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公开(公告)号：EP1587787A1
公开(公告)日：2005-10-26
申请号：EP04703130.7
申请日：2004-01-19
发明人： BEAULIEU, Pierre Louis , BROCHU, Christian , CHABOT, Catherine , JOLICOEUR, Eric , KAWAI, Stephen , POUPART, Marc-André , TSANTRIZOS, Youla S.
IPC分类号： C07D209/08 , C07D405/04 , C07D405/14 , C07D401/06 , C07D409/04 , C07D409/14 , C07D401/14 , C07D417/14 , C07D401/04 , C07D413/14 , C07D513/04 , C07D209/30 , A61K31/404 , A61P31/12
CPC分类号： C07D401/04 , C07D209/08 , C07D209/30 , C07D401/06 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
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公开(公告)号：EP1771442A1
公开(公告)日：2007-04-11
申请号：EP05768261.9
申请日：2005-07-15
发明人： BEAULIEU, Pierre, L. , BROCHU, Christian , KAWAI, Stephen , RANCOURT, Jean , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , TSANTRIZOS, Youla, S.
IPC分类号： C07D417/04 , A61P31/14 , A61K31/4439 , A61K31/506 , A61K31/497 , A61K31/4155 , A61K31/404 , A61K31/427 , C07D209/42 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
CPC分类号： C07D403/04 , C07D209/08 , C07D209/12 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04
摘要： A compound, represented by formula (I) or an enantiomer, diastereoisomer or tautomer thereof : wherein either A or B is nitrogen and the other B or A is C, and the radicals R1, R2, R3, R5, R6, R7, R9, and R10 are as defined herein, or a salt, ester or derivative thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particulary those viral polymerases within the Flaviviridae family, more particulary to HCV polymerase.
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公开(公告)号：EP2220076B1
公开(公告)日：2012-01-18
申请号：EP08848765.7
申请日：2008-11-03
发明人： TSANTRIZOS, Youla S. , BAILEY, Murray D. , BILODEAU, François , CARSON, Rebekah J. , FADER, Lee , HALMOS, Teddy , KAWAI, Stephen , LANDRY, Serge , LAPLANTE, Steven , SIMONEAU, Bruno
IPC分类号： C07D413/04 , A61K31/47 , A61K31/4709 , A61K31/538 , A61P31/18 , C07D215/02 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/06
CPC分类号： C07D413/14 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/38 , C07D215/48 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/12 , C07D417/14 , C07D491/04
摘要： Compounds of formula I : wherein c, R2, R3, R4, R5, R6, R7 and R8 are defined herein, are useful as inhibitors of HIV replication.
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公开(公告)号：EP2220046A1
公开(公告)日：2010-08-25
申请号：EP08800314.0
申请日：2008-09-11
发明人： TSANTRIZOS, Youla, S. , BAILEY, Murray, D. , BILODEAU, François , CARSON, Rebekah, J. , COULOMBE, René , FADER, Lee , HALMOS, Teddy , KAWAI, Stephen , LANDRY, Serge , LAPLANTE, Steven , MORIN, Sébastien , PARISIEN, Mathieu , POUPART, Marc-André , SIMONEAU, Bruno
IPC分类号： C07D215/14 , A61K31/47 , A61K31/4709 , A61K31/538 , A61P31/18 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D491/06
CPC分类号： C07D215/14 , A61K31/47 , A61K31/4709 , A61K31/473 , A61K31/4741 , A61K31/538 , A61K31/5383 , C07D215/18 , C07D221/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D491/06 , C07D498/06
摘要： Compounds of formula (I): wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译： 式（I）化合物：其中R 4，R 6和R 7如本文所定义，可用作HIV复制的抑制剂。
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公开(公告)号：EP2220095A1
公开(公告)日：2010-08-25
申请号：EP08850892.4
申请日：2008-11-03
发明人： CARSON, Rebekah J. , FADER, Lee , KAWAI, Stephen , LANDRY, Serge , TSANTRIZOS, Youla S. , BROCHU, Christian , MORIN, Sébastien , PARISIEN, Mathieu , SIMONEAU, Bruno
IPC分类号： C07D495/04 , A61K31/4365 , A61K31/4709 , A61K31/4741 , A61K31/538 , A61P31/18 , C07D519/00
CPC分类号： C07D495/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection
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公开(公告)号：EP2220084A1
公开(公告)日：2010-08-25
申请号：EP08850525.0
申请日：2008-11-13
发明人： TSANTRIZOS, Youla, S. , BAILEY, Murray, D. , BHARDWAJ, Punit, K. , BROCHU, Christian , EDWARDS, Paul, J. , FADER, Lee , JAKALIAN, Araz , KAWAI, Stephen , PARISIEN, Mathieu , POUPART, Marc-André , SIMONEAU, Bruno
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61P31/18
CPC分类号： C07D471/04
摘要： Compounds of formula (I): wherein c, X, Y, R2, R4 and R5 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译： 式（I）化合物：其中c，X，Y，R2，R4和R5如本文所定义，可用作HIV复制的抑制剂。
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公开(公告)号：EP2429993B1
公开(公告)日：2015-01-21
申请号：EP10774456.7
申请日：2010-05-13
发明人： YOAKIM, Christiane , BAILEY, Murray, D . , BILODEAU, Francois , CARSON, Rebekah, J . , FADER , Lee , KAWAI, Stephen , LAPLANTE, Steven , SIMONEAU, Bruno , SURPRENANT, Simon , THIBEAULT , Carl , TSANTRIZOS, Youla, S . , MORIN, Sebastien
IPC分类号： C07D213/55 , A61K31/44 , A61K31/5375 , A61K31/54 , A61P31/18 , C07D213/60 , C07D401/00 , C07D405/00 , C07D413/00 , C07D417/00 , C07D471/04 , C07D491/06 , C07D498/06
CPC分类号： C07D213/81 , A61K31/4375 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4741 , A61K31/501 , A61K31/506 , A61K31/538 , A61K31/5383 , A61K45/06 , C07D213/55 , C07D401/12 , C07D405/10 , C07D405/14 , C07D411/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D491/06 , C07D498/06
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8.发明公开DERIVATIVES OF 1-PHENYL-1,5-DIHYDRO-BENZO[B][1.4]DIAZEPINE-2.4-DIONE AS INHIBITORS OF HIV REPLICATION 审中-公开衍生物1-苯基-1,5-二氢苯并[B] - [1,4-]二氮杂-2,4-二氢S S S S ER ER ER ER ER ER ER
公开(公告)号：EP2539341A1
公开(公告)日：2013-01-02
申请号：EP11744230.1
申请日：2011-02-09
发明人： SIMONEAU, Bruno , DEROY, Patrick , FADER, Lee , FAUCHER, Anne-Marie , GAGNON, Alexandre , GRAND-MAITRE, Chantal , KAWAI, Stephen , LANDRY, Serge , MERCIER, Jean-Francois , RANCOURT, Jean
IPC分类号： C07D487/04 , A61K31/55 , A61K31/551 , A61P31/18 , C07D243/12 , C07D255/04 , C07D401/10 , C07D403/10
CPC分类号： C07D513/04 , A61K31/55 , A61K31/551 , C07D243/12 , C07D255/04 , C07D401/10 , C07D403/10 , C07D409/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： Compounds of formula (I) wherein m, R
1 , R
2 , R
3 , X and Y are defined herein, are useful as inhibitors of HIV replication.-
公开(公告)号：EP2220076A1
公开(公告)日：2010-08-25
申请号：EP08848765.7
申请日：2008-11-03
发明人： TSANTRIZOS, Youla S. , BAILEY, Murray D. , BILODEAU, François , CARSON, Rebekah J. , FADER, Lee , HALMOS, Teddy , KAWAI, Stephen , LANDRY, Serge , LAPLANTE, Steven , SIMONEAU, Bruno
IPC分类号： C07D413/04 , A61K31/47 , A61K31/4709 , A61K31/538 , A61P31/18 , C07D215/02 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/06
CPC分类号： C07D413/14 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/38 , C07D215/48 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/12 , C07D417/14 , C07D491/04
摘要： Compounds of formula I : wherein c, R2, R3, R4, R5, R6, R7 and R8 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译： 式I化合物：其中c，R2，R3，R4，R5，R6，R7和R8如本文所定义，可用作HIV复制的抑制剂。
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