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公开(公告)号：EP1730165A1
公开(公告)日：2006-12-13
申请号：EP05724112.7
申请日：2005-02-24
申请人： SCHERING CORPORATION
发明人： BOGEN, Stephane, L. , PAN, Weidong , RUAN, Sumei , CHEN, Kevin, X. , ARASAPPAN, Ashok , VENKATRAMAN, Srikanth , NAIR, Latha, G. , SANNIGRAHI, Mousumi , BENNETT, Frank , SAKSENA, Anil, K. , NJOROGE, F., George , GIRIJAVALLABHAN, Viyyoor, M.
IPC分类号： C07K5/02 , C07D209/52 , C07D417/12 , C07D401/12 , C07D409/12 , C07D403/12 , C07D407/12 , C07D413/12 , C07D491/04 , C07D209/70 , C07D495/10 , C07D207/10 , C07D295/16 , A61K31/403 , A61K31/427
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds of formula (I) which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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12.发明公开NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS 有权与来自丙型肝炎病毒NS3丝氨酸蛋白酶的抗循环P4作为抑制剂NEW酮酰胺
公开(公告)号：EP1730142A1
公开(公告)日：2006-12-13
申请号：EP05723688.7
申请日：2005-02-24
申请人： SCHERING CORPORATION
发明人： CHEN, Kevin, X. , NJOROGE, F., George , SANNIGRAHI, Mousumi , NAIR, Latha, G. , YANG, Weiying , VIBULBHAN, Bancha , VENKATRAMAN, Srikanth , ARASAPPAN, Ashok , BOGEN, Stephane, L. , BENNETT, Frank , GIRIJAVALLABHAN, Viyyoor, M.
IPC分类号： C07D417/12 , C07D513/04 , C07D401/12 , C07D209/52 , C07K5/08 , A61K31/40 , A61P31/12
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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公开(公告)号：EP1664092A1
公开(公告)日：2006-06-07
申请号：EP04784827.0
申请日：2004-09-23
申请人： SCHERING CORPORATION
发明人： VENKATRAMAN, Srikanth , NJOROGE, F., George , WU, Wanli , GIRIJAVALLABHAN, Viyyoor, M. , MCKITTRICK, Brian , SU, Jing , VELAZQUEZ, Francisco , PINTO, Patrick, A.
IPC分类号： C07K5/12 , C07D245/00 , A61K38/12
CPC分类号： C07D245/04 , A61K31/33 , A61K38/12 , A61K38/21 , A61K38/212 , C04B35/632 , C07D401/12 , C07D403/12 , C07D409/12 , C07D487/04 , C07D513/04 , C07K5/0217 , C07K5/0802 , A61K2300/00
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. The novel compounds typically include a 15-20 member macrocycle and have the general structure of structural Formula (1): wherein Z', L', M', R1, X and D are defined herein.
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公开(公告)号：EP1660477A1
公开(公告)日：2006-05-31
申请号：EP04779960.6
申请日：2004-08-04
申请人： SCHERING CORPORATION
发明人： ZHU, Hugh, Y. , COOPER, Alan, B. , DESAI, Jagdish, A. , WANG, James, J-S. , RANE, Dinanath, F. , DOLL, Ronald, J. , NJOROGE, F., George , GIRIJAVALLABHAN, Viyyoor, M.
IPC分类号： C07D401/06 , C07D401/14 , A61K31/415 , A61P35/00
CPC分类号： C07D401/06
摘要： Disclosed are novel tricyclic compounds of the formula (I) and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.
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15.发明授权
公开(公告)号：EP0934303B1
公开(公告)日：2004-12-29
申请号：EP97946875.8
申请日：1997-09-11
申请人： SCHERING CORPORATION
发明人： TAVERAS, Arthur, G. , MALLAMS, Alan, K. , AFONSO, Adriano , REMISZEWSKI, Stacy, W. , NJOROGE, F., George , DOLL, Ronald, J. , LALWANI, Tarik , ALVAREZ, Carmen
IPC分类号： C07D401/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Novel tricyclic compounds of formula (1.0) are disclosed. Compounds of formula (1.0) are represented by the compounds of formulas (1.4) or (1.5) wherein R?1, R3 and R4¿ are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.
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16.发明公开TRICYCLIC CARBAMATE COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环氨基甲酸酯衍生物用于抑制G-蛋白质功能和用于治疗增生性疾病
公开(公告)号：EP0817632A1
公开(公告)日：1998-01-14
申请号：EP96908751.0
申请日：1996-03-21
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J. , WOLIN, Ronald, L. , TAVERAS, Arthur, G. , REMISZEWSKI, Stacy, W.
CPC分类号： C07D401/12 , A61K31/4545 , A61K31/496 , C07D221/16 , C07D401/04 , C07D401/14
摘要： A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound selected from (800.00), (801.00), (802.00), (803.00), (804.00), or (805.00). Compounds of structures (800.00) - (805.00) are novel compounds.
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17.发明公开TRICYCLIC AMIDE AND UREA COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环酰胺和脲衍生物如适用G-蛋白质功能和抑制剂治疗增殖疾病治疗
公开(公告)号：EP0815100A1
公开(公告)日：1998-01-07
申请号：EP96909651.0
申请日：1996-03-21
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J. , WOLIN, Ronald, L. , TAVERAS, Arthur, G. , REMISZEWSKI, Stacy, W.
CPC分类号： C07D231/12 , A61K31/444 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds wherein X is N, C or OH and R is (I) or (II) are disclosed.
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18.发明公开TRICYCLIC AMIDE AND UREA COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环AMID用作G蛋白功能衍生物及其抑制剂增殖性疾病治疗
公开(公告)号：EP0815099A1
公开(公告)日：1998-01-07
申请号：EP96909650.0
申请日：1996-03-21
申请人： SCHERING CORPORATION
CPC分类号： C07D401/04 , C07D401/14 , C07D417/14
摘要： Novel compounds of formula (7.0a), (7.0b) or (7.0c) are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of formula (7.0a), (7.0b) or (7.0c) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
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公开(公告)号：EP2081922B1
公开(公告)日：2012-02-01
申请号：EP07870161.2
申请日：2007-12-17
申请人： Schering Corporation
发明人： BENNETT, Frank , VENKATRAMAN, Srikanth , NJOROGE, F., George , CHEN, Kevin, X. , SHIH, Neng-yang , ROSENBLUM, Stuart, B. , KOZLOWSKI, Joseph, A.
IPC分类号： C07D401/04
CPC分类号： C07D513/04 , C07D401/04 , C07D471/04 , C07D491/04
摘要： The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
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20.发明授权SULFUR COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE 有权硫化合物AS丙型肝炎病毒的NS3丝氨酸蛋白酶抑制剂的
公开(公告)号：EP1730110B9
公开(公告)日：2011-11-02
申请号：EP05723607.7
申请日：2005-02-24
申请人： Schering Corporation
发明人： BENNETT, Frank , LOVEY, Raymond G. , HUANG, Yuhua , HENDRATA, Siska , SAKSENA, Anil, K. , BOGEN, Stephane, L. , LIU, Yi-Tsung , NJOROGE, F., George , VENKATRAMAN, Srikanth , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , ARASAPPAN, Ashok , GIRIJAVALLABHAN, Viyyoor, M. , VELAZQUEZ, Francisco , NAIR, Latha
IPC分类号： C07D209/52 , C07D209/56 , C07D491/04 , C07K5/08 , C07K5/02 , A61K31/403 , A61K31/407 , A61P31/12
CPC分类号： C07D209/52 , A61K38/00 , C07D207/16 , C07D209/56 , C07D405/12 , C07D409/12 , C07D411/12 , C07D491/04 , C07K5/0202
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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