公开(公告)号：EP2566958B1

公开(公告)日：2015-12-30

申请号：EP11716419.4

申请日：2011-04-28

申请人： GlaxoSmithKline Biologicals S.A.

发明人： ANDRE, Bruno, Rene ,  CHAMPLUVIER, Benoit, Paul, Suzanne

IPC分类号： C12N7/06 ,  A61K39/12 ,  A61K39/145

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5252 ,  C12N7/00 ,  C12N2760/16134 ,  C12N2760/16163 ,  C12N2760/16263

公开(公告)号：EP2327419A4

公开(公告)日：2015-12-30

申请号：EP09773249

申请日：2009-05-22

申请人： HISAMITSU PHARMACEUTICAL CO ,  CHEMO SERO THERAPEUT RES INST

发明人： NOZAKI CHIKATERU ,  KAMINAKA KAZUYOSHI ,  MATSUDA JUNICHI ,  TERAHARA TAKAAKI ,  KUWAHARA TETSUJI ,  TOKUMOTO SEIJI

IPC分类号： A61K39/145 ,  A61K9/00 ,  A61K9/70 ,  A61K39/00 ,  A61K39/39 ,  A61K47/10 ,  A61K47/34 ,  A61K47/36 ,  A61L31/00 ,  A61M37/00 ,  A61P31/16

CPC分类号： A61K39/145 ,  A61B17/205 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/70 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0061 ,  C12N2760/16134 ,  C12N2760/16234

摘要： The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.

公开(公告)号：EP2947094A1

公开(公告)日：2015-11-25

申请号：EP15176239.0

申请日：2008-09-12

申请人： Temasek Life Sciences Laboratory Limited

发明人： QIAN, Hong Liang ,  HE, Fang ,  KWANG, Hwei-sing

IPC分类号： C07K16/10 ,  A61K39/145 ,  A61P31/16 ,  C12N7/00 ,  G01N33/53 ,  G01N33/577

CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/76 ,  C12N2760/16111 ,  G01N33/56983 ,  G01N2333/11

摘要： Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.

摘要翻译： 单克隆抗体及相关的结合蛋白没有特异性结合H5亚型禽流感或流感病毒（AIV）的N1亚型神经氨酸酶糖蛋白的包膜糖蛋白提供。 单克隆抗体和相关结合蛋白的检测H5禽流感病毒和N1的亚型，包括H5N1亚型有用的，并为危险病毒感染的诊断，监测和治疗手段。

公开(公告)号：EP2943221A1

公开(公告)日：2015-11-18

申请号：EP14700356.0

申请日：2014-01-10

申请人： Novartis AG

发明人： BERTHOLET GIRARDIN, Sylvie Carine ,  GEALL, Andrew

IPC分类号： A61K39/145 ,  C12N15/867 ,  C12N7/04

CPC分类号： A61K39/145 ,  A01K67/0278 ,  A01K2217/072 ,  A61K9/127 ,  C12N15/86 ,  C12N2760/16234 ,  C12N2760/16334 ,  C12N2770/36143

摘要： Immunogenic compositions comprise a RNA component and a polypeptide component. The RNA component is a self-replicating RNA. The polypeptide component comprises an epitope from an influenza virus antigen (the first epitope), and the RNA component encodes a polypeptide which also comprises an epitope from an influenza virus antigen (the second epitope). Delivery of epitopes in these two different manners can enhance the immune response to influenza virus as compared to immunization with the RNA or the polypeptide alone.

公开(公告)号：EP2758038A4

公开(公告)日：2015-11-04

申请号：EP12834398

申请日：2012-09-24

申请人： US HEALTH

发明人： NABEL GARY J M D ,  KANEKIYO MASARO ,  WEI CHIH-JEN ,  MCTAMNEY PATRICK M ,  YASSINE HADI M ,  BOYINGTON JEFFREY C

IPC分类号： A61K9/14 ,  A61K39/145

CPC分类号： A61K39/145 ,  A61K39/105 ,  A61K39/12 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/6031 ,  A61K2039/70 ,  C07K14/005 ,  C07K14/205 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/35 ,  C07K2319/40 ,  C07K2319/735 ,  C12N7/00 ,  C12N2760/16022 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16134 ,  C12N2760/16234 ,  G01N33/56983

摘要： Novel vaccines are provided that elicit broadly neutralizing anti-influenza antibodies. Some vaccines comprise nanoparticles that display hemagglutinin trimers from influenza virus on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of ferritin joined to at least a portion of an influenza hemagglutinin protein. Some portions comprise the ectodomain while some portions are limited to the stem region. The fusion proteins self-assemble to form the hemagglutinin-displaying nanoparticles. Some vaccines comprise only the stem region of an influenza hemagglutinin protein joined to a trimerization domain. Such vaccines can be used to vaccinate an individual against infection by heterologous influenza viruses and influenza virus that are antigenically divergent from the virus from which the nanoparticle hemagglutinin protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.

摘要翻译： 提供了引发广泛中和的抗流感抗体的新型疫苗。 一些疫苗包括在其表面上显示流感病毒的血凝素三聚体的纳米颗粒。 纳米颗粒包含融合蛋白，其包含与至少一部分流感血凝素蛋白结合的铁蛋白单体亚单位。 一些部分包含胞外域，而一些部分被限制在茎区。 融合蛋白自组装形成血凝素显示纳米粒子。 一些疫苗仅包含连接到三聚域的流感血凝素蛋白的茎区。 这样的疫苗可以用于接种个体，以抵抗来自获得纳米颗粒血凝素蛋白质的病毒的抗原性分歧的异源流感病毒和流感病毒的感染。 还提供了编码这种蛋白质的融合蛋白和核酸分子。

公开(公告)号：EP2450379B1

公开(公告)日：2015-11-04

申请号：EP12153013.3

申请日：2007-09-06

申请人： Crucell Holland B.V.

发明人： Van Den Brink, Edward Norbert ,  De Kruif, Cornelis Adriaan ,  Throsby, Mark

IPC分类号： C07K16/10 ,  A61K39/145 ,  C12N5/10 ,  C12N15/09 ,  A61K39/00

CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C12N2760/16122

公开(公告)号：EP2271360B1

公开(公告)日：2015-09-23

申请号：EP09732491.7

申请日：2009-04-16

申请人： GlaxoSmithKline Biologicals S.A.

发明人： BALLOU JR, William Ripley ,  HANON, Emmanuel Jules

IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/09 ,  A61K39/102 ,  A61K39/12 ,  A61K39/145 ,  A61K39/295 ,  A61K39/39

CPC分类号： A61K39/092 ,  A61K39/102 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16234

公开(公告)号：EP2914283A1

公开(公告)日：2015-09-09

申请号：EP13851144.9

申请日：2013-10-30

申请人： Georgia State University Research Foundation, Inc.

发明人： KANG, Sang-Moo ,  KIM, Min-Chul

IPC分类号： A61K39/145 ,  C07K19/00 ,  A61P31/16

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5258 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55516 ,  A61K2039/58 ,  A61K2039/6068 ,  A61K2039/6075 ,  A61K2039/70 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/40 ,  C12N7/00 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2799/026

摘要： Disclosed are universal influenza A vaccines capable of providing broader crossprotection. The vaccine contains a fusion protein comprising tandem repeats of heterologous M2e epitope sequences that have been molecularly and genetically designed to provide broad cross-protection. The fusion protein may be incorporated into virus-like particles (VLPs) or a replicating live attenuated influenza virus vaccine, and administered alone or in combination with other influenza vaccines.

公开(公告)号：EP2902484A1

公开(公告)日：2015-08-05

申请号：EP14193954.6

申请日：2005-05-20

申请人： MedImmune, LLC

发明人： Kemble, George ,  Yang, Chin-Fen

IPC分类号： C12N7/00 ,  C12N7/04 ,  C07K14/11 ,  A61K39/145

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/543 ,  A61K2039/58 ,  C07K14/005 ,  C12N2501/70 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16161 ,  C12N2760/16162 ,  C12N2760/16171 ,  C12Q1/701

摘要： Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemaglutinin and neuraminidase variants are provided.

摘要翻译： 提供了包含（禽流感）流感血凝素和神经氨酸酶变体的多肽，多核苷酸，方法，组合物和疫苗。

公开(公告)号：EP2442826B1

公开(公告)日：2015-07-08

申请号：EP09846104.9

申请日：2009-06-15

申请人： National University of Singapore ,  Institut Pasteur De Lille ,  Institut National de la Santé et de la Recherche Médicale

发明人： ALONSO, Sylvie ,  LI, Rui ,  CHOW, Vincent ,  LOCHT, Camille

IPC分类号： A61K39/00 ,  A61K39/10 ,  A61K39/145 ,  A61K31/16 ,  A61P31/16

CPC分类号： A61K39/099 ,  A61K9/0043 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/521 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/543 ,  A61K2039/55566 ,  A61K2039/58 ,  C12N2760/16134

摘要： The invention relates to compositions and vaccines that include a mutated Bordetella strain for treating or preventing an influenza infection in a mammal. In addition, the invention further provides methods for protecting a mammal against infection by influenza and/or eliciting an immune response against an influenza virus in a mammal using the composition or vaccine.