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公开(公告)号：EP3119759A1
公开(公告)日：2017-01-25
申请号：EP15710774.9
申请日：2015-03-18
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred , GEISLER, Jens
IPC分类号： C07D401/14 , A61K31/427 , A61K31/433 , A61K31/444 , A61K31/497 , A61K31/506 , C07D401/04 , C07D417/04 , C07D417/14
CPC分类号： C07D417/14 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/14 , C07D409/04 , C07D417/04
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及如本文所述和定义的通式（I）的Wnt信号传导途径的抑制剂，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，药物组合物和包含所述化合物和 所述化合物用于制造用于治疗或预防疾病，特别是过度增殖性疾病的药物组合物作为单独药剂或与其他活性成分组合的用途。
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12.发明公开1,3,4-THIADIAZOL-2-YL-BENZAMIDE DERIVATIVES AS INHIBITORSOF THE WNT SIGNALLING PATHWAY 审中-公开作为WNT信号通路抑制剂的1,3,4-噻二唑-2-基苯甲酰胺衍生物
公开(公告)号：EP3259268A1
公开(公告)日：2017-12-27
申请号：EP16704644.0
申请日：2016-02-16
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William J. , GIESE, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred , GEISLER, Jens
IPC分类号： C07D417/12 , C07D417/14 , A61K31/454 , A61K31/496 , A61P35/00 , A61P37/02
CPC分类号： C07D285/135 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.
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13.发明授权3-ACETYLAMINO-1-(PHENYL-HETEROARYL-AMINOCARBONYL OR PHENYL-HETEROARYL-CARBONYLAMINO)BENZENE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS 有权3-乙酰氨基-1-（苯基 - 芳基 - 氨基羰基）苯基 - 邻苯二甲酰亚胺基）苯甲醛衍生物ZUR BEHANDLUNG VON HYPERPROLIFERATIVEN ERKRANKUNGEN
公开(公告)号：EP2976327B1
公开(公告)日：2017-06-21
申请号：EP14712631.2
申请日：2014-03-17
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William J. , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D213/75 , C07D498/08 , C07D277/46 , C07D277/56 , C07D333/38 , C07D213/82 , C07D263/34 , C07D207/34 , C07D285/135 , C07D271/06 , C07D231/14 , C07D271/07 , C07D401/12 , C07D417/12 , C07D487/08 , C07D271/113 , A61K31/4418 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/433 , A61K31/4418 , A61K31/4439 , A61K31/496 , A61K31/4995 , A61K31/5386 , A61K31/551 , A61K31/553 , A61K45/06 , C07C205/45 , C07C205/59 , C07C229/64 , C07C233/15 , C07C233/54 , C07C255/56 , C07C317/44 , C07D207/34 , C07D213/73 , C07D213/75 , C07D213/76 , C07D213/82 , C07D231/14 , C07D263/34 , C07D271/06 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D285/135 , C07D295/15 , C07D295/155 , C07D333/38 , C07D401/12 , C07D417/12 , C07D487/08 , C07D498/08
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公开(公告)号：EP3532474A2
公开(公告)日：2019-09-04
申请号：EP17797091.0
申请日：2017-10-25
申请人： Bayer AG , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , President and Fellows of Harvard College , The General Hospital Corporation
发明人： GRADL, Stefan, Nikolaus , NGUYEN, Duy , EIS, Knut , GUENTHER, Judith , STELLFELD, Timo , JANZER, Andreas , CHRISTIAN, Sven , MUELLER, Thomas , EL SHEIKH, Sherif , ZHOU, Han, Jie , ZHAO, Changjia , SYKES, David B , FERRARA, Steven, James , LIU, Kery , HERBERT, Simon, Anthony , MERZ, Claudia , NIEHUES, Michael , NISING, Carl, Friedrich , SCHÄFER, Martina , ZIMMERMANN, Katja , KNAEBLEIN, Jörg , THEDE, Kai , FAUPEL, Thomas
IPC分类号： C07D471/04 , A61K31/4196 , C07D487/04 , C07D498/04 , C07D513/04 , C12N15/70
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15.发明公开3-CARBAMOYLPHENYL-4-CARBOXAMIDE AND ISOPHTALAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY 审中-公开作为WNT信号通路抑制剂的3-氨基甲酰基苯基-4-甲酰胺和异鼠李素衍生物
公开(公告)号：EP3259263A1
公开(公告)日：2017-12-27
申请号：EP16704456.9
申请日：2016-02-16
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William j. , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PÜHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D401/14 , C07D213/73 , C07D213/75 , C07D401/12 , A61K31/435 , A61P35/00 , C07C15/04
CPC分类号： A61K31/435 , C07C237/44 , C07D213/73 , C07D213/75 , C07D401/12 , C07D401/14
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients, in which: R1 represents a group selected from: C1-C3-alkoxy-C2-C5-alkyl-, (A), (B), (C), (D), (E), (F), (G) or (H); wherein * indicates the point of attachment to the rest of the molecule; R2 represents a group selected from: (I), (J) or (K); wherein * indicates the point of attachment to the rest of the molecule.
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16.发明公开N-PHENYL-(MORPHOLIN-4-YL OR PIPERAZINYL)ACETAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE WNT SIGNALLING PATHWAYS 审中-公开N-苯基 - （吗啉-4-基或哌嗪基）乙酰胺衍生物及其作为Wnt信号通路抑制剂的用途
公开(公告)号：EP3259251A1
公开(公告)日：2017-12-27
申请号：EP16704645.7
申请日：2016-02-16
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William, J. , GIESE, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PÜEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D213/73 , C07D231/12 , C07D403/04 , C07D239/26 , C07D239/34 , C07D239/42 , C07D213/40 , C07D213/61 , C07D213/64 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/5377 , A61K45/06 , C07D213/40 , C07D213/61 , C07D213/64 , C07D213/73 , C07D231/12 , C07D239/26 , C07D239/34 , C07D239/42 , C07D403/04
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) wherein LA represents *CH2** or *Δ**; wherein indicates the point of attachment to the carbonyl group, and ** indicates the point of attachment to R1; LB represents *N(H)-C(=O)** or *C(=O)-N(H)**; wherein * indicates the point of attachment to R2, and ** indicates the point of attachment to the phenyl group; R1 represents a group selected from: (AA); wherein * indicates the point of attachment to LA, R2 represents: (BB) wherein * indicates the point of attachment to R3, and ** indicates the point of attachment to LB R3 represents a group selected from: (CC); wherein * indicates the point of attachment to R2; R4 and R5 represent a hydrogen atom; and R6 represents a halogen atom or group selected from: -CH3, -O-CH3, -O-CHF2, -O-CF3, and -O-cyclopropyl; to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular, of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3119787A1
公开(公告)日：2017-01-25
申请号：EP15710498.5
申请日：2015-03-18
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William , GIESE, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred , GEISLER, Jens
IPC分类号： C07D491/08 , C07D491/04 , C07D403/04 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/28 , C07D253/07 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/506 , A61K31/53 , A61P35/00
CPC分类号： C07D491/08 , A61K9/0007 , A61K9/0019 , A61K9/0056 , A61K9/08 , A61K9/10 , A61K9/19 , A61K9/2018 , A61K9/205 , A61K9/2054 , A61K9/2063 , A61K9/4858 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K45/06 , C07C205/45 , C07C205/59 , C07C229/64 , C07C233/25 , C07C233/54 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/24 , C07D241/28 , C07D253/07 , C07D295/15 , C07D401/04 , C07D403/04 , A61K2300/00
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及如本文所述和定义的通式（I）的Wnt信号传导途径的抑制剂，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合， 使用所述化合物制造用于治疗或预防疾病，特别是高增殖性疾病的药物组合物作为唯一试剂或与其它活性成分组合。
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18.发明公开SUBSTITUTED N-BIPHENYL-3-ACETYLAMINO-BENZAMIDES AND N-[3-(ACETYLAMINO)PHENYL]-BIPHENYL-CARBOXAMIDES AND THEIR USE AS INHIBITORS OF THE WNT SIGNALLING PATHWAY 审中-公开N-BIPHENYL-3-乙酰氨基苯甲酰胺在N- [3-（乙酰氨基）苯基] - 联苯甲酰胺在DEREN VERWENDUNG ALS INHIBITOREN DES WNT-SIGNALTRANSDUKESWEGES
公开(公告)号：EP2976343A2
公开(公告)日：2016-01-27
申请号：EP14711513.3
申请日：2014-03-20
发明人： THEDE, Kai , SCOTT, William Johnston , BENDER, Eckhard , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PÜHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred , RICHTER, Anja , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , ZORN, Ludwig
IPC分类号： C07D491/08 , C07C271/24 , C07D231/12 , C07C317/48 , C07C317/50 , C07D413/12 , C07C323/63 , C07C233/54 , C07C233/80 , C07D205/04 , C07D265/30 , C07D491/10 , A61K31/4418 , A61P35/00 , C07C237/40
CPC分类号： C07D295/15 , C07C233/54 , C07C233/80 , C07C237/40 , C07C237/42 , C07C237/44 , C07C271/24 , C07C317/44 , C07C317/48 , C07C317/50 , C07C323/63 , C07C2601/02 , C07D205/04 , C07D207/12 , C07D211/42 , C07D211/44 , C07D211/46 , C07D231/10 , C07D231/12 , C07D265/30 , C07D267/10 , C07D295/145 , C07D295/26 , C07D307/54 , C07D333/24 , C07D413/12 , C07D491/08 , C07D491/10 , C07D491/107 , C07D498/08
摘要： The present invention relates to substituted N-biphenyl-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-biphenyl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及如本文所述和定义的取代的N-联苯-3-乙酰氨基 - 苯甲酰胺和通式（I）的N- [3-（乙酰氨基）苯基] - 联苯 - 甲酰胺，制备所述化合物的方法， 可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述化合物用于制备用于治疗或预防疾病，特别是过度增殖性疾病的药物组合物作为唯一试剂的用途或 与其他活性成分组合。
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19.发明公开3-ACETYLAMINO-1-(PHENYL-HETEROARYL-AMINOCARBONYL OR PHENYL-HETEROARYL-CARBONYLAMINO)BENZENE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS 有权3-乙酰基氨基-1-（苯基 - 杂芳基 - 氨基羰基，或苯基 - 杂芳基 - 羰基氨基）苯衍生物用于治疗过度增生性疾病的治疗
公开(公告)号：EP2976327A2
公开(公告)日：2016-01-27
申请号：EP14712631.2
申请日：2014-03-17
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William J. , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D213/75 , C07D498/08 , C07D277/46 , C07D277/56 , C07D333/38 , C07D213/82 , C07D263/34 , C07D207/34 , C07D285/135 , C07D271/06 , C07D231/14 , C07D271/07 , C07D401/12 , C07D417/12 , C07D487/08 , C07D271/113 , A61K31/4418 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/433 , A61K31/4418 , A61K31/4439 , A61K31/496 , A61K31/4995 , A61K31/5386 , A61K31/551 , A61K31/553 , A61K45/06 , C07C205/45 , C07C205/59 , C07C229/64 , C07C233/15 , C07C233/54 , C07C255/56 , C07C317/44 , C07D207/34 , C07D213/73 , C07D213/75 , C07D213/76 , C07D213/82 , C07D231/14 , C07D263/34 , C07D271/06 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D285/135 , C07D295/15 , C07D295/155 , C07D333/38 , C07D401/12 , C07D417/12 , C07D487/08 , C07D498/08
摘要： The present invention relates to substituted N-(phenyl-heteroaryl)-3-acetylamino-benzamides and N- [3-(acetylamino)phenyl]-phenyl-heteroaryl-carboxamides of general formula(I) as described and defined herein,to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.
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公开(公告)号：EP4114528A1
公开(公告)日：2023-01-11
申请号：EP21709020.8
申请日：2021-03-05
发明人： THEDE, Kai , BUCHGRABER, Philipp , SIEMEISTER, Gerhard , STEIGEMANN, Patrick , WENGNER, Antje, Margret , BÖMER, Ulf , BARAK, Naomi , LIENAU, Philip
IPC分类号： A61P35/00 , A61K31/53 , C07D487/04
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