公开(公告)号：WO2013160670A1

公开(公告)日：2013-10-31

申请号：PCT/GB2013/051030

申请日：2013-04-24

Applicant: THE UNIVERSITY OF SUSSEX

Inventor： MOORE, Anthony Lennox ,  ALBURY, Mary Susan ,  YOUNG, Luke Edward ,  ELLIOTT, Catherine

IPC: C07C39/24 ,  A01N35/04 ,  A61K31/11 ,  C07C69/63 ,  C07C39/373 ,  C07C43/178 ,  C07C47/565 ,  C07C49/835 ,  A61P31/04 ,  A61P31/10 ,  C07C255/53 ,  C07C235/60 ,  A01N49/00

CPC classification number: C07C255/53 ,  A01N31/16 ,  A01N35/04 ,  A01N37/02 ,  A01N37/24 ,  A01N37/34 ,  A01N37/40 ,  A01N37/44 ,  A01N49/00 ,  A01N63/04 ,  A61K31/055 ,  A61K31/085 ,  A61K31/11 ,  A61K31/12 ,  A61K31/166 ,  A61K31/222 ,  A61K31/277 ,  C07C39/245 ,  C07C39/373 ,  C07C43/1787 ,  C07C43/23 ,  C07C47/565 ,  C07C49/835 ,  C07C65/28 ,  C07C69/157 ,  C07C69/18 ,  C07C69/21 ,  C07C69/63 ,  C07C69/84 ,  C07C235/60 ,  Y02A50/409

Abstract: The invention provides compounds for use in inhibiting a microbial alternative oxidase (AOX) and/or cytochrome bc 1 complex. The invention extends to the use of such inhibitors in agrochemicals and in pharmaceuticals, for treating microbial infections, including fungal infections.

Abstract translation: 本发明提供了用于抑制微生物替代氧化酶（AOX）和/或细胞色素bc1复合物的化合物。 本发明延伸到这样的抑制剂在农业化学品和药物中的用途，用于治疗微生物感染，包括真菌感染。

公开(公告)号：WO0213764A3

公开(公告)日：2002-07-25

申请号：PCT/US0125466

申请日：2001-08-15

Applicant: UNIV NORTHEASTERN OHIO ,  UNIV KENT STATE OHIO ,  DOCHERTY JOHN ,  TSAI CHUN-CHE

Inventor： DOCHERTY JOHN ,  TSAI CHUN-CHE

IPC: A61P31/04 ,  A61K31/045 ,  A61K31/047 ,  A61K31/05 ,  A61P31/22 ,  C07C39/205 ,  C07C39/373

CPC classification number: A61K31/05

Abstract: The present invention provides a method of inhibiting the formation of infectious herpes virus particles, particularly infectious herpes simplex virus (HSV) particles, in a host cell. The method involves administering an effective amount of a hydroxylated tolan, particularly a polyhydroxylated tolan, to a herpes virus infected host cell. The present invention also provides a method of treating a herpes virus infection, particularly an HSV infection. The method comprises administering a topical composition comprising a therapeutically effective amount of a hydroxylated tolan to a herpes virus-infected site. The present invention also relates to a topical composition for treating a herpes virus infection selected from the group consisting of an HSV infection, a cytomegalovirus infection, and a varicella zoster virus infection. The present invention also provides a method of treating a subject infected with Neisseria gonorrhea.

Abstract translation: 本发明提供在宿主细胞中抑制感染性疱疹病毒颗粒，特别是感染性单纯疱疹病毒（HSV）颗粒的形成的方法。 该方法包括给疱疹病毒感染的宿主细胞施用有效量的羟基化的to lan，特别是多羟基化的to。。 本发明还提供治疗疱疹病毒感染，特别是HSV感染的方法。 该方法包括给疱疹病毒感染部位施用包含治疗有效量的羟基化to。的局部组合物。 本发明还涉及用于治疗选自HSV感染，巨细胞病毒感染和水痘带状疱疹病毒感染的疱疹病毒感染的局部组合物。 本发明还提供了治疗感染淋病奈瑟氏球菌的受试者的方法。

公开(公告)号：WO99000346A1

公开(公告)日：1999-01-07

申请号：PCT/US1998/013265

申请日：1998-06-26

IPC: A61P25/22 ,  A61K31/05 ,  A61K31/055 ,  A61K31/085 ,  A61K31/121 ,  A61K31/192 ,  A61P25/24 ,  C07C39/15 ,  C07C39/21 ,  C07C39/367 ,  C07C39/373 ,  C07C59/52 ,  C07C59/56 ,  C07C63/70

CPC classification number: C07C39/21

Abstract: The synthesis and use of the anxiolytic compound dihydrohonokiol, its derivatives, analogs and homologs are disclosed. A method for reducing anxiety in a mammal is also disclosed.

Abstract translation: 公开了抗焦虑化合物二氢胡酮醇及其衍生物，类似物和同系物的合成和应用。 还公开了一种减轻哺乳动物焦虑的方法。

公开(公告)号：WO2023043197A1

公开(公告)日：2023-03-23

申请号：PCT/KR2022/013736

申请日：2022-09-14

Applicant: 강원대학교 산학협력단

Inventor： 이구연

IPC: C07C39/23 ,  C07C39/373 ,  C07C323/16 ,  C07C323/18 ,  C07C245/08 ,  C07C255/33 ,  C07C205/16 ,  C07C311/29 ,  C07C329/06 ,  C07C43/23

Abstract: 본 발명은 카나비디올 유도체, 이의 제조방법 및 이를 포함하는 인지기능 개선용 조성물을 제공한다. 본 발명의 신규한 카나바디올 유도체는 아세틸콜린에스테라제 저해 효능 및 부틸릴콜린에스테라제 저해 효능뿐만 아니라 모노아민 옥시다아제 B에 대한 저해 효능을 나타내는 것으로 확인되어, 치매 환자들에게서 나타나는 뇌조직 내의 아세틸콜린 수준 저하 및 혈중 부티릴콜린 수준 저하를 동시에 달성할 수 있고, 뇌세포 손상을 막음으로써 보다 효과적인 인지기능 개선 치료 효과를 기대할 수 있다. 따라서, 본 발명의 카나비디올 유도체, 이의 제조방법, 및 이를 유효성분으로 포함하는 인지기능 개선용 조성물은 아세틸콜린에스테라제, 부티릴콜린에스테라제 및 모노아민 옥시다아제 B를 동시에 저해하는 물질로 의약 및 건강기능식품 분야에서 인지기능 개선 물질로서 유용하게 사용될 수 있다.

公开(公告)号：WO2008124878A1

公开(公告)日：2008-10-23

申请号：PCT/AU2008/000519

申请日：2008-04-14

Applicant: CRYPTOPHARMA PTY LTD ,  STEWART, Alastair ,  BANWELL, Martin ,  LEUNG, Brenda ,  AUGUSTINE, Anu ,  KITCHING, Jacki ,  BILSKI, Tomasz

Inventor： STEWART, Alastair ,  BANWELL, Martin ,  LEUNG, Brenda ,  AUGUSTINE, Anu ,  KITCHING, Jacki ,  BILSKI, Tomasz

IPC: C07C15/12 ,  C07C13/465 ,  C07C205/20 ,  A61K31/015 ,  C07C13/48 ,  C07C251/32 ,  A61K31/025 ,  C07C13/66 ,  C07C251/52 ,  A61K31/04 ,  C07C22/06 ,  C07C251/54 ,  A61K31/15 ,  C07C25/18 ,  C07C251/56 ,  A61K31/36 ,  C07C39/18 ,  C07C251/86 ,  A61K31/365 ,  C07C39/21 ,  C07D231/56 ,  A61K31/416 ,  C07C39/23 ,  C07D271/12 ,  A61P11/06 ,  C07C39/373 ,  C07D317/50 ,  A61P43/00 ,  C07C205/06 ,  C07J41/00 ,  C07C13/19 ,  C07C205/11

CPC classification number: C07C45/68 ,  C07C45/298 ,  C07C45/30 ,  C07C45/59 ,  C07C45/63 ,  C07C45/673 ,  C07C45/71 ,  C07C47/575 ,  C07C49/753 ,  C07C49/84 ,  C07C251/32 ,  C07C251/52 ,  C07C251/54 ,  C07C251/56 ,  C07C251/86 ,  C07D231/56 ,  C07D271/12 ,  C07D317/58

Abstract: The present invention relates to non-steroidal compounds useful in the treatment of inflammatory conditions and pharmaceutical compositions comprising them. A representative example of these compounds is formula (III).

Abstract translation: 本发明涉及用于治疗炎性病症的非甾体化合物和包含它们的药物组合物。 这些化合物的代表性实例是式（III）。

公开(公告)号：WO2004041758A8

公开(公告)日：2005-09-29

申请号：PCT/CA0301692

申请日：2003-11-04

Applicant: INST NAT SANTE RECH MED ,  CASPER ROBERT F ,  SAVOURET JEAN-FRANCOIS ,  POIROT MARC ,  DE MEDINA PHILIPPE

Inventor： CASPER ROBERT F ,  SAVOURET JEAN-FRANCOIS ,  POIROT MARC ,  DE MEDINA PHILIPPE

IPC: A23L29/00 ,  A24D3/14 ,  A61K31/035 ,  A61K31/05 ,  A61K31/055 ,  A61P17/00 ,  A61P19/10 ,  A61P31/12 ,  A61P31/18 ,  C07C22/08 ,  C07C25/24 ,  C07C25/28 ,  C07C39/21 ,  C07C39/215 ,  C07C39/373 ,  C07C43/215 ,  C07C43/225 ,  C07C43/23 ,  A23L1/03

CPC classification number: C07C43/215 ,  C07C22/08 ,  C07C25/24 ,  C07C39/215 ,  C07C43/225

Abstract: The invention relate to stilbene derivatives having formula (I): wherein R3, R4 and R5 and R3', R4' and R5' are identical or different and represent H, OH, O-alkoxy or hal, said alkoxy group being a C1-C6 alkoxy and "hal" being F, C1 or CF3, with the proviso that one of R4', R3 and R5 or R4, R3' and R5' does not represent OH, OCH3 or OCH2 CH3 when the two other substituents are both OH, OCH3, OCH2CH3, respectively, and the symmetrical derivatives. Use of said stilbene derivatives particularly as pharmaceutical compositions and food additives.

Abstract translation: 本发明涉及具有式（I）的二苯乙烯衍生物：其中R3，R4和R5以及R3'，R4'和R5'相同或不同，代表H，OH，O-烷氧基或卤素，所述烷氧基是C1- C6烷氧基和“hal”是F，C1或CF3，条件是当两个其它取代基都是OH时，R 4'，R 3和R 5或R 4，R 3'和R 5'中的一个不表示OH，OCH 3或OCH 2 CH 3 ，OCH3，OCH2CH3和对称衍生物。 所述1,2-二苯乙烯衍生物特别用作药物组合物和食品添加剂。

公开(公告)号：WO99013714A1

公开(公告)日：1999-03-25

申请号：PCT/US1998/019447

申请日：1998-09-15

IPC: A61K31/05 ,  A61K31/165 ,  A61K31/275 ,  A61K31/655 ,  A61K31/69 ,  C07C39/373 ,  C07C235/56 ,  C07C245/08 ,  A01N29/10 ,  C07C39/20 ,  C07C233/77 ,  C07C255/53

CPC classification number: A61K31/69 ,  A61K31/05 ,  A61K31/165 ,  A61K31/275 ,  A61K31/655 ,  C07C39/373 ,  C07C235/56 ,  C07C245/08

Abstract: The present invention provides azo and stilbene compounds having structure (I): wherein XY is N=N, CH=CH, (C=O)-NH or NH-(C=O); wherein Z is CR6 or N; wherein R1, R2 and R5 are independently hydrogen, halogen, NO2 or CF3; wherein R3 is hydrogen, halogen, CF3, aryl or heteroaryl, NO2 or OCF3; wherein R4 is hydrogen, halogen, CF3, aryl or heteroaryl, NO2 or linear or branched chain alkoxy; wherein R6 is hydrogen or linear or branched alkyl; wherein R7 is hydrogen, cyano, hydroxyalkyl, carboxyl, halogen, hydroxyl, formyl, NO2 or halogen; and wherein R8 is hydroxyl or substituted or unsubstituted amino; and wherein R9 and R10 are independently hydrogen, CN or hydroxyalkyl. Said compounds are useful as antifungal therapeutics, fungicides and fungistats. The present invention also provides methods of inhibiting fungal RNA transcription and treating fungal infections in human and animal subjects and fungal infestations in plants.

Abstract translation: 本发明提供具有结构（I）的偶氮和二苯乙烯化合物：其中XY是N = N，CH = CH，（C = O）-NH或NH-（C = O）; 其中Z为CR 6或N; 其中R1，R2和R5独立地是氢，卤素，NO2或CF3; 其中R 3是氢，卤素，CF 3，芳基或杂芳基，NO 2或OCF 3; 其中R4是氢，卤素，CF3，芳基或杂芳基，NO2或直链或支链烷氧基; 其中R6是氢或直链或支链烷基; 其中R 7是氢，氰基，羟基烷基，羧基，卤素，羟基，甲酰基，NO 2或卤素; 并且其中R8是羟基或取代或未取代的氨基; 并且其中R 9和R 10独立地为氢，CN或羟烷基。 所述化合物可用作抗真菌治疗剂，杀真菌剂和真菌剂。 本发明还提供抑制真菌RNA转录和治疗人和动物受试者的真菌感染和植物真菌感染的方法。

公开(公告)号：WO2018132445A1

公开(公告)日：2018-07-19

申请号：PCT/US2018/013120

申请日：2018-01-10

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY

Inventor： LASKOSKI, Matthew ,  KELLER, Teddy, M.

IPC: C07C2/86 ,  C07C15/54 ,  C07C37/62 ,  C07C39/373 ,  C07C303/28 ,  C07C309/65

CPC classification number: C07C2/868 ,  C07C37/62 ,  C07C303/28 ,  C07C2523/44 ,  C07C2523/72 ,  C07C2531/22 ,  C07C2531/24 ,  C07C39/245 ,  C07C15/54 ,  C07C309/66

Abstract: A method of: reacting a dihydroxybenzene with bromine to form a bromodihydroxybenzene; reacting the bromodihydroxybenzene with trifluoromethanesulfonyl chloride or trifluoromethanesulfonic anhydride to form a bromotrifluorometiianesulfonatobenzene; and reacting the bromotrifluoromethanesulfonatobenzene with phenyl acetylene to form a phenyl ethynylbenzene.

公开(公告)号：WO2018102667A1

公开(公告)日：2018-06-07

申请号：PCT/US2017/064185

申请日：2017-12-01

Applicant: ARKEMA INC.

Inventor： SMITH, Gary S. ,  WANG, Lijuan ,  FORTMAN, George C.

IPC: C07C39/06 ,  C07C39/373 ,  C07C321/24 ,  H01M4/02 ,  H01M4/60 ,  H01M10/052

Abstract: Metal-sulfur batteries, such as lithium-sulfur batteries, are prepared using one or more organosulfur species such as organic polysulfides and organic polythiolates as part of the liquid or gel electrolyte solution, as part of the cathode, as part of the anode (or used to treat the anode), and/or as part of a functionalized porous polymer providing an intermediate separator element.

公开(公告)号：WO2012087289A1

公开(公告)日：2012-06-28

申请号：PCT/US2010/061428

申请日：2010-12-21

Applicant: COLGATE-PALMOLIVE COMPANY ,  SUBRAMANYAM, Ravi ,  XU, Guofeng ,  GRONLUND, Jennifer ,  ANSARI, Shamim

Inventor： SUBRAMANYAM, Ravi ,  XU, Guofeng ,  GRONLUND, Jennifer ,  ANSARI, Shamim

IPC: C07C39/373 ,  A61K31/055 ,  A61P17/10 ,  A61P1/02 ,  A61K8/34 ,  A61Q11/00

CPC classification number: C07C39/373 ,  A61K8/347 ,  A61Q11/00 ,  A61Q19/06

Abstract: Described herein are compounds of Formula (I): or a salt thereof; wherein: R1 and R5 are independently selected from H, OH and alkoxy; R 2 -R 4 and R 6 -R 8 are independently selected from H, OH, F, Cl, Br, and I; R 9 and R 10 are independently selected from H, alkyl, alkenyl, alkynyl, and aryl; with the proviso that: at least one of R 1 and R 5 is OH or alkoxy; and at least one of R 2 -R 4 and R 6 -R 8 is F, Cl, Br or I; compositions comprising said compounds; and methods of making and using the same.

Abstract translation: 本文描述的是式（I）的化合物或其盐; 其中：R 1和R 5独立地选自H，OH和烷氧基; R2-R4和R6-R8独立地选自H，OH，F，Cl，Br和I; R 9和R 10独立地选自H，烷基，烯基，炔基和芳基; 条件是：R 1和R 5中的至少一个是OH或烷氧基; 并且R 2 -R 4和R 6 -R 8中的至少一个是F，Cl，Br或I; 包含所述化合物的组合物; 以及制作和使用它们的方法。