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    CHARGE BALANCING CIRCUIT AND STIMULATOR CIRCUIT
    111.
    发明公开
    CHARGE BALANCING CIRCUIT AND STIMULATOR CIRCUIT 有权
    LADUNGSAUSGLEICHSSCHALTUNG UND STIMULATORSCHALTUNG

    公开(公告)号：EP3100766A1

    公开(公告)日：2016-12-07

    申请号：EP15170554.8

    申请日：2015-06-03

    申请人： Albert-Ludwigs-Universität Freiburg

    发明人： Muller, Natalie ,  Kuhl, Matthias ,  Manoli, Yiannos

    IPC分类号： A61N1/37

    CPC分类号： A61N1/3782 ,  A61N1/025 ,  A61N1/05 ,  A61N1/3706

    摘要： A charge balancing circuit (CBC) adapted to be connected to an electrode (E) and to a stimulation source (CS) is provided. The charge balancing circuit (CBC) comprises an electrode terminal (ET) for receiving an electrode voltage (V E ), an amplifier (A) coupled to the electrode terminal (ET) and adapted to amplify and invert the electrode voltage (V E ) for generating an intermediate voltage (V in ) and a compensation stage (CP). The compensation stage (CP) is adapted to generate an output current (I out ) if the electrode voltage (V E ) lies outside a specified safety range and to generate the output current (I out ) depending on the intermediate voltage (V in ). The compensation stage (CP) is further adapted to supply the output current (I out ) to the electrode terminal (ET) for driving the electrode voltage (V E ) towards and/or into the safety range.

    摘要翻译： 提供了适于连接到电极（E）和刺激源（CS）的电荷平衡电路（CBC）。 电荷平衡电路（CBC）包括用于接收电极电压（VE）的电极端子（ET），耦合到电极端子（ET）的放大器（A），并适于放大和反转电极电压（VE） 中间电压（V in）和补偿级（CP）。 如果电极电压（V E）在指定的安全范围之外，补偿级（CP）适于产生输出电流（I out），并根据中间电压（V in）产生输出电流（I out）。 补偿级（CP）还适于向电极端子（ET）提供输出电流（I out），用于驱动电极电压（V E）和/或进入安全范围。

    REVERSIBLE PEGYLATION OF NANOCARRIERS
    115.
    发明公开
    REVERSIBLE PEGYLATION OF NANOCARRIERS 有权
    UMKEHRBARE PEGYLIERUNG VONNANOTRÄGERN

    公开(公告)号：EP3077007A1

    公开(公告)日：2016-10-12

    申请号：EP14806237.5

    申请日：2014-12-01

    申请人： Albert-Ludwigs-Universität Freiburg

    发明人： WEBER, Wilfried ,  REBMANN, Balder ,  ZURBRIGGEN, Matias

    IPC分类号： A61K47/48 ,  A61K9/127 ,  A61P35/00

    摘要： The present invention relates to the preparation and use of reversibly PEGylated nanocarriers. The reversibly PEGgylated nanocarrier system comprises an inner core comprising or consisting of a nanoparticle and/or at least one pharmaceutical compound; optionally at least one lipid bilayer on the surface of the inner core; a first ligand bound to the surface of said inner core, or if present, to the surface of the at least one lipid bilayer; a second ligand bound to the first ligand, the second ligand being covalently bound to poly(ethylene glycol) or a derivative thereof. The reversibly PEGgylated nanocarrier system is characterized in that binding of the second ligand to the first ligand is non-covalent and reversible. Pharmaceutical compositions and use of such compounds and compositions in the field of e.g. cancer therapy, gene therapy, inflammatory diseases and pain therapy are also disclosed.

    摘要翻译： 本发明涉及可逆聚乙二醇化纳米载体的制备和应用。 可逆的聚乙二醇化纳米载体系统包含包含纳米颗粒和/或至少一种药物化合物或由其组成的内核; 任选地在所述内核的表面上具有至少一个脂质双层; 结合到所述内芯的表面上的第一配体，或者如果存在，则与所述至少一种脂质双层的表面结合; 与第一配体结合的第二配体，第二配体与聚（乙二醇）或其衍生物共价结合。 可逆的聚乙二醇化纳米载体系统的特征在于第二配体与第一配体的结合是非共价的和可逆的。 药物组合物和这些化合物和组合物在本领域的应用。 还公开了癌症治疗，基因治疗，炎性疾病和疼痛治疗。