microbial organism having a muconate pathway having at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate. The muconate pathway including an enzyme selected from the group consisting of a beta-ketothiolase, a beta-ketoadipyl-CoA hydrolase, a beta-ketoadipyl-CoA transferase, a beta-ketoadipyl-CoA ligase, a 2- fumarylacetate reductase, a 2-fumarylacetate dehydrogenase, a trans -3-hydroxy-4- hexendioate dehydratase, a 2-fumarylacetate aminotransferase, a 2-fumarylacetate aminating oxidoreductase, a trans -3-amino-4-hexenoate deaminase, a beta-ketoadipate enol-lactone hydrolase, a muconolactone isomerase, a muconate cycloisomerase, a beta-ketoadipyl-CoA dehydrogenase, a 3-hydroxyadipyl-CoA dehydratase, a 2,3-dehydroadipyl-CoA transferase, a 2,3-dehydroadipyl-CoA hydrolase, a 2,3-dehydroadipyl-CoA ligase, a muconate reductase, a 2-maleylacetate reductase, a 2-maleylacetate dehydrogenase, a cis -3-hydroxy-4-hexendioate dehydratase, a 2-maleylacetate aminoatransferase, a 2-maleylacetate aminating oxidoreductase, a cis -3-amino-4-hexendioate deaminase, and a muconate cis/trans isomerase. Other muconate pathway enzymes also are provided. Additionally provided are methods of producing muconate.

    摘要翻译： 本发明提供了一种非天然存在的微生物，其具有一种具有至少一种外源核酸的粘蛋白途径的微生物生物，所述外源核酸编码以足够量表达的粘蛋白途径酶以产生粘多糖。 粘膜途径包括选自β-酮硫解酶，β-酮己二酰辅酶A水解酶，β-酮己二酰辅酶A转移酶，β-酮己二酰辅酶A连接酶，2-富马酸乙酰酯还原酶，2- 富马酰乙酸脱氢酶，反式-3-羟基-4-己二酸脱水酶，2-富马酸乙酯氨基转移酶，2-富马酸乙酯胺化氧化还原酶，反式-3-氨基-4-己烯酸脱氨酶，β-酮己二酸烯醇内酯水解酶， 粘蛋白内酯异构酶，粘蛋白环异构酶，β-酮己二酰辅酶A脱氢酶，3-羟基己二酰辅酶A脱水酶，2,3-脱氢阿迪普基-CoA转移酶，2,3-脱氢阿迪普基-CoA水解酶，2,3-脱氢阿迪普酯 - CoA连接酶，粘蛋白还原酶，2-马来酰乙酸酯还原酶，2-马来酰乙酸酯脱氢酶，顺式-3-羟基-4-己二酸脱水酶，2-马来酰乙酸酯氨基转移酶，2-马来酰乙酸胺胺化氧化还原酶，顺式-3-氨基 -4-十六酸脱氨酶和粘蛋白顺式/反式异构酶。 还提供了其它粘蛋白途径酶。 另外提供了生产粘蛋白的方法。

    REGULATOR OF COMPLEMENT ACTIVATION AND USES THEREOF
    4.
    发明申请
    REGULATOR OF COMPLEMENT ACTIVATION AND USES THEREOF 审中-公开
    补充活动的调节器及其用途

    公开(公告)号：WO2013142362A1

    公开(公告)日：2013-09-26

    申请号：PCT/US2013/032350

    申请日：2013-03-15

    申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  UNIVERSITY ULM ,  LAMBRIS, John D. ,  SCHMIDT, Christoph ,  RICKLIN, Daniel

    发明人： LAMBRIS, John D. ,  SCHMIDT, Christoph ,  RICKLIN, Daniel

    IPC分类号： A61K38/17 ,  A61P37/00 ,  A61P43/00

    CPC分类号： C12N9/88 ,  A61K38/00 ,  A61K38/51 ,  C07K14/472 ,  C12Y402/01002

    摘要： A potent complement regulator is disclosed. The complement regulator comprises a complement regulatory region connected by a flexible linker to a multifunctional binding region that enables binding to C3b activation/inactivation products and/or oxidation end products, as well as to polyanionic surface markers on host cells. An embodiment of the invention utilizes factor H SCRs 1-4 as the complement regulatory region and factor H SCRs 19 and 20 as the multifunctional binding region, linked together by a poly-Gly linker at least 12 residues in length. Pharmaceutical compositions comprising the complement regulator and methods of using the complement regulator are also disclosed.

    摘要翻译： 公开了一种有效的补体调节剂。 补体调节物包含通过柔性接头连接到能够结合C3b激活/失活产物和/或氧化终产物以及宿主细胞上的聚阴离子表面标记的多功能结合区的补体调节区。 本发明的一个实施方案利用因子H SCR 1-4作为补体调节区和因子H SCR 19和20作为多功能结合区，通过长度至少为12个残基的聚-Gly接头连接在一起。 还公开了包含补体调节剂的药物组合物和使用补体调节剂的方法。

    SPECIFIC COMPLEMENT PROTEINS AND EFFICACY OF ANTIBODY THERAPY
    6.
    发明申请
    SPECIFIC COMPLEMENT PROTEINS AND EFFICACY OF ANTIBODY THERAPY 审中-公开
    特异性补体蛋白和抗体治疗效果

    公开(公告)号：WO2014194213A1

    公开(公告)日：2014-12-04

    申请号：PCT/US2014/040262

    申请日：2014-05-30

    申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

    发明人： WEINER, George

    IPC分类号： C07K16/18 ,  C07K14/47 ,  C07K19/00 ,  A61K39/395 ,  A61K38/17 ,  A61P37/00

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/472 ,  C07K16/2887 ,  C07K2317/732 ,  C07K2319/00 ,  C12Y402/01002

    摘要： Disclosed are methods, kits, and compositions for treating, diagnosing, and/or prognosing diseases based on immunotherapy. The methods, kits, and compositions may utilize at least one of complement factor H-related protein 1 (CFHR1), complement factor H-related protein 3 (CFHR3), and/or variants thereof for treating a patient in need thereof in conjunction with a therapeutic antibody or antigen-binding fragment. The methods, kits, and compositions may utilize diagnostic antibodies to CFHR1 and/or diagnostic antibodies to CFHR3 for diagnosing or prognosing a patient prior to treatment with a therapeutic antibody. The methods, kits, and compositions also may utilize reagents for detecting a polymorphism in rs3766404.

    摘要翻译： 公开了用于治疗，诊断和/或预防基于免疫治疗的疾病的方法，试剂盒和组合物。 方法，试剂盒和组合物可以利用补体因子H相关蛋白1（CFHR1），补体因子H相关蛋白3（CFHR3）和/或其变体中的至少一种来治疗有此需要的患者与 治疗性抗体或抗原结合片段。 方法，试剂盒和组合物可以利用CFHR1的诊断抗体和/或对CFHR3的诊断抗体用于在用治疗性抗体治疗之前诊断或预测患者。 方法，试剂盒和组合物还可以利用用于检测rs3766404中的多态性的试剂。