利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

898 条记录 (耗时 0.016 秒)

    3-Phenoxy(or phenylthio)cyclopentanecarbonylamino acid analogues
    123.
    发明公开
    3-Phenoxy(or phenylthio)cyclopentanecarbonylamino acid analogues 失效
    3-苯氧基（或叔戊基）环丙氨基甲酰胺酸类似物

    公开(公告)号：EP0231619A3

    公开(公告)日：1988-01-27

    申请号：EP86309629

    申请日：1986-12-10

    申请人： ONO PHARMACEUTICAL CO., LTD.

    发明人： Imaki, Katsuhiro ,  Okegawa, Tadao ,  Arai, Yoshinobu

    IPC分类号： C07C103/737 ,  C07D333/22 ,  C07C102/04 ,  C07C103/76 ,  C07D333/56 ,  C07D307/46 ,  A61K31/195 ,  A61K31/34 ,  A61K31/38

    CPC分类号： C07D333/22

    摘要： This invention relates to compounds presented by the general formula:
    [wherein R¹ and R² are:
    (i) R¹, R² and carbon atoms to which R¹ and R² are linked, together represent the group of the general formula:
    (wherein R⁵ and R⁶ represent hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl or phenyl, independently, with the proviso that R⁵ and R⁶ is not hydrogen atoms at the same time), or
    (ii) R¹ represents hydrogen and R² represents the group of the formula: -COR⁷ (wherein R⁷ represents the group of the formula: (wherein Y represents a single-bond, alkylene, alkenylene, W represents oxygen or sulfur, m represents 1 to 3, R⁸ represents hydrogen, halogen, nitro, hydroxy, alkyl or alkoxy, with the proviso that when m represents more than two, plural R⁸s may be different each, and R⁹ represents hydrogen, alkyl or phenyl group, with the proviso that two of R⁹ may be different each)), R³ represents hydrogen, halogen, alkyl group or two of R³ and phenyl to which two of R³ are linked, together represent naphthyl of the formula:
    (wherein R¹⁰ represents hydrogen, halogen or alkyl), with the proviso that when R¹ represents hydrogen, the atom may be replaced by R³, and n represents 1 to 3, with the proviso that when n represents two or more, plural R³s may be different each, X represents oxygen or sulfur and R⁴ represents amino acid-residue], or a non-toxic salt thereof, and methods for their preparation and treating agents for cerebral edema containing them as active ingredients.

    Aminopropanolderivate von substituierten 2-Hydroxy-propiophenonen, Verfahren zu ihrer Herstellung und diese enthaltende therapeutische Mittel
    128.
    发明授权
    Aminopropanolderivate von substituierten 2-Hydroxy-propiophenonen, Verfahren zu ihrer Herstellung und diese enthaltende therapeutische Mittel 失效
    取代的2-羟基丙酸的氨基壬酸衍生物，其制备和治疗药物的方法

    公开(公告)号：EP0152556B1

    公开(公告)日：1987-01-21

    申请号：EP84114255.7

    申请日：1984-11-26

    申请人： BASF Aktiengesellschaft

    发明人： Franke, Albrecht, Dr. ,  Spiegler, Wolfgang, Dr. ,  Siegel, Hardo, Dr. ,  Mueller, Claus D. Dr. ,  von Philipsborn, Gerda, Dr. ,  Lenke, Dieter, Prof. Dr. ,  Gries, Josef, Dr.

    IPC分类号： C07D333/22 ,  C07D307/46 ,  C07D213/50 ,  C07D207/32 ,  C07D231/12 ,  A61K31/38 ,  A61K31/34 ,  A61K31/44 ,  A61K31/40 ,  A61K31/41

    CPC分类号： C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

    摘要： 1. Claims (for the Contracting states : BE, CH, DE, FR, GB, IT, LI, NL, SE) An aminopropanol derivative of the formula see diagramm : EP0152556,P11,F4 where R**1 and R**2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of up to 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of up to a total of 9 carbon atoms, or phenylalkyl or phenoxyalkyl, where the alkyl radical is of up to 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of up to 3 carbon atoms, or R**1 and R**2 , together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and - Het is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrryl-2, 1-alkylpyrryl-3 or 1-alkylpyrazol-4-yl, alkyl being of 1 to 3 carbon atoms, and its physiologically tolerated addition salts with acids. 1. Claims (for the Contracting state : AT) A process for the preparation of an aminopropanol derivative of the formula I see diagramm : EP0152556,P12,F5 where R**1 and R**2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of up to 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of up to a total of 9 carbon atoms, or phenylalkyl or phenoxyalkyl, where the alkyl radical is of up to 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of up to 3 carbon atoms, or R**1 and R**2 , together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and - Het is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrr-2-yl, 1-alkylpyrr-3-yl or 1-alkylpyrazol-4-yl, alkyl being of 1 to 3 carbon atoms, and its physiologically tolerated addition salts with acids, wherein a) a compound of the formula II see diagramm : EP0152556,P13,F1 where A is see diagramm : EP0152556,P13,F2 or see diagramm : EP0152556,P13,F3 B being a nucleofugic leaving group, is reacted with an amine of the formula HNR**1 R**2 where R**1 and R**2 have the stated meanings, or b) a compound of the formula IV see diagramm : EP0152556,P13,F4 where R**1 and R**2 have the stated meanings, is hydrogenated catalytically, and, if desired, the resulting compound is converted into its addition salts with physiologically tolerated acids.

    摘要翻译： 1.索赔（对于缔约国：BE，CH，DE，FR，GB，IT，LI，NL，SE）下式的氨基丙醇衍生物见图表：EP0152556，P11，F4，其中R ** 1和R ** 2各自相同或不同，各自为至多6个碳原子的氢，烷基，环烷基，烯基，炔基或羟基烷基，烷氧基烷基，烷硫基烷基或二烷基氨基烷基，各自总共9个碳原子，或苯基烷基或苯氧基烷基， 其中烷基具有多达6个碳原子，并且苯基未被取代或被烷基或烷氧基取代，各自至多3个碳原子，或者R ** 1和R ** 2与连接的氮原子一起 它们形成可被一个或两个苯基和/或羟基取代的5元至7元饱和杂环，并且可以含有氧或氮原子作为环中的另外的杂原子，并且这种另外的氮 原子可以被1至3个碳原子的烷基或苯基取代，而Het是噻吩-2-基，噻吩-3-基 1，吡啶-2-基，吡啶-3-基，吡啶-4-基，呋喃-2-基，1-烷基吡啶-2,1-烷基吡啶-3或1-烷基吡唑-4-基，烷基为1 至3个碳原子，以及其与酸的生理上耐受的加成盐。 1.权利要求（对于缔约国：AT）制备式I的氨基丙醇衍生物的方法见图示：EP0152556，P12，F5，其中R ** 1和R ** 2相同或不同，各自为氢 烷基，环烷基，烯基，炔基或羟基烷基，各自至多6个碳原子，烷氧基烷基，烷硫基烷基或二烷基氨基烷基，各自总共9个碳原子，或苯基烷基或苯氧基烷基，其中烷基最多为6 碳原子和苯基是未取代的或被烷基或烷氧基取代，各自至多3个碳原子，或者R ** 1和R ** 2与连接它们的氮原子一起形成5元至7元 可以被一个或两个苯基和/或羟基自由基取代并且可以含有氧或氮原子作为环中的另外的杂原子，并且这样的另外的氮原子可以被1至 3个碳原子或苯基，和-Het是噻吩-2-基，噻吩基-3 - 基，吡啶-2-基，吡啶-3-基，吡啶-4-基，呋喃-2-基，1-烷基吡咯-2-基，1-烷基吡咯-3-基或1-烷基吡唑-4-基 烷基具有1至3个碳原子，以及其与酸的生理上可耐受的加成盐，其中a）式II化合物参见图表EP0152556，P13，F1，其中A见图示：EP0152556，P13，F2或参见图 ：EP0152556，P13，F3B为离核离去基团，与式HNR ** 1 R ** 2的胺反应，其中R ** 1和R ** 2具有所述含义，或b） 式IV参见图表：EP0152556，P13，F4，其中R ** 1和R ** 2具有所述含义，被氢化催化，如果需要，所得化合物被转化为其与生理上耐受的酸的加成盐。

    Cyclohexane-1,3-dione derivatives, compositions containing them, processes for preparing them, and their use as herbicides and plant growth regulators
    129.
    发明公开
    Cyclohexane-1,3-dione derivatives, compositions containing them, processes for preparing them, and their use as herbicides and plant growth regulators 失效
    环己烷-1,3-二酮衍生物，含有它们的组合物，它们的制备方法和它们作为除草剂和植物生长调节剂的用途。

    公开(公告)号：EP0202042A1

    公开(公告)日：1986-11-20

    申请号：EP86303033.4

    申请日：1986-04-22

    申请人： ICI AUSTRALIA LIMITED

    发明人： Watson, Keith Geoffrey

    IPC分类号： C07C251/34 ,  C07D207/335 ,  C07D333/22 ,  C07D307/52 ,  A01N35/10

    CPC分类号： C07D207/335 ,  A01N35/10 ,  A01N37/50 ,  A01N41/06 ,  A01N43/10 ,  C07D307/52 ,  C07D333/22

    摘要： The invention concerns novel compounds of the formula

    wherein:

    Y is selected from phenyl, furyl, thienyl and pyrrolyl rings (each optionally substituted by group X), optionally branched alkylene or alkylenethio(oxy)alkylene;
    X which may be the same or different are independently selecfed from halogen, nitro, alkyl, substituted alkyl, hydroxy, alkoxy, carboxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, amino, substituted amino and alkanoyl;
    R' is selected from hydrogen, acyl and an inorganic or organic cation;
    R 2 is selected from alkyl, substituted alkyl, alkenyl haloalkenyl and alkynyl;
    R 3 is selected from alkyl; and
    R 4 is selected from hydrogen, alkyl, and alkoxycarbonyl. The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.

    摘要翻译： 式的本发明涉及新颖的化合物worin：Y选自苯基，呋喃基，噻吩基和吡咯基环（其各自任选substituiertem通过基团X），任选支链亚烷基或亚烷硫基（氧）亚烷基中选择; X可以是相同或选自卤素，硝基，烷基，烷基substituiertem，羟基，烷氧基，羧基，烷氧基羰基，alkyithio，烷基亚磺酰基，烷基磺酰基，氨磺酰基被unabhängig选择的不同，substituiertem氨磺酰基，氨基，氨基substituiertem和烷酰基; [R <1>选自氢，酰基和无机或有机阳离子的选择; [R <2>选自烷基，substituiertem烷基，烯基和卤代炔基; [R <3>选自烷基; 且R <4>选自氢，烷基，烷氧基羰基和选择。 本发明显示的化合物的除草特性和植物生长调节性能，在进一步的实施方案，本发明提供制备式的化合物的制备方法I，在式I，组合物含有作为活性成分的化合物的化合物的制备中有用的中间体 式I，和除草和植物生长调节过程利用式I的化合物。