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公开(公告)号：EP1115863B1
公开(公告)日：2007-11-28
申请号：EP99969439.1
申请日：1999-09-15
申请人： GENENTECH, INC.
发明人： ADAMS, Sean , PAN, James , ZHONG, Alan
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/47 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins ("UCPs") and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及与某些人解偶联蛋白质（“UCP”）具有同源性的新多肽以及编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体和用于产生本发明多肽的方法 发明。
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12.发明公开SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开多米诺骨牌多糖在多巴哥的KODIERENDE NUKLEINSURE
公开(公告)号：EP1259614A2
公开(公告)日：2002-11-27
申请号：EP01945919.7
申请日：2001-02-28
申请人： Genentech, Inc.
发明人： BAKER, Kevin, P. , CHEN, Jian , DESNOYERS, Luc , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , PAN, James , SMITH, Victoria , WATANABE, Colin, K. , WOOD, William, I. , ZHANG, Zemin
CPC分类号： C07K14/70532
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：EP1169442A2
公开(公告)日：2002-01-09
申请号：EP00917717.1
申请日：2000-03-01
申请人： Genentech, Inc.
发明人： DESNOYERS, Luc , EATON, Dan, L. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , PAN, James , STEWART, Timothy, A. , WATANABE, Colin, K. , WOOD, William, I. , ZHANG, Zemin
CPC分类号： C07K14/70578 , C07K14/47 , C07K2319/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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14.发明公开COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF DISORDERS INVOLVING ANGIOGENESIS 审中-公开组合物和诊断方法和治疗疾病的为其血管生成的作用
公开(公告)号：EP1309620A2
公开(公告)日：2003-05-14
申请号：EP01957073.8
申请日：2001-06-20
申请人： Genentech, Inc.
发明人： BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary, E. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , HILLAN, Kenneth, J. , MARSTERS, Scot, A. , PAN, James , PAONI, Nicholas, F. , STEPHAN, Jean-Philippe, F. , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I. , YE, Weilan
CPC分类号： C07K14/47
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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15.发明公开
公开(公告)号：EP1208195A2
公开(公告)日：2002-05-29
申请号：EP00936172.6
申请日：2000-05-22
申请人： Genentech Inc.
发明人： ASHKENAZI,Avi,J , BAKER,Kevin,P , BOTSTEIN, David , DESNOYERS, Luc , EATON, Dan, L. , FERRARA, Napoleone , FONG, Sherman , GAO, Wei-Qiang , GERBER, Hanspeter , GERRITSEN,Mary, E. , GODDARD, Audrey , GODOWSKI,Paul,J , GURNEY, Austin,L , KLJAVIN, Ivar, J , MATHER,Jennie,P , NAPIER, Mary,A , PAN, James , PAONI, Nicholas,F , ROY, Margaret,Ann , TUMAS, Daniel , WATANABE, Colin,K , WILLIAMS, P, Mickey , WOOD,William, I , ZHANG, Zemin
CPC分类号： C07K14/495 , C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1173563A1
公开(公告)日：2002-01-23
申请号：EP00907270.3
申请日：2000-02-11
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi, J. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , HILLAN, Kenneth, J. , MARSTERS, Scot, A. , PAN, James , PITTI, Robert, M. , ROY, Margaret, Ann , SMITH, Victoria , STONE, Donna, M. , WATANABE, Colin, K. , WOOD, William, I.
CPC分类号： G01N33/57484 , A61K31/7088 , A61K39/395 , A61K45/00 , A61K45/06 , A61K48/00 , C07K14/47 , C07K14/705 , C07K14/72 , C07K14/82 , C07K16/18 , C07K16/30 , C07K16/32 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , G01N33/15 , G01N33/50 , G01N33/574 , G01N33/57496
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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17.发明公开
公开(公告)号：EP1169448A1
公开(公告)日：2002-01-09
申请号：EP00923254.7
申请日：2000-04-12
申请人： Genentech, Inc.
发明人： GODDARD, Audrey , PAN, James , YAN, Minhong
IPC分类号： C12N15/12 , C07K14/715 , C07K16/28 , A61K38/17
CPC分类号： C12N15/10 , A61K38/00 , C07K14/4703 , C07K14/4705 , C07K14/70578 , C12N2799/026 , C12Q1/686 , C12Q2531/113 , C12Q2521/331
摘要： The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1141299A2
公开(公告)日：2001-10-10
申请号：EP99968539.9
申请日：1999-12-22
申请人： Genentech, Inc.
发明人： GODDARD, Audrey , PAN, James
CPC分类号： C07K14/545 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to the IL-1-like family of proteins and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1115863A1
公开(公告)日：2001-07-18
申请号：EP99969439.1
申请日：1999-09-15
申请人： Genentech, Inc.
发明人： ADAMS, Sean , PAN, James , ZHONG, Alan
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/47 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins ('UCPs') and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及与某些人解偶联蛋白质（“UCPs”）具有同源性的新多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体和用于产生本发明多肽的方法 发明。
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