公开(公告)号：WO2023288299A1

公开(公告)日：2023-01-19

申请号：PCT/US2022/073769

申请日：2022-07-15

Applicant: FARBER PARTNERS, LLC

Inventor： OLSZEWSKI, Kellen ,  RABINOWITZ, Joshua, D. ,  KIM, Hahn

IPC: A61K31/045 ,  A61K39/395 ,  A61P35/00 ,  C07C41/00

Abstract: Provided herein are methods of using methanol, or a prodrug thereof, in therapy, e.g., for promoting an immune response, treating cancer, enhancing an immunotherapy and/or treating immune dysfunction. Also provided herein are methanol prodrugs of the following structural formula: Formula (I), or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., R, X, R2, n) are as described herein.

公开(公告)号：WO2022117071A1

公开(公告)日：2022-06-09

申请号：PCT/CN2021/135325

申请日：2021-12-03

Applicant: 福建海创医药科技有限公司

Inventor： 黄培培 ,  陈锦辉

IPC: C07C43/235 ,  C07C41/09 ,  C07C41/00

Abstract: 公开了一种从多羟基酚合成苄基醚的方法，其特征在于，所述方法包括在碱和催化剂的存在下，在添加水的有机溶剂中使所述多羟基酚与苄基化试剂反应，从而获得完全苄基化的苄基醚。公开的的方法简单，生产成本低，产物收率高，减少了溶剂的使用以及对环境造成的污染，从而在工业放大的过程中，易于实施。

公开(公告)号：WO2014082838A1

公开(公告)日：2014-06-05

申请号：PCT/EP2013/073400

申请日：2013-11-08

Applicant: EXXONMOBIL CHEMICAL PATENTS INC. ,  HAMILTON, Paul

Inventor： HAMILTON, Paul

IPC: C10G3/00 ,  C07C41/00 ,  C07C2/04

CPC classification number: C07C2/08 ,  C07C7/10 ,  C10G3/00 ,  Y02P30/20 ,  C07C11/02 ,  C07C11/06

Abstract: Embodiments disclosed herein relate to a process for the oligomerization of olefins, the process including at least one olefin feedstream that includes ammonia and contacting the at least one olefin feedstream with a liquid including alkaline water to remove at least a portion of the ammonia to produce at least one treated olefin feedstream and subsequently contacting the at least one treated olefin feedstream with a catalyst under oligomerization conditions to produce an oligomer product. In several embodiments disclosed herein, the at least one olefin feedstream includes one or more C 3 -C 15 olefins, preferably, C 3 -C 5 olefins, any isomer thereof, one or more paraffins having the same or different carbon number as the olefins, and mixtures thereof.

Abstract translation: 本文公开的实施方案涉及烯烃低聚的方法，该方法包括至少一种包含氨的烯烃进料流，并使至少一种烯烃进料流与包含碱性水的液体接触以除去至少一部分氨以在 至少一种经处理的烯烃进料流，随后在低聚条件下使至少一种经处理的烯烃进料流与催化剂接触以产生低聚物产物。 在本文公开的几个实施方案中，至少一种烯烃进料流包括一种或多种C 3 -C 15烯烃，优选C 3 -C 5烯烃，其任何异构体，一种或多种具有与烯烃相同或不同碳数的链烷烃，及其混合物 。

公开(公告)号：WO2013025627A2

公开(公告)日：2013-02-21

申请号：PCT/US2012/050619

申请日：2012-08-13

Applicant: MCALISTER TECHNOLOGIES, LLC ,  MCALISTER, Roy, Edward

Inventor： MCALISTER, Roy, Edward

IPC: C10L1/02 ,  C07C31/00 ,  C07C1/02 ,  C07C2/00 ,  C07C41/00

CPC classification number: C10L1/02 ,  C07C1/0405 ,  C07C29/1518 ,  C10L1/023 ,  C10L2200/0492 ,  C10L2290/06 ,  C10L2290/26 ,  C10L2290/42 ,  Y02E50/18 ,  C07C9/04 ,  C07C31/04

Abstract: Techniques, systems, apparatus and material are disclosed for regeneration or recycling of carbon substances into renewable fuel and materials. In one aspect, a method of recycling carbon to produce a renewable fuel can include harvesting carbon donors, such as carbon dioxide (CO2), emitted from an agricultural process. Hydrogen donors, such as from biomass waste, can be dissociated under an anaerobic reaction to produce hydrogen. The harvested carbon dioxide can be reacted with the waste-produced hydrogen under pressure and temperature to generate a renewable fuel, such as methanol fuel.

Abstract translation: 公开了将碳物质再生或再循环到可再生燃料和材料中的技术，系统，装置和材料。 一方面，再循环碳以产生可再生燃料的方法可以包括从农业过程中收集碳供体，例如二氧化碳（CO 2）。 氢能供体，例如生物质废物，可以在厌氧反应下解离以产生氢。 收获的二氧化碳可以在压力和温度下与废物产生的氢气反应以产生可再生燃料，例如甲醇燃料。

公开(公告)号：WO2012138221A3

公开(公告)日：2012-11-22

申请号：PCT/NL2012050228

申请日：2012-04-05

Applicant: UNIV LEIDEN ,  LIPPITS MEINDERT JAN ,  NIEUWENHUIJS BERNARD EGBERT

Inventor： LIPPITS MEINDERT JAN ,  NIEUWENHUIJS BERNARD EGBERT

IPC: C07C1/24 ,  B01J23/66 ,  B01J23/78 ,  B01J23/83 ,  C07C11/04 ,  C07C41/00

CPC classification number: B01J23/66 ,  B01J21/04 ,  B01J23/78 ,  B01J23/83 ,  B01J35/0013 ,  B01J35/006 ,  B01J37/0205 ,  B01J37/035 ,  C07C1/24 ,  C07C41/09 ,  C07C213/04 ,  C07C2521/04 ,  C07C2523/04 ,  C07C2523/10 ,  C07C2523/52 ,  C07C2523/72 ,  C07D301/22 ,  Y02P20/52 ,  C07C11/04 ,  C07C215/08 ,  C07C43/06

Abstract: The invention is directed a process to prepare a catalyst composition comprising a gamma-alumina carrier, metal nano-particles, wherein the metal is selected from silver, copper or gold, and an additive selected from the group of an alkaline metal compound as present as an oxide or hydroxide of the alkaline metal wherein: in a first catalyst preparation step a gamma-alumina carrier is contacted with an aqueous solution comprising a salt of the alkaline metal in an impregnation step to obtain a loaded alumina carrier,and wherein the weight of alkaline metal as deposited on the alumina surface of the alumina carrier is greater than the weight of alkaline metal as present in the final catalyst composition, drying the loaded alumina carrier and subjecting the dried loaded alumina carrier to a calcination step, loading the silver, copper or gold metal to the calcined loaded carrier in a second catalyst preparation step by contacting with an aqueous solution of a silver, copper or gold metal salt and drying to obtain the catalyst.

Abstract translation: 本发明涉及一种制备包含γ-氧化铝载体，金属纳米颗粒的催化剂组合物的方法，其中金属选自银，铜或金，以及添加剂，其选自碱金属化合物，如 碱金属的氧化物或氢氧化物，其中：在第一催化剂制备步骤中，在浸渍步骤中将γ-氧化铝载体与包含碱金属的盐的水溶液接触以获得负载的氧化铝载体，并且其中重量 沉积在氧化铝载体的氧化铝表面上的碱金属大于存在于最终催化剂组合物中的碱金属的重量，干燥负载的氧化铝载体并使干燥的负载氧化铝载体进行煅烧步骤，将银，铜 或金属金属通过与银，铜或金属金属的水溶液接触而在第二催化剂制备步骤中经煅烧负载的载体 盐并干燥得到催化剂。

公开(公告)号：WO2011098315A1

公开(公告)日：2011-08-18

申请号：PCT/EP2011/050320

申请日：2011-01-12

Applicant: EVONIK GOLDSCHMIDT GMBH ,  WENK, Hans Henning ,  KOTTKE, Ulrike ,  PONDER, Jennifer Beth

Inventor： WENK, Hans Henning ,  KOTTKE, Ulrike ,  PONDER, Jennifer Beth

IPC: D06M13/148 ,  C07C41/00 ,  C08G65/00 ,  D06M13/00

CPC classification number: D06M13/2243 ,  C07C41/09 ,  C07C67/08 ,  C08G65/34 ,  C08G65/48 ,  C08G2650/54 ,  D06M15/53 ,  D06M2200/50 ,  C07C43/135 ,  C07C69/33

Abstract: The present invention relates to polyglycerol partial esters of linear, unsubstituted carboxylic acids with the provisos that the polyglycerol obtained by hydrolysis or alcoholysis of the polyglycerol partial ester comprises an average degree of polymerization of from 2 to 8 and the polydispersity index of said polyglycerol is greater than 0.75.

Abstract translation: 本发明涉及线性，未取代的羧酸的聚甘油偏酯，条件是通过聚甘油偏酯的水解或醇解获得的聚甘油的平均聚合度为2至8，并且所述聚甘油的多分散指数更大 大于0.75。

公开(公告)号：WO2010044531A3

公开(公告)日：2010-06-17

申请号：PCT/KR2009002948

申请日：2009-06-03

Applicant: KOREA RES INST CHEM TECH ,  KCI LTD ,  HAN YOO HAN ,  KIM HYUNG ROK ,  HAN IN SUN ,  CHOI HYUN OUNG ,  KIM HYUN SIC ,  AN SO YOUNG ,  YOUN YOUNG HO

Inventor： HAN YOO HAN ,  KIM HYUNG ROK ,  HAN IN SUN ,  CHOI HYUN OUNG ,  KIM HYUN SIC ,  AN SO YOUNG ,  YOUN YOUNG HO

IPC: B01J21/00 ,  B01J23/02 ,  C07C41/00 ,  C07C43/10

CPC classification number: B01J23/02 ,  B01J23/002 ,  B01J35/002 ,  B01J37/031 ,  B01J2523/00 ,  C01F7/164 ,  C01F11/02 ,  C01P2002/72 ,  C07C41/09 ,  C08G65/34 ,  B01J2523/23 ,  B01J2523/31 ,  C07C43/135

Abstract: The present invention relates to a metal oxide catalyst represented by the following Formula 1, which is useful for the production of linear polyglycerol via etherification of glycerol, and a method for its preparation thereof: [Formula 1] (CaO)a?Ca12Al14O33)100-a wherein a refers to a weight ratio of CaO based on 100 parts by weight of the total catalyst. When the alkaline binary metal oxide catalyst according to the present invention is used in the glycerol etherification, it can produce a large amount of linear polyglycerol glycerol. Therefore, the metal oxide catalyst prepared according to the present invention can be effectively used in the production of polyglycerol suitable as cosmetic or food additives.

Abstract translation: 本发明涉及一种用于通过甘油醚化生产线性聚甘油的由下式1表示的金属氧化物催化剂及其制备方法：[式1]（CaO）a·Ca12Al14O33）100 -a其中a表示基于100重量份总催化剂的CaO的重量比。 当本发明的碱性二元金属氧化物催化剂用于甘油醚化时，可产生大量的线性聚甘油甘油。 因此，根据本发明制备的金属氧化物催化剂可以有效地用于生产适合作为化妆品或食品添加剂的聚甘油。

公开(公告)号：WO2008069980A1

公开(公告)日：2008-06-12

申请号：PCT/US2007/024664

申请日：2007-11-30

Applicant: E. I. DU PONT DE NEMOURS AND COMPANY ,  MANZER, Leo, Ernest ,  D'AMORE, Michael, B. ,  MILLER, Edward, S.

Inventor： MANZER, Leo, Ernest ,  D'AMORE, Michael, B. ,  MILLER, Edward, S.

IPC: C07C41/00 ,  C07C43/04 ,  B01J27/053 ,  C07C41/06 ,  C07B61/00

CPC classification number: C07C29/34 ,  C07C41/09 ,  C07C43/04 ,  C07C31/12

Abstract: The present invention relates to processes for making dibutyl ethers using aqueous ethanol optionally obtained from a fermentation broth. The dibutyl ethers so formed find use as additives for fuels, including transportation fuels.

Abstract translation: 本发明涉及使用任选从发酵液中获得的含水乙醇制备二丁基醚的方法。 如此形成的二丁醚可用作燃料的添加剂，包括运输燃料。

公开(公告)号：WO2004087061A3

公开(公告)日：2004-10-14

申请号：PCT/US2004/009417

申请日：2004-03-26

Applicant: OXIGENE, INC. ,  BAYLOR UNIVERSITY ,  PINNEY, Kevin, G. ,  MOCHARLA, Vani, P. ,  CHEN, Zhi ,  GARNER, Charles, M. ,  GHATAK, Anjan ,  HADIMANI, Mallinath ,  KESSLER, Jimmy ,  DORSEY, James, M. ,  EDVARDSON, Klaus ,  CHAPLIN, David, J. ,  PREZIOSO, Joseph ,  JELINEK, Christopher

Inventor： PINNEY, Kevin, G. ,  MOCHARLA, Vani, P. ,  CHEN, Zhi ,  GARNER, Charles, M. ,  GHATAK, Anjan ,  HADIMANI, Mallinath ,  KESSLER, Jimmy ,  DORSEY, James, M. ,  EDVARDSON, Klaus ,  CHAPLIN, David, J. ,  PREZIOSO, Joseph ,  JELINEK, Christopher

IPC: C07C41/00

Abstract: A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.

公开(公告)号：WO00023409A1

公开(公告)日：2000-04-27

申请号：PCT/US1999/024441

申请日：1999-10-15

IPC: C07C45/63 ,  C07C45/71 ,  C07C319/20 ,  C07C323/19 ,  C07D307/12 ,  C07D307/14 ,  C07D307/16 ,  C07C39/02 ,  C07C39/04 ,  C07C41/00 ,  C07C45/00 ,  C07C205/00 ,  C07D317/00 ,  C07D333/12 ,  C07D333/18 ,  C07D405/00

CPC classification number: C07D307/16 ,  C07C45/63 ,  C07C45/71 ,  C07C319/20 ,  C07C323/19 ,  C07D307/12 ,  C07D307/14 ,  C07C49/84

Abstract: A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (+/-)trans-2- [5-(N'-methyl- N'-hydroxyureidyl- methyl)-3-methoxy- 4-p-chlorophenylthioethoxyphenyl]- 5-(3,4,5- trimethoxyphenyl)- tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.

Abstract translation: 提供了合成二芳基取代的杂环化合物，特别是2,5-二芳基取代的四氢呋喃和四氢噻吩的方法。 也提供合成起始原料和中间体的方法。 本发明的重要应用是合成CMI-392，（+/-）反式-2- [5-（N'-甲基-N'-羟基脲基甲基）-3-甲氧基-4-对氯苯硫基乙氧基苯基 ] - 5-（3,4,5-三甲氧基苯基） - 四氢呋喃，一种治疗炎症和免疫疾病的高效药物。 本发明还包括可用作所公开的合成方法中的原料和中间体的新化合物。