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101.发明公开Polyglucuronic acid as remitting agent for nephrotic syndrome and hepatopathy symptoms 失效Polyglucuronsäureals remittierendes Mittelfürdas nephrotische Syndrom und Symptome von Hepatopathie。
公开(公告)号：EP0635519A1
公开(公告)日：1995-01-25
申请号：EP94305146.6
申请日：1994-07-14
发明人： Ye, Guoji , Kajihara, Jun-ichi , Kirihara, Sei , Kato, Kazuo , Abe, Hiroko
IPC分类号： C08B37/00
CPC分类号： A61K31/715 , C08B37/006
摘要： A remitting agent for nephrotic syndrome and hepatopathy symptoms comprises a water-soluble polysaccharides having poly-D-galacturonic acid or a methyl ester thereof as an effective constituent. The polysaccharide can be a pectic substance and preferably is an aqueous extract of Tanjin having the following characteristics:
A. Sugar content: 60 to 100 %
(1) Sugar composition:
40 to 80 % of uronic acid (composed almost entirely of D-galacturonic acid) and
10 to 30 % of neutral sugars
(2) Neutral sugar composition:
0 to 15 % of rhamnose
0 to 15 % of glucose
25 to 55 % of galactose
30 to 60 % of arabinose
0 to 15 % of mannose
B. Molecular weight: 150,000 to 300,000.摘要翻译： 肾病综合征和肝病症状的缓解剂包括具有聚-D-半乳糖醛酸或其甲酯的水溶性多糖作为有效成分。 多糖可以是果胶物质，优选为Tanjin的水提物，具有以下特征：A.糖含量：60〜100％（1）糖组成：40〜80％的糖醛酸（几乎完全由D-半乳糖醛酸组成 酸）和10至30％的中性糖（2）中性糖组成：0至15％的鼠李糖0至15％的葡萄糖25至55％的半乳糖30至60％的阿拉伯糖0至15％的甘露糖B.分子 体重：15万到30万。 小号
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102.发明公开
公开(公告)号：EP0614370A1
公开(公告)日：1994-09-14
申请号：EP93900696.0
申请日：1992-11-19
发明人： HOROWITZ, Bernard , SHULMAN, Richard, W. , SETTON, Adrianne, J. , NISHIMURA, Toyohiko , KAWASHIMA, Yoichi
CPC分类号： A61K38/39 , A61K9/0048 , Y10S514/912
摘要： L'invention concerne une solution ophtalmique multidose stable et soluble. La solution contient de la fibronectine, un acide aminé, un sucre et un p-hydroxybenzoate d'alkyle inférieur. Un procédé de traitement de blessures ophtalmiques utilisant la solution ophtalmique de l'invention, un procédé de préparation de fibronectine à usage ophtalmique, un procédé de lyophilisation d'une solution aqueuse de fibronectine exempt d'albumine, un procédé permettant d'empêcher les bactéries de se développer dans une solution ophtalmique tout en préservant les caractéristiques d'adhésion cellulaire et de cicatrisation des blessures de la fibronectine, et un procédé de traitement de blessures ophtalmiques consistant à administrer une solution accélérant la cicatrisation des blessures sont également décrits.
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103.发明公开Products containing active milk protein components and process for producing the same 失效Aktive Milchproteinkomponent enthaltende Produkten，und Verfahren zu ihrer Herstellung。
公开(公告)号：EP0605219A1
公开(公告)日：1994-07-06
申请号：EP93310512.4
申请日：1993-12-23
CPC分类号： C12N7/00 , A23C21/08 , A23J3/08 , C12N2770/32361
摘要： Milk plasma or milk serum is heat sterilized in the liquid phase without denaturation of active milk protein components thereof in the presence of a stabilizer selected from sugar alcohols, disaccharides and mixtures of a sugar alcohol or a disaccharide with an amino acid and at pH 6 to 8. Ammonium sulfate can be added to the heat treated mixture to precipitate the protein components.
摘要翻译： 乳液等离子体或乳清液在液相中被热灭菌，而不会在选自糖醇，二糖和糖醇或二糖与氨基酸的混合物和pH6至6的稳定剂存在下，使活性乳蛋白组分变性 8.可将硫酸铵加入到经热处理的混合物中以沉淀蛋白质组分。
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公开(公告)号：EP0310413B1
公开(公告)日：1994-03-16
申请号：EP88309093.8
申请日：1988-09-30
IPC分类号： G01N33/552 , G01N33/76
CPC分类号： G01N33/74 , G01N33/552
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公开(公告)号：EP0219295B1
公开(公告)日：1994-01-19
申请号：EP86307707.9
申请日：1986-10-06
IPC分类号： C07K3/26
CPC分类号： C07K14/615 , A61K38/00 , A61K38/27 , A61L2/0017 , A61L2/022
摘要： A membrane filter of 0.025 to 0.05 mu m pore size is previously treated by passing a solution of a water-soluble high molecular substance such as albumin, dextran,polyvinylpyrrolidone, polyethyleneglycol, gelatin or the like through the filter. Employing the filter thus treated, a solution of human growth hormone (HGH) is filtered at high recovery rate of HGH activity to remove Creutzfeldt-Jacob disease pathogen which may exist in HGH preparations.
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106.发明公开Method of preparing primers for polymerase chain reaction and DNA amplification using said primers 失效制备聚合酶链反应的引物的方法和使用上述引物的DNA扩增
公开(公告)号：EP0438292A3
公开(公告)日：1991-09-18
申请号：EP91300326.5
申请日：1991-01-17
CPC分类号： C12N15/10
摘要： Primers for a polymerase chain reaction are prepared by treating a double-standard DNA fragment with an exonuclease. DNA is amplified in vitro by the polymerase chain reaction using such primers. Chromosomal genes are amplified by carrying out the inverted polymerase chain reaction using as a primer, a DNA fragment obtained by treating a double-stranded DNA fragment with an exonuclease capable of digesting one chain of the double-stranded DNA in a manner such that mononucleotides are released therefrom in the direction from the 5′ terminus to the 3′ terminus and, as a template, a circular DNA obtained by cleaving the chromosomal gene with a restriction enzyme and subjecting the resultant fragment to self-ligation.
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107.发明公开
公开(公告)号：EP0426488A1
公开(公告)日：1991-05-08
申请号：EP90312027.7
申请日：1990-11-02
CPC分类号： C12N9/0089 , C08G65/33396
摘要： A polymeric carbonyl diimidazole derivative of the formula:-
wherein R is the residue of a water soluble polymer of molecular weight 2000 to 10,000, eg. monomethoxy polyethylene glycol, is produced by reacting the polymer at a concentration of 0.15 to 0.35M with carbonyldiimidazole at a concentration ratio of 1:1 to 1:3. A modified superoxide dismutase of the formula:-
R-O- -NH-SOD
is produced by reacting said derivative with superoxide dismutase in the presence of a 0.1M to 0.5M concentration of an alkaline buffer having a pH of 9 to 11 at a temperature of 30 to 70 o C.摘要翻译： 下式的聚合羰基二咪唑衍生物：其中R是分子量为2000至10,000的水溶性聚合物的残基，例如。 通过使浓度为0.15〜0.35M的聚合物与羰基二咪唑以1:1〜1:3的浓度比反应制备单甲氧基聚乙二醇。 通过使所述衍生物与超氧化物歧化酶在0.1M至0.5M浓度的pH为9至11的碱性缓冲液存在下，在温度下反应来制备下式的修饰的超氧化物歧化酶： - RO - 为30〜70℃。
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公开(公告)号：EP0382551A2
公开(公告)日：1990-08-16
申请号：EP90301373.8
申请日：1990-02-09
申请人： NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JCR PHARMACEUTICALS CO., LTD , NODA SHOKUKIN KOGYO KABUSHIKI KAISHA, also known as NODA SHOKUKIN KOGYO CO., LTD.
IPC分类号： A61K35/84 , A61K31/715
CPC分类号： A61K36/07
摘要： LEM which is an aqueous extract of a mycelial culture of Lentinus Edodes and has a sugar composition comprised of arabinose, xylose, glucose, mannose, and galactose, fucose and rhamnose, as well as a fraction of LEM which corresponds to molecular weights of 10,000 to 1,000,000 daltons and has a sugar composition comprised of arabinose, xylose, glucose, mannose and galactose are provided as agents for inhibiting the adsorption of herpes viruses such as herpes simplex to the cells.
摘要翻译： LEM是Lentinus Edodes的菌丝体培养物的水提取物，并且具有由阿拉伯糖，木糖，葡萄糖，甘露糖和半乳糖，岩藻糖和鼠李糖组成的糖组合物，以及一部分对应于分子量为10,000至 提供1,000,000道尔顿，并且具有由阿拉伯糖，木糖，葡萄糖，甘露糖和半乳糖组成的糖组合物作为用于抑制疱疹病毒如单纯疱疹的细胞吸附的试剂。
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公开(公告)号：EP0219295A3
公开(公告)日：1989-03-22
申请号：EP86307707.9
申请日：1986-10-06
IPC分类号： C07K3/26
CPC分类号： C07K14/615 , A61K38/00 , A61K38/27 , A61L2/0017 , A61L2/022
摘要： A membrane filter of 0.025 to 0.05 µm pore size is previously treated by passing a solution of a water-soluble high molecular substance such as albumin, dextran,polyvinylpyrrolidone, polyethyleneglycol, gelatin or the like through the filter. Employing the filter thus treated, a solution of human growth hormone (HGH) is filtered at high recovery rate of HGH activity to remove Creutzfeldt-Jacob disease pathogen which may exist in HGH preparations.
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公开(公告)号：EP4424325A1
公开(公告)日：2024-09-04
申请号：EP22895690.0
申请日：2022-11-18
IPC分类号： A61K39/395
CPC分类号： A61K31/7088 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/38 , A61K38/43 , A61K38/46 , A61K38/48 , A61K39/395 , A61K39/44 , A61K45/00 , A61K47/62 , A61K47/64 , A61K47/65 , A61K47/68 , A61K48/00 , A61P3/00 , A61P3/08 , A61P9/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07K14/435 , C07K14/475 , C07K14/48 , C07K14/485 , C07K14/50 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12N5/10 , C12N9/14 , C12N15/52 , C12N15/62 , C12N15/63 , C12N15/74 , C12N15/80 , C12N15/81
摘要： The present invention relates, in one embodiment thereof, to a peptide having affinity for human transferrin receptor, which can be used for binding to any of compounds (a protein, a nucleic acid, a low molecular weight compound, and the like) that should be caused to function in the central nervous system (CNS), in order to allow the compound to pass through the blood-brain barrier, and the use of the peptide. The peptide is, for example, a peptide having the amino acid sequence selected from the group consisting of amino acid sequences set forth in SEQ ID NOs:3 to 7 and 55, or a mutant thereof.
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