VOLATILE ORGANIC GASES AS BIOINDICATORS FOR TRANSPLANT REJECTION
    1.
    发明申请
    VOLATILE ORGANIC GASES AS BIOINDICATORS FOR TRANSPLANT REJECTION 审中-公开
    挥发性有机气体作为生物燃料用于运输垃圾

    公开(公告)号:WO2015017354A1

    公开(公告)日:2015-02-05

    申请号:PCT/US2014/048502

    申请日:2014-07-28

    IPC分类号: G01N33/48

    摘要: A method comprising (a) obtaining one or more biological samples from a subject wherein the subject has undergone an organ transplant; (b) determining the amount and type of one or more volatile organic compounds in the biological sample; and (c) correlating the amount of volatile organic compounds to a degree of transplant rejection. A device comprising a plurality of sensors configured to detect a plurality of volatile organic compounds in a biological sample of a subject having undergone an organ transplant.

    摘要翻译: 一种方法,包括(a)从受试者获得器官移植的受试者获得一种或多种生物样品; (b)确定生物样品中一种或多种挥发性有机化合物的量和类型; 和(c)将挥发性有机化合物的量与移植排斥程度相关联。 一种装置,包括多个传感器,所述传感器被配置为检测已经经受器官移植的受试者的生物样品中的多种挥发性有机化合物。

    EARLY DETECTION OF RECURRENT BREAST CANCER USING METABOLITE PROFILING
    4.
    发明申请
    EARLY DETECTION OF RECURRENT BREAST CANCER USING METABOLITE PROFILING 审中-公开
    早期检测使用代谢物轮廓的乳腺癌

    公开(公告)号:WO2011119772A1

    公开(公告)日:2011-09-29

    申请号:PCT/US2011/029681

    申请日:2011-03-23

    IPC分类号: G01N33/50

    摘要: A monitoring test for recurrent breast cancer with a high degree of sensitivity and specificity is provided that detects the presence of a panel of multiplicity of biomarkers that were identified using metabolite profiling methods. The test is capable of detecting breast cancer recurrence about a years earlier than current available monitoring diagnostic tests. The panel of biomarkers is identified using a combination of nuclear magnetic resonance (NMR) and two dimensional gas chromatography-mass spectrometry (GCxGC-MS) to produce the metabolite profiles of serum samples. The NMR and GCxGC-MS data are analyzed by multivariate statistical methods to compare identified metabolite signals between samples from patients with recurrence of breast cancer and those from patients having no evidence of disease.

    摘要翻译: 提供具有高灵敏度和特异性的复发性乳腺癌的监测测试,其检测使用代谢物分析方法鉴定的多个生物标志物的存在。 该测试能够比当前可用的监测诊断测试早一年检测乳腺癌复发。 使用核磁共振(NMR)和二维气相色谱 - 质谱(GCxGC-MS)的组合鉴定生物标志物组,以产生血清样品的代谢物谱。 通过多变量统计学方法分析NMR和GCxGC-MS数据,以比较乳腺癌复发患者和无疾病证据患者的样本之间的鉴定代谢信号。

    LAB-ON-VALVE ANALYTICAL SYSTEM
    5.
    发明申请
    LAB-ON-VALVE ANALYTICAL SYSTEM 审中-公开
    LAB-ON-VALVE分析系统

    公开(公告)号:WO2011036622A3

    公开(公告)日:2011-08-04

    申请号:PCT/IB2010054245

    申请日:2010-09-20

    摘要: A lab-on-valve analytical system includes a rotary sample preparation assembly having a stator and a rotor. The rotor includes a plurality of integral syringe pumps which can be aligned with passages formed within the stator. The stator passages can be connected with fluid inlet connector which connect the sample preparation assembly with fluid sources, and fluid outlet connectors which connect the sample preparation assembly with one or more wet chemical analytical devices. Some embodiments can include a mixer and optical sensor connected with the fluid outlets. One or more drive motors can be used to control simultaneous actuation of one or more of the syringe pumps, thereby providing for simultaneous delivery of metered volumes of fluid.

    摘要翻译: 实验室阀门分析系统包括具有定子和转子的旋转样品制备组件。 转子包括可与定子内形成的通道对准的多个整体式注射泵。 定子通道可以与将样品制备组件与流体源连接的流体入口连接器和将样品制备组件与一个或多个湿化学分析装置连接的流体出口连接器连接。 一些实施例可以包括与流体出口连接的混合器和光学传感器。 可以使用一个或多个驱动马达来控制一个或多个注射器泵的同时致动,由此提供计量体积的流体的同时输送。

    ANALYTICAL METHOD AND APPARATUS
    7.
    发明申请
    ANALYTICAL METHOD AND APPARATUS 审中-公开
    分析方法和装置

    公开(公告)号:WO2009079689A1

    公开(公告)日:2009-07-02

    申请号:PCT/AU2008/001864

    申请日:2008-12-18

    发明人: ROSS, Fraser John

    IPC分类号: G01N31/16 G01N33/18

    摘要: A method for determining the amount of a chemical species in a sample, in particular the amount of weak acid dissociable cyanide or total cyanide in a sample, and an apparatus for performing said method. The method comprises the steps of: i) treating the sample to liberate the chemical species into a gaseous stream; ii) directing the gaseous stream to a scrubber; iii) absorbing the chemical species into a scrubber solution; and iv) determining the amount of chemical species absorbed into the scrubber solution, wherein any remaining chemical species not absorbed into the scrubber solution is directed or recirculated to the scrubber in the gaseous stream and step iii) is repeated to increase absorption of the chemical species prior to performing step iv).

    摘要翻译: 用于确定样品中化学物质的量的方法,特别是样品中弱酸可离解氰化物或总氰化物的量以及用于执行所述方法的装置。 该方法包括以下步骤:i)处理样品以将化学物质释放成气流; ii)将气流引导至洗涤器; iii)将化学物质吸收到洗涤器溶液中; 以及iv)确定吸收到洗涤器溶液中的化学物质的量,其中未吸收到洗涤器溶液中的任何剩余化学物质被引导或再循环到气流中的洗涤器,并且重复步骤iii)以增加化学物质的吸收 在执行步骤iv)之前。