The invention provides a control method of a cooling system and a vehicle. The control method of the cooling system comprises the steps that S1, the water temperature of an engine is determined; and S2, flow distribution of coolants in a bypass loop, a large circulation loop and an engine oil cooler loop is controlled according to the water temperature of the engine. According to the control method of the cooling system, oil consumption can be effectively reduced, emissions can be reduced, and taking comfort can be improved.