公开(公告)号：EP2603493A1

公开(公告)日：2013-06-19

申请号：EP11749148.0

申请日：2011-08-12

申请人： Abbott GmbH & Co. KG ,  AbbVie Inc.

发明人： POHLKI, Frauke ,  AMBERG, Wilhelm ,  LANGE, Udo ,  OCHSE, Michael ,  BEHL, Berthold ,  HORNBERGER, Wilfried ,  MEZLER, Mario ,  HUTCHINS, Charles

IPC分类号： C07D217/02 ,  C07D401/12 ,  A61K31/472 ,  A61K31/4725 ,  A61P25/18

CPC分类号： C07D401/12 ,  A61K31/357 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/538 ,  C07D217/02 ,  C07D217/08 ,  C07D217/22 ,  C07D217/26

摘要： The present invention relates to phenalkylamine derivatives of the formula (I) or (II); or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such phenalkylamine derivatives, and the use of such phenalkylamine derivatives for therapeutic purposes. The phenalkylamine derivatives are GlyT1 inhibitors.

公开(公告)号：EP2396323A1

公开(公告)日：2011-12-21

申请号：EP10704812.6

申请日：2010-02-16

申请人： Abbott GmbH & Co. KG

发明人： LANGE, Udo ,  HEUTLING, Andreas ,  AMBERG, Wilhelm ,  OCHSE, Michael ,  BEHL, Berthold ,  HORNBERGER, Wilfried ,  MEZLER, Mario

IPC分类号： C07D471/04 ,  C07D471/14 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  A61K31/4355 ,  A61K31/4375 ,  A61P25/24

CPC分类号： C07D471/04 ,  C07D471/14 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

摘要： The present invention relates to heterocyclic compounds of the formula (I) or a physiologically tolerated salt thereof. The present invention also relates to pharmaceutical compositions comprising such heterocyclic compounds, and the use of such heterocyclic compounds for the manufacture of a medicament for inhibiting the glycine transporter GIyT1.

公开(公告)号：EP2271625A2

公开(公告)日：2011-01-12

申请号：EP09727055.7

申请日：2009-03-31

申请人： Abbott GmbH & Co. KG ,  Abbott Laboratories

发明人： AMBERG, Wilhelm ,  OCHSE, Michael ,  LANGE, Udo ,  BRAJE, Wilfried ,  BEHL, Berthold ,  HORNBERGER, Wilfried ,  MEZLER, Mario ,  HUTCHINS, Charles W.

IPC分类号： C07D217/18 ,  C07D401/06 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12 ,  C07D498/04 ,  C07D513/04 ,  A61K31/472 ,  A61P25/28

CPC分类号： C07D217/18 ,  C07D401/04 ,  C07D401/06 ,  C07D401/08 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D498/04 ,  C07D513/04

摘要： The present invention relates to tetrahydroisoquinoline of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such tetrahydroisoquinolines, and the use of such tetrahydroisoquinolines for therapeutic purposes. The tetrahydroisoquinolines are GIyT1 inhibitors.

公开(公告)号：EP1917244A2

公开(公告)日：2008-05-07

申请号：EP06791627.0

申请日：2006-08-23

申请人： Abbott GmbH & Co. KG

发明人： AMBERG, Wilhelm ,  NETZ, Astrid ,  KLING, Andreas ,  OCHSE, Michael ,  LANGE, Udo ,  HUTCHINS, Charles, W. ,  GARCIA-LADONA, Francisco, Javier ,  WERNET, Wolfgang

IPC分类号： C07D213/75 ,  C07D409/04 ,  C07D215/38 ,  C07D239/42 ,  C07D217/22 ,  C07D213/84 ,  C07D213/85 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/47 ,  A61P25/00 ,  A61K31/505

CPC分类号： C07D213/75 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  C07D213/84 ,  C07D213/85 ,  C07D215/38 ,  C07D217/22 ,  C07D239/42 ,  C07D409/04

摘要： The invention relates to the hetaryl-substituted guanidine compounds of general formula (I), enantiomeres, diastereomeres and/or tautomeres thereof, in addition to the pharmaceutically acceptable salts thereof and the prodrugs of the known compounds. The invention also relates to the use of said hetaryl-substituted guanidine compounds as binding partners for 5-HT5-receptors for treating and/or for the prophylaxis of illnesses which are modulated by a 5-HT5-receptor activity, in particular, for treating and/or for the prophylaxis of neurodegenerative and neuropsychiatric disorders, and signs, symptoms and dysfunctions associated with said disorders.

公开(公告)号：EP2603481A2

公开(公告)日：2013-06-19

申请号：EP11757790.8

申请日：2011-08-12

申请人： Abbott GmbH & Co. KG ,  Abbott Laboratories

发明人： LANGE, Udo ,  AMBERG, Wilhelm ,  OCHSE, Michael ,  POHLKI, Frauke ,  BEHL, Berthold ,  HUTCHINS, Charles

IPC分类号： C07C11/10 ,  C07C311/14 ,  C07D205/04 ,  C07D231/18 ,  C07D233/84 ,  A61K31/397 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/18 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24

CPC分类号： C07C311/14 ,  C07C311/10 ,  C07C2601/02 ,  C07C2602/08 ,  C07D205/04 ,  C07D231/18 ,  C07D233/84 ,  C07D403/12

摘要： The present invention relates to aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminoindane derivatives, and the use of such aminoindane derivatives for therapeutic purposes. The aminoindane derivatives are GlyT1 inhibitors.

摘要翻译： 本发明涉及式（I）的氨基茚满衍生物或其生理上耐受的盐。 本发明涉及包含这种氨基茚满衍生物的药物组合物，以及这种氨基茚满衍生物用于治疗目的的用途。 氨基茚满衍生物是GlyT1抑制剂。

公开(公告)号：EP2396296A1

公开(公告)日：2011-12-21

申请号：EP10706575.7

申请日：2010-02-16

申请人： Abbott GmbH & Co. KG ,  Abbott Laboratories

发明人： AMBERG, Wilhelm ,  OCHSE, Michael ,  LANGE, Udo ,  KLING, Andreas ,  BEHL, Berthold ,  HORNBERGER, Wilfried ,  MEZLER, Mario ,  HUTCHINS, Charles

IPC分类号： C07C215/70 ,  C07C311/00 ,  C07C317/00 ,  C07C233/00 ,  C07D213/71 ,  C07D231/18 ,  C07D233/84 ,  C07D249/12 ,  C07D261/08 ,  C07D275/02 ,  C07D305/08 ,  C07D333/04 ,  C07F7/10 ,  A61K31/16 ,  A61P25/00

CPC分类号： C07C311/05 ,  C07C215/64 ,  C07C217/74 ,  C07C233/18 ,  C07C233/19 ,  C07C233/69 ,  C07C255/58 ,  C07C271/24 ,  C07C307/06 ,  C07C309/65 ,  C07C311/07 ,  C07C311/09 ,  C07C311/10 ,  C07C311/13 ,  C07C311/14 ,  C07C311/17 ,  C07C311/18 ,  C07C311/20 ,  C07C311/24 ,  C07C317/18 ,  C07C317/28 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2602/10 ,  C07D205/04 ,  C07D207/09 ,  C07D207/10 ,  C07D207/12 ,  C07D207/27 ,  C07D207/36 ,  C07D207/48 ,  C07D213/71 ,  C07D231/18 ,  C07D233/84 ,  C07D249/12 ,  C07D261/08 ,  C07D265/30 ,  C07D275/02 ,  C07D295/096 ,  C07D295/135 ,  C07D305/08 ,  C07D333/34 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07F7/0818

摘要： The present invention relates to aminotetraline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminotetraline derivatives, and the use of such aminotetraline derivatives for therapeutic purposes. The aminotetraline derivatives are GlyT1 inhibitors.

摘要翻译： 本发明涉及式（I）的氨基四氢化萘衍生物或其生理上耐受的盐。 本发明涉及包含这种氨基四氢化萘衍生物的药物组合物以及这种氨基四氢化萘衍生物用于治疗目的的用途。 氨基四氢叶酸衍生物是GlyT1抑制剂。

公开(公告)号：EP1917245A1

公开(公告)日：2008-05-07

申请号：EP06777002.4

申请日：2006-08-21

申请人： Abbott GmbH & Co. KG

发明人： AMBERG, Wilhelm ,  NETZ, Astrid ,  KLING, Andreas ,  OCHSE, Michael ,  LANGE, Udo ,  HUTCHINS, Charles, W. ,  GARCIA-LADONA, Francisco, Javier ,  WERNET, Wolfgang

IPC分类号： C07D215/38 ,  C07D239/84 ,  C07D401/12 ,  C07D409/12 ,  C07D471/04 ,  C07D493/04 ,  A61K31/498 ,  A61K31/4741 ,  A61K31/4709 ,  A61K31/4375 ,  A61K31/5377 ,  A61P25/00

CPC分类号： C07D491/056 ,  C07D215/38 ,  C07D239/84 ,  C07D401/04 ,  C07D401/12 ,  C07D405/06 ,  C07D409/04 ,  C07D409/12 ,  C07D471/04 ,  C07D491/04

摘要： The invention relates to compounds of general formula (I), corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof and the prodrugs of said compounds. The invention also relates to the use of said compounds as binding partners for 5-HT5 receptors for treating diseases that are modulated by a 5-HT5 receptor activity, in particular, for treating neurodegenerative and neuropsychiatric disorders as well as signs, symptoms and dysfunctions.

公开(公告)号：EP0892786B1

公开(公告)日：2004-06-09

申请号：EP97915481.2

申请日：1997-04-04

申请人： Abbott GmbH & Co. KG

发明人： RIECHERS, Hartmut ,  KLINGE, Dagmar ,  AMBERG, Wilhelm ,  KLING, Andreas ,  HILLEN, Heinz ,  UNGER, Liliane ,  ELGER, Bernd

IPC分类号： C07D239/52 ,  C07D239/34 ,  C07D239/60 ,  C07D239/70 ,  C07D403/12 ,  A61K31/505

CPC分类号： C07D239/46

摘要： Carboxylic acid derivatives having the formula (I) are disclosed, as well as the production of these compounds and their use as medicaments. In the formula, the radicals have the meanings defined in the description.

公开(公告)号：EP0892787B1

公开(公告)日：2003-06-11

申请号：EP97918110.4

申请日：1997-04-04

申请人： Abbott GmbH & Co. KG

发明人： KLINGE, Dagmar ,  AMBERG, Wilhelm ,  BAUMANN, Ernst ,  KLING, Andreas ,  RIECHERS, Hartmut ,  UNGER, Liliane ,  RASCHACK, Manfred ,  HERGENRÖDER, Stefan ,  SCHULT, Sabine

IPC分类号： C07D239/52 ,  C07D239/60 ,  C07D239/34 ,  C07D239/70 ,  C07D405/12 ,  A61K31/505

CPC分类号： C07D217/22 ,  C07D239/34 ,  C07D239/48 ,  C07D239/52 ,  C07D239/56 ,  C07D239/60 ,  C07D239/80 ,  C07D239/96 ,  C07D251/20 ,  C07D251/22 ,  C07D251/30 ,  C07D251/38 ,  C07D251/52 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

摘要： The present invention relates to carboxylic acid derivatives of the formula (I) in which the radicals have the meaning given in the description, the production of these compounds and their use as medicaments.