公开(公告)号：WO99051169A1

公开(公告)日：1999-10-14

申请号：PCT/FR1999/000790

申请日：1999-04-06

IPC: A61F2/24

CPC classification number: A61F2/2472 ,  Y10S623/921 ,  Y10S623/922

Abstract: The invention concerns a device for the peroperative exploration of the human or animal cardiovascular system, characterised in that it consists of a generally transparent blind tube, defining a cavity (2) wherein can be housed, optical display means (3), the tube open end (4) being shaped to be urged to be axially pressed sealed on an artery (5) or vein duct which has been previously at least partially cut such that the tube cavity (2) and the artery (5) or vein inside form a common chamber (6) which can be at least partially occluded with a cusp (7), said tube, maintained in pressed position by a suitable fixing member (8), comprising at least an additional opening (9A, 9B) for inserting in the tube cavity a physiological fluid (10) under pressure.

Abstract translation: 本发明涉及一种用于人或动物心血管系统的术中探查的装置，其特征在于，其由通常透明的盲管组成，限定可容纳的腔（2），光学显示装置（3），管打开 端部（4）被成形为被推动以轴压地密封在预先至少部分切割的动脉（5）或静脉管上，使得管腔（2）和动脉（5）或静脉内部形成 所述公共室（6）可以至少部分地与尖端（7）封闭，所述管通过合适的固定构件（8）保持在按压位置，所述固定构件（8）至少包括用于插入所述孔的附加开口（9A，9B） 管腔内有生理液体（10）。

公开(公告)号：WO1996024307A1

公开(公告)日：1996-08-15

申请号：PCT/US1996001367

申请日：1996-02-01

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  HU, Can, B. ,  MA, Minh, T. ,  NGUYEN, Than ,  RHEE, Richard ,  MYERS, Keith

IPC: A61F02/06

CPC classification number: A61F2/062 ,  A61L27/507 ,  Y10S623/921

Abstract: An apparatus for sodding onto the inner lumenal surface of a synthetic graft of harvested and concentrated microvessel endothelial cells from liposuctioned fat tissues, which harvested cells are formed into a "pellet" of isolated endothelial cells in loose aggregations, includes a sodding tube having a single rigid outer wall bounding a sodding chamber. A filter pack assembly is provided to communicate the pellet of cells from a processing vessel to the graft. This filter pack assembly includes a series of successively finer filter members cooperatively defining a series of turbulent-flow chambers in which aggregations of cells too large to pass through a particular filter are exposed to liquid flow turbulence which is effective to break up the aggregations. A check valve assembly ensures that liquid flow is unidirectional so that sodding of the cells onto the inner lumenal surface of the graft is not interfered with by possible liquid reflux, and sodded cells are similarly not dislodged from the graft by such liquid reflux.

Abstract translation: 将收集的细胞收集和浓缩的微血管内皮细胞的合成移植物的内腔表面上的沉淀物形成为松散聚集的分离的内皮细胞的“沉淀”的装置，包括具有单个 刚性外墙围住了一个饮料室。 提供过滤器组件以将细胞团从处理容器传递到移植物。 该过滤器组件包括一系列相继更细的过滤器构件，其协作地限定一系列湍流室，其中太大而不能通过特定过滤器的单元的聚集物暴露于有效破坏聚集的液体流动湍流。 止回阀组件确保液体流动是单向的，使得细胞在移植物的内腔表面上的唾液分解不会被可能的液体回流干扰，并且经过这种液体回流的同样，细胞也不会从移植物移出。

公开(公告)号：WO1995024873A1

公开(公告)日：1995-09-21

申请号：PCT/US1995002350

申请日：1995-02-27

Applicant: CRYOLIFE, INC.

Inventor： CRYOLIFE, INC. ,  GOLDSTEIN, Steven

IPC: A61F02/24

CPC classification number: A61L27/3687 ,  A61L27/3604 ,  A61L27/3625 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3895 ,  A61L2430/40 ,  Y10S623/92 ,  Y10S623/921

Abstract: This disclosure includes a method for generating a functional hybrid bioprosthesis. Tissue formed naturally of interstitial collagens is treated to kill native cells and remove potentially immunologically active soluble molecules. Then it may be treated sequentially with extracellular matrix adhesion factor, extracellular matrix glycosaminoglycan, and growth factor appropriate to the cell type required to function within the matrix, and incubating the transplant tissue matrix with cells that are either allogeneic or autologous for the recipient thereby imparting to the matrix the characteristics of the cell type and tissue selected. Tissues with a variety of functional bioactivities can thus be formed in vitro prior to graft transplantation or implantation which will exhibit reduced or no stimulation of an immunological response in the recipient.

Abstract translation: 本公开包括用于产生功能性混合生物假体的方法。 处理由间质胶原天然形成的组织以杀死天然细胞并去除潜在的免疫活性可溶性分子。 然后可以依次使用细胞外基质粘附因子，细胞外基质糖胺聚糖和适合于在基质内起作用的细胞类型的生长因子，并将移植组织基质与同种异体或自体的细胞孵育给接受者，从而赋予 对基质的细胞类型和组织的特征进行选择。 因此，可以在移植物移植或植入之前体外形成具有多种功能生物活性的组织，这将在受体中表现出减少或不刺激免疫应答。

公开(公告)号：WO1990007950A1

公开(公告)日：1990-07-26

申请号：PCT/US1990000236

申请日：1990-01-12

Applicant: EATON, John, W.

IPC: A61M25/00

CPC classification number: A61L33/128 ,  Y10S623/92 ,  Y10S623/921

Abstract: A biocompatible prosthetic device is provided which comprises a solid polymeric body incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a physiological fluid containing albumin. A method of increasing the albumin-binding ability of a prosthetic device is also provided.

公开(公告)号：WO2005113620A1

公开(公告)日：2005-12-01

申请号：PCT/JP2005/009086

申请日：2005-05-18

Applicant: 大阪有機化学工業株式会社 ,  北野 博巳 ,  源明 誠 ,  猿渡 欣幸 ,  向山 高広

Inventor： 北野 博巳 ,  源明 誠 ,  猿渡 欣幸 ,  向山 高広

IPC: C08F220/36

CPC classification number: C08F220/36 ,  C08F220/18 ,  Y10S623/903 ,  Y10S623/921 ,  Y10S623/926

Abstract: A biocompatible material which little causes interaction with biocomponents such as proteins or blood cells and is excellent in biocompatibility, that is, a biocompatible material consisting of a polymer obtained by polymerizing a monomer composition which comprises an amino acid type betaine monomer represented by the general formula (I) [wherein R is hydrogen or methyl; R is C1-6 alkylene; R and R are each independently C1-4 alkyl; R is C1-4 alkylene; and Z is oxygen or -NH] and a polymerizable monomer represented by the general formula (II) [wherein R is as defined above; and R is a monovalent organic group] at a (I)/(II) weight ratio of 1/99 to 100/1. This material is applicable to food, food additives, drugs, quasi drugs, medical supplies, cosmetics, toiletries, and so on.

Abstract translation: 生物相容性物质很少引起与生物成分如蛋白质或血液细胞的相互作用，并且生物相容性优异，即由通过聚合单体组合物得到的聚合物组成的生物相容性材料，该单体组合物包含由通式 （I）[其中R 1是氢或甲基; R 2是C 1-6亚烷基; R 3和R 4各自独立地为C 1-4烷基; R 5是C 1-4亚烷基; 和Z为氧或-NH]和由通式（II）表示的可聚合单体[其中R 1如上所定义; （I）/（II）重量比为1/99〜100/1，R 6为1价有机基团。 本材料适用于食品，食品添加剂，药品，准药品，医疗用品，化妆品，化妆品等。

公开(公告)号：WO98055048A1

公开(公告)日：1998-12-10

申请号：PCT/US1998/011717

申请日：1998-06-05

IPC: A61F2/958 ,  A61F2/00 ,  A61F2/06 ,  A61F2/82 ,  B24B31/00 ,  B24B31/116 ,  B24C3/32

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/068 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2240/001 ,  B24B31/003 ,  B24B31/116 ,  B24C3/32 ,  B24C3/327 ,  B24C5/005 ,  Y10S623/901 ,  Y10S623/921

Abstract: A method for polishing radially expandable surgical stents is disclosed where fluid abrasive media M flows over surfaces of the stent (10) causing the surfaces of the stent (10) to be polished and streamlined. The stent (10) is temporarily provided with cylindrical support ends (20), which are not radially expandable to support the stent (10) during the polishing process. An interior polishing fixture (100) is provided which has cylindrical chambers (135) therein adapted to receive a stent (10) therein. Fluid abrasive media M then flows into bores (108) in the fixture (100) leading to the cylindrical chambers (135) and adjacent the inner diameter surfaces of the stent (10). Surfaces of the stent (10) forming the outer diameter are polished by placing the stent (10) within an exterior polishing fixture (200) which has a cylindrical recess (220) therein. The cylindrical recess (220) has a diameter greater than a diameter of outer surfaces of the stent (10) and includes a cylindrical shaft (270) passing axially through the cylindrical recess (220) upon which the stent (10) is located. Slanted bores (208) pass through walls of the exterior polishing fixture (200) and into the cylindrical recess (220), directing the abrasive media M adjacent exterior surfaces of the stent (10) and causing polishing of the exterior surfaces of the stent (10). The direction of abrasive media M flow can be reversed to make streamlining of segments of the stent (10) occur in a symmetrical fashion. After polishing of the stent (10) is completed, the cylindrical support ends (20) are removed and the stent (10) is ready for implantation and radial expansion within a body lumen L. When polished and streamlined, the radially expandable surgical stent (10) more effectively supports a body lumen L without excessive thrombus, restenosis and other medical complications.

Abstract translation: 公开了一种用于抛光径向可扩张的外科支架的方法，其中流体研磨介质M流过支架（10）的表面，导致支架（10）的表面被抛光和流线型化。 支架（10）临时设置有圆柱形支撑端（20），其在抛光过程中不可径向扩张以支撑支架（10）。 提供了内部抛光固定件（100），其具有适于在其中容纳支架（10）的圆柱形腔室（135）。 流体研磨介质M然后流入固定装置（100）中通向圆柱形腔室（135）并邻近支架（10）的内径表面的孔（108）。 通过将支架（10）放置在其内具有圆柱形凹部（220）的外部抛光夹具（200）内，来对形成外径的支架（10）的表面进行抛光。 圆柱形凹部（220）的直径大于支架（10）的外表面的直径，并且包括轴向穿过支架（10）所在的圆柱形凹部（220）的圆柱形轴（270）。 倾斜孔（208）穿过外部抛光夹具（200）的壁并进入圆柱形凹部（220），将研磨介质M引导到支架（10）的外表面附近并引起支架外表面 10）。 研磨介质M流动的方向可以反转，以使得支架（10）的段的精简以对称的方式发生。 在完成支架（10）的抛光之后，移除圆柱形支撑端（20）并且支架（10）准备好在体腔L内进行植入和径向扩张。当抛光和流线时，可径向扩张的手术支架 10）更有效地支撑体腔L，而不会有过多的血栓，再狭窄等医疗并发症。

公开(公告)号：WO9707834A3

公开(公告)日：1997-03-27

申请号：PCT/US9612996

申请日：1996-08-12

Applicant: MEDTRONIC INC

Inventor： VERHOEVEN MICHEL ,  CAHALAN LINDA L ,  HENDRIKS MARC ,  FOUACHE BENEDICTE ,  CAHALAN PATRICK T

IPC: A61L33/10 ,  A61L33/00

CPC classification number: A61L33/0011 ,  A61L33/0023 ,  A61L33/0029 ,  Y10S623/921

Abstract: An improved method of making a medical device having immobilized heparin on a blood-contacting surface in which heparin is admixed with sufficient periodate to react with not more than two sugar units per heparin molecule in a buffer solution having a pH in the range of about 4.5-8. This mixture is reacted for at least 3 hours while protected from light and is then applied to the immobilized amine groups. This is an improvement over the prior art methods which included using an excess of periodate and then stopping the reaction at a desired point by the addition of glycerol since the conversion of only a few of the natural functional groups to aldehydes better preserves the antithrombotic bioeffectiveness of the heparin molecules bound to the surface. The invention also avoids the prior art steps of drying and reconstituting the heparin by providing a reacted mixture of heparin and periodate that can be stored as a stable liquid and applied directly to the aminated surface several days later.

公开(公告)号：WO1993015661A1

公开(公告)日：1993-08-19

申请号：PCT/US1992001155

申请日：1992-02-12

Applicant: INTERFACE BIOMEDICAL LABORATORIES CORP.

Inventor： INTERFACE BIOMEDICAL LABORATORIES CORP. ,  SAWYER, Philip, N.

IPC: A61B17/00

CPC classification number: A61F2/88 ,  A61F2/0095 ,  A61F2/958 ,  A61F2250/0036 ,  Y10S623/901 ,  Y10S623/921

Abstract: An anti-turbulent, anti-thrombogenic intravascular stent (100) of a helically shaped titanium or aluminum strip having an airfoil on internal surfaces thereof for increasing blood flow through the stent without creating areas of stagnant or turbulent flow therein. Also, a method for cleaning the stent for optimum performance in the intended application, and the stents which are cleaned by the process, and novel devices (200, 300) for introducing the stents of the invention into the body of a patient.

Abstract translation: 螺旋状钛或铝条的抗湍流，抗血栓形成的血管内支架（100），其内表面具有翼型，用于增加通过支架的血液流动，而不会在其中产生停滞或湍流的区域。 此外，用于清洁支架以在预期应用中获得最佳性能的方法以及通过该方法清洁的支架以及用于将本发明的支架引入患者体内的新型装置（200,300）。

公开(公告)号：WO1990002145A1

公开(公告)日：1990-03-08

申请号：PCT/AU1989000356

申请日：1989-08-22

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... ,  TELECTRONICS PTY. LIMITED ,  STEELE, John ,  JOHANSEN, Oddvar ,  JOHNSON, Graham ,  HODGKIN, Johnathon

Inventor： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... ,  TELECTRONICS PTY. LIMITED

IPC: C08F259/08

CPC classification number: C12N5/0068 ,  C08F8/36 ,  C08F259/08 ,  C08J7/12 ,  C12N2533/30 ,  C12N2533/52 ,  Y10S623/915 ,  Y10S623/921 ,  C08F220/06

Abstract: A surface for the attachment and growth of cells is prepared by first grafting polyacrylic acid chains to a fluorocarbon polymer substrate so that its weight increases by between 0.1 % and 20 %. The surface is then treated with concentrated sulphuric acid under such conditions that will separately decarboxylate, aromatize and sulphonate an effective proportion of the grafted polyacrylic acid chains before being dried, soaked in a concentrated acid and brought to a substantially neutral pH for cell attachment and growth thereupon. The surface may also be used as a human tissue implant.

Abstract translation: 通过首先将聚丙烯酸链接枝到碳氟聚合物基材上使其重量增加0.1％至20％来制备用于细胞附着和生长的表面。 然后将表面用浓硫酸处理，在这样的条件下，其将在干燥之前分别脱羧，芳构化和磺化有效比例的接枝聚丙烯酸链，浸在浓酸中并使其达到基本上中性的pH以使细胞附着和生长 于是。 该表面也可以用作人体组织植入物。

公开(公告)号：WO2004080277A3

公开(公告)日：2005-10-13

申请号：PCT/US2004006275

申请日：2004-03-01

Applicant: GELSUS RES AND CONSULTING INC ,  SCEUSA NICHOLAS A

Inventor： SCEUSA NICHOLAS A

IPC: A61F2/82 ,  A61N1/10 ,  A61F2/06 ,  A61B19/00 ,  A61F2/00 ,  A61F9/00 ,  A61F11/00 ,  B05D3/00

CPC classification number: A61N1/10 ,  A61F2/82 ,  Y10S623/921

Abstract: An implanted device such as a stent is provided which is capable of holding an induced charge of sufficient magnitude that the device may, by electrostatic means, attract the bioactive material to itself. The charge, either positive or negative, or relative to the bioactive material sufficiently positive or negative, is deposited into the implantable device via an exterior induction coil. The implantable device itself becomes an introduced "dosage form", becoming part of a biologically closed electric circuit, through which the bioactive material is attracted to the implanted device.

Abstract translation: 提供了诸如支架的植入装置，其能够保持足够大的感应电荷，使得装置可以通过静电方式将生物活性材料吸引到其自身。 通过外部感应线圈将电荷（正或负或相对于足够正或负的生物活性材料）沉积到可植入装置中。 植入式装置本身变成引入的“剂型”，成为生物闭合电路的一部分，生物活性材料通过该生物活性材料被吸引到植入装置。