公开(公告)号：WO2023060233A1

公开(公告)日：2023-04-13

申请号：PCT/US2022/077760

申请日：2022-10-07

Applicant: AMICUS THERAPEUTICS, INC. ,  SANFORD HEALTH

Inventor： BRUDVIG, Jon ,  WEINER, Jill ,  JOHNSON, Tyler ,  CAIN, Jacob ,  TIMM, Derek

IPC: G01N33/68 ,  A61K48/00 ,  G01N33/92 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2227/108 ,  A01K2267/03 ,  C07K14/47 ,  C12N9/00 ,  G01N2570/00 ,  G01N2800/04 ,  G01N2800/38 ,  G01N33/6893

Abstract: Methods of determining a disease score of a patient diagnosed with lysosomal storage disease (LSD) are described. The disease score includes one or more of the following: (i) one or more biofluid biomarkers; (ii) one or more neurophysiological measurements; and (iii) one or more neurobehavior measurement. Also described method of treating LSD including determining the disease score and administering to the patient a therapy. The therapy includes one or more of the following: (i) enzyme replacement therapy, (ii) gene therapy; and (iii) a small molecule.

公开(公告)号：WO2020205626A1

公开(公告)日：2020-10-08

申请号：PCT/US2020/025471

申请日：2020-03-27

Applicant: GENENTECH, INC. ,  F. HOFFMANN-LA ROCHE AG

Inventor： MARTINEZ-MARTIN, Nadia ,  TURLEY, Shannon, J. ,  VERSCHUEREN, Erik

IPC: G01N33/574 ,  A61K39/00 ,  A61K39/395 ,  C07K14/705 ,  C12N5/071 ,  C12Q1/6886 ,  A61K2039/505 ,  A61K39/0011 ,  C07K14/70532 ,  C07K14/70596 ,  C07K16/2827 ,  C07K2317/24 ,  C07K2317/76 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N2500/02 ,  G01N2570/00 ,  G01N2800/52

Abstract: Provided herein are methods for identifying modulators of cell surface protein interactions and activities, as well as modulators of cell surface protein interactions and activities.

公开(公告)号：WO2022009142A2

公开(公告)日：2022-01-13

申请号：PCT/IB2021/056136

申请日：2021-07-08

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.

Inventor： KRAVCHENKO-BALASHA, Nataly

IPC: G01N33/574 ,  A61P35/00 ,  C12Q1/68 ,  C40B30/04 ,  A61K31/4427 ,  A61K31/439 ,  A61K31/497 ,  A61K31/7084 ,  G01N2570/00 ,  G16B20/00 ,  G16B25/10 ,  G16B5/00

Abstract: Methods of determining a therapy for a solid cancer comprising thermodynamic-based analysis of single-cell proteomic data from tumor-derived cells are provided. Methods for determining a combination therapy comprising thermodynamic-based analysis of single cell proteomic data from tumor-derived cells that have received a first therapy are also provided. Methods of treating a subject suffering from triple-negative breast cancer, comprising administering radiotherapy, anti-Her2 therapy and anti-cMet therapy are also provided.

公开(公告)号：WO2021127607A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/066275

申请日：2020-12-19

Applicant: ADEPTRIX CORP.

Inventor： BERGO, Vladislav, B.

IPC: G01N33/543 ,  G01N33/68 ,  G01N2440/00 ,  G01N2570/00 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/6845 ,  G01N33/6848 ,  G01N33/6878

Abstract: Bead-based assays for measuring protein biomarkers of proteolytic activity in biological systems are disclosed. In an embodiment, an assay involves incubating a sample containing multiple fragments of a naturally occurring protein with a bead array and subsequently analyzing individual reactive sites of the bead array by mass spectrometry.

公开(公告)号：WO2022015925A1

公开(公告)日：2022-01-20

申请号：PCT/US2021/041741

申请日：2021-07-15

Applicant: 13.8, INC.

Inventor： FAN, Hei Mun Christina ,  FODOR, Stephen P.A.

IPC: C07K1/13 ,  C40B20/04 ,  C40B30/04 ,  C40B40/04 ,  G01N1/28 ,  G01N33/543 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6834 ,  C12Q1/6841 ,  G01N2458/10 ,  G01N2570/00 ,  G01N33/5308 ,  G01N33/54326

Abstract: The invention(s) cover a composition, where units of the composition are configured to interact with each other (e.g., as neighbors) in order enable decoding of positions of captured target material relative to neighboring units of the composition. In embodiments, the composition includes: a body; and a set of molecules coupled to the body, the set of molecules comprising a first subset and a second subset, wherein the first subset is structured for target analyte capture, and wherein the second subset is structured for interactions with one or more neighboring objects. The invention(s) also cover systems incorporating one or more units of the composition and methods implementing units of the composition.

公开(公告)号：WO2021256710A1

公开(公告)日：2021-12-23

申请号：PCT/KR2021/006230

申请日：2021-05-18

Applicant: 부산대학교 산학협력단

Inventor： 정진

IPC: G01N33/569 ,  C12Q1/689 ,  C12Q2600/158 ,  G01N2570/00 ,  G01N2800/2821 ,  G01N33/56911

Abstract: 본 발명은 구강 미생물(oral microbiome)을 활용하여 알츠하이머의 위험도 예측 또는 진단을 위한 바이오마커 및 이를 이용한 알츠하이머 예측 또는 진단하는 용도에 관한 것이다.

公开(公告)号：WO2020014586A1

公开(公告)日：2020-01-16

申请号：PCT/US2019/041562

申请日：2019-07-12

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： MARCOTTE, Edward ,  SWAMINATHAN, Jagannath ,  ELLINGTON, Andrew ,  BOULGAKOV, Alexander ,  LAURENT, Jon ,  SHROFF, Raghav ,  XIONG, Erhu ,  BHADRA, Sanchita ,  ANSLYN, Eric ,  FLOYD, Brendan

IPC: C12N15/10 ,  C12Q1/6855 ,  G01N33/68 ,  C12N15/1065 ,  C12Q1/6806 ,  G01N2458/00 ,  G01N2570/00 ,  G01N33/6812 ,  G01N33/6818 ,  G16B15/00

Abstract: The present disclosure provides methods for molecular neighborhood detection of molecules, such as by iterative proximity ligation or split-and-pool methods for obtaining positional information.

公开(公告)号：WO2022226427A2

公开(公告)日：2022-10-27

申请号：PCT/US2022/026231

申请日：2022-04-25

Applicant: DUKE UNIVERSITY ,  METABOLOMICS LABORATORY ,  METABOLOMICS LABORATORY, BAKER HEART & DIABETES INSTITUTE ,  UNIVERSITY OF TX HEALTH CENTER AT SAN ANTONIO ,  UNIVERSITY OF TEXAS HEALTH CENTER AT SAN ANTONIO ,  INDIANA, University ,  INDIANA ALZHEIMER DISEASE CENTER AND DEPT. OF RADIOLOGY AND IMAGING SCIENCES ,  SUNY DOWNSTATE MEDICAL CENTER ,  INSTITUTE FOR SYSTEMS BIOLOGY ,  INSTITUTE OF COMPUTATIONAL BIOLOGY ,  HELMHOLTZ ZENTRUM MUNCHEN - GERMAN RESEARCH CENTER FOR ENVIRONMENTAL HEALTH ,  KADDURAH-DAOUK, Rima ,  LOUIE, Gregory ,  ARNOLD, Matthias ,  BAILLE, Rebecca ,  MEIKLE, Peter ,  HAN, Xianlin ,  SAYKIN, Andrew ,  NHO NHO, Kwangsik ,  MORENO, Herman, W. ,  FUNK, Cory ,  BALONI, Priyanka ,  KASTENMUELLER, Gabi

Inventor： LOUIE, Gregory ,  ARNOLD, Matthias ,  BAILLE, Rebecca ,  MEIKLE, Peter ,  HAN, Xianlin ,  SAYKIN, Andrew ,  NHO NHO, Kwangsik ,  MORENO, Herman, W.

IPC: C12Q1/68 ,  A61K31/164 ,  A61P25/28 ,  G01N33/92 ,  A61B6/037 ,  A61B6/501 ,  A61B6/5205 ,  A61B6/5217 ,  A61P25/00 ,  G01J3/00 ,  G01N2570/00 ,  G01N2800/50 ,  G01N2800/56 ,  G01N33/6896 ,  G16B20/00 ,  G16H30/00

Abstract: Lipids, including sphingomyelins (SMs), have been shown to be disrupted in Alzheimer's disease (AD). The impacts of lipid alterations on AD pathogenesis are not fully understood. What is needed are methods for assessing and modulating the levels of novel biological targets, such as ceramide and sphingomyelin, in neurological disorders such as AD, Parkinson's Disease, and multiple sclerosis. Described herein are compositions and methods for assessing and modulating ceramide and sphingomyelin in neurological disorders.

公开(公告)号：WO2021150558A1

公开(公告)日：2021-07-29

申请号：PCT/US2021/014111

申请日：2021-01-20

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： ZHAO, Yiming ,  CHEN, Hunter ,  WANG, Shao-Chun ,  RIEHLMAN, Timothy ,  CARREAU, Gabriel ,  WANG, Ying

IPC: G01N33/58 ,  C07K1/26 ,  G01N33/68 ,  G01N2400/00 ,  G01N2440/38 ,  G01N2570/00 ,  G01N27/44791 ,  G01N33/582 ,  G01N33/6842

Abstract: The disclosure relates to methods of analyzing a post-translationally modified protein of interest using electrophoresis, the methods comprising deglycosylating the protein of interest after labeling.

公开(公告)号：WO2021127532A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/066166

申请日：2020-12-18

Applicant: ADEPTRIX CORP.

Inventor： BERGO, Vladislav, B.

IPC: G01N33/68 ,  G01N33/72 ,  G01N2440/00 ,  G01N2570/00 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/6845 ,  G01N33/6848 ,  G01N33/6878

Abstract: Bead-based assays for measuring protein biomarkers of proteolytic activity in biological systems are disclosed. In an embodiment, an assay involves incubating a sample containing multiple fragments of a naturally occurring protein with a bead array and subsequently analyzing individual reactive sites of the bead array by mass spectrometry.