公开(公告)号：WO2022260764A2

公开(公告)日：2022-12-15

申请号：PCT/US2022/025724

申请日：2022-04-21

Applicant: NORTHWESTERN UNIVERSITY ,  WILLIAM MARSH RICE UNIVERSITY

Inventor： VEISEH, Omid ,  ROBINSON, Jacob ,  RIVNAY, Jonathan ,  HILTON, Isaac ,  FLEURY, Samantha T. ,  PARKER, Matthew C. ,  GOELL, Jacob H. ,  LI, Jing ,  WANG, Kaiyuan

IPC: A61M2205/3306 ,  A61M37/00 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1723 ,  C12N15/85 ,  C12N5/06

Abstract: An engineered cell expressing a therapeutic agent and a reporter agent, the engineered cell comprising a first transgene containing a light sensing DNA sequence encoding a light sensing protein, and a second transgene containing a calcium activated promoter, a therapeutic agent DNA encoding a therapeutic agent, and a reporter agent DNA encoding a reporter agent.

公开(公告)号：WO2021091804A8

公开(公告)日：2021-05-14

申请号：PCT/US2020/058462

申请日：2020-11-02

Applicant: MEDTRONIC, INC.

Inventor： BODNER, Jeffrey P.

IPC: A61M39/00 ,  A61M2025/006 ,  A61M2025/0073 ,  A61M2039/0009 ,  A61M2039/0273 ,  A61M2039/0276 ,  A61M2039/0282 ,  A61M25/0021 ,  A61M25/007 ,  A61M39/02 ,  A61M39/0247 ,  A61M5/14276

Abstract: A medical device configured to restrict medicament dispersion within a cerebrospinal fluid flow of the patient. The medical device including an implantable catheter having a distal end configured to be positioned within a flow of the cerebrospinal fluid, a proximal end, a body defining a lumen extending lengthwise along the implantable catheter configured to enable a flow of medicament from the proximal end to an infusion port located in proximity to the distal end, and a contoured surface defined by an exterior of the body in proximity to the infusion port configured to inhibit dispersion of the medicament within the cerebrospinal fluid.

公开(公告)号：WO2021250589A1

公开(公告)日：2021-12-16

申请号：PCT/IB2021/055066

申请日：2021-06-09

Applicant: STEVANATO GROUP S.P.A.

Inventor： CALASSO, Irio ,  DE DONATIS, Matteo ,  TROES, Nadine

IPC: A61L2/08 ,  A61M5/00 ,  A61M39/00 ,  A61L2/10 ,  A61M2005/3114 ,  A61M2207/10 ,  A61M2209/045 ,  A61M2209/10 ,  A61M5/14248 ,  A61M5/14276 ,  A61M5/24

Abstract: An apparatus (4) for sterilizing and assembling a cartridge (8) containing a medical substance to a device (12) for dispensing said medical substance, comprising: a cartridge (8) containing the medical substance to be dispensed, the cartridge being provided with a cap (24), a device (12) for dispensing said medical substance, the device being provided with at least one needle (28) configured to pierce the cap (24) of the cartridge (8) and allow the withdrawal of the medical substance from the cartridge (8), a first interface (32) that may be sealingly joined to the cap (24) of the cartridge (8) by means of the interposition of a first gasket (36), a second interface (40) joined to the dispensing device (12) near said needle (28), wherein the second interface (40) has a seal (44) that isolates the needle (28) from the external environment in a sterile volume (48), and is provided with a second gasket (52) which may be sealingly joined to the first interface (32) in order to identify a sealed chamber (56) delimited between a portion of the cap (24) facing said needle (28) and said seal (44), the second gasket (52) being external to said sterile volume (48), and a sterilizing device (80) configured to irradiate and sterilize said sealed chamber (56).

公开(公告)号：WO2021097403A1

公开(公告)日：2021-05-20

申请号：PCT/US2020/060673

申请日：2020-11-16

Applicant: CARDIAC ASSIST HOLDINGS, LLC

Inventor： GELLMAN, Barry, N. ,  KANTROWITZ, Allen, B. ,  DASSE, Kurt, A.

IPC: A61M1/00 ,  A61B5/00 ,  A61B5/053 ,  A61F13/02 ,  A61B2562/029 ,  A61B5/445 ,  A61F13/00051 ,  A61F13/00068 ,  A61F13/0206 ,  A61F13/0216 ,  A61M1/964 ,  A61M1/966 ,  A61M2205/3317 ,  A61M2205/3592 ,  A61M39/0247 ,  A61M5/14276 ,  A61M60/861

Abstract: Percutaneous access devices (PAD), bandages, or other implantable medical devices are provided that are equipped with filters, environmental controls, and sensors that promote the formation of a natural biologic seal between the skin and the device to form a barrier to microbial invasion into the body. Levels of humidity and pressure are monitored and dynamically controlled to optimize wound closure about an implanted device or when a PAD is not present a wound itself. Methods and systems for actively assessing wound closure are incorporated into the design of percutaneous skin access devices (PAD), bone anchors, or a wound dressing or bandage alone without at PAD. Pressure and humidity sensors provide active feedback for making changes to the ecology of the wound site or PAD insertion site. A filter is used to aerate the wound while also preventing pathogens in the ambient air from reaching the wound.

公开(公告)号：WO2023031065A2

公开(公告)日：2023-03-09

申请号：PCT/EP2022/073859

申请日：2022-08-26

Applicant: MEDICALTREE PATENTS LTD.

Inventor： FORSELL, Peter

IPC: A61M5/142 ,  A61M5/158 ,  A61M5/162 ,  A61M2005/14284 ,  A61M2039/0223 ,  A61M2205/0205 ,  A61M2205/04 ,  A61M2205/3584 ,  A61M2205/582 ,  A61M2205/8206 ,  A61M2205/8243 ,  A61M2209/01 ,  A61M5/1413 ,  A61M5/14276

Abstract: The present disclosure relates to an at least partly implantable system for injecting a substance into a patient's body, comprising: - a housing adapted for implantation inside the patient's body, the housing having an outer wall with a penetration area, - at least one infusion needle disposed in the housing, and - a drive unit arranged for advancing and retracting the at least one infusion needle in opposite advancing and retracting directions so that a tip end of the at least one infusion needle penetrates, upon advancement of the at least one infusion needle, said penetration area so as to allow for injecting the substance through said penetration area via the at least one infusion needle.

公开(公告)号：WO2023031062A2

公开(公告)日：2023-03-09

申请号：PCT/EP2022/073856

申请日：2022-08-26

Applicant: MEDICALTREE PATENTS LTD

Inventor： FORSELL, Peter

IPC: A61M5/142 ,  A61M5/158 ,  A61M5/162 ,  A61F2/26 ,  A61M2005/14284 ,  A61M2005/1583 ,  A61M2005/1585 ,  A61M2205/04 ,  A61M2205/3515 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/8243 ,  A61M2210/167 ,  A61M5/1409 ,  A61M5/14276 ,  A61M5/3291 ,  A61M5/3298

Abstract: The present disclosure relates to an at least partly implantable system for injecting a substance into a patient's body, comprising: - a housing adapted for implantation inside the patient's body, the housing having an outer wall with a penetration area, - at least one infusion needle disposed in the housing, and - a drive unit arranged for advancing and retracting the at least one infusion needle in opposite advancing and retracting directions so that a tip end of the at least one infusion needle penetrates, upon advancement of the at least one infusion needle, said penetration area so as to allow for injecting the substance through said penetration area via the at least one infusion needle.