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公开(公告)号：EP1632470A2
公开(公告)日：2006-03-08
申请号：EP05077693.9
申请日：1992-08-21
IPC分类号： C07C211/27 , C07D209/14 , C07C229/38 , C07C217/58
CPC分类号： A61K31/70 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/275 , A61K31/395 , A61K31/40 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C2601/14 , C07C2602/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07K14/705 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N2500/10 , G01N2500/20 , G01N2800/04
摘要： Method and composition useful for treating a patient having a disease characterized by an abnormal level of one or more components, the activity of which is regulated or affected by activity of one or more Ca 2+ receptors. Novel compounds useful in these methods and compositions are also provided. The method includes administering to the patient a therapeutically effective amount of a molecule active at one or more Ca 2+ receptors as an agonist or antagonist. Preferably, the molecule is able to act as either a selective agonist or antagonist at a Ca 2+ receptor of one or more but not all cells chosen from the group consisting of parathyroid cells, bone osteoclasts, juxtaglomerular kidney cells, proximal tubule kidney cells, keratinocytes, parafollicular thyroid cells and placental throphoblasts and a pharmaceutically acceptable carrier.
摘要翻译： 用于治疗具有以一种或多种成分异常水平为特征的疾病的患者的方法和组合物，其活性受一种或多种Ca 2+受体的活性调节或影响。 还提供了可用于这些方法和组合物的新型化合物。 该方法包括向患者施用治疗有效量的作为激动剂或拮抗剂的一种或多种Ca 2+受体活性的分子。 优选地，该分子能够作为一种或多种但不是全部选自甲状旁腺细胞，骨破骨细胞，近肾小球肾细胞，近端肾小管肾细胞的Ca 2+受体的选择性激动剂或拮抗剂， 角质形成细胞，旁分子甲状腺细胞和胎盘滋养细胞和药学上可接受的载体。
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12.发明公开
公开(公告)号：EP1613606A2
公开(公告)日：2006-01-11
申请号：EP04749815.9
申请日：2004-04-07
IPC分类号： C07D239/36 , C07D239/91
CPC分类号： C07D239/36 , C07D239/70 , C07D239/91 , C07D401/04
摘要： Pyrimidinone compounds are disclosed. Methods of preparing the pyrimidinone compounds are also disclosed.
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公开(公告)号：EP1070048B1
公开(公告)日：2005-08-31
申请号：EP99916516.0
申请日：1999-04-08
发明人： BHATNAGAR, Pradip, Kumar , BURGESS, Joelle, Lorraine , CALLAHAN, James, Francis , CALVO, Raul, Rolando , DEL MAR, Eric, G. , LAGO, Maria, Amparo , NGUYEN, Thomas, The
IPC分类号： C07C255/33 , C07C217/56 , C07C217/32 , C07C255/55 , C07C217/90 , C07C311/06 , C07D209/48 , A61K31/195 , A61K31/275 , A61K31/40 , A61K31/135 , A61K31/215
CPC分类号： C07D209/48 , C07C217/22 , C07C217/60 , C07C255/37 , C07C255/54 , C07C255/57 , C07C311/06
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14.发明授权ISOVALERAMIDE FOR THE TREATMENT OF CONVULSIONS, EPILEPSY, HEADACHE AND SPASTICITY 失效Isovaleramide用于治疗惊风，癫痫，头痛，痉挛
公开(公告)号：EP0938304B1
公开(公告)日：2004-12-15
申请号：EP97941381.2
申请日：1997-08-29
摘要： Preparations and extracts of valerian, as well as isovaleramide, isovaleric acid, and its pharmaceutically acceptable salts, esters, and substituted amides, exhibit clinically significant pharmacological properties which implicate a treatment for a variety of pathological conditions, including spasticity and convulsions, which are ameliorated by effecting a mild depression of CNS activity. The compositions in question generally are non-cytotoxic and do not elicit weakness or sedative activity at doses that are effective for the symptomatic treatment of such pathological conditions.
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15.发明授权INORGANIC ION RECEPTOR-ACTIVE COMPOUNDS 失效VERBINDUNGEN，DIE AUF ANORGANISCHE IONEN-REZEPTOREN WIRKEN
公开(公告)号：EP0907631B1
公开(公告)日：2003-06-18
申请号：EP97922601.6
申请日：1997-04-30
发明人： MOE, Scott, T. , VAN WAGENEN, Bradford, C. , DELMAR, Eric, G. , TROVATO, Richard , BALANDRIN, Manuel, F.
IPC分类号： C07C211/27 , C07C211/28 , C07C211/30 , A61K31/135
CPC分类号： C07C255/58 , A61K31/137 , A61K31/36 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C255/54 , C07C2601/02 , C07D307/81 , C07D317/58
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.
摘要翻译： 本发明的特征在于可以调节一种或多种无机离子受体活性的化合物和使用这些化合物治疗疾病或病症的方法。 优选的化合物可以模拟或阻断细胞外钙对细胞表面钙受体的作用。
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公开(公告)号：EP1258471A2
公开(公告)日：2002-11-20
申请号：EP02018228.3
申请日：1997-04-30
IPC分类号： C07C211/28 , C07C217/62 , C07C217/58 , A61K31/135 , A61P19/10
CPC分类号： C07C217/58 , A61K31/137 , A61K31/36 , C07C211/29 , C07C211/30 , C07C217/62 , C07C255/54 , C07C255/58 , C07C2601/02 , C07D307/81 , C07D317/58
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.
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公开(公告)号：EP1226164A1
公开(公告)日：2002-07-31
申请号：EP00973832.9
申请日：2000-10-25
发明人： KRAPCHO, Karen,NPS Pharmaceuticals, Inc. , STORMANN, Thomas,NPS Pharmaceuticals, Inc. , LEVINTHAL, Cynthia,NPS Pharmaceuticals, Inc. , HAMMERLAND, Lance,NPS Pharmaceuticals, Inc. , STORJOHANN, Laura
IPC分类号： C07K14/435 , C07K14/705 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/63 , G01N33/53
CPC分类号： C07K14/70571 , A61K38/00 , C07K2319/00 , G01N33/9406 , G01N2500/00
摘要： A novel human metabotropic glutamate receptor (mGluR) protein is identified, sequenced, and cloned. The receptor may be used to screen for compounds that modulate the activity of the mGluR. The recombinant mGluR as well as compounds that modulate mGluR activity may be used in the diagnosis and treatment of neurological disorders and diseases.
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18.发明公开METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES 审中-公开为中央神经系统疾病的治疗代谢型谷氨酸受体拮抗剂
公开(公告)号：EP1037878A2
公开(公告)日：2000-09-27
申请号：EP98959535.0
申请日：1998-11-20
发明人： VAN WAGENEN, Bradford, C. , MOE, Scott, T. , SMITH, Daryl, L. , SHEEHAN, Susan, M. , SHCHERBAKOVA, Irina , TRAVATO, Richard , WALTON, Ruth , BARMORE, Robert , DELMAR, Eric, G. , STORMANN, Thomas, M.
IPC分类号： C07D215/38 , C07D241/44 , C07D277/72 , A61K31/47 , A61K31/495 , A61K31/425
CPC分类号： C07D213/81 , C07D213/82 , C07D215/12 , C07D215/20 , C07D215/38 , C07D215/48 , C07D215/54 , C07D217/26 , C07D231/12 , C07D233/56 , C07D241/42 , C07D241/44 , C07D249/08 , C07D277/68 , C07D277/70 , C07D491/04
摘要： The present invention provides compounds, and pharmaceutical compositions containing those compounds, that act as antagonists at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
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公开(公告)号：EP0901459A1
公开(公告)日：1999-03-17
申请号：EP97917848.0
申请日：1997-04-04
发明人： VAN WAGENEN, Bradford, C. , DEL MAR, Eric, G. , SHEEHAN, Derek , BARMORE, Robert, M. , KEENAN, Richard, M. , KOTECHA, Nikesh, R. , THOMPSON, Mervyn , CALLAHAN, James, F.
IPC分类号： G01N33 , A61K31 , A61P19 , C07C217 , C07C255 , C07C311 , C07C323 , C07D209 , C07D213 , C07D317 , C07D333
CPC分类号： C07C311/29 , A61K31/137 , A61K31/18 , A61K31/277 , C07C217/30 , C07C217/60 , C07C217/62 , C07C255/46 , C07C255/54 , C07C323/25 , C07C2601/14 , C07C2603/74 , C07D213/65 , C07D317/58 , C07D333/70
摘要： The present invention features calcilytic compounds. 'Calcilytic compounds' refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
摘要翻译： 本发明的特征在于钙溶胶化合物。 “Calcilytic化合物”是指能够抑制钙受体活性的化合物。 还描述了钙溶解化合物在患者中抑制钙受体活性和/或实现有益作用的用途; 和可用于获得额外的钙溶解化合物的技术。
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公开(公告)号：EP0812328A1
公开(公告)日：1997-12-17
申请号：EP96907062.0
申请日：1996-02-16
CPC分类号： C07K14/43568 , A01N63/00 , A01N63/02 , C12N2799/026
摘要： This invention relates to the purification of a group of insecticidally effective toxins isolated from the wasp, Bracon hebetor, characterized by their neurotoxic effect on insect pest and low mammalian toxicity. The cDNA sequences for two of these toxins have been isolated, and the complete coding sequence is provided. This invention also discloses methods for producing recombinant toxins, as well as methods of utilizing these toxins as insecticidal agents.
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