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23 条记录 (耗时 0.02 秒)

    RECEPTOR FOR A BACILLUS THURINGIENSIS TOXIN
    11.
    发明公开
    RECEPTOR FOR A BACILLUS THURINGIENSIS TOXIN 失效
    受体苏云金芽孢杆菌毒素

    公开(公告)号：EP1005547A1

    公开(公告)日：2000-06-07

    申请号：EP98926445.2

    申请日：1998-06-08

    申请人： THE UNIVERSITY OF WYOMING

    发明人： BULLA, Lee, A.

    IPC分类号： C12N15/12 ,  C07K14/435 ,  C07K16/18 ,  G01N33/566

    CPC分类号： C07K14/43563

    摘要： The cDNA that encodes a glycoprotein receptor from the tobacco hornworm which binds a Bacillus thuringiensis toxin has been obtained and sequenced. The availability of this cDNA permits the retrieval of DNAs encoding homologous receptors in other insects and organisms as well as the design of assays for the cytotoxicity and binding affinity of potential pesticides and the development of methods to manipulate natural and/or introduced homologous receptors and, thus, to destroy target cells, tissues and/or organisms.

    5-AZIDO DEOXYURIDINE COMPOUNDS AND METHOD OF SYNTHESIS OF THE SAME
    13.
    发明授权
    5-AZIDO DEOXYURIDINE COMPOUNDS AND METHOD OF SYNTHESIS OF THE SAME 失效
    5-氨基脱氧羟基化合物及其合成方法

    公开(公告)号：EP0218701B1

    公开(公告)日：1993-08-04

    申请号：EP86902752.4

    申请日：1986-04-22

    申请人： THE UNIVERSITY OF WYOMING

    发明人： HALEY, Boyd, E. Markey Cancer Center ,  EVANS, Robert, K. Markey Cancer Center

    IPC分类号： C07H19/06 ,  C07H19/067 ,  C07H19/073 ,  C07H19/10

    CPC分类号： C07H19/10

    摘要： 5-azido-2'-deoxyuridine nucleoside and nucleotide compounds and a method of producing them. The method involves reacting a 5'-deoxyuridine compound with nitrosonium tetrafluoroborate to produce a 5-nitro-deoxyuridine compound. The 5-nitro-deoxyuridine compound is reduced to a 5-amino-deoxyuridine compound in the presence of metallic zinc. The 5-amino-deoxyuridine compound is acidified and reacted with sodium nitrite to produce a 5-diazo-deoxyuridine compound. The diazo-deoxyuridine compound is then reacted with sodium azide to produce a 5-azido-deoxyuridine compound. The latter, in the monophosphate form, is further reacted with diphenylchlorophosphate to produce the photoactive triphosphate, 5-azido-2'-deoxyuridine-5'-triphosphate or 5-azido-dUTP. The photoactive compound, when added to DNA in an in vitro synthesis reaction, produces photoactive DNA.

    METHODS AND COMPOSITIONS FOR CONTROLLED RELEASE OF DRUGS
    16.
    发明公开
    METHODS AND COMPOSITIONS FOR CONTROLLED RELEASE OF DRUGS 有权
    羟考酮控释

    公开(公告)号：EP1501352A1

    公开(公告)日：2005-02-02

    申请号：EP02787047.6

    申请日：2002-12-16

    申请人： THE UNIVERSITY OF WYOMING

    发明人： CORCORAN, Robert, C.

    IPC分类号： A01N25/00 ,  A01N43/42 ,  A61K47/00 ,  A61K47/30 ,  A61K47/32 ,  A61K47/34 ,  A61K31/44

    CPC分类号： A61K31/74 ,  A61K31/4468 ,  A61K31/485 ,  A61K47/56 ,  A61K47/58 ,  A61K47/60

    摘要： This invention provides a method and compositions for the controlled release of drugs that have been attached by means of a covalent bond to a polymer or other moiety that blocks activity of the drug until it has been released. A two-stage process is provided in which an unmasking reaction results in the formation of a chemical group that can then undergo a second reaction to release the drug. In a preferred embodiment, the narcotic analgesic fentanyl covalently attached to an inert polymer by way of its nitrogen through the formation of a quaternary vinylammonium salt, and then released by a sequence involving hydrolysis of an acetal that exposes an alcohol that may then undergo an intramolecular nucleophilic substitution reaction involving displacement of the nitrogen of oxycodone. The rate of this process may be controlled by controlling either or both of the rates of the acetal hydrolysis or the intramolecular substitution reaction, but is preferably controlled by the latter through varying the number of atoms in the chain connecting the alcohol group and the vinylic carbon, as well as by the addition of substituents on that chain. The drug-delivery molecules of this invention are useful for release of amine, alcohol and thiol drugs, including a number of narcotic analgesics, tricyclic amine antidepressants, and many others.

    PROCESS FOR WASTE PLASTIC RECYCLING
    17.
    发明公开
    PROCESS FOR WASTE PLASTIC RECYCLING 失效
    中回收的废塑料

    公开(公告)号：EP0688354A1

    公开(公告)日：1995-12-27

    申请号：EP94916504.0

    申请日：1994-03-08

    申请人： THE UNIVERSITY OF WYOMING

    发明人： GUFFEY, Frank, D. ,  BARBOUR, Floyd, Alan

    IPC分类号： C10G1

    CPC分类号： C10G1/10

    摘要： A process for recycling or decomposing waste plastic where such waste plastic is decomposed in a diluent such as hot oil through actions involving free radical precursor, such as polyvinyl chloride or polyurethane, is achieved at low temperature. The thermal decomposition (or pyrolysis) reaction is for about 1 hour at 375 °C and usable products, such as distillate, coke, and oil are recovered. Additionally the diluent may be recycled within the process.

    Cell specific cytotoxic agents
    19.
    发明公开
    Cell specific cytotoxic agents 失效
    Zell-spezifische细胞毒素Mittel。

    公开(公告)号：EP0332174A2

    公开(公告)日：1989-09-13

    申请号：EP89104119.6

    申请日：1989-03-08

    申请人： THE UNIVERSITY OF WYOMING

    发明人： Villemez, Clarence L. ,  Myers, Dean A.

    IPC分类号： C07K13/00 ,  A61K37/02

    CPC分类号： C07K14/34 ,  A61K38/00 ,  C07K19/00

    摘要： This invention relates to a modified diphtheria toxin (DT) having the following amino acid sequence: and method of preparing the same in which two carboxy-terminal truncated forms of DT are prepared by specific chemical proteolysis generating two new proteins HA51DT and HA48DT which can be chemically linked to a cell specific binding moiety to produce potent cytotoxins. This invention further relates to carboxy terminal peptides formed in accordance with said proteolysis generating three peptides HA11DT, HA7DT and HA3DT.

    摘要翻译： 本发明涉及具有以下氨基酸序列的修饰的白喉毒素（DT）及其制备方法：其中通过特异性化学蛋白水解制备两个羧基末端截短形式的DT，产生两种新蛋白质HA51DT和HA48DT 其可以与细胞特异性结合部分化学连接以产生有效的细胞毒素。 本发明还涉及根据产生三种肽HA11DT，HA7DT和HA3DT的所述蛋白水解形成的羧基末端肽。