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公开(公告)号：EP3532474A2
公开(公告)日：2019-09-04
申请号：EP17797091.0
申请日：2017-10-25
申请人： Bayer AG , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , President and Fellows of Harvard College , The General Hospital Corporation
发明人： GRADL, Stefan, Nikolaus , NGUYEN, Duy , EIS, Knut , GUENTHER, Judith , STELLFELD, Timo , JANZER, Andreas , CHRISTIAN, Sven , MUELLER, Thomas , EL SHEIKH, Sherif , ZHOU, Han, Jie , ZHAO, Changjia , SYKES, David B , FERRARA, Steven, James , LIU, Kery , HERBERT, Simon, Anthony , MERZ, Claudia , NIEHUES, Michael , NISING, Carl, Friedrich , SCHÄFER, Martina , ZIMMERMANN, Katja , KNAEBLEIN, Jörg , THEDE, Kai , FAUPEL, Thomas
IPC分类号： C07D471/04 , A61K31/4196 , C07D487/04 , C07D498/04 , C07D513/04 , C12N15/70
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公开(公告)号：EP3532468A1
公开(公告)日：2019-09-04
申请号：EP17788234.7
申请日：2017-10-25
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute Inc. , President and Fellows of Harvard College , The General Hospital Corporation
发明人： GRADL, Stefan, Nikolaus , NGUYEN, Duy , EIS, Knut , GÜNTHER, Judith , STELLFELD, Timo , JANZER, Andreas , CHRISTIAN, Sven , MUELLER, Thomas , EL SHEIKH, Sherif El , ZHOU, Han, Jie , ZHAO, Changjia , SYKES, David Brian , FERRARA, Steven, James , LIU, Kery , KRÖBER, Michael , MERZ, Claudia , NIEHUES, Michael , SCHÄFER, Martina , ZIMMERMANN, Katja , NISING, Carl, Friedrich
IPC分类号： C07D403/12 , C07D401/12 , C07D405/12 , C07D413/12 , C07D249/12 , A61K31/4196 , A61P35/02
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公开(公告)号：EP3458459A1
公开(公告)日：2019-03-27
申请号：EP17734982.6
申请日：2017-05-17
发明人： JOHANNES, Sarah Anna Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , CHRIST, Clara , FERNANDEZ-MONTALVAN, Amaury, Ernesto , MÖWES, Manfred , LIENAU, Philipp , EIS, Knut , SACK, Ulrike , MÖNNING, Ursula , SCHOLZ, Arne , KUHNKE, Joachim , THEDE, Kai , WERBECK, Nicolas , SERRANO-WU, Michael H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61K31/4162 , A61P35/00
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公开(公告)号：EP3576742A1
公开(公告)日：2019-12-11
申请号：EP18704189.2
申请日：2018-02-01
申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc. , Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft
发明人： LEWIS, Timothy, A. , WU, Xiaoyun , GREULICH, Heidi , MEYERSON, Matthew , ELLERMANN, Manuel , LIENAU, Philip , EIS, Knut , WENGNER, Antje, Margret , KOPITZ, Charlotte, Christine , LANGE, Martin
IPC分类号： A61K31/501 , C07D413/10 , A61P35/00
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5.发明公开
公开(公告)号：EP3411037A1
公开(公告)日：2018-12-12
申请号：EP17704195.1
申请日：2017-02-03
申请人： Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana Farber Cancer Institute, Inc.
发明人： WENGNER, Antje, Margret , EIS, Knut , LIENAU, Philip , SACK, Ulrike , LANGE, Martin , GREULICH, Heidi , MEYERSON, Matthew , DE WAAL, Luc , SCHENONE, Monica , BURGIN, Alex , LEWIS, Timothy, A. , WU, Xiaoyun
IPC分类号： A61K31/50 , A61K31/5375 , A61K45/00 , G01N33/68 , A61P35/00
CPC分类号： A61K31/50 , A61K31/5375 , A61P35/00 , G01N33/68 , G01N2333/4703 , G01N2333/916 , G01N2800/52
摘要： The present invention features improved Compounds, especially (I) methods of identifying patients having Cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3Ll) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).
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公开(公告)号：EP3781565A1
公开(公告)日：2021-02-24
申请号：EP19720074.4
申请日：2019-04-15
发明人： WORTMANN, Lars , SAUTIER, Brice , EIS, Knut , BRIEM, Hans , BÖHNKE, Niels , VON NUSSBAUM, Franz , HILIG, Roman , BADER, Benjamin , SCHRÖDER, Jens , PETERSEN, Kirstin , LIENAU, Philip , WENGNER, Antje, Margret , MOOSMAYER, Dieter , WANG, Qiuwen
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
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公开(公告)号：EP3157914A1
公开(公告)日：2017-04-26
申请号：EP15730130.0
申请日：2015-06-17
发明人： GRAHAM, Keith , KLAR, Ulrich , BRIEM, Hans , HITCHCOCK, Marion , BÄRFACKER, Lars , EIS, Knut , SCHULZE, Volker , SIEMEISTER, Gerhard , BONE, Wilhelm , SCHRÖDER, Jens , HOLTON, Simon , LIENAU, Philip , TEMPEL, René , SONNENSCHEIN, Helmut , BÁLINT, Jozsef , GRAUBAUM, Heinz
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/056 , A61K31/4439 , A61K31/444 , A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , A61K31/436 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/056
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：EP3390387A1
公开(公告)日：2018-10-24
申请号：EP16829402.3
申请日：2016-12-15
发明人： SCHULZE, Volker , HEINRICH, Tobias , PRINZ, Florian , LEFRANC, Julien , SCHRÖDER, Jens , MENGEL, Anne , BONE, Wilhelm , BÁLINT, Joszef , WENGNER, Antje Margret , EIS, Knut , IRLBACHER, Horst , KOPPITZ, Marcus , BÖMER, Ulf , BADER, Benjamin , BRIEM, Hans , LIENAU, Philip , CHRIST, Clara , STÖCKIGT, Detlef , HILLIG, Roman , EHEIM, Ashley , KOSEMUND, Dirk , MÖNNING, Ursula , HARB, Hassan, Y.
IPC分类号： C07D401/14 , C07D405/14 , C07D401/12 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08 , A61K31/407
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08
摘要： The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3177619B1
公开(公告)日：2018-04-25
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3177619A1
公开(公告)日：2017-06-14
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译： 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是过度增殖的药物组合物的所述化合物的用途 疾病作为唯一的药剂或与其他活性成分组合。
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