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公开(公告)号：EP3700907A1
公开(公告)日：2020-09-02
申请号：EP18785674.5
申请日：2018-10-18
发明人： KOPPITZ, Marcus , SIEBENEICHER, Holger , BRÄUER, Nico , POOK, Elisabeth , ROTGERI, Andrea , NEUHAUS, Roland , FISCHER, Oliver, Martin , NAGEL, Jens , DAVENPORT, Adam, James , CARR, James, Lindsay , TOWNSEND, Robert, James , CONNELLY URSINYOVA, Nina , PARROTT, Shelley, Anne
IPC分类号： C07D487/04 , A61P15/00 , A61P13/00 , A61K31/4985
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公开(公告)号：EP3083603A1
公开(公告)日：2016-10-26
申请号：EP14814837.2
申请日：2014-12-16
发明人： PETERS, Olaf , BRÄUER, Nico , BOTHE, Ulrich , KOPPITZ, Marcus , NAGEL, Jens , LANGER, Gernot
IPC分类号： C07D403/04 , A61K31/4184 , A61P5/00
CPC分类号： C07D403/04 , A61K45/06
摘要： The present invention relates to novel benzimidazole derivatives of the general formula (I), to methods for preparation thereof and to the use thereof for producing pharmaceutical compositions for treating disorders and indications associated with the EP4 receptor.
摘要翻译： 本发明涉及通式（I）的新型苯并咪唑衍生物，其制备方法及其用于制备用于治疗与EP4受体相关的疾病和适应症的药物组合物。
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">3.发明公开PHARMAZEUTISCHE ZUSAMMENSETZUNG UND DEREN VERWENDUNG SOWIE ANWENDUNGSREGIME DIESER PHARMAZEUTISCHEN ZUSAMMENSETZUNG ZUR BEDARFSWEISEN ( ON-DEMAND") KONTRAZEPTION 审中-公开药物组合物及其使用和本制度药物组合物，买家方式的应用（ON-DEMAND“）避孕
公开(公告)号：EP2999469A1
公开(公告)日：2016-03-30
申请号：EP14724746.4
申请日：2014-05-16
发明人： LINDENTHAL, Bernhard , BRÄUER, Nico , SERNO, Peter , ROTGERI, Andrea , FUHRMANN, Ulrike , BUCHMANN, Bernd , MENGEL, Anne , RÖHN, Ulrike , TER LAAK, Antonius
IPC分类号： A61K31/416 , A61K31/4439 , A61K31/505 , A61K31/5415 , A61P15/18
CPC分类号： A61K31/454 , A61K31/18 , A61K31/192 , A61K31/196 , A61K31/365 , A61K31/405 , A61K31/407 , A61K31/416 , A61K31/42 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/5415 , A61K31/542 , A61K31/635 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition for an on-demand non-hormonal contraception and to a method for producing said pharmaceutical composition. The composition contains 2H-indazoles as novel EP2 receptor antagonists in combination with COX inhibitors. The invention further relates to a method for the female-controlled on-demand non-hormonal contraception, wherein a pharmaceutical composition which contains EP2 receptor antagonists in combination with COX inhibitors is taken on-demand prior to an expected sexual intercourse.
摘要翻译： 本发明涉及一种用于按需以及制备该药用组合物处理非激素避孕的药物组合物。 后者包括2H-吲唑与COX抑制剂的组合新颖EP2受体拮抗剂。 本发明进一步更提供用于非激素女性控制点播避孕其中包括EP2受体拮抗剂与COX抑制剂的组合的药物组合物采取之前预期性交需求的方法。
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公开(公告)号：EP3458443B1
公开(公告)日：2020-08-19
申请号：EP17724498.5
申请日：2017-04-26
发明人： WERNER, Stefan , MESCH, Stefanie , CLEVE, Arwed , BRÄUER, Nico , HERBERT, Simon, Anthony , KOCH, Markus , DAHLLÖF, Henrik , OSMERS, Maren , HARDAKER, Elizabeth , LISHCHYNSKYI, Anton
IPC分类号： C07D213/85
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公开(公告)号：EP3307715A1
公开(公告)日：2018-04-18
申请号：EP16727209.5
申请日：2016-06-07
发明人： WERNER, Stefan , MESCH, Stefanie , BRÄUER, Nico , POOK, Elisabeth , DAHLLÖF, Henrik , NUBBEMEYER, Reinhard , OSMERS, Maren , KALTHOF, Bernd
IPC分类号： C07D213/71 , C07D213/75 , C07D309/06 , C07D213/84 , C07D309/08 , C07D309/12 , C07D317/64 , C07D319/12 , C07D319/18 , C07C303/38 , C07D231/18 , C07C303/40 , C07D231/20 , C07D333/32 , A61P29/00 , A61P25/04 , C07D233/22 , C07D333/48 , C07D233/60 , C07B59/00 , C07C311/17
CPC分类号： A61K31/5377 , A61K31/444 , A61K31/496 , C07B59/001 , C07B2200/05 , C07C235/84 , C07C311/17 , C07C311/46 , C07C317/22 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/12 , C07D207/24 , C07D207/27 , C07D211/40 , C07D211/42 , C07D211/46 , C07D213/46 , C07D213/56 , C07D213/61 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/71 , C07D213/75 , C07D213/84 , C07D231/18 , C07D231/20 , C07D233/22 , C07D233/60 , C07D239/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D263/24 , C07D265/32 , C07D277/24 , C07D295/096 , C07D295/185 , C07D295/192 , C07D305/06 , C07D305/08 , C07D307/12 , C07D307/77 , C07D307/79 , C07D309/06 , C07D309/08 , C07D309/12 , C07D317/64 , C07D319/12 , C07D319/18 , C07D333/32 , C07D333/48 , C07D401/10 , C07D413/10 , C07D417/04
摘要： Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.
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公开(公告)号：EP2928884A1
公开(公告)日：2015-10-14
申请号：EP13798684.0
申请日：2013-12-03
发明人： PETERS, Olaf , BRÄUER, Nico , BLUME, Thorsten , TER LAAK, Antonius , ZORN, Ludwig , NAGEL, Jens , KAULFUSS, Stefan , LANGER, Gernot , KUHNKE, Joachim
IPC分类号： C07D403/04 , A61K31/4184 , A61P5/00
CPC分类号： C07D471/04 , A61K31/4184 , A61K31/437 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14
摘要： The present invention relates to novel benzimidazole derivatives of the general formula (I), processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected with the receptor EP4.
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7.发明公开SUBSTITUTED PYRIDYL-CYCLOALKYL-CARBOXYLIC ACIDS, COMPOSITIONS CONTAINING THEM AND MEDICAL USES THEREOF 审中-公开取代的吡啶基 - 环烷基 - 羧酸，含有它们的组合物及其医疗用途
公开(公告)号：EP3233802A1
公开(公告)日：2017-10-25
申请号：EP15810650.0
申请日：2015-12-16
发明人： BRÄUER, Nico , NAGEL, Jens , IRLBACHER, Horst , ROTGERI, Andrea , SCHWEDE, Wolfgang , DAHLLÖF, Henrik , KOPPITZ, Marcus , PETERS, Michaele , GODINHO-COELHO, Anne-Marie
IPC分类号： C07D213/84 , C07D405/12 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , A61K31/4418 , A61P1/00 , A61P15/00 , A61P29/00
CPC分类号： A61K31/167 , A61K31/44 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/84 , C07D405/12
摘要： The present invention relates to substituted Pyridyl-cycloalkyl- carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.
摘要翻译： 本发明涉及通式（I）的取代的吡啶基 - 环烷基 - 羧酸，涉及包含所述化合物的药物组合物和组合以及涉及所述化合物在制备用于治疗或预防疾病的药物组合物中的用途，特别是 在哺乳动物中，例如与疼痛相关的疾病，或用于治疗或预防疼痛综合征（急性和慢性），炎性诱导疼痛，骨盆疼痛，癌症相关疼痛，子宫内膜异位症相关疼痛以及子宫内膜异位症和子宫腺肌病等 ，癌症本身以及像子宫内膜异位症那样的增殖性疾病。
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公开(公告)号：EP2928884B1
公开(公告)日：2017-05-24
申请号：EP13798684.0
申请日：2013-12-03
发明人： PETERS, Olaf , BRÄUER, Nico , BLUME, Thorsten , TER LAAK, Antonius , ZORN, Ludwig , NAGEL, Jens , KAULFUSS, Stefan , LANGER, Gernot , KUHNKE, Joachim
IPC分类号： C07D403/04 , A61K31/4184 , A61P5/00
CPC分类号： C07D471/04 , A61K31/4184 , A61K31/437 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14
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公开(公告)号：EP3458443A1
公开(公告)日：2019-03-27
申请号：EP17724498.5
申请日：2017-04-26
发明人： WERNER, Stefan , MESCH, Stefanie , CLEVE, Arwed , BRÄUER, Nico , HERBERT, Simon, Anthony , KOCH, Markus , DAHLLÖF, Henrik , OSMERS, Maren , HARDAKER, Elizabeth , LISHCHYNSKYI, Anton
IPC分类号： C07D213/85
摘要： Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.
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公开(公告)号：EP3083603B1
公开(公告)日：2017-09-13
申请号：EP14814837.2
申请日：2014-12-16
发明人： PETERS, Olaf , BRÄUER, Nico , BOTHE, Ulrich , KOPPITZ, Marcus , NAGEL, Jens , LANGER, Gernot
IPC分类号： C07D403/04 , A61K31/4184 , A61P5/00
CPC分类号： C07D403/04 , A61K45/06
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