公开(公告)号：EP3126836A4

公开(公告)日：2017-11-08

申请号：EP15772587

申请日：2015-04-01

申请人： PRINCE HENRY'S INSITUTE OF MEDICAL RES TRADING AS THE HUDSON INST OF MEDICAL RES

发明人： SALAMONSEN LOIS ,  EDGELL TRACEY ,  HANNAN NATALIE ,  ROMBAUTS LUK

IPC分类号： G01N33/53 ,  A61K35/54 ,  C12Q1/68

CPC分类号： G01N33/689 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2333/49 ,  G01N2333/52 ,  G01N2333/535 ,  G01N2333/5421 ,  G01N2800/368

摘要： The present disclosure teaches an assay to determine the likelihood of a successful implantation of an embryo into a female subject leading to a pregnancy. Enabled herein is an improved assisted reproduction technology protocol based on a prognostic evaluation of pregnancy outcomes. Taught herein is a composition comprising reagents required for the prognostic evaluation. Taught herein are assays comprising determination of levels of the biomarkers IL-8, G-CSF and/or VEGFA in a biological fluid sample taken before embryo implantation.

公开(公告)号：EP2999799A2

公开(公告)日：2016-03-30

申请号：EP14800459.1

申请日：2014-05-22

申请人： Five Prime Therapeutics, Inc. ,  Glaxosmithkline Intellectual Property (No. 2) Limited

发明人： BELLOVIN, David ,  BAKER, Kevin ,  BRENNAN, Thomas ,  PANDITE, Arundathy Nirmalini ,  MOOKERJEE, Bijoyesh ,  DEYOUNG, Maurice P. ,  KUMAR, Rakesh

IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K38/17 ,  A61K38/00 ,  A61K38/18 ,  A61P35/00

CPC分类号： A61K38/179 ,  A61K31/337 ,  A61K31/519 ,  A61K31/555 ,  A61K33/24 ,  A61K45/06 ,  C07K14/71 ,  C07K2319/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57496 ,  G01N2333/49 ,  G01N2333/50 ,  G01N2333/503 ,  G01N2333/515 ,  G01N2800/52

摘要： Methods of treating cancers comprising administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule are provided. Methods of treating cancers comprising administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule and at least one anti-angiogenic agent are provided.

摘要翻译： 提供了治疗癌症的方法，包括施用成纤维细胞生长因子受体1（FGFR1）胞外结构域（ECD）和/或FGFR1 ECD融合分子。 提供了治疗癌症的方法，包括施用成纤维细胞生长因子受体1（FGFR1）胞外结构域（ECD）和/或FGFR1ECD融合分子和至少一种抗血管生成剂。

公开(公告)号：EP2769321A4

公开(公告)日：2015-05-13

申请号：EP12841790

申请日：2012-10-19

申请人： NESTEC SA

发明人： PRINCEN FRED ,  LOCKTON STEVEN ,  CRONER LISA J ,  FLETCHER FREDERICK A ,  STOCKFISCH THOMAS ,  SINGH SHARAT

IPC分类号： C12Q1/68 ,  G01N33/48 ,  G01N33/53 ,  G06F19/00

CPC分类号： G06F19/3431 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/54306 ,  G01N33/6854 ,  G01N33/6893 ,  G01N2333/4737 ,  G01N2333/49 ,  G01N2333/70525 ,  G01N2333/70542 ,  G01N2333/775 ,  G01N2800/065 ,  G01N2800/60 ,  G06F19/18 ,  G06F19/24 ,  G16H50/30 ,  Y02A90/24 ,  Y02A90/26

摘要： The present invention provides methods and systems to predict and diagnose inflammatory bowel disease (IBD) and subtypes such as ulcerative colitis (UC) and Crohn's disease (CD) by detecting the presence, absence, level, and/or genotype of one or more sero-genetic-inflammation markers. Advantageously, with the present invention, it is possible to provide a diagnosis of IBD versus non-IBD, to rule out IBD that is inconclusive for CD and UC, and to differentiate between CD and UC with increased accuracy.

公开(公告)号：EP2649449A4

公开(公告)日：2014-05-21

申请号：EP11877185

申请日：2011-12-09

申请人： STEYN ANDRIES J C ,  CROSSMAN DAVID K ,  HENOSTROZA GERMAN ,  KIMERLING MICHAEL

发明人： STEYN ANDRIES J C ,  CROSSMAN DAVID K ,  HENOSTROZA GERMAN ,  KIMERLING MICHAEL

IPC分类号： G01N33/569 ,  C12Q1/04 ,  G01N33/68 ,  G06F17/00 ,  G06F19/18

CPC分类号： G01N33/5695 ,  G01N33/56988 ,  G01N33/6863 ,  G01N33/6869 ,  G01N2333/35 ,  G01N2333/49 ,  G01N2333/523 ,  G01N2333/525 ,  G01N2333/535 ,  G01N2333/5412 ,  G01N2333/5415 ,  G01N2333/5418 ,  G01N2333/5434 ,  G01N2333/55 ,  G01N2333/70503 ,  G01N2333/70546 ,  G01N2333/715 ,  G01N2800/60 ,  G06F19/10 ,  G06F19/18

公开(公告)号：EP2289537A1

公开(公告)日：2011-03-02

申请号：EP10179119.2

申请日：2002-09-19

申请人： Neuronova AB

发明人： Delfani, Kioumars ,  Janson, Ann Marie ,  Kuhn, Georg H ,  Plate, Karlheinz ,  Schanzer, Anne ,  Wachs, Frank-Peter ,  Zhao, Ming

IPC分类号： A61K38/18 ,  A61K48/00 ,  A61P25/00

CPC分类号： A61K38/1858 ,  A61K35/30 ,  A61K38/179 ,  A61K38/1866 ,  A61K45/06 ,  A61K48/00 ,  G01N33/5008 ,  G01N2333/49 ,  G01N2333/515 ,  A61K2300/00

摘要： The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells. These methods are useful for reducing at least one symptom of the disorder. The reagent used is platelet-derived growth factor (PDGF) or a PDGF agonist.

摘要翻译： 本发明一般涉及影响中枢神经系统细胞以产生可用于治疗CNS疾病的后代的方法。 更具体地，本发明包括将患有这种病症的患者暴露于调节中枢神经系统细胞的增殖，迁移，分化和存活的试剂的方法。 这些方法可用于减少病症的至少一种症状。 所使用的试剂是血小板衍生生长因子（PDGF）或PDGF激动剂。

公开(公告)号：EP1786933A4

公开(公告)日：2008-07-16

申请号：EP04781055

申请日：2004-08-16

申请人： PTC THERAPEUTICS INC

发明人： CAO LIANGXIAN ,  MEHTA ANURADHA ,  NARYSHKIN NIKOLAI A ,  PELLIGRINI MATTHEW C ,  ROMFO CHARLES M ,  TRIFILLIS PANAYIOTA ,  TROTTA CHRISTOPHER R

IPC分类号： C12Q1/70 ,  C12N15/10 ,  C12N15/63 ,  C12Q1/68

CPC分类号： G01N33/5023 ,  C12Q1/6897 ,  G01N33/74 ,  G01N2333/49 ,  G01N2333/90241

摘要： The invention relates to the fields of screening assays, compounds, and methods for altering gene expression and protein levels. In particular, the invention includes assays to screen for agents capable of modulating gene expression in a UTR-dependent manner and agents capable of modulating gene expression.

公开(公告)号：EP1282723A4

公开(公告)日：2007-11-21

申请号：EP01935627

申请日：2001-05-17

申请人： LUDWIG INST CANCER RES

发明人： LI XURI ,  AASE K ,  ERIKSSON U

IPC分类号： G01N33/50 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/574

CPC分类号： G01N33/57484 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N2333/49

摘要： A method and kit for detecting the presence of tumor cells in an animal by detecting expression of VEGF-B186, determining an increased expression of VEGF-B186, or by determining an increased expression of VEGF-B186 relative to expression of VEGF-B167. The kit comprises a receptacle adapted to receive a sample and a means for detecting expression of VEGF-B186 from the sample. Also, a method for screening for anti-tumor agents.

公开(公告)号：EP1786933A1

公开(公告)日：2007-05-23

申请号：EP04781055.1

申请日：2004-08-16

申请人： PTC Therapeutics, Inc.

发明人： CAO, Liangxian ,  MEHTA, Anuradha ,  NARYSHKIN, Nikolai A. ,  PELLIGRINI, Matthew C. ,  ROMFO, Charles M. ,  TRIFILLIS, Panayiota ,  TROTTA, Christopher R.

IPC分类号： C12Q1/70 ,  C12Q1/68 ,  C12N15/63

CPC分类号： G01N33/5023 ,  C12Q1/6897 ,  G01N33/74 ,  G01N2333/49 ,  G01N2333/90241

摘要： The invention relates to the fields of screening assays, compounds, and methods for altering gene expression and protein levels. In particular, the invention includes assays to screen for agents capable of modulating gene expression in a UTR-dependent manner and agents capable of modulating gene expression.

公开(公告)号：EP0456766B1

公开(公告)日：1999-04-28

申请号：EP90905022.1

申请日：1990-02-08

申请人： THE UNITED STATES OF AMERICA

发明人： MATSUI, Toshimitsu ,  AARONSON, Stuart, A. ,  PIERCE, Jacalyn, H.

IPC分类号： C12N15/12 ,  C07K14/00 ,  C07H21/04 ,  C12Q1/68 ,  G01N33/53

CPC分类号： A61K51/103 ,  A61K38/00 ,  A61K2123/00 ,  C07K14/71 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/77 ,  C07K2319/30 ,  G01N33/74 ,  G01N2333/49 ,  G01N2333/71 ,  Y10S435/81

摘要： Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used successfully to produce a hitherto unknown type of human Platelet-Derived Growth Factor (PDGF) receptor protein (see genetic map, figure 2) free of other PDGF receptors. These proteins can be produced from DNA segments in cells in various functional forms. These forms variously enable biochemical and functional studies of these novel receptors as well as production of antibodies. Means are described for determining the level of expression of genes for specific types of PDGF receptor proteins, for example, by measuring mRNA in cell with PDGF receptor type-specific DNA probes or by measuring antigene in biological samples with type-specific antibodies.

摘要翻译： 公开了发现，显示重组DNA技术的特定方面可成功用于产生迄今未知类型的不含其他PDGF受体的人血小板衍生生长因子（PDGF）受体蛋白质（参见遗传图谱，图2）。 这些蛋白质可以以各种功能形式的细胞中的DNA片段产生。 这些形式不同地使这些新受体的生物化学和功能研究以及抗体的产生成为可能。 描述了用于确定特定类型的PDGF受体蛋白质的基因表达水平的手段，例如通过用PDGF受体型特异性DNA探针测量细胞中的mRNA或通过用类型特异性抗体测量生物样品中的抗原。

公开(公告)号：EP3252171A1

公开(公告)日：2017-12-06

申请号：EP17177845.9

申请日：2014-05-22

申请人： Five Prime Therapeutics, Inc. ,  GlaxoSmithKline Intellectual Property (No. 2) Limited

发明人： BELLOVIN, David ,  BAKER, Kevin ,  BRENNAN, Thomas ,  PANDITE, Arundathy Nirmalini ,  MOOKERJEE, Bijoyesh ,  DEYOUNG, Maurice P. ,  KUMAR, Rakesh

IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K38/17 ,  A61K38/00 ,  A61K38/18 ,  A61P35/00

CPC分类号： A61K38/179 ,  A61K31/337 ,  A61K31/519 ,  A61K31/555 ,  A61K33/24 ,  A61K45/06 ,  C07K14/71 ,  C07K2319/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57496 ,  G01N2333/49 ,  G01N2333/50 ,  G01N2333/503 ,  G01N2333/515 ,  G01N2800/52

摘要： The invention relates to methods of treating mesothelioma comprising administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule and at least one therapeutic agent selected from pemetrexed, cisplatin, paclitaxel, carboplatin, and docetaxel are provided.

摘要翻译： 本发明涉及治疗间皮瘤的方法，其包括施用成纤维细胞生长因子受体1（FGFR1）胞外结构域（ECD）和/或FGFR1 ECD融合分子和选自培美曲塞，顺铂，紫杉醇，卡铂和多西他赛的至少一种治疗剂 被提供。